Incidental prostate cancer after transurethral resection of the prostate: analysis of incidence and risk factors in 458 patients

Aim: To identify the rate of incidental prostate cancer in patients undergone Transurethral resection of prostate(TURP) over a period of 5 years in our center. Methods: A Retrospective review was conducted using Histopathological department database on all TURP specimens over a period of 5 years from January 2015 to December 2019. Results: Out of 570 cases of TURP during our study period, 1.9% had incidental prostate cancer. Most of these positive cases had a Gleasons score of 10, which represent poorly differentiated Adenocarcinoma. Conclusion: The value of pathologic review of TURP specimens is limited but a detailed review helps to reduce under detection of prostate cancer.

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Incidental prostate cancer diagnosed following a transurethral resection of the prostate: A national database analysis in England

Journal of Clinical Urology ◽

10.1177/2051415815603275 ◽

2015 ◽

Vol 9 (3) ◽

pp. 170-176 ◽

Cited By ~ 1

Author(s):

Eleni Anastasiadis ◽

Jan van der Meulen ◽

Mark Emberton

Keyword(s):

Prostate Cancer ◽

Transurethral Resection ◽

National Database ◽

Database Analysis ◽

Incidental Prostate Cancer

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PSCA mRNA expression in preoperatively negative prostate biopsies predicts incidental prostate cancer in patients undergoing transurethral resection of the prostate for benign prostatic hyperplasia

Journal of Surgical Oncology ◽

10.1002/jso.21996 ◽

2011 ◽

Vol 104 (6) ◽

pp. 672-678 ◽

Cited By ~ 4

Author(s):

Zhigang Zhao ◽

Wenjing Ma ◽

Guohua Zeng ◽

Defeng Qi

Keyword(s):

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Mrna Expression ◽

Transurethral Resection ◽

Prostatic Hyperplasia ◽

Incidental Prostate Cancer ◽

Prostate Biopsies

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MP35-20 PREVALENCE OF INCIDENTAL PROSTATE CANCER IN HISTOLOGICAL SPECIMEN AFTER HOLMIUM LASER ENUCLEATION VERSUS TRANSURETHRAL RESECTION OF THE PROSTATE

The Journal of Urology ◽

10.1016/j.juro.2016.02.1612 ◽

2016 ◽

Vol 195 (4S) ◽

Author(s):

Annika Herlemann ◽

Kerstin Wegner ◽

Alexander Roosen ◽

Christian G. Stief ◽

Christian Gratzke ◽

...

Keyword(s):

Prostate Cancer ◽

Transurethral Resection ◽

Holmium Laser ◽

Incidental Prostate Cancer ◽

Laser Enucleation ◽

Holmium Laser Enucleation ◽

Histological Specimen

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Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20172095 ◽

2017 ◽

Vol 5 (6) ◽

pp. 2373 ◽

Cited By ~ 1

Author(s):

Anuja Sharma ◽

Mahima Sharma ◽

Shivani Gandhi ◽

Arvind Khajuria ◽

K. C. Goswami

Keyword(s):

Prostate Cancer ◽

Transurethral Resection ◽

Intraepithelial Neoplasia ◽

Premalignant Lesions ◽

Transurethral Resection Of Prostate ◽

Incidental Prostate Cancer ◽

Mortality And Morbidity ◽

Graduate Department ◽

Causes Of Mortality ◽

Prostatic Diseases

Background: Prostatic diseases like inflammation, benign prostatic hyperplasia and tumors are important causes of mortality and morbidity in males. The incidence of these lesions increases with advancing age. The second most common cancer among males is prostate cancer, next to lung cancer worldwide. Transurethral resection of prostate (TURP) is most frequently preformed surgical procedure in the clinical practice. The purpose of the study is to evaluate histomorphological spectrum of prostate lesions in TURP specimen with focus on premalignant lesions and incidental carcinomas.Methods: The present study includes 245 cases of TURP specimen from January 2015 to December 2016 received in the post graduate department of pathology, ASCOMS and Hospital. H and E stained sections were examined. The relevant clinical details pertaining to age, clinical complaints and microscopic details were analysed and compared with other similar studies.Results: Of the total 245 TURP specimen, 223 (91.02%) were of nodular hyperplasia, 14 (5.71%) were of prostatic intraepithelial neoplasia and 8 (3.26%) cases were malignant. Benign hyperplasia of prostate (BHP) alone accounted for 91.02% of TURP specimen. Less frequent findings were granulomatous prostatitis in 3.70% and atypical adenomatous hyperplasia (1.22%). All the 8 cases of prostate cancer were incidental carcinoma, 5 of which were poorly differentiated and 3 were moderately differentiated adenocarcinoma.Conclusions: The present study showed that non-neoplastic lesions of prostate are more common than neoplastic ones. The most frequently encountered prostatic lesion was BHP, commonly seen in the age group of 61-70 years. The malignant lesions were common among the males of more than 60 years. TURP can be helpful in early identification of premalignant lesions and incidental prostate cancer which can improve the treatment outcome of patients.

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Risk factors for incidental prostate cancer-who should not undergo vaporization of the prostate for benign prostate hyperplasia?

The Prostate ◽

10.1002/pros.21349 ◽

2011 ◽

Vol 71 (12) ◽

pp. 1325-1331 ◽

Cited By ~ 9

Author(s):

Susan Voigt ◽

Friederike Hüttig ◽

Rainer Koch ◽

Stefan Propping ◽

Catharina Propping ◽

...

Keyword(s):

Prostate Cancer ◽

Risk Factors ◽

Benign Prostate Hyperplasia ◽

Incidental Prostate Cancer ◽

Prostate Hyperplasia ◽

Benign Prostate

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Preoperative parameters to predict incidental (T1a and T1b) prostate cancer

Canadian Urological Association Journal ◽

10.5489/cuaj.1890 ◽

2014 ◽

Vol 8 (11-12) ◽

pp. 815 ◽

Cited By ~ 4

Author(s):

Hirofumi Sakamoto ◽

Kazuhiro Matsumoto ◽

Nozomi Hayakawa ◽

Takahiro Maeda ◽

Atsuko Sato ◽

...

Keyword(s):

Prostate Cancer ◽

Risk Factors ◽

Needle Biopsy ◽

Prostate Volume ◽

External Validation ◽

Specific Antigen ◽

Patient Age ◽

Incidental Prostate Cancer ◽

Patient Âgé ◽

Independent Risk Factors

Introduction: Prostate cancer has been found incidentally in transurethral resection of the prostate (TURP) specimens without prior diagnosis in 5% to 13% of the patients. We evaluated whether incidental prostate cancer (stages T1a and T1b) could be predicted preoperatively.Methods: TURP was performed in 307 patients between 2006 and 2011. Patient age, prostate-specific antigen (PSA) level, total prostate volume, transitional zone volume, PSA density, history of needle biopsy, and pathological diagnosis on TURP specimen were assessed. We analyzed the association between these parameters and prostate cancer detection.Results: Incidental prostate cancer was found in 31 patients (10.1%), and 13 cases (4.2%) had cancer with T1b and/or Gleason ≥7. Multivariate analysis demonstrated that age ≥75 years (odds ratio [OR] 2.58, p = 0.022), prostate volume ≤50 cc (OR 4.11, p < 0.001), and the absence of preoperative needle biopsy despite PSA ≥4 ng/mL (OR 2.65, p = 0.046) were independent risk factors. In patients who had 2 or 3 of these risk factors, incidental prostate cancer and cancer with T1b and/or Gleason ≥7 were observed in 25% to 50% and 16% to 25% cases, respectively.Conclusions: Older patient age, small prostate volume, and the absence of previous needle biopsy (despite a high PSA level) might be independent risk factors for detecting incidental prostate cancer, although external validation is warranted to confirm our results.

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