scholarly journals Effects of processing parameters on the properties of amphiphilic block copolymer micelles prepared by supercritical carbon dioxide evaporation method

2018 ◽  
Vol 20 (1) ◽  
pp. 81-86
Author(s):  
Zhen Jiao ◽  
Ziyi Wang ◽  
Xiudong Wang ◽  
Wenjing Fan
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Drug Loading ◽  
Volume Ratio ◽  
Spherical Shape ◽  
Entrapment Efficiency ◽  
Processing Parameters ◽  
Evaporation Method ◽  
Drug Entrapment Efficiency ◽  
Supercritical Carbon

Abstract The operation parameters for the supercritical carbon dioxide (ScCO2) evaporation method greatly affect the properties of the prepared drug-loaded micelles. In this study, the effects of those key parameters on the drug-loading content (LC) and drug entrapment efficiency (EE) are discussed. It is observed that EE and LC of the micelles are slightly increased with the enhancing temperature and the copolymer molecular ratio of hydrophilic/hydrophobic segment, while decreased with the enhancing ScCO2 evaporation rate. The pressure and volume ratio of ScCO2 to H2O are observed the optimum condition. In addition, the verification experiment is carried out under the obtained optimizing parameters. The prepared micelles exhibit relatively regular spherical shape and narrow size distribution with the EE and LC value of 70.7% and 14.1%, respectively.

Response Surface Modeling of Drug-Loaded Micelles Prepared Through Supercritical Carbon Dioxide Evaporation Method Using Box-Behnken Experimental Design

2019 ◽  
Vol 19 (6) ◽  
pp. 3616-3620 ◽  
Author(s):  
Zhen Jiao ◽  
Xianjun Zha ◽  
Ziyi Wang ◽  
Xiudong Wang ◽  
Wenjing Fan
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Response Surface ◽  
Release Rate ◽  
Volume Ratio ◽  
Spherical Shape ◽  
Entrapment Efficiency ◽  
Evaporation Method ◽  
Supercritical Carbon

The nanoscale drug-loaded micelles can be prepared by the supercritical carbon dioxide evaporation method. Here, response surface methodology is used to optimize this process. The effects of pressure, ScCO2 release rate and the volume ratio of water against ScCO2 on the drug entrapment efficiency (EE) of the obtained micelles are discussed in detail. The obtained second-order polynomial equation can successfully predict the drug EE of the drug-loaded micelles. The maximum EE can reach 70.1% under optimal conditions in which the pressure is 12.27 MPa, the release rate is 10 L min−1 and the volume ratio of water against ScCO2 is 3.67:1. The prepared micelles exhibit a narrow size distribution and relatively regularly spherical shape. In vitro drug release study reveals that the release of paclitaxel from the micelles is slow and sustained.

Preparation of Liposome Particle of Atractylone by Supercritical Carbon Dioxide Process

2010 ◽  
Vol 92 ◽  
pp. 177-182 ◽  
Author(s):  
Zhen Wen ◽  
Bo Liu ◽  
Zong Kun Zheng ◽  
Xin Kui You ◽  
Yi Tao Pu ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Physicochemical Properties ◽  
Drug Loading ◽  
Entrapment Efficiency ◽  
Liposome Suspension ◽  
Liposomal Suspension ◽  
Atractylodes Macrocephala ◽  
Average Size ◽  
Supercritical Carbon

The liposome particle entrapping atractylone extracted from Atractylodes macrocephala Koidz.was prepared and characterized. The liposome suspension of atractylone was formed by supercritical carbon dioxide (SC-CO2) expansion process and was dried by vacuum freezing. The physicochemical properties of the liposome particle including microstructure, size, entrapment efficiency and drug loading content were measured. The liposome formation could be controlled by adjusting the processing conditions such as pressure, temperature of SC-CO2 and mole fraction of ethanol in SC-CO2 [ x (CH3CH2OH)]. The entrapment efficiency, loading content, and average size of liposome particle were 83.1％, 5.1％ and 506.5nm respectively under the optimum conditions of 30MPa，338K and x (CH3CH2OH) = 15％.The liposome particle presented good performance of redispersion to liposomal suspension. The physicochemical properties of liposome particle including entrapment efficiency, dissolution rate and stability complied with the provisions of Chinese pharmacopoeia. The results show the liposome particle can be used as an solid immediate for hepatic target of drugs.

scholarly journals Preparation of Liposomes Modified with Lipopeptides Using a Supercritical Carbon Dioxide Reverse-phase Evaporation Method

2011 ◽  
Vol 60 (5) ◽  
pp. 209-215 ◽  
Author(s):  
Kenichi Aburai ◽  
Nobuhiro Yagi ◽  
Yuusaku Yokoyama ◽  
Hiroaki Okuno ◽  
Kenichi Sakai ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Reverse Phase ◽  
Evaporation Method ◽  
Supercritical Carbon

scholarly journals Microencapsulation and Nanoencapsulation Using Supercritical Fluid (SCF) Techniques

Pharmaceutics ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 21 ◽  
Author(s):  
Soon Hong Soh ◽  
Lai Yeng Lee
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Fluid ◽  
Supercritical Co2 ◽  
Drug Loading ◽  
Particle Morphology ◽  
Operating Conditions ◽  
Rapid Expansion ◽  
Comprehensive Overview ◽  
Supercritical Carbon

The unique properties of supercritical fluids, in particular supercritical carbon dioxide (CO2), provide numerous opportunities for the development of processes for pharmaceutical applications. One of the potential applications for pharmaceuticals includes microencapsulation and nanoencapsulation for drug delivery purposes. Supercritical CO2 processes allow the design and control of particle size, as well as drug loading by utilizing the tunable properties of supercritical CO2 at different operating conditions (flow ratio, temperature, pressures, etc.). This review aims to provide a comprehensive overview of the processes and techniques using supercritical fluid processing based on the supercritical properties, the role of supercritical carbon dioxide during the process, and the mechanism of formulation production for each process discussed. The considerations for equipment configurations to achieve the various processes described and the mechanisms behind the representative processes such as RESS (rapid expansion of supercritical solutions), SAS (supercritical antisolvent), SFEE (supercritical fluid extraction of emulsions), PGSS (particles from gas-saturated solutions), drying, and polymer foaming will be explained via schematic representation. More recent developments such as fluidized bed coating using supercritical CO2 as the fluidizing and drying medium, the supercritical CO2 spray drying of aqueous solutions, as well as the production of microporous drug releasing devices via foaming, will be highlighted in this review. Development and strategies to control and optimize the particle morphology, drug loading, and yield from the major processes will also be discussed.

Sign in / Sign up

Export Citation Format

Share Document