Feeding Plate of an Eight-day-old Patient Having Veau Type III Cleft Lip and Palate

Congenital Cleft lip and palate is a craniofacial defect which results into difficulty in feeding because of the communication between the oral and nasal cavities. Feeding plate restores the gap between the oral and nasal cavities and helps in feeding and reduces the chances of airway problems, regurgitations. This clinical report describes a design and method of fabricating a feeding plate in an 8-day old neonate with a cleft lip and palate.

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Impact of cleft palate repair on speech and development of dentoalveolar deformities

Voprosy praktičeskoj pediatrii ◽

10.20953/1817-7646-2021-3-47-53 ◽

2021 ◽

Vol 16 (3) ◽

pp. 47-53

Author(s):

Yu.V. Stebeleva ◽

◽

Ad.A. Mamedov ◽

Yu.O. Volkov ◽

A.B. McLennan ◽

...

Keyword(s):

Cleft Palate ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Surgical Techniques ◽

Normal Functioning ◽

Primary Surgery ◽

Cleft Palate Repair ◽

Congenital Cleft ◽

Palate Repair ◽

Late Postoperative Period

Surgical repair of cleft palate is quite difficult because it aims not only to eliminate the anatomical defect of the palate, but also to ensure normal functioning, including speech. Moreover, successful surgery implies no or minimal deformation of the middle face that can be corrected in the late postoperative period. No doubt that primary surgery (both in terms of technique and time) is crucial for further growth and development of the maxilla. However, surgical techniques and the age of primary cleft palate repair vary between different clinics, which makes this literature review highly relevant. Key words: cleft palate repair, cleft palate, congenital cleft lip and palate

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MOLECULAR GENETIC STUDY OF THE IMPACT OF SNP C677T OF THE GENE MTHFR IN THE DEVELOPMENT OF CONGENITAL ISOLATED CLEFT LIP AND PALATE

Kuban Scientific Medical Bulletin ◽

10.25207/1608-6228-2018-25-5-104-110 ◽

2018 ◽

Vol 25 (5) ◽

pp. 104-110

Author(s):

V. S. Uchaeva ◽

Yu. A. Vasiliev ◽

A. S. Gracheva ◽

O. V. Gulenko ◽

I. G. Udina

Keyword(s):

Genetic Study ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Control Group ◽

Population Genetic Study ◽

Molecular Genetic Study ◽

Increased Risk ◽

Significant Difference ◽

Congenital Cleft ◽

The Impact

Aim. This research was designed to conduct an associative population genetic study for the consideration of the impact of SNP C677T of the gene MTHFR in the congenital maxillofacial developmental anomalies (CMDA): congenital cleft lip (CCL), congenital cleft palate (CCP), congenital cleft lip and palate (CCLP) in the Krasnodar territory. The aim of the study is to establish the associations between SNP C677T of the gene MTHFR and the development of congenital cleft lip and/ or palate.Materials and methods. In this research, the peculiarities of distribution of SNP C667T of the gene MTHFR in children with congenital cleft lip and/or palate (n=223) and their mothers (n=78) in comparison with the control group (n=124) were studied in the Krasnodar territory. The genetic demographic questionnaires were gathered for children with CMDA, the information about diagnosis was obtained from the medical records. The biological samples, including blood or scrapings of oral mucosa, were collected from children with the pathology and their mothers. The DNA was extracted from the samples by the standard method. The study of the peculiarities of distribution of alleles of SNP C677T of the gene MTHFR was performed by PCR-PFLP with endonuclease Hinf I or by tetra-primer ARMS-PCR method in children with CCL, CCP, CCLP, their mothers and the control group. Statistical processing of the obtained data was performed by the algorithms of the “Statistica” program.Results. While comparing the profiles of frequencies of SNP C677T in children with CCL, CCP and CCLP with the control group, there were identified no significant differences in the frequency of this SNP and no peculiarities of genotypes distribution. There was identified a significant difference in the peculiarities of genotypes distribution with the control group (G=19,5232, d.f.=1, p<0,001) as well as united genotypes (С/C и С/T) in accordance to T/T (G=10,4657, d.f.=1; p<0,001) and united genotypes (C/T и T/T) in accordance to C/C (G=15,1896, d.f.=1, p<0,001) for the mothers of children with CCL, CCP and CCLP.Conclusion. As a result of the study, we established the association of SNP C677T of the MTHFR gene with the development of congenital cleft lip and/or palate: mothers’ T/T genotype is associated with the increased risk of giving birth to a child with CCL, CCP and CCLP (in comparison with mothers with C/C+C/T genotype): odds ratio [OR]=16,63, 95% CI: 3,86-71,71; p=0,0003 and also for mothers with genotypes (C/T+T/T) in comparison with mothers with genotypes C/C: OR=3,22, CI:1,71-6,08; p=0,0002. The amount of risk is not significant in children with CMDA for T/T genotype. So it is possible to make a conclusion about the impact of C677T of the gene MTHFR in the development of CCL, CCP and CCLP only in mother’s genotype.

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Defects of immune system function in immunocompromised children with congenital cleft lip and palate and recurrent respiratory infections

Immunologiya ◽

10.33029/0206-4952-2020-41-1-64-73 ◽

2020 ◽

Vol 41 (1) ◽

pp. 64-73

Author(s):

I.V. Nesterova ◽

◽

M.N. Mitropanova ◽

G.A. Chudilova ◽

S.V. Kovaleva ◽

...

Keyword(s):

Immune System ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Respiratory Infections ◽

System Function ◽

Recurrent Respiratory Infections ◽

Immune System Function ◽

Congenital Cleft

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Congenital cleft lip and palate in children from Tajikistan in 2009–2019

Aspirantskiy Vestnik Povolzhiya ◽

10.17816/2072-2354.2020.20.1.75-79 ◽

2020 ◽

Vol 20 (1-2) ◽

pp. 75-79

Author(s):

Abdugafor Z. Abdurahmonov

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Medical Center ◽

Archival Data ◽

Number Of Children ◽

National Medical ◽

Outpatient Visits ◽

Congenital Cleft ◽

The Republic

We analyzed the dynamics of congenital cleft lip and palate in children and studied the archival data of the National Medical Center Shifobakhsh (Dushanbe) of the Republic of Tajikistan on the incidence of outpatient visits due to this abnormality in the Republic of Tajikistan over the period from 2009 to 2019. The number of children born with congenital cleft has been increasing for the last ten years. We found out this pathology to develop in families with in-and-in marriage, it also depends upon the sex of a child. Boys are more prone to maxillofacial anomalies.

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The local interferon-corrective therapy in children with congenital cleft lip and palate, suffering from the recurrent respiratory infections

Russian Journal of Infection and Immunity ◽

10.15789/2220-7619-tli-1352 ◽

2020 ◽

Vol 10 (2) ◽

pp. 368-374

Author(s):

I. V. Nesterova ◽

M. N. Mitropanova ◽

G. A. Chudilova ◽

S. V. Kovaleva ◽

E. O. Khalturina

Keyword(s):

Oral Fluid ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Viral Infections ◽

Respiratory Infections ◽

Control Group ◽

Recurrent Respiratory Infections ◽

Congenital Cleft ◽

Group 2 ◽

Group 1

It is known that children with congenital cleft lip and palate are suffering from recurrent respiratory infections, which worsen the state of their health, and also complicate the results of reconstructive surgical treatment. The aim of the study was to detect defects of mucosal immunity in children with congenital cleft lip and palate, suffering from recurrent respiratory infections, and to create the program of local interferon corrective therapy with an assessment of its effectiveness. The studies included 56 children from the age of 1 to 3 years. Three groups of children were formed: group 1 – 26 children with congenital cleft lip and palate (antibiotic therapy); group 2 — 30 children with congenital cleft lip and palate (antibiotic therapy + local interferon therapy), group 3 — the control group. The clinical examination included a medical history, an assessment of the symptoms of recurrent episodes of acute respiratory infections and exacerbations of chronic infections. Microbiological studies were performed using standard methods. The status of local immunity was detected: the concentrations of secretory IgA, cytokines IL-17, IL-4, IL-6, IL-1β, IFNγ in the oral fluid were tested by ELISA. Results of the study established that in group 1 and group 2 clinical criteria of immunodeficiency with an infectious syndrome were revealed: repeated acute respiratory viral infections from 10 or more times a year, complicated by frequent exacerbations of chronic bacterial infection (up to 10 or more per year). Assessment of the state of local immunity in children with congenital cleft lip and palate revealed a lack of sIgA compared with the control group. Before treatment in group 2 oral fluid level of IL-17, IL-6 were statistically significant increase (p < 0.05); the results of the study also established increase in the level of IL-1β and a decrease in anti-inflammatory IL-4 and regulatory IFNγ relative to the control group (p > 0.05). After complex treatment with the inclusion of local interferon therapy in group 2 the appearance of sIgA, increase in the concentration of IL-4, IL-1β and a decrease IL-17 in oral fluid were observed (p > 0.05). The concentrations of IL-6, IFNγ did not change (p > 0.05). After treatment in group 2 there were a decrease in exacerbations of chronic upper respiratory tract infection and in frequency of acute respiratory viral infections compared with group 1 (p < 0.05). Positive clinical efficacy of local interferon therapy (the gel of recombinant IFNα2b in combination with oxidants — Viferon gel) in the process of staged rehabilitation of children with congenital cleft lip and palate has a protective clinical effect in reducing the frequency of acute respiratory viral infections, reducing the number of postoperative complications, reducing hospital stay, duration of antibacterial therapy and the number of exacerbations of chronic bacterial infection.

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Successful Management of Feeding Difficulties in Patient with Severe Bilateral Cleft Lip and Palate

Journal of Contemporary Dentistry ◽

10.5005/jp-journals-10031-1081 ◽

2014 ◽

Vol 4 (2) ◽

pp. 124-126

Author(s):

Dimple Padawe ◽

Vilas Takate ◽

Tanay Gunjikar

Keyword(s):

Cleft Lip ◽

Developmental Disorder ◽

Cleft Lip And Palate ◽

Failure To Thrive ◽

Later Life ◽

Successful Management ◽

Feeding Difficulties ◽

Psychological Maladjustment ◽

Bilateral Cleft Lip ◽

Feeding Plate

ABSTRACT Cleft lip and palate is one of the most common developmental disorder found in humans. A child born with cleft lip and palate has plethora of complex problems, such as feeding difficulties, middle ear diseases, dentofacial abnormalities, slow weight gain, and even failure to thrive. Feeding difficulties are the main cause of distress for both the child and mother, and may also lead to psychological maladjustment of child in later life. Various methods have been described to overcome feeding difficulties faced child and mother. This case report describes a case of severe bilateral cleft lip and palate (Veau's class IV cleft) successfully managed by fabrication of simple feeding plate and counseling of mother. How to cite this article Padawe D, Takate V, Gunjikar T. Successful Management of Feeding Difficulties in Patient with Severe Bilateral Cleft Lip and Palate. J Contemp Dent 2014; 4(2):124-126.

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THE MAIN DIRECTIONS IN THE COMPLEX REHABILITATION OF CHILDREN WITH CLEFT LIP AND PALATE

Pediatric Traumatology Orthopaedics and Reconstructive Surgery ◽

10.17816/ptors1136-43 ◽

2013 ◽

Vol 1 (1) ◽

pp. 36-43 ◽

Cited By ~ 1

Author(s):

Yulia Vladimirovna Stepanova ◽

Margarita Sergeevna Tsyplakova

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Social Adaptation ◽

Psychological Help ◽

Complex Treatment ◽

Upper Lip ◽

Orthopedic Treatment ◽

Professional Psychological Help ◽

Specialized Center ◽

Congenital Cleft

Complex treatment of children with cleft lip and palate is complicated and multi-step. Treatment is conducted by high-skilled specialists. The organization and execution of this complex are possible only at the large specialized center. Coordinator of this work is the maxillofacial surgeon. The performance of rehabilitation circuits includes preoperative orthodontic and orthopedic treatment, operative intervention (reconstructive and plastic surgery), orthodontic and orthopedic treatment after operation. Post-operative conservative treatment prevents the development of secondary deformities of the nose and upper lip. Professional psychological help and long supervision promote the achievement of good social adaptation of patients with congenital cleft lip and palate, improvement of their health.

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