Long Term Results of Treatment for Locally Advanced Thyroid Cancer.

The study objective is to assess long-term results of treatment for patients with locally advanced external ear skin cancer.Materials and methods. This research work based on a retrospective and prospective analysis case history for patients with locally advanced external ear skin cancer. These are 45 patients, who received treatment in surgical department of head and neck tumors in Blokhin National Medical Research Center of Oncology between 1994 and 2020. Patient observation time averaged 30.0 ± 32.3 months (from 0.7 to 117.4 months, median 12.0 months). We divided patients into 3 groups depending on treatment methods. Group 1 consisted of patients who received combined or complex treatment (33.3 %, n = 15). Treatment for first group patients involved subtotal, lateral temporal bone resection or incomplete lateral resection and postoperative radiation therapy on the area of primary tumor and regional metastasis zone (total focal dose from 60 Gy). In the case of complex treatment, radiation therapy had carried out against background cisplatin introduction. The second group consisted of patients who received only surgical treatment (40.0 %, n = 18). Temporal bone resections were not performed for patients of the third group (26.7 %, n = 12). Treatment for patients of the third group involved one of the treatment methods: cryodestruction, laser destruction, photodynamic therapy, radiotherapy or chemoradiation treatment.Results. Five-year survival without signs of progression in a group of patients with locally advanced of the ear skin cancer, who received combined or complex treatment was 73.8 ± 13.1. Median progression-free survival not achieved. In the surgical treatment group 5 year progression-free survival was 40.4 ± 13.0, median was 34.1 months. In a group of patients who did not undergo temporal bone resection (3rd group) median progression-free survival was 4.5 months. Group differences are statistically significant (p <0.05). The most significant adverse prognosis factors that reduce overall survival for patients with locally advanced external ear skin cancer are positive histological margin (p = 0.0001, hazard ratio (HR) = 10.611, 95 % confidence interval (CI) 3.058-36.820), signs of destruction branch of the lower jaw/ zygomatic bone (p = 0.027, HR = 4.65, 95 % CI 1.193-18.116). Facial paralysis is the most unfavorable prognosis factor, reducing tumor-specific survival in patients with locally advanced outer ear skin cancer (p = 0.0001, HR = 19.146, 95 % CI 4.056-90.388).Conclusion. Combined/complex treatment of patients with locally advanced ear skin cancer (surgery with postoperative radiotherapy/chemoradiotherapy) provides better long-term results compared to other treatment options.

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Long-term analysis of the efficacy and tolerability of sorafenib in advanced radio-iodine refractory differentiated thyroid carcinoma: final results of a phase II trial

Acta Endocrinologica ◽

10.1530/eje-12-0405 ◽

2012 ◽

Vol 167 (5) ◽

pp. 643-650 ◽

Cited By ~ 74

Author(s):

T C Schneider ◽

R M Abdulrahman ◽

E P Corssmit ◽

H Morreau ◽

J W A Smit ◽

...

Keyword(s):

Thyroid Cancer ◽

Phase Ii ◽

Differentiated Thyroid Cancer ◽

Locally Advanced ◽

Evaluation Criteria ◽

Progression Free Survival ◽

Differentiated Thyroid Carcinoma ◽

Long Term Results ◽

Best Response

Objective We conducted a prospective phase II clinical trial to determine the efficacy of sorafenib in patients with advanced radio-iodine refractory differentiated thyroid cancer. In this article, the long-term results are presented. Patients and methods Thirty-one patients with progressive metastatic or locally advanced radioactive iodine refractory differentiated thyroid cancer received sorafenib 400 mg orally twice daily. The study end points included response rate, progression-free survival (PFS), overall survival (OS), best response by Response Evaluation Criteria in Solid Tumors criteria 1.0, and toxicity. Results Median PFS was 18 months (95% confidence interval (95% CI): 7–29 months) and median OS was 34.5 months (95% CI: 19–50 months). Eight patients (31%) achieved a partial response and 11 patients (42%) showed stable disease after a median follow-up of 25 months (range 3.5–39 months). Toxicity mostly included hand foot syndrome, weight loss, diarrhea, and rash. Conclusion Sorafenib has clinically relevant antitumor activity in patients with progressive metastatic or locally advanced radio-iodine refractory differentiated thyroid cancer. Sorafenib can nowadays be considered as the standard option in these patients.

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PO-165: Long-term results of locally-advanced and metastatic thyroid cancer surgical treatment

Radiotherapy and Oncology ◽

10.1016/s0167-8140(15)34925-2 ◽

2015 ◽

Vol 114 ◽

pp. 77

Author(s):

I. Reshetov ◽

A. Polyakov ◽

A. Golubtsov

Keyword(s):

Thyroid Cancer ◽

Surgical Treatment ◽

Locally Advanced ◽

Long Term Results ◽

Metastatic Thyroid Cancer

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Inflammatory disease of the womans reproductive system: modern trends in diagnosis and therapy (literature review)

GYNECOLOGY ◽

10.26442/20795696.2018.6.180072 ◽

2018 ◽

Vol 20 (6) ◽

pp. 35-41

Author(s):

T Yu Pestrikova ◽

I V Yurasov ◽

E A Yurasova

Keyword(s):

Genital Tract ◽

Inflammatory Diseases ◽

Diagnosis And Treatment ◽

Long Term Results ◽

Modern Approach ◽

Pelvic Organs ◽

Results Of Treatment ◽

Number Of Patients ◽

Diagnostic Approaches

Medical, social and economic relevance of inflammatory diseases of the woman's reproductive organs requires a very careful attitude to the diagnosis and treatment of this pathology. The number of patients with genital infections and inflammatory diseases of the pelvic organs can takes the first place in structure of gynecological morbidity, and is 60.4-65.0%, and this fact is not unique to Russia, but all over the world. Incidence rate of inflammatory diseases of the pelvic organs in the first decade of the twenty-first century is increased at 1.4 times in patients who are from 18 to 24 years old and at 1.8 times in patients aged 25-29 years. At the same time, the cost of diagnosis and treatment has increased, reaching 50-60% of the total cost of providing gynecological care for population. The inflammatory diseases of pelvic organs are a collective concept. It includes of various nosological forms. There are numerous contradictions in the views on diagnostic approaches and treatment tactics, the nature of screening and control over the long-term results of treatment, the etiological and pathogenetic significance of various microorganisms found in the genital tract in patients with inflammatory diseases of the pelvic organs. Currently, there are many opinions among specialists about diagnostic approaches and treatment tactics, the type of screening and monitoring the long-term results of treatment, the etiological and pathogenetic role of various microorganisms which can be found in the genital tract in patients with inflammatory diseases. This review presents the results of a modern approach to the diagnosis, management and rehabilitation of patients with inflammatory diseases of the pelvic organs.

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Lumbar periarticular cysts of arcorray joint

Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) ◽

10.33920/med-01-2003-06 ◽

2020 ◽

pp. 47-57

Author(s):

Anton Yarikov ◽

Maxim Shpagin ◽

Iliya Nazmeev ◽

Sergey Gorelov ◽

Olga Perlmutter

Keyword(s):

Minimally Invasive ◽

Severe Pain ◽

Pain Syndrome ◽

Long Term Results ◽

Lumbar Region ◽

Results Of Treatment ◽

Invasive Method ◽

Facet Syndrome

The immediate and long-term results of treatment of 30 patients with severe pain syndrome of the lumbar region, who underwent operations on denervation of DOS, were studied. The aim of the study was to evaluate the effectiveness of minimally invasive technologies for the treatment of pain in the lumbar region (denervation of DOS), to study the near and distant results of these treatment methods. Denervation DOS is an effective minimally invasive method for the treatment of facet syndrome caused by spondylarthrosis. It allows in the early and distant postoperative periods to significantly reduce the pain syndrome and improve the quality of life of patients.

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P-44 Long-term results of hypofractionated radiotherapy in locally advanced laryngeal cancer: Single institution experience

Oral Oncology ◽

10.1016/s1368-8375(21)00332-8 ◽

2021 ◽

Vol 118 ◽

pp. 4

Author(s):

Brendan Zhen Yang Law ◽

Kim Ah-See ◽

Muhammad Shakeel ◽

Akhtar Hussain ◽

David Hurman ◽

...

Keyword(s):

Laryngeal Cancer ◽

Locally Advanced ◽

Long Term Results ◽

Hypofractionated Radiotherapy ◽

Single Institution

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Tensa retraction cholesteatoma: treatment and long-term results

The Journal of Laryngology & Otology ◽

10.1017/s0022215100108321 ◽

1989 ◽

Vol 103 (2) ◽

pp. 149-157 ◽

Cited By ~ 18

Author(s):

T. Lau ◽

M. Tos

Keyword(s):

Ossicular Chain ◽

Observation Time ◽

Long Term Results ◽

Mastoid Process ◽

Canal Wall ◽

Pars Tensa ◽

Results Of Treatment ◽

Acquired Cholesteatoma ◽

Canal Wall Down

AbstractTo obtain the best possible results of treatment of acquired cholesteatoma, we made a subdivision of cholesteatoma types into attic and pars tensa cholesteatomas, and subdivided the latter further into tensa retraction cholesteatoma and sinus cholesteatomas. Tensa retraction cholesteatoma is defined as arising from a retraction or perforation of the whole pars tensa, whereas sinus cholesteatoma is defined as arising from a retraction or perforation of the postero-superior part of the tensa. We present the long-term results obtained in tensa retraction cholesteatomas treated with one stage surgery from 1964 to 1980. Median observation time was 9 years, range 2 to 19 years. Sixty-one ears were treated without mastoidectomy, whereas 71 ears had canal wall-up mastoidectomy and 64 ears had canal wall-down mastoidectomy. The total recurrence rate was 13.3 per cent; 17 ears had residual cholesteatoma, and nine ears had recurrent cholesteatoma. The best results were obtained in ears with an intact ossicular chain where mastoidectomy was not performed. In 49 per cent of the cases, the cholesteatoma was confined to the tympanic cavity without reaching the aditus, antrum or mastoid process. About one-third to one-quarter of the ears had tympanoplasty only, with removal of the cholesteatoma through the ear canal.

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Long-term results of treatment of patients with limb arterial embolism

Kazan medical journal ◽

10.17816/kazmj70553 ◽

1986 ◽

Vol 67 (4) ◽

pp. 300-300

Author(s):

I. I. Strelnikov

Keyword(s):

Myocardial Infarction ◽

Causes Of Death ◽

Long Term Results ◽

Peripheral Artery ◽

Arterial Embolism ◽

Cardiac Defects ◽

Results Of Treatment ◽

Artery Embolism ◽

Conservative And Surgical Treatment

We followed the fate of 166 patients with limb arterial embolism in the late stage of the disease after conservative and surgical treatment from 6 months to 10 years. Of 166 patients, 44 (26.5%) died after hospital discharge. Thirty of them were older than 61 years. The most frequent causes of death in the long-term period were acute cerebrovascular disease (11), myocardial infarction (7), progressive cardiovascular insufficiency due to cardiac defects (6), repeated peripheral artery embolism causing limb gangrene (7). In 7 patients the cause of death was not determined.

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