scholarly journals Relationship of Placental TLR-7 Expression with Cord Blood HBV DNA and Placental HBV DNA

2021 ◽  
Vol 4 (2) ◽  
pp. 125-133
Author(s):  
Naeny Fajriah ◽  
◽  
Maisuri T. Chalid ◽  
Lenny Lisal ◽  
Efendi Lukas ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Placental Tissue ◽  
Intrauterine Infection ◽  
Hbv Dna ◽  
Staining Result ◽  
Paraffin Block ◽  
Relationship Of

Abstract Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood. Method: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining. Result: 16 of 38 samples were acquired from mothers aged 26-30 years old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p=1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p=0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p=0.082; p = 1.000). Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a significant association between TLR-7 expression and maternal HBV DNA. Key word: toll-like receptor (TLR) 7, HBV DNA, umbilical cord, placental, Hepatitis B, intrauterine infection

scholarly journals HBsAg in Cord Blood Qf Newborns of HBsAg-Positive Mothers

2018 ◽  
Vol 34 (5-6) ◽  
pp. 125-8
Author(s):  
Adnan S. Wiharta ◽  
Evi Setiadi ◽  
H. M. Sjaifullah Noer ◽  
Triyatmo Rachimhadhi ◽  
Asri Rasad
Keyword(s):  
Hepatitis B ◽  
Cord Blood ◽  
Vertical Transmission ◽  
Placental Tissue ◽  
Intrauterine Infection ◽  
Hepatitis B Infection ◽  
Fetal Circulation ◽  
Positive Hbsag ◽  
Infancy And Early Childhood ◽  
Pregnant Mothers

Vertical transmission of hepatitis B infection that may occur during pregnancy at delivery-, in infancy, and early childhood has an important role in the development of chronic hepatitis B. Intrauterine infection is suspected to occur when hepatitis B viruses cross the placenta into fetal circulation due to failure of placental tissue function. In Cipto Mangunkusumo Hospital, Jakarta, 98 (6.4%) of 1536 pregnant mothers obseiVed during 3 years (1987 -1990) showed positive HBsAg. Six (8.3%) of 60 babies of born to HBsAg positive mothers showed positive HBsAg in their cord blood, but this disappeared after one month. All babies born to HBsAg positive mothers were vaccinated on months 0, 1, 2, and 12. HBsAg in cord blood might not play an important role in vertical transmission.

scholarly journals Acute life-threatening cardiovascular toxicity with umbilical cord blood infusion: The role of dextran

2010 ◽  
Vol 85 (9) ◽  
pp. 722-724 ◽  
Author(s):  
Robert W. Ma ◽  
John M. Kwan ◽  
David D. Ma ◽  
Keith C. Fay
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cardiovascular Toxicity ◽  
Life Threatening

scholarly journals Hepatitis B Virus Replication in CD34+ Hematopoietic Stem Cells From Umbilical Cord Blood

2016 ◽  
Vol 22 ◽  
pp. 1673-1681 ◽  
Author(s):  
Yanxin Huang ◽  
Qin Yan ◽  
Rongshan Fan ◽  
Shupeng Song ◽  
Hong Ren ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hematopoietic Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Virus Replication ◽  
Umbilical Cord Blood ◽  
Hematopoietic Stem ◽  
B Virus

The study on the role of Hepatitis B virus X protein and apoptosis in HBV intrauterine infection

2011 ◽  
Vol 285 (4) ◽  
pp. 943-949 ◽  
Author(s):  
Guiqin Bai ◽  
Yueling Wang ◽  
Lingyan Zhang ◽  
Yao Tang ◽  
Fengping Fu
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Intrauterine Infection ◽  
X Protein ◽  
B Virus

scholarly journals Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yong Li ◽  
Chuanlong Zhu ◽  
Faxi Wang ◽  
Tiantian Zhu ◽  
Jun Li ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Treatment Response ◽  
Chronic Hepatitis B ◽  
Hepg2 Cells ◽  
Hbv Dna ◽  
Stat Signaling ◽  
Ifn Treatment

Interferon-α (IFN-α) has limited response rate in the treatment of chronic hepatitis B (CHB). The underlying mechanism of differential responsiveness to IFN remains elusive. It has been recently reported that SART1 mediates antiviral effects of IFN-α in the hepatitis C virus (HCV) cell culture model. In this study, we investigated the role of SART1 in antiviral activity of IFN-α against hepatitis B virus (HBV) using blood and liver biopsy samples from chronic hepatitis B patients treated with pegylated IFN-α and HepG2 cells transfected with cloned HBV DNA. We observed that the basal SART1 expression in liver and PBMCs before IFN treatment was significantly higher in responders than in nonresponders. Furthermore, baseline SART1 expression level positively correlated with the degree of HBV DNA and HBeAg decline after IFN treatment. Mechanistically, silencing SART1 abrogated the antiviral activity of IFN-α, reduced the expression of IFN-stimulated genes (ISGs) Mx, OAS, and PKR, and attenuated JAK-STAT signaling in HepG2 cells, suggesting that SART1 regulates IFN-mediated antiviral activity through JAK-STAT signaling and ISG expression. Our study elucidates the important role of SART1 in IFN-mediated anti-HBV response and provides new insights into understanding variation of IFN treatment response in CHB patients.

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