DIFFERENTIAL-DIAGNOSTIC CRITERIA OF SEVERITY OF THE URINARY SYSTEM FUNCTIONAL STATE DISORDERS IN TERM NEWBORNS IN CASE OF PATHOLOGY OF EARLY NEONATAL PERIOD

Sirenomelia is extremely rare congenital malformation that characterized by the complete or incomplete fusion of the low extremities and associated by the various organs’ disorders, such as urinary system, which determined the poor outcome in these infants that died during antenatal or early neonatal period. Prenatal ultrasonography, especially during first-second trimester, permits to establish the presence of sirenomelia. Due to the rarity of this malformation, the own observation of first case of sirenomelia in one infant from twins is presented, which borne in Ukraine. Diagnosis of sirenomelia was established at the planned ultrasonographic screening of multigravida mother. After the birth, neonate with sirenomelia was transferred at the intensive care unit of Lviv regional children’s clinical hospital «OXMATDYT». At the first examination, the throughout fusion of lower extremities, the absent of one kidney, bladder, and external genitalia was revealed. With increasing signs of renal and respiratory failure baby died at 9 days after birth. Conclusions. Sirenomelia is extremely rare congenital malformation that associated with the high mortality during early neonatal period due to the presence of underlying congenital malformations, such as urinary system. Ultrasonography during the prenatal period is the screening methods for the diagnosis of this malformation. No conflict of interest was declared by the authors. Key words: sirenomelia, diagnostic, twins.

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Influence of SARS-CoV-2 acute respiratory viral disease on pregnancy and childbirth

Reproductive health of woman ◽

10.30841/2708-8731.2.2021.232515 ◽

2021 ◽

Vol 2 ◽

pp. 15-18

Author(s):

S.М. Turyanytsya ◽

O.O. Korchins’ka ◽

A.V. Sabova ◽

O.A. Baloga ◽

V.O. Petrov

Keyword(s):

Pregnant Women ◽

Neonatal Period ◽

Viral Disease ◽

Maternity Hospital ◽

Clear Correlation ◽

Pregnancy And Childbirth ◽

Early Neonatal Period ◽

Term Newborns ◽

Acute Respiratory Viral Infection ◽

Physiological Childbirth

Acute Respiratory Viral Disease SARS - CoV2 - 19 is a new poorly understood disease with an unpredictable course. This article is devoted to the analysis of coronavirus disease and its impact on the condition of newborns.The objective: to identify and investigate the relationship between the detected and revealed SARS-CoV-2 disease and the course of pregnancy and childbirth, dependence on the term in which the diagnosis was established and the consequences of the disease on the course of pregnancy, childbirth and the condition of newborns; to investigate the frequency of detected complications during pregnancy and the peculiarities of the course of pregnancy with combined pathology.Materials and methods. We analyzed 57 stories of pregnancy and childbirth of women who were admitted to the Uzhgorod City Maternity Hospital in the period from May 2020 to January 2021 with a positive result of the SARS-CoV-2 PLR study.Results. Of 57 patients, pregnancy is ongoing in 18 women, and in 39 it has already ended. Of these, 17 (29.8%) women had vaginal physiological childbirth, 21 (36.8%) women had pathological course of labor, of which 16 (28%) patients underwent cesarean section. In general, 34 pregnant women (59.6%) were asymptomatic. A mild course of the disease was in 20 pregnant women (35%), and a severe course was in three patients (5.2%). As a result of 39 births, 41 children were born (two biochorial twins). Of these, 38 children were born alive (92.7%), stillborn - 4 (5.3%). 31 children were born on time (81.6%). The physiological course of the early neonatal period was observed in all full-term newborns. Perinatal loss was observed in three women at 23, 25 and 28 weeks.Conclusions. In children born of mothers with COVID-19, there was no increase in the frequency of the pathological course of the early neonatal period or detected signs of acute respiratory viral infection. It was also found that there is no clear correlation between the severity of the course of coronavirus infection and complications in pregnant women. So, with a relatively easy mile, even an asymptomatic course, threatening complications were observed, since premature detachment of a normally located placenta was evident, but there was no clear correlation between coronavirus, while with a moderate course of pregnancy, we observed a fairly good result of delivery. The sample of patients is very small and does not allow us to draw definitive conclusions about the effect of coronavirus on pregnancy and fetal health. But these data give us the basis for the next studies on the influence of the new SARS-CoV-2 virus on the course of the gestational process, childbirth and the condition of newborns.

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PATHOGENIC ASPECTS OF FUNCTIONAL DISORDERS OF THE URINARY SYSTEM IN TERM NEONATES WITH PATHOLOGY OF EARLY NEONATAL PERIOD

Neonatology surgery and perinatal medicine ◽

10.24061/2413-4260.vii.3.25.2017.6 ◽

2017 ◽

Vol 7 (3(25)) ◽

pp. 34-42

Author(s):

A. G. Babintseva

Keyword(s):

Neonatal Period ◽

Urinary System ◽

Functional Disorders ◽

Term Neonates ◽

Early Neonatal Period

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FUNCTIONAL STATE OF KIDNEYS WITH DESYNCHRONY NEURONOGENESIS IN CHILDREN EXTREMELY LOW BODY WEIGHT IN THE EARLY NEONATAL PERIOD

SCIENTIFIC MEDICAL BULLETIN OF UGRA ◽

10.25017/2306-1367-2019-22-4-31-37 ◽

2019 ◽

Vol 22 (4) ◽

pp. 31-37

Author(s):

Tatyana Nikolaevna Ugleva ◽

◽

Vladimir Leonidovich Yanin ◽

Liliya Aleksandrovna Alekseenko ◽

Elena Dmitrievna Hadieva ◽

...

Keyword(s):

Body Weight ◽

Functional State ◽

Neonatal Period ◽

Early Neonatal Period

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C reactive protein and procalcitonin: Reference intervals for preterm and term newborns during the early neonatal period

Clinica Chimica Acta ◽

10.1016/j.cca.2011.02.020 ◽

2011 ◽

Vol 412 (11-12) ◽

pp. 1053-1059 ◽

Cited By ~ 94

Author(s):

Claudio Chiesa ◽

Fabio Natale ◽

Roberto Pascone ◽

John F. Osborn ◽

Lucia Pacifico ◽

...

Keyword(s):

Neonatal Period ◽

Reference Intervals ◽

C Reactive Protein ◽

Reactive Protein ◽

Early Neonatal Period ◽

Term Newborns

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A Case of Congenital Glucose Galactose Malabsorption with a New Mutation in the SLC5A1 Gene

Journal of Pediatric Genetics ◽

10.1055/s-0040-1719161 ◽

2020 ◽

Author(s):

Hasan Akduman ◽

Dilek Dilli ◽

Serdar Ceylaner

Keyword(s):

Mutation Analysis ◽

Autosomal Recessive ◽

Glucose Transporter ◽

Neonatal Period ◽

Autosomal Recessive Disorder ◽

Homozygous Mutation ◽

New Mutation ◽

Early Neonatal Period ◽

Sodium Dependent ◽

Hypernatremic Dehydration

AbstractCongenital glucose-galactose malabsorption (CGGM) is an autosomal recessive disorder originating from an abnormal transporter mechanism in the intestines. It was sourced from a mutation in the SLC5A1 gene, which encodes a sodium-dependent glucose transporter. Here we report a 2-day-old girl with CGGM who presented with severe hypernatremic dehydration due to diarrhea beginning in the first hours of life. Mutation analysis revealed a novel homozygous mutation NM_000343.3 c.127G > A (p.Gly43Arg) in the SLC5A1 gene. Since CGGM can cause fatal diarrhea in the early neonatal period, timely diagnosis of the disease seems to be essential.

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