Epidemiology and prevention strategies of SARS-CoV-2 infection in pediatric hematology and oncology centers in Poland

AbstractIntroductionEpidemiological analysis of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections in pediatric hematology and oncology (PHO) and hematopoietic cell transplant (HCT) centers in a Polish nationwide study, as well as analysis of the preventive strategies in these centers.MethodsAll of the 18 PHO/HCT centers participated in eight surveys and questionnaires conducted over the first 5 months of the SARS-CoV-2/coronavirus disease 2019 (COVID-19) pandemic in Poland. Epidemiological data were collected at eight regular time points, and the strategy of preventive management was done once after 4 months of the pandemic.ResultsDuring this analyzed period, eight patients were positive for SARS-CoV-2. The estimated incidence of SARS-CoV-2 positivity in Polish PHO/HCT centers was 0.5%. After exclusion of HCT patients (with one patient being infected), the estimated incidence of SARSCoV-2 positivity was between 0.5 and 0.6%. In all but one case, the course of COVID-19 was asymptomatic or mild, and it was moderate in one case. None of them developed SARS or respiratory insufficiency, none of them required treatment in the intensive care unit (ICU), and no patient died due to SARS-CoV-2 infection. As of July 1, parents staying in the hospital together with their children were regularly tested for the virus in 13 centers. Asymptomatic healthcare personnel were regularly tested for the virus in seven centers.ConclusionsThe estimated incidence of SARS-CoV-2 infection among PHO/HCT patients is lower than in Western Europe; however, these patients cannot be regarded as a low-risk group. The low COVID-19 incidence should be interpreted as a result of strictly and continuously implemented detailed preventive measures in the PHO/HCT wards and in hospitals.

Download Full-text

Abnormal Vital Signs Predict Critical Deterioration in Hospitalized Pediatric Hematology-Oncology and Post-hematopoietic Cell Transplant Patients

Frontiers in Oncology ◽

10.3389/fonc.2020.00354 ◽

2020 ◽

Vol 10 ◽

Author(s):

Asya Agulnik ◽

Jeffrey Gossett ◽

Angela K. Carrillo ◽

Guolian Kang ◽

R. Ray Morrison

Keyword(s):

Vital Signs ◽

Hematopoietic Cell ◽

Cell Transplant ◽

Hematopoietic Cell Transplant ◽

Pediatric Hematology ◽

Transplant Patients

Download Full-text

Evaluation of Aminophylline for the Treatment of Acute Kidney Injury in Pediatric Hematology/Oncology Patients

The Journal of Pediatric Pharmacology and Therapeutics ◽

10.5863/1551-6776-26.5.484 ◽

2021 ◽

Vol 26 (5) ◽

pp. 484-490

Author(s):

Hannah E. Sauer ◽

Kristine R. Crews ◽

Jennifer L. Pauley ◽

Melissa S. Bourque ◽

Allison W. Bragg ◽

...

Keyword(s):

Acute Kidney Injury ◽

Kidney Injury ◽

Standard Of Care ◽

Primary Diagnosis ◽

Hematopoietic Cell ◽

Control Group ◽

Cell Transplant ◽

Hematopoietic Cell Transplant ◽

Pediatric Hematology ◽

Historical Controls

OBJECTIVE The purpose of this study was to compare acute kidney injury (AKI)–related outcomes of patients who received aminophylline in addition to standard of care with matched historical controls who received standard of care alone. METHODS This was a single center, retrospective, historical control cohort study that included patients treated for AKI. Patients who received aminophylline from January 2017 to June 2018 were matched for age, sex, primary diagnosis, and hematopoietic cell transplant history in a 1:2 ratio to historical controls treated for AKI from July 2015 to September 2016. The primary outcome was improvement in AKI stage at 5 and 10 days from treatment initiation. RESULTS Twenty-seven patients who received aminophylline were matched to 54 historical controls. Fifty-eight patients (72%) had recently undergone hematopoietic cell transplant. At day 5, improvement in AKI stage was observed in 56% of patients in each group (p = 1.0); at day 10, improvement in AKI stage was observed in 75% of patients in the aminophylline group vs 70% of historical controls (p = 0.76). By day 10, serum creatinine levels had returned to baseline in 21% of patients in the aminophylline group and 34% of patients in the control group (p = 0.37). CONCLUSIONS Findings of this study demonstrated no difference in the rate of AKI resolution or in the proportion of patients with resolved AKI when aminophylline was added to standard of care for the treatment of AKI in this pediatric hematology/oncology population.

Download Full-text

EPIDEMIOLOGICAL DATA ON LARYNGEAL PAPILLOMATOSIS IN THE MOSCOW REGION

Science and Innovations in Medicine ◽

10.35693/2500-1388-2018-0-1-19-21 ◽

2018 ◽

Vol 3 (1) ◽

pp. 19-21

Author(s):

D M Mustafaev ◽

V I Egorov

Keyword(s):

Preventive Measures ◽

Epidemiological Data ◽

Hpv Infection ◽

Health Problems ◽

Moscow Region ◽

Healthy Population ◽

Laryngeal Papillomatosis ◽

Epidemiological Analysis ◽

Adults And Children

Im - to evaluate the prevalence of laryngeal papillomatosis in adults and children, to analyze the structure of the disease and to generalize the dynamics of the disease in the Moscow region. Materials and methods. The authors have carried out an epidemiological analysis of laryngeal papillomatosis in the Moscow region in the period from 2008 to 2014. Results. According to the received data, the prevalence of laryngeal papillomatosis in the Moscow region is 2.3 per 100000 children and 1.95 per 100000 adults. Discussion. Based on the epidemiological data, the significance of laryngeal papillomatosis in adults and children has been proved, and increased morbidity has been revealed. Laryngeal papillomatosis is one of the most important social and health problems. Taking into account the significant increase in the incidence of laryngeal papillomatosis in adults and children, it is necessary to focus on the organization of preventive measures aimed not only at preventing relapses, but also against the spread of HPV infection among healthy population in the Moscow region. To conclude, it is necessary to carry out annual analysis of the structure and course of the disease in the Moscow region.

Download Full-text