scholarly journals HBsAg in Cord Blood Qf Newborns of HBsAg-Positive Mothers

2018 ◽  
Vol 34 (5-6) ◽  
pp. 125-8
Author(s):  
Adnan S. Wiharta ◽  
Evi Setiadi ◽  
H. M. Sjaifullah Noer ◽  
Triyatmo Rachimhadhi ◽  
Asri Rasad
Keyword(s):  
Hepatitis B ◽  
Cord Blood ◽  
Vertical Transmission ◽  
Placental Tissue ◽  
Intrauterine Infection ◽  
Hepatitis B Infection ◽  
Fetal Circulation ◽  
Positive Hbsag ◽  
Infancy And Early Childhood ◽  
Pregnant Mothers

Vertical transmission of hepatitis B infection that may occur during pregnancy at delivery-, in infancy, and early childhood has an important role in the development of chronic hepatitis B. Intrauterine infection is suspected to occur when hepatitis B viruses cross the placenta into fetal circulation due to failure of placental tissue function. In Cipto Mangunkusumo Hospital, Jakarta, 98 (6.4%) of 1536 pregnant mothers obseiVed during 3 years (1987 -1990) showed positive HBsAg. Six (8.3%) of 60 babies of born to HBsAg positive mothers showed positive HBsAg in their cord blood, but this disappeared after one month. All babies born to HBsAg positive mothers were vaccinated on months 0, 1, 2, and 12. HBsAg in cord blood might not play an important role in vertical transmission.

scholarly journals Influence of Hepatitis B immunization to prevent vertical transmission of Hep-B virus in infants bam from Hep-B positive mother

2016 ◽  
Vol 50 (6) ◽  
pp. 321 ◽  
Author(s):  
Liza Fitria ◽  
Hartono Gunardi ◽  
Arwin A. P. Akib
Keyword(s):  
Hepatitis B ◽  
Cord Blood ◽  
Vertical Transmission ◽  
Perinatal Transmission ◽  
Term Infants ◽  
Positive Mother ◽  
Positive Hbsag ◽  
Blood Specimens ◽  
Hbsag Positive Mother ◽  
Hep B

Background Hepatitis B is one of the most common infectious diseases worldv.ide. Indonesia has moderate-high endemicity for hepatitis B infection. Perinatal transmission increases the risk for chronic hepatitis B. Infants from HBsAg-positive mothers should receive hepatitis B immunoglobulin (HBIG) and vaccination within 12 hours of birth, but this practice is not routinely done in Indonesia due to financial constraints.Objectives To detennine the influence of Hep-B immunization on preventing Hepatitis B vertical transmission. Methods A descriptive cohort study was conducted from May 2009 - January 2010. Subjects were term infants born from HBsAg-positive mothers v.ith no history of HBIG administration. They had received complete hepatitis B immunization and 1 month after the last dose were evaluated for HBsAg and anti-HBs. Cord blood was also taken during labor to measure HBsAg.Results There were 22 infants born from HBsAg-positive mother who met the inclusion criteria. HBsAgwas positive in 6 of22 cord blood specimens. There were 15 infants who completed this study. One of 15 infants had positive HBsAg after completed hepatitis B immunization and 12 of 15 infants had protective level of anti-HBs. Effectiveness of hepatitis B immunization to prevent vertical transmission in this study was 70-90%.Conclusion Hepatitis B immunization can prevent vertical transmission of hepatitis B in infants born to mothers who are HBsAg-positive even without administration of HBIG.

scholarly journals Relationship of Placental TLR-7 Expression with Cord Blood HBV DNA and Placental HBV DNA

2021 ◽  
Vol 4 (2) ◽  
pp. 125-133
Author(s):  
Naeny Fajriah ◽  
◽  
Maisuri T. Chalid ◽  
Lenny Lisal ◽  
Efendi Lukas ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Placental Tissue ◽  
Intrauterine Infection ◽  
Hbv Dna ◽  
Staining Result ◽  
Paraffin Block ◽  
Relationship Of

Abstract Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood. Method: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining. Result: 16 of 38 samples were acquired from mothers aged 26-30 years old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p=1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p=0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p=0.082; p = 1.000). Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a significant association between TLR-7 expression and maternal HBV DNA. Key word: toll-like receptor (TLR) 7, HBV DNA, umbilical cord, placental, Hepatitis B, intrauterine infection

Mother-to-child transmission of hepatitis B infection

1998 ◽  
Vol 10 (2) ◽  
pp. 109-119
Author(s):  
Marie-Louise Newell ◽  
Catherine Peckham
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Newborn Infant ◽  
Vertical Transmission ◽  
Hepatitis B Infection ◽  
Child Transmission ◽  
Infected Woman ◽  
B Virus ◽  
Vaginal Secretions ◽  
Mother To Child

Most transmission of hepatitis B virus (HBV) infection occurs around the time of delivery through contact with contaminated vaginal secretions or blood. Hence, interventions to reduce vertical transmission of HBV depend on identification of the infected woman during pregnancy so that the newborn infant exposed to infection can be given immunoglobulin immediately after birth, and a course of immunization can be started.

scholarly journals Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255189
Author(s):  
Muhammad Israr ◽  
Fawad Ali ◽  
Arif Nawaz ◽  
Muhammad Idrees ◽  
Aishma Khattak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Transfusion ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Educational Level ◽  
Khyber Pakhtunkhwa ◽  
History Of ◽  
Associated Risk Factors ◽  
Pregnant Mothers

Background & aim Hepatitis B and C infections are global issues that are associated with a massive financial burden in developing countries where vertical transmission is the major mode and remains high. This cross-sectional study was designed to investigate the seroepidemiology and associated risk factors of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among 375 pregnant women attending antenatal care health facilities at Bacha Khan Medical Complex (BKMC) Shahmansoor and District Head Quarter (DHQ) Hospital Swabi, Khyber Pakhtunkhwa, Pakistan. Methodology From a total of 375 pregnant women selected using systematic random sampling from both hospitals, 10 ml of blood samples were collected and alienated serum was examined for indicators identification through the Immuno-Chromatographic Test (ICT) and 3rd Generation Enzyme-Linked Immunosorbent Assay (ELISA). A pre-structured questionnaire was used to collect the socio-demographic data and possible risk factors. The data was analyzed via SPSS 23.0 statistical software. A chi-square analysis was performed to determine the association between variables. P-value < 0.05 was set statistically significant. Results The overall frequency of HBV and HCV among 375 pregnant women involved in the study was 3.7% and 2.1% respectively. None of the pregnant women were co-infected with HBV and HCV. Dental extraction (P = 0.001) and blood transfusion (P = 0.0005) were significantly allied with HBV infection while surgical procedure (P = 0.0001) was significantly associated with HCV infection. Moreover the sociodemographic characteristics: residential status (P = 0.017) and educational level (P = 0.048) were found significant risk factors of HBsAg and maternal age (P = 0.033) of anti-HCV, respectively. Conclusion & recommendation HBV and HCV infections are intermediary endemic in the study area. A higher prevalence of HBV was detected among pregnant mothers with a history of dental extraction, history of blood transfusion, resident to the urban area and low educational level. The age and surgical procedures were the potential risk factors found significantly associated with HCV positivity among pregnant mothers in our setup. Future negotiations to control vertical transmission should include routine antenatal screening for these infections early in pregnancy and the requirement of efficient preventive tools including the birth dose of the hepatitis B vaccine in combination with hepatitis B immune globulins to the neonate.

scholarly journals Relationship between expression of HBV-infection markers in placenta and clinical data of mothers and their newborns

2021 ◽  
Vol 13 (2) ◽  
pp. 95-101
Author(s):  
M. A. Belopolskaya ◽  
V. E. Karev ◽  
V. Yu. Avrutin ◽  
A. V. Dmitriev ◽  
D. A. Gusev
Keyword(s):  
Viral Load ◽  
Hepatitis B ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Vertical Transmission ◽  
Umbilical Cord Blood ◽  
Structural Changes ◽  
Antiviral Treatment ◽  
Undetectable Viral Load ◽  
Hbv Infection

Vertical transmission of viral hepatitis B (HBV) is one of the main transmission ways in endemic regions. There is a relationship between structural changes in the placenta and the clinical course of HBV infection. The risk of vertical transmission of hepatitis B depends on the condition of the placenta.The goal of this work was to study the relationship between HBsAg and / or HBcorAg expression in placenta on the one hand, and clinical parameters of mothers and newborns on the other hand.The study included 19 patients with CHB who gave birth at the Botkins infectious disease hospital in 2019. The first group included patients with markers of HBV infection (HBsAg and / or HBcorAg) detectable via immunohistochemical examination in at least one of the layers of the placenta. In patients from the second group, no markers of HBV infection were detected in any layer of the placenta. Inflammatory changes in placenta were detected in all women from the first group and in 9 (64%) women from the second group. HBsAg in umbilical cord blood was detected in 3 (16%) newborns. In two patients, whose children had HBsAg in the umbilical cord blood, no markers of HBV infection were detected in placenta. In the first group, only one newborn had HBsAg in umbilical cord blood. In two patients receiving an antiviral treatment during pregnancy, markers of HBV infection were identified in the placenta. Markers of HBV infection in placenta were also detected in women with undetectable viral load.ConclusionsMarkers of HBV infection can be found in placenta at low maternal viral load.HBsAg in umbilical cord blood can be detected even in patients with no markers of HBV infection in placenta.Antiviral treatment during pregnancy does not prevent the possibility of placenta’s infection with HBV.

scholarly journals Hepatitis B serologic patterns in children of HBV carriers or infected mothers

2016 ◽  
Vol 44 (5) ◽  
pp. 176
Author(s):  
Julfina Bisanto ◽  
Imral Chair ◽  
Dyah Istikowati
Keyword(s):  
Chronic Illness ◽  
Child Health ◽  
Hepatitis B ◽  
Vertical Transmission ◽  
Cross Sectional Study ◽  
Hepatitis B Vaccine ◽  
Blood Transfusions ◽  
Hepatitis B Infection ◽  
Sectional Study ◽  
Cross Sectional

Background Vertical transmission is usually the cause of increas-ing carrier rates for hepatitis B infection, especially in highly en-demic areas.Objective To determine the serologic patterns of hepatitis B inchildren of HBV carrier/infected mothers.Methods This was a cross sectional study on children of HBVcarrier/infected mothers. Subjects were recruited consecutively andexamined at the Department of Child Health, Cipto MangunkusumoHospital during January–July 2003. Children were included if theywere generally healthy and their parents gave permission. Chil-dren with chronic illness, previous blood transfusions, or drug abusewere excluded.Results Fifty-nine children of 32 HBV carrier/infected mothers wererecruited. HBsAg was positive in 8 children, anti-HBs in 37, andanti-HBc in 4 children. Seventy-three percent of children had beenvaccinated against HBV but only 81% had positive anti-HBs. Ofeighteen children who received hepatitis B vaccine and HBIg atbirth, none was infected. Six out of 25 children who received onlyhepatitis B vaccine were infected.Conclusion HBsAg, anti-HBs, and anti-HBc were positive in 14%,36%, and 7% of children of HBV carrier/infected mothers, respec-tively

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