scholarly journals Omics-based Medicine and Systems Pathology A New Perspective for Personalized and Predictive Medicine

2009 ◽  
Vol 05 (01) ◽  
Author(s):  
Tanaka H
Keyword(s):  
Predictive Medicine ◽  
Systems Pathology ◽  
New Perspective ◽  
Based Medicine

Omics-based Medicine and Systems Pathology

2010 ◽  
Vol 49 (02) ◽  
pp. 173-185 ◽  
Author(s):  
H. Tanaka
Keyword(s):  
First Generation ◽  
Genomic Medicine ◽  
Disease Process ◽  
System Level ◽  
Predictive Medicine ◽  
Human Genomics ◽  
Model Driven ◽  
Systems Pathology ◽  
Molecular Information ◽  
Based Medicine

Summary Objectives: Recent important advances in the human genomics and post-genomic “omics” are now bringing about a new medical care which we call “omics-based medicine”. In this article, we investigated the development and future possibilities of omics-based medicine. Methods: We divided the development of omics-based medicine into three generations in order to clarify the main clinical goals and characteristics of informatics method of each generation, together with its future possibilities. Results: The first generation of omics-based medicine started with “genomic medicine” based on the inborn individual differences of genome. It has opened the study of genetic polymorphism of the diseases and promoted the personalized medication based on the pharmacogenetic/pharmacogenomic difference of the drug response. In the second generation of omics-based medicine, owing to the advances in the high-throughput technology, vast amount of the various post-genomic disease omics data containing comprehensive molecular information of diseased somatic cells has become available. It reflects the ongoing state of diseases more closely and enables the predictive medicine such as prognosis prediction of disease by applying the data-driven analysis. Finally, due to the rapidly growing knowledge about the cellular molecular network, system-level understanding of the disease, called systems pathology, becomes possible. It can fully exploit the substantial contents of disease omics and will lead to a comprehensive understanding of disease process by using model-driven analysis. Conclusion: Omics-based medicine and systems pathology will realize a new personalized and predictive medicine.

scholarly journals NEW APPROACHES TO DESIGN PRACTICE

2011 ◽  
Author(s):  
Douglas MacLeod
Keyword(s):  
Evidence Based ◽  
Design Engineering ◽  
Design Practice ◽  
New Approach ◽  
Design Based Research ◽  
Future Design ◽  
New Perspective ◽  
Based Medicine ◽  
Work Done ◽  
The Way

Contemporary design practice is both borrowing from and contributing to other disciplines. This paper will examine two significant trends – design-based research and evidence-based design – that will have an impact on current and future design practices. Design-based research is currently popular in the field of education and borrows from the way architects and engineers work to develop their ideas in real-world contexts and as such it provides a new perspective into design engineering itself. Evidence-based design borrows from work done in evidence-based medicine to carefully observe and analyze the way people use the products of design. Taken together these two trends provide a new approach to design and a better means of connecting with collaborators, consumers and users.

Why we cannot consider ourselves Darwinists anymore (Why Dunant won over Darwin)

2010 ◽  
pp. 129-132
Author(s):  
Costantino Cipolla
Keyword(s):  
Regenerative Medicine ◽  
Applied Science ◽  
The Self ◽  
Predictive Medicine ◽  
New Developments ◽  
Western Countries ◽  
Organic Life ◽  
The Rich ◽  
Based Medicine

The new developments in medicine pose serious questions on the assumption of Darwinistic views. Considering the sixty or more operative specialities (and the sub-specialities), the new borders of medicine, at least in the rich Western countries, may be summarized in three main branches: genetic-based medicine, or predictive medicine; regenerative medicine of organs, for an organic life without physical death, even with the death of self-consciousness; adaptive medicine, based on the adaptation to the self-conscious aims of a person, or enhancement medicine. These three kinds of applied science, in different and peculiar ways, put the free game of the natural Darwinistic evolution in crisis turning it on itself.

SREM observation of the interaction between the in-situ deposited Pd small particles and MgO cleavage surface

1986 ◽  
Vol 44 ◽  
pp. 382-383
Author(s):  
H.-J. Ou
Keyword(s):  
Electron Microscopy ◽  
Small Particle ◽  
Small Particles ◽  
Cleavage Surface ◽  
Metallic Particles ◽  
Microscopy Technique ◽  
Ceramic Surfaces ◽  
Reflection Electron Microscopy ◽  
New Perspective

The understanding of the interactions between the small metallic particles and ceramic surfaces has been studied by many catalyst scientists. We had developed Scanning Reflection Electron Microscopy technique to study surface structure of MgO hulk cleaved surface and the interaction with the small particle of metals. Resolutions of 10Å has shown the periodic array of surface atomic steps on MgO. The SREM observation of the interaction between the metallic particles and the surface may provide a new perspective on such processes.

Articulation Training: A New Perspective

1979 ◽  
Vol 10 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Sallie W. Hillard ◽  
Laura P. Goepfert
Keyword(s):  
Life Experience ◽  
Remediation Measures ◽  
New Perspective

This paper describes the concept of teaching articulation through words which have inherent meaning to a child’s life experience, such as a semantically potent word approach. The approach was used with six children. Comparison of pre/post remediation measures indicated that it has promise as a technique for facilitating increased correct phoneme production.

Case Exercise: Toxic Exposure-Related Illness: Causation, Diagnosis, and Permanent Impairment

2007 ◽  
Vol 12 (2) ◽  
pp. 4-8
Author(s):  
Frederick Fung
Keyword(s):  
Concentration Level ◽  
Treatment Plan ◽  
Toxic Exposure ◽  
Dose Response Relationship ◽  
Specialty Board ◽  
History Of ◽  
Subjective Complaints ◽  
Based Medicine ◽  
Illness Causation ◽  
Rule Out

Abstract A diagnosis of toxic-related injury/illness requires a consideration of the illness related to the toxic exposure, including diagnosis, causation, and permanent impairment; these are best performed by a physician who is certified by a specialty board certified by the American Board of Preventive Medicine. The patient must have a history of symptoms consistent with the exposure and disease at issue. In order to diagnose the presence of a specific disease, the examiner must find subjective complaints that are consistent with the objective findings, and both the subjective complaints and objective findings must be consistent with the disease that is postulated. Exposure to a specific potentially causative agent at a defined concentration level must be documented and must be sufficient to induce a particular pathology in order to establish a diagnosis. Differential diagnoses must be entertained in order to rule out other potential causes, including psychological etiology. Furthermore, the identified exposure at the defined concentration level must be capable of causing the diagnosis being postulated before the examiner can conclude that there has been a cause-and-effect relationship between the exposure and the disease (dose-response relationship). The evaluator's opinion should make biological and epidemiological sense. The treatment plan and prognosis should be consistent with evidence-based medicine, and the rating of impairment must be based on objective findings in involved systems.

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