scholarly journals Congenital cleft lip and palate in children from Tajikistan in 2009–2019

2020 ◽  
Vol 20 (1-2) ◽  
pp. 75-79
Author(s):  
Abdugafor Z. Abdurahmonov
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Medical Center ◽  
Archival Data ◽  
Number Of Children ◽  
National Medical ◽  
Outpatient Visits ◽  
Congenital Cleft ◽  
The Republic

We analyzed the dynamics of congenital cleft lip and palate in children and studied the archival data of the National Medical Center Shifobakhsh (Dushanbe) of the Republic of Tajikistan on the incidence of outpatient visits due to this abnormality in the Republic of Tajikistan over the period from 2009 to 2019. The number of children born with congenital cleft has been increasing for the last ten years. We found out this pathology to develop in families with in-and-in marriage, it also depends upon the sex of a child. Boys are more prone to maxillofacial anomalies.

scholarly journals CLINICAL AND ANATOMICAL FORMS OF CONGENITAL CLEFT LIP AND PALATE IN THE REGION WITH ECOTOXICANTS

2019 ◽  
Vol 15 (3) ◽  
pp. 127-132 ◽  
Author(s):  
Сергей Чуйкин ◽  
Sergey Chuykin ◽  
Назим Джумартов ◽  
Nazim Dzhumartov ◽  
Олег Чуйкин ◽  
...  
Keyword(s):  
Petrochemical Industry ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Maxillofacial Surgery ◽  
Industrial Area ◽  
Medical Documentation ◽  
Number Of Children ◽  
Republic Of Bashkortostan ◽  
Congenital Cleft ◽  
The Republic

Subject: the study of the features of clinical and anatomical forms of congenital cleft lip and palate in the region with the petrochemical industry. Objectives ― determination of the clinical-anatomical forms of congenital cleft lip and palate, the identification of the frequency of severe forms in the region with the petrochemical industry and in the region without industrial eco-toxicants. Methods. We have studied medical documentation in the Department of Maxillofacial Surgery of the Republican Children's Clinical Hospital for the period from January 1, 1985 to December 31, 2018 to study the structure of the clinical and anatomical forms of congenital clefts of the lips and palate in children living in the Republic of Bashkortostan. During the analyzed period, 3463 children from birth to 16 years with congenital cleft lip and palate underwent treatment and dispensary observation. Results. Our data suggest that in the area with petrochemical ecotoxicants, the percentage of severe forms of congenital cleft lip and palate is higher (77.5%) than in an area without petrochemical ecotoxicants (68.7%). Conclusions. Thus, environmental pollution by petrochemical ecotoxicants leads to an increase in the number of children with congenital cleft lip and palate. There is a relationship between the level of air pollution by gross emissions from petrochemical enterprises and the severity of the clinical-anatomical forms of congenital cleft lip and palate in children living in an industrial area. It is important and important in the prenatal prevention of congenital clefts of the lip and palate.

scholarly journals ORTHODONTIC TREATMENT FOR CONGENITAL CLEFT LIP AND PALATE IN CHILDREN

2021 ◽  
Vol 11 (1) ◽  
pp. 162-166
Author(s):  
Mikhail Postnikov ◽  
Abdugafor Abdurakhmonov ◽  
Nataliia Pankratova ◽  
Svetlana Chigarina ◽  
Zulfiya Yakubova ◽  
...  
Keyword(s):  
Group Treatment ◽  
Orthodontic Treatment ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Statistical Processing ◽  
Cast Model ◽  
Congenital Cleft ◽  
Maxillofacial Abnormalities ◽  
The Republic ◽  
Close Relatives

One in 1,000 newborns appears with a congenital maxillofacial anomaly, which accounts for about 0.04% of the world's entire population of the planet. Patients with cleft lip and palate have a significantly lower quality of life. Early orthodontic treatment (EOT) offered to children from the first days of life is a preparatory link in the preoperative period, laying favorable grounds for surgical intervention. EOT is a reasonable option to separate the oral cavity from the nasal cavity, to prevent consequent issues as well as to bring feeding back to the normal. This study involved clinical examinations and early orthodontic treatment of 84 children with congenital bilateral cleft upper lip and palate (CBCULP) from the first days of life and infants based on their referrals coming from all regions of the Republic of Tajikistan embracing the period of 2015 to 2019. Newborns with bilateral CULP within 5 days following birth, and infants who were referred for early orthodontic treatment, had their upper jaw cast model prepared using specially designed and modified spoons for taking impressions in case of cleft lip and palate. Within the study, unrelated marriages prevailed 3.4 times over related ones, which accounted for 22.6% of the cases examined. There were 1.58 times more boys than girls. Close relatives featured congenital maxillofacial abnormalities in 16.1% of the cases. The share of related marriages was 12.9%. Follow-up period — 2016–2017; the patients' age — from the birth period to 1 year. The children were divided into two groups. In the main group, EOT was performed using a dental obturator for orthodontic treatment of children with CBCULP prior to the surgery (n=43). In the comparison group, treatment was carried out in the conventional way (n=41). Before the surgery, all the children were examined through clinical, anthropometric and photometric methods. The statistical processing of the obtained data revealed that before the start of treatment, the studied groups were comparable with no statistically significant differences identified. After the treatment, the age, the weight, as well as the height of the children expectably changed in both groups (p<0.001).

ESTIMATION OF ENDOSCOPIC SYNUSOTHOMY EFFICIENCY IN CHRONIC RHINOSINUSITIS WITH NASAL POLYPS BASED ON DATA OF ENT CLINIC OF PUBLIC INSTITUTION «NATIONAL MEDICAL CENTER» OF THE REPUBLIC OF TAJIKISTAN

2017 ◽  
Vol 19 (1) ◽  
Author(s):  
Mahmadulo Ikromov ◽  
◽  
Diloshub Davlatov ◽  
Mohira Nazirmadova ◽  
Abduzokir Abduhalilov ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Medical Center ◽  
Public Institution ◽  
National Medical ◽  
The Republic

Impact of cleft palate repair on speech and development of dentoalveolar deformities

2021 ◽  
Vol 16 (3) ◽  
pp. 47-53
Author(s):  
Yu.V. Stebeleva ◽  
◽  
Ad.A. Mamedov ◽  
Yu.O. Volkov ◽  
A.B. McLennan ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Surgical Techniques ◽  
Normal Functioning ◽  
Primary Surgery ◽  
Cleft Palate Repair ◽  
Congenital Cleft ◽  
Palate Repair ◽  
Late Postoperative Period

Surgical repair of cleft palate is quite difficult because it aims not only to eliminate the anatomical defect of the palate, but also to ensure normal functioning, including speech. Moreover, successful surgery implies no or minimal deformation of the middle face that can be corrected in the late postoperative period. No doubt that primary surgery (both in terms of technique and time) is crucial for further growth and development of the maxilla. However, surgical techniques and the age of primary cleft palate repair vary between different clinics, which makes this literature review highly relevant. Key words: cleft palate repair, cleft palate, congenital cleft lip and palate

scholarly journals MOLECULAR GENETIC STUDY OF THE IMPACT OF SNP C677T OF THE GENE MTHFR IN THE DEVELOPMENT OF CONGENITAL ISOLATED CLEFT LIP AND PALATE

2018 ◽  
Vol 25 (5) ◽  
pp. 104-110
Author(s):  
V. S. Uchaeva ◽  
Yu. A. Vasiliev ◽  
A. S. Gracheva ◽  
O. V. Gulenko ◽  
I. G. Udina
Keyword(s):  
Genetic Study ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Control Group ◽  
Population Genetic Study ◽  
Molecular Genetic Study ◽  
Increased Risk ◽  
Significant Difference ◽  
Congenital Cleft ◽  
The Impact

Aim. This research was designed to conduct an associative population genetic study for the consideration of the impact of SNP C677T of the gene MTHFR in the congenital maxillofacial developmental anomalies (CMDA): congenital cleft lip (CCL), congenital cleft palate (CCP), congenital cleft lip and palate (CCLP) in the Krasnodar territory. The aim of the study is to establish the associations between SNP C677T of the gene MTHFR and the development of congenital cleft lip and/ or palate.Materials and methods. In this research, the peculiarities of distribution of SNP C667T of the gene MTHFR in children with congenital cleft lip and/or palate (n=223) and their mothers (n=78) in comparison with the control group (n=124) were studied in the Krasnodar territory. The genetic demographic questionnaires were gathered for children with CMDA, the information about diagnosis was obtained from the medical records. The biological samples, including blood or scrapings of oral mucosa, were collected from children with the pathology and their mothers. The DNA was extracted from the samples by the standard method. The study of the peculiarities of distribution of alleles of SNP C677T of the gene MTHFR was performed by PCR-PFLP with endonuclease Hinf I or by tetra-primer ARMS-PCR method in children with CCL, CCP, CCLP, their mothers and the control group. Statistical processing of the obtained data was performed by the algorithms of the “Statistica” program.Results. While comparing the profiles of frequencies of SNP C677T in children with CCL, CCP and CCLP with the control group, there were identified no significant differences in the frequency of this SNP and no peculiarities of genotypes distribution. There was identified a significant difference in the peculiarities of genotypes distribution with the control group (G=19,5232, d.f.=1, p<0,001) as well as united genotypes (С/C и С/T) in accordance to T/T (G=10,4657, d.f.=1; p<0,001) and united genotypes (C/T и T/T) in accordance to C/C (G=15,1896, d.f.=1, p<0,001) for the mothers of children with CCL, CCP and CCLP.Conclusion. As a result of the study, we established the association of SNP C677T of the MTHFR gene with the development of congenital cleft lip and/or palate: mothers’ T/T genotype is associated with the increased risk of giving birth to a child with CCL, CCP and CCLP (in comparison with mothers with C/C+C/T genotype): odds ratio [OR]=16,63, 95% CI: 3,86-71,71; p=0,0003 and also for mothers with genotypes (C/T+T/T) in comparison with mothers with genotypes C/C: OR=3,22, CI:1,71-6,08; p=0,0002. The amount of risk is not significant in children with CMDA for T/T genotype. So it is possible to make a conclusion about the impact of C677T of the gene MTHFR in the development of CCL, CCP and CCLP only in mother’s genotype. 

scholarly journals Defects of immune system function in immunocompromised children with congenital cleft lip and palate and recurrent respiratory infections

Immunologiya ◽  
2020 ◽  
Vol 41 (1) ◽  
pp. 64-73
Author(s):  
I.V. Nesterova ◽  
◽  
M.N. Mitropanova ◽  
G.A. Chudilova ◽  
S.V. Kovaleva ◽  
...  
Keyword(s):  
Immune System ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Respiratory Infections ◽  
System Function ◽  
Recurrent Respiratory Infections ◽  
Immune System Function ◽  
Congenital Cleft

scholarly journals The local interferon-corrective therapy in children with congenital cleft lip and palate, suffering from the recurrent respiratory infections

2020 ◽  
Vol 10 (2) ◽  
pp. 368-374
Author(s):  
I. V. Nesterova ◽  
M. N. Mitropanova ◽  
G. A. Chudilova ◽  
S. V. Kovaleva ◽  
E. O. Khalturina
Keyword(s):  
Oral Fluid ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Control Group ◽  
Recurrent Respiratory Infections ◽  
Congenital Cleft ◽  
Group 2 ◽  
Group 1

It is known that children with congenital cleft lip and palate are suffering from recurrent respiratory infections, which worsen the state of their health, and also complicate the results of reconstructive surgical treatment. The aim of the study was to detect defects of mucosal immunity in children with congenital cleft lip and palate, suffering from recurrent respiratory infections, and to create the program of local interferon corrective therapy with an assessment of its effectiveness. The studies included 56 children from the age of 1 to 3 years. Three groups of children were formed: group 1 – 26 children with congenital cleft lip and palate (antibiotic therapy); group 2 — 30 children with congenital cleft lip and palate (antibiotic therapy + local interferon therapy), group 3 — the control group. The clinical examination included a medical history, an assessment of the symptoms of recurrent episodes of acute respiratory infections and exacerbations of chronic infections. Microbiological studies were performed using standard methods. The status of local immunity was detected: the concentrations of secretory IgA, cytokines IL-17, IL-4, IL-6, IL-1β, IFNγ in the oral fluid were tested by ELISA. Results of the study established that in group 1 and group 2 clinical criteria of immunodeficiency with an infectious syndrome were revealed: repeated acute respiratory viral infections from 10 or more times a year, complicated by frequent exacerbations of chronic bacterial infection (up to 10 or more per year). Assessment of the state of local immunity in children with congenital cleft lip and palate revealed a lack of sIgA compared with the control group. Before treatment in group 2 oral fluid level of IL-17, IL-6 were statistically significant increase (p < 0.05); the results of the study also established increase in the level of IL-1β and a decrease in anti-inflammatory IL-4 and regulatory IFNγ relative to the control group (p > 0.05). After complex treatment with the inclusion of local interferon therapy in group 2 the appearance of sIgA, increase in the concentration of IL-4, IL-1β and a decrease IL-17 in oral fluid were observed (p > 0.05). The concentrations of IL-6, IFNγ did not change (p > 0.05). After treatment in group 2 there were a decrease in exacerbations of chronic upper respiratory tract infection and in frequency of acute respiratory viral infections compared with group 1 (p < 0.05). Positive clinical efficacy of local interferon therapy (the gel of recombinant IFNα2b in combination with oxidants — Viferon gel) in the process of staged rehabilitation of children with congenital cleft lip and palate has a protective clinical effect in reducing the frequency of acute respiratory viral infections, reducing the number of postoperative complications, reducing hospital stay, duration of antibacterial therapy and the number of exacerbations of chronic bacterial infection.

scholarly journals THE MAIN DIRECTIONS IN THE COMPLEX REHABILITATION OF CHILDREN WITH CLEFT LIP AND PALATE

2013 ◽  
Vol 1 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Yulia Vladimirovna Stepanova ◽  
Margarita Sergeevna Tsyplakova
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Social Adaptation ◽  
Psychological Help ◽  
Complex Treatment ◽  
Upper Lip ◽  
Orthopedic Treatment ◽  
Professional Psychological Help ◽  
Specialized Center ◽  
Congenital Cleft

Complex treatment of children with cleft lip and palate is complicated and multi-step. Treatment is conducted by high-skilled specialists. The organization and execution of this complex are possible only at the large specialized center. Coordinator of this work is the maxillofacial surgeon. The performance of rehabilitation circuits includes preoperative orthodontic and orthopedic treatment, operative intervention (reconstructive and plastic surgery), orthodontic and orthopedic treatment after operation. Post-operative conservative treatment prevents the development of secondary deformities of the nose and upper lip. Professional psychological help and long supervision promote the achievement of good social adaptation of patients with congenital cleft lip and palate, improvement of their health.

Observed Social Interaction Patterns in Adolescents with and without Craniofacial Conditions

1997 ◽  
Vol 34 (5) ◽  
pp. 380-384 ◽  
Author(s):  
Kathleen A. Kapp-Simon ◽  
Dennis E. Mcguire
Keyword(s):  
Social Interaction ◽  
Social Interactions ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Social Contact ◽  
School Lunch ◽  
Interaction Patterns ◽  
Number Of Children ◽  
Type Frequency ◽  
Social Interaction Skills

Objective: This study examined social interactions of adolescents in a natural environment (school lunch room) to determine if there were identifiable differences in social behavior between children with and without craniofacial conditions (CFC). Design: This was an observational study comparing social interaction skills of children with CFC to peers without craniofacial conditions. Setting: The observations were conducted in the respective school lunch rooms of the adolescents with CFC. Participants: Clinical subjects were 13 adolescents (4 male) with various craniofacial conditions (5 cleft lip and palate) and 12 (4 male) peers without CFC present in the same lunch room. Main Outcome Measures: An unknown observer obtained 45 minutes of structured observational data on subject initiations, responses, nondirected comments, and extended conversations over two to three lunch room periods. Data was coded on the Epson HX-20 for type, frequency, and duration of social contact. Specific measures included: subject initiations and responses, peer initiations and responses, conversations events, and nondirected comments. Results: Statistically significant differences were found between CFC and comparison subjects (CS) on each social interaction variable measured. CS initiated more contacts, received positive responses more frequently, and engaged in longer conversations than CFC subjects ([F (1,24) = 14.1, p <.01; F (1,24) = 61.2, p <.001; F (1,24) = 5.50, p <.05]. CS were approached by and responded appropriately to peers more often [F (1,24) = 28.1, p <.001; F (1,24) = 43.2, p <.001]. Subjects with CFC were more likely to produce nondirected comments (N = 7, x = 0, p < .01). Conclusions: A significant number of children with CFC behaved differently than their peers in a natural, daily occurring situation. They were often at the periphery of the group, observers rather than participants in conversation.

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