Omics-based Medicine and Systems Pathology

2010 ◽  
Vol 49 (02) ◽  
pp. 173-185 ◽  
Author(s):  
H. Tanaka
Keyword(s):  
First Generation ◽  
Genomic Medicine ◽  
Disease Process ◽  
System Level ◽  
Predictive Medicine ◽  
Human Genomics ◽  
Model Driven ◽  
Systems Pathology ◽  
Molecular Information ◽  
Based Medicine

Summary Objectives: Recent important advances in the human genomics and post-genomic “omics” are now bringing about a new medical care which we call “omics-based medicine”. In this article, we investigated the development and future possibilities of omics-based medicine. Methods: We divided the development of omics-based medicine into three generations in order to clarify the main clinical goals and characteristics of informatics method of each generation, together with its future possibilities. Results: The first generation of omics-based medicine started with “genomic medicine” based on the inborn individual differences of genome. It has opened the study of genetic polymorphism of the diseases and promoted the personalized medication based on the pharmacogenetic/pharmacogenomic difference of the drug response. In the second generation of omics-based medicine, owing to the advances in the high-throughput technology, vast amount of the various post-genomic disease omics data containing comprehensive molecular information of diseased somatic cells has become available. It reflects the ongoing state of diseases more closely and enables the predictive medicine such as prognosis prediction of disease by applying the data-driven analysis. Finally, due to the rapidly growing knowledge about the cellular molecular network, system-level understanding of the disease, called systems pathology, becomes possible. It can fully exploit the substantial contents of disease omics and will lead to a comprehensive understanding of disease process by using model-driven analysis. Conclusion: Omics-based medicine and systems pathology will realize a new personalized and predictive medicine.

scholarly journals Diet and Cancer Prevention: Evidence-based Medicine to Genomic Medicine

2004 ◽  
Vol 134 (12) ◽  
pp. 3513S-3516S ◽  
Author(s):  
Vay Liang W. Go ◽  
Debra A. Wong ◽  
Yu Wang ◽  
Ritva R. Butrum ◽  
Helen A. Norman ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Evidence Based Medicine ◽  
Genomic Medicine ◽  
Evidence Based ◽  
Diet And Cancer ◽  
Based Medicine

scholarly journals Evidence based medicine meets genomic medicine

2007 ◽  
Vol 9 (12) ◽  
pp. 799-800 ◽  
Author(s):  
Jim Evans ◽  
Muin J Khoury
Keyword(s):  
Evidence Based Medicine ◽  
Genomic Medicine ◽  
Evidence Based ◽  
Based Medicine

Model-Driven Design and ASM-Based Validation of Embedded Systems

2010 ◽  
pp. 24-54 ◽  
Author(s):  
Angelo Gargantini ◽  
Elvinia Riccobene ◽  
Patrizia Scandurra
Keyword(s):  
Embedded System ◽  
Graphical Models ◽  
Code Generation ◽  
Formal Method ◽  
System Level ◽  
Levels Of Abstraction ◽  
Model Driven ◽  
The Embedded System ◽  
On Chip ◽  
High Level

In the embedded system and System-on-Chip (SoC) design area, the increasing technological complexity coupled with requests for more performance and shorter time to market have caused a high interest for new methods, languages and tools capable of operating at higher levels of abstraction than the conventional system level. This chapter presents a model-driven and tool-assisted development process of SoCs, which is based on high-level UML design of system components, guarantees SystemC code generation from graphical models, and allows validation of system behaviors on formal models automatically derived from UML models. An environment for system design and analysis is also presented, which is based on a UML profile for SystemC and the Abstract State Machine formal method.

scholarly journals Assessing Anticholinergic Effects in Older Adults

2020 ◽  
Author(s):  
Donna M. Lisi
Keyword(s):  
Older Adults ◽  
First Generation ◽  
Inappropriate Medication ◽  
Anticholinergic Drug ◽  
System Level ◽  
Blurred Vision ◽  
Anticholinergic Effects ◽  
Anticholinergic Medications ◽  
Inappropriate Medication Use ◽  
Drug Classes

Anticholinergic medications are widely used in older adults and are a common source of adverse events in this population. Common drug classes include antiarrhythmics, antidepressants, antiemetics, first generation antihistamines, urinary incontinence antimuscarinic agents, antiparkinsonian agents, antipsychotics, antispasmodics, and skeletal muscle relaxants. These drugs have been associated with delirium, cognitive impairment, sedation, dizziness, falls, fracture, constipation, urinary retention, blurred vision, tachycardia and dry mouth. If possible, these drugs should be avoided in older adults or less toxic agents within the class should be utilized. This chapter will explore the mechanism of action of anticholinergic drugs at both the cellular and organ system level; discuss how to assess for anticholinergic drug burden; list medications with anticholinergic effects as identified in the Beer’s criteria on potentially inappropriate medication use in older adults; review anticholinergic drug–drug interactions; describe contraindications to the use of anticholinergic agents; and explore practical considerations such as the availability of these substances in nonprescription medications, their use at end of life and deprescribing.

scholarly journals Model-driven system-level validation and verification on the space software domain

2021 ◽  
Author(s):  
Aarón Montalvo ◽  
Pablo Parra ◽  
Óscar Rodríguez Polo ◽  
Alberto Carrasco ◽  
Antonio Da Silva ◽  
...  
Keyword(s):  
Software Verification ◽  
Control Unit ◽  
System Level ◽  
Model Transformations ◽  
Validation And Verification ◽  
Model Driven ◽  
Ground Support ◽  
Software Applications ◽  
Engineering Standards ◽  
Validation Tests

AbstractThe development process of on-board software applications can benefit from model-driven engineering techniques. Model validation and model transformations can be applied to drive the activities of specification, requirements definition, and system-level validation and verification according to the space software engineering standards ECSS-E-ST-40 and ECSS-Q-ST-80. This paper presents a model-driven approach to completing these activities by avoiding inconsistencies between the documents that support them and providing the ability to automatically generate the system-level validation tests that are run on the Ground Support Equipment and the matrices required to complete the software verification. A demonstrator of the approach has been built using as a proof of concept a subset of the functionality of the software of the control unit of the Energetic Particle Detector instrument on-board Solar Orbiter.

An Overview and Summary

2008 ◽  
pp. 375-388
Author(s):  
Bill Karakostas ◽  
Yannis Zorgios
Keyword(s):  
Competitive Advantage ◽  
World Wide ◽  
First Generation ◽  
The Internet ◽  
Sustainable Competitive Advantage ◽  
Business Services ◽  
Profit Margins ◽  
Model Driven ◽  
The World ◽  
Model Driven Approach

This book has introduced a model-driven approach for identifying, designing, deploying, and managing business services in software. The concept of e-service is an extension of conventional business services, made possible thanks to the rapid explosion in popularity of the Internet and the World Wide Web (Rust & Kannan, 2003). The first generation of e-commerce was based largely on retailing commodity goods, such as books and CDs, and used mass media advertising to contact consumers. The premise of first generation e-commerce was that operational efficiencies (i.e., minimizing the need and therefore the expense to keep physical stores) would reduce the costs of selling. Unfortunately, selling commodities has low profit margins due to competition. An alternative is required, that allows companies to built sustainable competitive advantage, based on their capability to deliver more individualized and hence more profitable e-services.

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