scholarly journals Therapeutic Perspectives in Sneddon’s Syndrome

2021 ◽  
Vol 18 (5) ◽  
pp. 73-80
Author(s):  
Oana-Petronela Oancea ◽  
Alexandru-Dan Costache ◽  
Daniela Olaru ◽  
Răzvan Platon ◽  
Florin Mitu
Keyword(s):  
Chronic Disease ◽  
Disease Progression ◽  
Oral Anticoagulant ◽  
Oral Anticoagulant Therapy ◽  
Protein Z ◽  
Livedo Racemosa ◽  
Sneddon's Syndrome ◽  
Sneddon’S Syndrome ◽  
Cerebrovascular Events ◽  
Therapeutic Perspective

Abstract Sneddon’s syndrome is a rare but severe progressive chronic disease, characterized by multiple discoloration skin patches called Livedo racemosa and recurrent cerebrovascular events. It mainly affects women aged around 40. Considering the two main forms, antiphospholipid (APS) positive and negative, the available treatments are directed at either one of them. The idiopathic form (APS negative) is associated with a more severe prognosis as chronic oral anticoagulant therapy (COA) is more difficult to manage. One therapeutic perspective in controlling disease progression in these patients is by understanding the protein Z deficiency in these patients as a deciding factor in the success of the COA therapy.

A combination of livedo racemosa, occlusion of cerebral blood vessels, and nephropathy: Kidney involvement in sneddon's syndrome

1995 ◽  
Vol 26 (3) ◽  
pp. 511-515 ◽  
Author(s):  
Hiroshi Ohtani ◽  
Hirokazu Imai ◽  
Tadashi Yasuda ◽  
Hideki Wakui ◽  
Atsushi Komatsuda ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Cerebral Blood Vessels ◽  
Livedo Racemosa ◽  
Sneddon's Syndrome ◽  
Sneddon’S Syndrome ◽  
Kidney Involvement

scholarly journals Clinical, neurovascular and neuropathological features in sneddon's syndrome

2007 ◽  
Vol 65 (2b) ◽  
pp. 390-395 ◽  
Author(s):  
Jaqueline Luvisotto Marinho ◽  
Élcio Juliato Piovesan ◽  
Moacir Pereira Leite Neto ◽  
Luiz Roberto Kotze ◽  
Lúcia de Noronha ◽  
...  
Keyword(s):  
Young Women ◽  
Renal Involvement ◽  
Cerebral Atrophy ◽  
Anticardiolipin Antibodies ◽  
Livedo Reticularis ◽  
Sneddon's Syndrome ◽  
Sneddon’S Syndrome ◽  
Cerebrovascular Events ◽  
History Of ◽  
Ct And Mri

Sneddon's syndrome (SS) is characterized by ischemic cerebrovascular episodes and livedo reticularis. It is more common in young women and can also be associated with valvulopathy, a history of spontaneous abortion, renal involvement and vascular dementia. We describe three cases of young women with this disease. The patients had repeated ischemic cerebral episodes, livedo reticularis and thrombocytopenia. CT and MRI showed strokes and cerebral atrophy. Autopsy in one of the patients revealed cerebral infarctions. Anticardiolipin antibodies were detected in two patients. Antiphospholipid antibodies may be found in some patients with ischemic cerebrovascular events and livedo reticularis. SS may thus be associated with antiphospholipid syndrome. We described three new cases of SS and discuss the pathophysiology of this disease.

scholarly journals Sneddon's Syndrome (Livedo Racemosa and Cerebral Infarction) Presenting Psychiatric Disturbance and Shortening of Fingers and Toes.

1996 ◽  
Vol 35 (8) ◽  
pp. 668-673 ◽  
Author(s):  
Masaaki KUME ◽  
Hirokazu IMAI ◽  
Mutsuhito MOTEGI ◽  
Akira B. MIURA ◽  
Ikuro NAMURA
Keyword(s):  
Cerebral Infarction ◽  
Psychiatric Disturbance ◽  
Livedo Racemosa ◽  
Sneddon's Syndrome ◽  
Sneddon’S Syndrome

scholarly journals Livedo racemosa: a cutaneous manifestation of Sneddon’s syndrome

2019 ◽  
Vol 12 (11) ◽  
pp. e232670 ◽  
Author(s):  
Irene Timoney ◽  
Aoibheann Flynn ◽  
Niamh Leonard ◽  
Bairbre Wynne
Keyword(s):  
Cutaneous Manifestation ◽  
Livedo Racemosa ◽  
Sneddon's Syndrome ◽  
Sneddon’S Syndrome

scholarly journals Protein Z Deficiency in Antiphospholipid-Negative Sneddon’s Syndrome

Stroke ◽  
2004 ◽  
Vol 35 (6) ◽  
pp. 1329-1332 ◽  
Author(s):  
Nakhlé Ayoub ◽  
Gaetan Esposito ◽  
Stéphane Barete ◽  
Claudine Soria ◽  
Jean-Charles Piette ◽  
...  
Keyword(s):  
Protein Z ◽  
Sneddon's Syndrome ◽  
Sneddon’S Syndrome

Controlled Trial of the Sequential Use of Streptokinase and Ancrod in the Treatment of Deep Vein Thrombosis of Lower Limb

1977 ◽  
Vol 37 (02) ◽  
pp. 222-232 ◽  
Author(s):  
D. A Tibbutt ◽  
C. N Chesterman ◽  
E. W Williams ◽  
T Faulkner ◽  
A. A Sharp
Keyword(s):  
Deep Vein Thrombosis ◽  
Clinical Improvement ◽  
Anticoagulant Therapy ◽  
Lower Limb ◽  
Oral Anticoagulant ◽  
Controlled Trial ◽  
Oral Anticoagulant Therapy ◽  
Control Group ◽  
Vein Thrombosis ◽  
Deep Vein

SummaryTreatment with streptokinase (‘Kabikinase’) was given to 26 patients with venographically confirmed deep vein thrombosis extending into the popliteal vein or above. Treatment was continued for 4 days and the patients were allocated randomly to oral anticoagulant therapy or a course of treatment with ancrod (‘Arvin’) for 6 days followed by oral anticoagulant therapy. The degree of thrombolysis as judged by further venographic examination at 10 days was not significantly different between the 2 groups. The majority of patients showed clinical improvement but there was no appreciable difference between the groups at 3 and 6 months. Haemorrhagic complications were a more serious problem during the period of treatment with ancrod than during the equivalent period in the control group.

Relationship Between Total Prothrombin, Native Prothrombin and the International Normalized Ratio (INR)

1992 ◽  
Vol 68 (02) ◽  
pp. 160-164 ◽  
Author(s):  
P J Braun ◽  
K M Szewczyk
Keyword(s):  
Anticoagulant Therapy ◽  
Oral Anticoagulant ◽  
Inverse Relationship ◽  
Low Dose ◽  
Oral Anticoagulant Therapy ◽  
International Normalized Ratio ◽  
Antigen Assay ◽  
Dose Oral ◽  
Anticoagulated Patients ◽  
Sensitive Method

SummaryPlasma levels of total prothrombin and fully-carboxylated (native) prothrombin were compared with results of prothrombin time (PT) assays for patients undergoing oral anticoagulant therapy. Mean concentrations of total and native prothrombin in non-anticoagulated patients were 119 ± 13 µg/ml and 118 ± 22 µg/ml, respectively. In anticoagulated patients, INR values ranged as high as 9, and levels of total prothrombin and native prothrombin decreased with increasing INR to minimum values of 40 µg/ml and 5 µg/ml, respectively. Des-carboxy-prothrombin increased with INR, to a maximum of 60 µg/ml. The strongest correlation was observed between native prothrombin and the reciprocal of the INR (1/INR) (r = 0.89, slope = 122 µg/ml, n = 200). These results indicated that native prothrombin varied over a wider range and was more closely related to INR values than either total or des-carboxy-prothrombin. Levels of native prothrombin were decreased 2-fold from normal levels at INR = 2, indicating that the native prothrombin antigen assay may be a sensitive method for monitoring low-dose oral anticoagulant therapy. The inverse relationship between concentration of native prothrombin and INR may help in identification of appropriate therapeutic ranges for oral anticoagulant therapy.

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