C reactive protein and procalcitonin: Reference intervals for preterm and term newborns during the early neonatal period

2011 ◽  
Vol 412 (11-12) ◽  
pp. 1053-1059 ◽  
Author(s):  
Claudio Chiesa ◽  
Fabio Natale ◽  
Roberto Pascone ◽  
John F. Osborn ◽  
Lucia Pacifico ◽  
...  
Keyword(s):  
Neonatal Period ◽  
Reference Intervals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Early Neonatal Period ◽  
Term Newborns

Reference intervals for procalcitonin and C-reactive protein after major abdominal surgery

2002 ◽  
Vol 62 (3) ◽  
pp. 189-194 ◽  
Author(s):  
M. Lindberg ◽  
A. Åsberg ◽  
H. E. Myrvold ◽  
A. Hole ◽  
A. Rydning ◽  
...  
Keyword(s):  
Abdominal Surgery ◽  
Reference Intervals ◽  
Major Abdominal Surgery ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Serial Measurements of C-Reactive Protein and Interleukin-6 in the Immediate Postnatal Period: Reference Intervals and Analysis of Maternal and Perinatal Confounders

2001 ◽  
Vol 47 (6) ◽  
pp. 1016-1022 ◽  
Author(s):  
Claudio Chiesa ◽  
Fabrizio Signore ◽  
Marcello Assumma ◽  
Elsa Buffone ◽  
Paola Tramontozzi ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Early Onset ◽  
Gestational Hypertension ◽  
Neonatal Infection ◽  
Reference Intervals ◽  
Postnatal Period ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Wide Range ◽  
Near Term

Abstract Background: There is a wide range of reported sensitivities and specificities for C-reactive protein (CRP) and interleukin-6 (IL-6) in the detection of early-onset neonatal infection. This prompted us to assess reference intervals for CRP and IL-6 during the 48-h period immediately after birth and to identify maternal and perinatal factors that may affect them. Methods: CRP and IL-6 values were prospectively obtained for 148 healthy babies (113 term, 35 near-term) at birth and at 24 and 48 h of life, and from their mothers at delivery. Results: Upper reference limits for CRP at each neonatal age were established. At birth, CRP was significantly lower than at 24 and 48 h of life. Rupture of membranes ≥18 h, perinatal distress, and gestational hypertension significantly affected the neonatal CRP dynamics, but at specific ages. There was no correlation between CRP concentrations in mothers and their offspring at birth. The IL-6 values observed in the delivering mothers and in their babies at all three neonatal ages were negatively associated with gestational age. In the immediate postnatal period, IL-6 dynamics for term babies were significantly different from those for near-term babies. Maternal IL-6 concentrations correlated with babies’ IL-6 concentrations only for term deliveries. Apgar score had a significant effect on babies’ IL-6 values at birth. Conclusions: The patterns of CRP and IL-6 responses in the healthy neonate should be taken into account to optimize their use in the diagnosis of early-onset neonatal sepsis.

scholarly journals 1193 How to Use C-Reactive Protein in Septic Screening of Term and Near Term Newborns?

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A341-A342
Author(s):  
D. Rebelo ◽  
T. Santos ◽  
M. Albuquerque ◽  
G. Oliveira ◽  
T. Rodrigues
Keyword(s):  
C Reactive Protein ◽  
Reactive Protein ◽  
Term Newborns ◽  
Near Term

scholarly journals Influence of SARS-CoV-2 acute respiratory viral disease on pregnancy and childbirth

2021 ◽  
Vol 2 ◽  
pp. 15-18
Author(s):  
S.М. Turyanytsya ◽  
O.O. Korchins’ka ◽  
A.V. Sabova ◽  
O.A. Baloga ◽  
V.O. Petrov
Keyword(s):  
Pregnant Women ◽  
Neonatal Period ◽  
Viral Disease ◽  
Maternity Hospital ◽  
Clear Correlation ◽  
Pregnancy And Childbirth ◽  
Early Neonatal Period ◽  
Term Newborns ◽  
Acute Respiratory Viral Infection ◽  
Physiological Childbirth

Acute Respiratory Viral Disease SARS - CoV2 - 19 is a new poorly understood disease with an unpredictable course. This article is devoted to the analysis of coronavirus disease and its impact on the condition of newborns.The objective: to identify and investigate the relationship between the detected and revealed SARS-CoV-2 disease and the course of pregnancy and childbirth, dependence on the term in which the diagnosis was established and the consequences of the disease on the course of pregnancy, childbirth and the condition of newborns; to investigate the frequency of detected complications during pregnancy and the peculiarities of the course of pregnancy with combined pathology.Materials and methods. We analyzed 57 stories of pregnancy and childbirth of women who were admitted to the Uzhgorod City Maternity Hospital in the period from May 2020 to January 2021 with a positive result of the SARS-CoV-2 PLR study.Results. Of 57 patients, pregnancy is ongoing in 18 women, and in 39 it has already ended. Of these, 17 (29.8%) women had vaginal physiological childbirth, 21 (36.8%) women had pathological course of labor, of which 16 (28%) patients underwent cesarean section. In general, 34 pregnant women (59.6%) were asymptomatic. A mild course of the disease was in 20 pregnant women (35%), and a severe course was in three patients (5.2%). As a result of 39 births, 41 children were born (two biochorial twins). Of these, 38 children were born alive (92.7%), stillborn - 4 (5.3%). 31 children were born on time (81.6%). The physiological course of the early neonatal period was observed in all full-term newborns. Perinatal loss was observed in three women at 23, 25 and 28 weeks.Conclusions. In children born of mothers with COVID-19, there was no increase in the frequency of the pathological course of the early neonatal period or detected signs of acute respiratory viral infection. It was also found that there is no clear correlation between the severity of the course of coronavirus infection and complications in pregnant women. So, with a relatively easy mile, even an asymptomatic course, threatening complications were observed, since premature detachment of a normally located placenta was evident, but there was no clear correlation between coronavirus, while with a moderate course of pregnancy, we observed a fairly good result of delivery. The sample of patients is very small and does not allow us to draw definitive conclusions about the effect of coronavirus on pregnancy and fetal health. But these data give us the basis for the next studies on the influence of the new SARS-CoV-2 virus on the course of the gestational process, childbirth and the condition of newborns.

scholarly journals Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications

1997 ◽  
Vol 43 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Elizabeth M Macy ◽  
Timothy E Hayes ◽  
Russell P Tracy
Keyword(s):  
Clinical Chemistry ◽  
Reference Interval ◽  
Reference Intervals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Analytical Variability ◽  
Subject Variability ◽  
Donor Population ◽  
Index Of Individuality ◽  
Small Index

Abstract We developed a reproducible ELISA for C-reactive protein (CRP), calibrated with WHO Reference Material, for which intra- and interassay CVs were 3.0% and 6.0%, respectively. Analytical recovery was 97.9%. The distribution of CRP in a healthy blood donor population (n = 143) was nongaussian, with 2.5th, 50th, and 97.5th percentile values of 0.08, 0.64, and 3.11 mg/L, respectively. There was no sex-related difference, and the association with age was weak. In a study of variability [by the method of Fraser and Harris (Crit Rev Clin Lab Sci 1989;27:409–37)], the analytical variability was 5.2%; the within-subject variability, CVI, was 42.2%; and the between-subject variability, CVG, was 92.5%. The critical difference for sequential values significant at P ≤0.05 (i.e., the smallest percentage change unlikely to be due to analytical variability or CVI) was calculated as 118%, and the index of individuality, CVI/CVG, was 0.46. This suggests that CRP, like many clinical chemistry analytes, has limited usefulness in detecting early disease-associated changes when used in conjunction with a healthy reference interval. From a molecular epidemiological standpoint, the usefulness of CRP in longitudinal studies is suggested by the small index of individuality and by observations that (a) short-term fluctuations were infrequent, (b) all data stayed within the reference interval, and (c) relative rankings of the subjects over 6 months only moderately deteriorated.

scholarly journals The role of biochemical markers as early indicators of cardiac damage and prognostic parameters of perinatal asphyxia

2014 ◽  
Vol 71 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Aleksandra Simovic ◽  
Jovan Kosutic ◽  
Sergej Prijic ◽  
Jasmina Knezevic ◽  
Ana Vujic ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Perinatal Asphyxia ◽  
Cardiac Troponin I ◽  
Full Term ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Term Newborns

Background/Aim. In recent years, the focus of interest of the scientific community is the application of heart markers as early indicators and prognostic parameters of perinatal asphyxia (PA). The aim of this study was to evaluate the significance of clinical application of heart markers in term newborns with perinatal asphyxia. Methods. During a 3- year period we analyzed 91 full-term newborns (55 with and 36 without perinatal asphyxia). In all the subjects within the first 24-48 h after birth, we simultaneously determined serum concentrations of cardiac troponin I, brain natriuretic peptide, MB fraction of creatine kinase (CK-MB) and Creactive protein. Results. In the group of full-term neonates with PA significantly higher levels of cardiac troponinI (p = 0.000), CK-MB fraction (p = 0.000), brain natriuretic peptide (p = 0.003) and C-reactive protein (p = 0.017) were found, compared to the group of healthy full-term newborns. In merged group (n = 91) cardiac troponin I level correlated with the fifth minute Apgar score (r = - 0.637, p = 0.000) and the serum lactate concentration in the first 12h after birth (r = 0.529, p = 0.000). Early increase in cardiac troponin I > 0.135 ?g/L predicted the risk of death with the sensitivity of 84.6% and specificity of 85.9%, while the increase in CK-MB fraction, brain natriuretic peptide and C-reactive protein did not have a predictive value with respect to a mortality outcome. Conclusion. Among the tested cardiac markers, cardiac troponin I is the most sensitive and the only reliable early predictor of mortality in fullterm neonates with perinatal asphyxia.

C reactive protein in healthy term newborns during the first 48 hours of life

2017 ◽  
Vol 103 (2) ◽  
pp. F163-F166 ◽  
Author(s):  
Serafina Perrone ◽  
Federica Lotti ◽  
Mariangela Longini ◽  
Annalisa Rossetti ◽  
Ilaria Bindi ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Reference Values ◽  
Antimicrobial Prophylaxis ◽  
Elective Caesarean Section ◽  
Mode Of Delivery ◽  
Perinatal Period ◽  
C Reactive Protein ◽  
Mean Values ◽  
Reactive Protein ◽  
Term Newborns

BackgroundEarly-onset neonatal sepsis (EOS) is a serious and potentially life-threatening disease in newborns. C reactive protein (CRP) is the most used laboratory biomarker for the detection of EOS. Little is known about normal reference values of CRP during the perinatal period as several factors are able to influence it.ObjectivesTo identify an appropriate range of CRP values in healthy term newborns during the first 48 hours of life.DesignCRP determination was performed in 859 term newborns at 12, 24 and 48 hours of life. Mode of delivery, maternal vaginal culture results, intrapartum antimicrobial prophylaxis (IAP) and other perinatal variables were recorded.ResultsCRP mean values were significantly higher at 48 hours (4.10 mg/L) than at both 24 (2.30 mg/L) and 12 hours of life (0.80 mg/L). CRP levels were affected by a number of perinatal proinflammatory variables. In particular, CRP mean values were significantly higher in babies born by vaginal delivery (3.80 mg/L) and emergency caesarean section (3.60 mg/L) than in babies born by elective caesarean section (2.10 mg/L). Completed course of IAP led to lower CRP mean values (2.90 mg/L) than IAP not completed (3.80 mg/L) or not performed (4.70 mg/L).ConclusionsPostnatal age and mode of delivery significantly influence CRP values. Reliable reference values are crucial in order to obtain an adequate diagnostic accuracy.

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