scholarly journals Female with Ankylosing Spondylitis from the 7th–6th century BCE Lori Berd burial (Armenia)

2021 ◽  
Vol 84 (1) ◽  
pp. 85-100
Author(s):  
Anahit Yu. Khudaverdyan ◽  
Seda H. Devejyan ◽  
Ruben H. Davtyan ◽  
Azat A. Yengibaryan ◽  
Arshak A. Hovhanesyan ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Advanced Stage ◽  
Bone Surface ◽  
Anterior Inferior Iliac Spine ◽  
Sacroiliac Joints ◽  
Greater Trochanter ◽  
Traumatic Death ◽  
Traumatic Lesions ◽  
Vertebral Bodies ◽  
The City

Abstract A female skeleton from the Lori Berd archaeological cemetery, located near the city of Stepanavan (Lori Province of Armenia) is described. Palaeopathological analysis revealed a variety pathology (ankylosis of the sacroiliac joints, ankylosis of the vertebrae, syndesmophytes, ankylosed of the costovertebral and costotransverse joint fusions, kyphosis, lordosis, fracture of the anterior inferior iliac spine and traumatic lesions). This paper reports a new case of ankylosing spondylitis in a skeleton and a differential diagnosis performed to determine the etiology of the condition. The vertebral bodies remodel and together with the associated syndesmophytes form a continuous, smooth bone surface that is sometimes referred to as “bamboo spine”. In this skeleton changes in the spine, ribs, the sacrum, acetabulum, head of the femur and greater trochanter, as well as the anterior inferior iliac spine are typical of ankylosing spondylitis in advanced stage. Addtionally, there were signs of a traumatic death with injuries sustained to the scapula and vertebra. Using osteological markers in combination with the reconstruction of the archaeological context, the burial pattern suggests that the pathology the female suffered was likely due to her physical deficiencies.

Axial Spondyloarthritis and New Bone Formation

2021 ◽  
Vol 30 (04) ◽  
pp. 311-318
Author(s):  
Uta Syrbe
Keyword(s):  
Bone Formation ◽  
Structural Damage ◽  
Axial Spondyloarthritis ◽  
Clinical Symptoms ◽  
Research Work ◽  
New Bone Formation ◽  
Sacroiliac Joints ◽  
Spine Mobility ◽  
Vertebral Bodies ◽  
Inflammatory Changes

AbstractAxial spondyloarthritis is an inflammatory disease of the axial skeleton. Its pathogenesis is only partly understood. At the beginning, there are inflammatory changes in the sacroiliac joints which are followed by inflammation in vertebral bodies and in facet joints. Low back pain occurring in the morning hours is the dominant clinical symptom. In the early phase, inflammatory changes are detectably by MRI. Inflammation promotes a process of joint remodelling in the sacroiliac joints which leads to erosions, sclerosis and bony bridging, i. e. ankylosis, which are detectable by X-ray. In the spine, vertical osteophytes developing at sites of previous inflammation connect vertebral bodies as syndesmophytes. Additional ossification of longitudinal ligaments contributes to the so-called bamboo spine. Ossification of the spine promotes fixation of a severe kyphosis of the thoracic spine which strongly impairs spine mobility and quality of life. High disease activity seems a prominent risk factor for development of structural damage. However, although NSAIDs improve clinical symptoms, they do not reduce new bone formation. In contrast, TNFα and IL-17 inhibitors seem to retard new bone formation apart from their clinical efficacy. Research work of the last years identified immunological pathways of inflammation. However, the trigger and cellular components of the immune reaction in the bone marrow are still poorly defined. Osteoclasts are involved in the destruction of the subchondral bone, while osteoblasts facilitate new bone formation and cartilage ossification. This review gives an overview about diagnostics and therapy of axSpA and about risk factors for the development of structural damage. Concepts about the immune pathogenesis and joint remodeling in AS are given under recognition of genetic and histopathological studies.

Anterior dural ectasia mimicking a lytic lesion in the posterior vertebral body in ankylosing spondylitis

2011 ◽  
Vol 15 (6) ◽  
pp. 636-640 ◽  
Author(s):  
Keerthiraj Bele ◽  
Hima Shriniwas Pendharkar ◽  
Easwer Venkat ◽  
Arun Kumar Gupta
Keyword(s):  
Ankylosing Spondylitis ◽  
Cauda Equina Syndrome ◽  
Imaging Finding ◽  
Cauda Equina ◽  
Lytic Lesion ◽  
Unique Case ◽  
Posterior Aspect ◽  
Rare Finding ◽  
Dural Ectasia ◽  
Vertebral Bodies

Anterior dural ectasia is an extremely rare finding in ankylosing spondylitis (AS). The authors describe a unique case of AS in which the patient presented with cauda equina syndrome as well as an unusual imaging finding of erosion of the posterior aspect of the L-1 (predominantly) and L-2 vertebral bodies due to anterior dural ectasia. Symptomatic patients with long-standing AS should be monitored for the presence of dural ectasia, which can be anterior in location, as is demonstrated in the present case.

A Prospective Study of Early Diagnostic Investigations in the Diagnosis of Ankylosing Spondylitis

2003 ◽  
Vol 48 (1) ◽  
pp. 21-23 ◽  
Author(s):  
C. J. Eastmond ◽  
E. M. Robertson
Keyword(s):  
New York ◽  
Ankylosing Spondylitis ◽  
Subsequent Development ◽  
Plain Film ◽  
Ct Scanning ◽  
Clinical History ◽  
Added Value ◽  
Hla B27 ◽  
Sacroiliac Joints ◽  
A Prospective Study

This study was designed to assess the relative values current of locally available investigations in the early diagnosis of inflammatory sacroiliitis. Consecutive patients attending routine rheumatology clinics in Aberdeen clinically considered by consultant rheumatologists to have inflammatory back disease but with insufficient criteria to firmly establish a diagnosis of ankylosing spondylitis were included. Patients were assessed using a standard questionnaire, clinical examination of spinal movements, plain radiology of the sacroiliac joints, computerised tomographic scanning of the sacroiliac joints and HLA-B27 typing. Patients were systematically followed up using repeated clinical and radiological examination for five years. Plain film evidence of grade 2 radiological sacroiliitis (bilateral or unilateral) was found to be the most reliable predictor for the development of ankylosing spondylitis satisfying the New York criteria at 5 year follow up. CT scanning and HLA-B27 typing were of no added value in this series and the clinical questionnaire lacked specificity. It is concluded that the combination of clinical history, examination and plain film radiology are currently reliable criteria for diagnosing the subsequent development of ankylosing spondylitis satisfying established criteria.

scholarly journals Can erosions on MRI of the sacroiliac joints be reliably detected in patients with ankylosing spondylitis? A cross-sectional study

2012 ◽  
Vol 14 (3) ◽  
pp. R124 ◽  
Author(s):  
Ulrich Weber ◽  
Susanne J Pedersen ◽  
Mikkel Ostergaard ◽  
Kaspar Rufibach ◽  
Robert G Lambert ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Sacroiliac Joints ◽  
Cross Sectional

Traumatic Death in Ankylosing Spondylitis

2010 ◽  
Vol 55 (4) ◽  
pp. 1126-1129 ◽  
Author(s):  
Asser H. Thomsen ◽  
Anne Grethe Jurik ◽  
Lars Uhrenholt ◽  
Annie Vesterby
Keyword(s):  
Ankylosing Spondylitis ◽  
Traumatic Death

What are axial spondyloarthritis and ankylosing spondylitis?

2016 ◽  
Author(s):  
Stefan Siebert ◽  
Sengupta Raj ◽  
Alexander Tsoukas
Keyword(s):  
Ankylosing Spondylitis ◽  
Inflammatory Arthritis ◽  
Structural Damage ◽  
Axial Spondyloarthritis ◽  
Negative Impact ◽  
Sacroiliac Joints ◽  
Chronic Inflammatory Arthritis ◽  
The Past ◽  
Assessment And Treatment

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting mainly the sacroiliac joints and spine, resulting in pain, stiffness, and reduced movement. AS has a major negative impact on patients’ quality of life. AS is part of a larger group of related spondyloarthritis (SpA) conditions and patients with AS often have extra-articular manifestations of these conditions. Over the past decade, there have been major advances in the understanding of the genetics and pathophysiology of the disease. Advances in imaging have allowed patients to be diagnosed without having to develop the radiographic structural damage that characterize AS, resulting in the concept of axial spondyloarthritis (axSpA). Together with the development of highly effective TNF inhibitors, these advances have transformed the management and outlook of patients with this condition. It is hoped that further advances in diagnosis, assessment and treatment of axSpA will lead to further progress in future.

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