After giving a short overview about the published instrumentation and control standards worldwide with regard to the separation measures, as released by the different safety authorities, this paper provides a first assessment of the different needs and requirements to be considered in the frame of separation measures which are to be implemented in the instrumentation and control design. According to this analysis the corresponding design aspects and features are derived and analyzed. The experience gained both in nuclear power plant modernization projects and new builds show that there are margins both for interpretation possibilities and for possible technical solutions, which can be proposed to the customer in order to fulfill the concerned standards. A conclusion about the design approach and solutions as well as possible future scenarios is given.