The Titan can help titin: from micro to macro myocardial elasticity

2006 ◽  
Vol 7 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Paolo Ferrazzi ◽  
Maria R Iascone ◽  
Michele Senni ◽  
Eugenio Quaini
Keyword(s):  
Myocardial Elasticity

Estimation of left ventricular myocardial elasticity and viscosity by a thick-walled spherical model

1993 ◽  
Vol 31 (4) ◽  
pp. 325-332 ◽  
Author(s):  
J. Tani ◽  
H. Yamamoto ◽  
H. Honda ◽  
K. Ootomo ◽  
Y. Koiwa ◽  
...  
Keyword(s):  
Spherical Model ◽  
Left Ventricular ◽  
Myocardial Elasticity

Noninvasive measurement of left ventricular myocardial elasticity

1994 ◽  
Vol 266 (3) ◽  
pp. H881-H890 ◽  
Author(s):  
H. Honda ◽  
Y. Koiwa ◽  
K. Takagi ◽  
J. Kikuchi ◽  
N. Hoshi ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Heart Sound ◽  
Mean Value ◽  
Left Ventricular ◽  
Vibration Sensor ◽  
First Heart Sound ◽  
Dimension Analysis ◽  
The Moment ◽  
Myocardial Elasticity ◽  
Eigen Frequency

We examined Advani and Lee's equation (ALeq) and a dimension analysis-derived equation (DAeq), both of which treat vibration of the elastic spherical shell and are able to estimate elasticity of the shell noninvasively when the sizes and eigen-frequency are provided. We confirmed that ALeq was numerically identical to DAeq and that both equations gave the precise elasticity of the silicone shell. Then we estimated left ventricular (LV) myocardial elasticity noninvasively at the moment of the first heart sound emission (1HS) in 25 healthy subjects and 14 hypertrophic cardiomyopathy (HCM) patients, based on the LV eigen-frequency detected by an intraesophageal miniature vibration sensor. HCM patients had a higher mean value of LV myocardial elasticity at 1HS than healthy subjects [102.3 +/- 33.4 vs. 70.7 +/- 24.4 kPa, P < 0.01 (Pa = N/m2 = 10 dyn/cm2)]. We thereby demonstrated the possibility of a noninvasive estimate of myocardial elasticity.

scholarly journals Acoustic Radiation Force-Driven Assessment of Myocardial Elasticity Using the Displacement Ratio Rate (DRR) Method

2011 ◽  
Vol 37 (7) ◽  
pp. 1087-1100 ◽  
Author(s):  
Richard R. Bouchard ◽  
Stephen J. Hsu ◽  
Mark L. Palmeri ◽  
Ned C. Rouze ◽  
Kathryn R. Nightingale ◽  
...  
Keyword(s):  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Displacement Ratio ◽  
Myocardial Elasticity

scholarly journals MR elastography of the human heart: Noninvasive assessment of myocardial elasticity changes by shear wave amplitude variations

2008 ◽  
Vol 61 (3) ◽  
pp. 668-677 ◽  
Author(s):  
Ingolf Sack ◽  
Jens Rump ◽  
Thomas Elgeti ◽  
Abbas Samani ◽  
Jürgen Braun
Keyword(s):  
Shear Wave ◽  
Human Heart ◽  
Wave Amplitude ◽  
Mr Elastography ◽  
Noninvasive Assessment ◽  
Myocardial Elasticity

Myocardial elasticity in pressure-overloaded cardiac hypertrophy

1992 ◽  
Vol 24 ◽  
pp. 246
Author(s):  
Akira Tanamura ◽  
Masahito Tsuchiya ◽  
Tohru Arino ◽  
Takaaki Iwai ◽  
Izuru Nakamura ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Myocardial Elasticity

Mesenchymal Stem Cell Injection After Myocardial Infarction Improves Myocardial Compliance

2007 ◽  
Author(s):  
Dennis Discher ◽  
Adam Engler
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Function ◽  
Cellular Therapy ◽  
Human Mesenchymal Stem Cells ◽  
Left Ventricular ◽  
Left Ventricular Geometry ◽  
Coronary Artery Ligation ◽  
Artery Ligation ◽  
Functional Benefit ◽  
Myocardial Elasticity

Cellular therapy for myocardial injury has improved ventricular function in both animal and clinical studies, though the mechanism of benefit is unclear. This study was undertaken to examine the effects of cellular injection after infarction on myocardial elasticity. Coronary artery ligation of Lewis rats was followed by direct injection of human mesenchymal stem cells (MSC) into the acutely ischemic myocardium. Two weeks post-infarct, myocardial elasticity was mapped by atomic force microscopy. MSC-injected hearts near the infarct region were two-fold stiffer than myocardium from non-infarcted animals but softer than myocardium from vehicle-treated infarcted animals. After eight weeks, the following variables were evaluated: MSC engraftment and left ventricular geometry by histologic methods; cardiac function with a pressure-volume conductance catheter; myocardial fibrosis by Masson trichrome staining; vascularity by immunohistochemistry; and apoptosis by TUNEL assay. The human cells engrafted and expressed a cardiomyocyte protein but stopped short of full differentiation and did not stimulate significant angiogenesis. MSC-injected hearts showed significantly less fibrosis than controls, as well as less left ventricular dilation, reduced apoptosis, increased myocardial thickness, and preservation of systolic and diastolic cardiac function. In summary, MSC injection after myocardial infarction did not regenerate contracting cardiomyocytes but reduced the stiffness of the subsequent scar and attenuated post-infarction remodeling, preserving some cardiac function. Improving scarred heart muscle compliance could be a functional benefit of cellular cardiomyoplasty.

Modelling the Left Ventricle for Determination of the Elasticity of the Myocardium

1994 ◽  
Vol 208 (1) ◽  
pp. 1-8 ◽  
Author(s):  
A L Yettram ◽  
B S Grewal ◽  
D G Gibson
Keyword(s):  
Elastic Modulus ◽  
Left Ventricle ◽  
Analytical Procedure ◽  
Geometric Model ◽  
Wall Stress ◽  
Myocardial Stiffness ◽  
The Third ◽  
Myocardial Elasticity

An analytical procedure has been developed for deriving an overall value of myocardial elasticity for patients in vivo. Here three other procedures for estimating myocardium stiffness, from other investigators, are applied to data representing the same set of patients. They relate to (a) myocardial stiffness as a function of pressure, (b) myocardial stiffness as a function of wall stress and (c) myocardial stiffness as a function of geometry and stress. An assessment of the validity of each of these three relationships is made. The first two of these are shown to be poor predictors of myocardial elastic modulus whereas the use of an ellipsoidal geometric model, as proposed in the third, was found to give qualitatively good results.

Sign in / Sign up

Export Citation Format

Share Document