scholarly journals Evaluating Bone Mineral Density in Pediatric Acute Lymphoblastic Leukemia Survivors: A Tertiary Care Hospital Experience

Author(s):  
Toret Ersin ◽  
Dural Burcu ◽  
Kar Yeter Duzenli ◽  
Ozdemir Zeynep Canan ◽  
Sivrikoz Ilknur Ak ◽  
...  
Haematologica ◽  
2009 ◽  
Vol 95 (5) ◽  
pp. 752-759 ◽  
Author(s):  
M. L. te Winkel ◽  
R. D. van Beek ◽  
S. M. P. F. de Muinck Keizer-Schrama ◽  
A. G. Uitterlinden ◽  
W. C. J. Hop ◽  
...  

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
S Tariq ◽  
A Stroiescu ◽  
J Mannion ◽  
N Caples ◽  
P O'Callaghan ◽  
...  

Abstract Background The strong association between heart failure (HF) and osteoporosis is well recognised. Heart failure, due to its multiple risk factors and common pathogenesis with osteoporosis can lead to low bone mineral density (BMD) and increase the risk of fragility fractures. The mortality of HF patients following these fractures is high. Current National Osteoporosis Foundation Guidelines recommend that pharmacological therapy should be reserved for postmenopausal women and men aged 50 years or older who present with a hip or vertebral fracture, where the vertebral fractures may be clinical or identified on a radiograph alone. Methods Most HF patients have frequent chest radiographs over their course years. We aimed to audit the prevalence of osteoporosis and current practice of prescribing BMD-protection in patients attending the HF clinic in a busy tertiary care hospital in Ireland. 100 patients attending the clinic in the last one year were randomly selected and clinical, medication and chest radiograph information on this cohort was collected via the hospital electronic information system. All those patients with Radiologist confirmed vertebral compression fractures (VCF) on their plain chest radiographs were audited regarding osteoporosis screening and bone protection prescription. Results Due to limited penetration,18 out of 100 chest radiographs were inconclusive,reducing the sample size to 82. 9 out of the remaining 82 patients had radiologist confirmed VCF on their plain chest radiographs whereas 2 patients had VCF incidentally picked up on their lumbar spine x-rays. All patients were aged more than 50. 4 were female and 7 male. Median ejection fraction calculated was 35%. 3 out of 11 were smokers,8 had atrial fibrillation and were on anticoagulation,4 had DM-II and 2 had CKD. 10 were on loop diuretics. Of note,4 patients were on calcium and vitamin D supplements but only 1 patient was on antiresorptive therapy for osteoporosis. Conclusion Despite its strong association with heart failure,Osteoporosis remains undertreated in this patient cohort.Due to the significant mortality and morbidity associated with major osteoporotic fractures, doctors should carefully assess and screen heart failure patients for osteoporosis and initiate specific therapy where indicated. FUNDunding Acknowledgement Type of funding sources: None.


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