The influence of supercritical carbon dioxide (SC-CO2) processing conditions on drug loading and physicochemical properties

2012 ◽  
Vol 439 (1-2) ◽  
pp. 92-99 ◽  
Author(s):  
Robert J. Ahern ◽  
Abina M. Crean ◽  
Katie B. Ryan
2010 ◽  
Vol 92 ◽  
pp. 177-182 ◽  
Author(s):  
Zhen Wen ◽  
Bo Liu ◽  
Zong Kun Zheng ◽  
Xin Kui You ◽  
Yi Tao Pu ◽  
...  

The liposome particle entrapping atractylone extracted from Atractylodes macrocephala Koidz.was prepared and characterized. The liposome suspension of atractylone was formed by supercritical carbon dioxide (SC-CO2) expansion process and was dried by vacuum freezing. The physicochemical properties of the liposome particle including microstructure, size, entrapment efficiency and drug loading content were measured. The liposome formation could be controlled by adjusting the processing conditions such as pressure, temperature of SC-CO2 and mole fraction of ethanol in SC-CO2 [ x (CH3CH2OH)]. The entrapment efficiency, loading content, and average size of liposome particle were 83.1%, 5.1% and 506.5nm respectively under the optimum conditions of 30MPa,338K and x (CH3CH2OH) = 15%.The liposome particle presented good performance of redispersion to liposomal suspension. The physicochemical properties of liposome particle including entrapment efficiency, dissolution rate and stability complied with the provisions of Chinese pharmacopoeia. The results show the liposome particle can be used as an solid immediate for hepatic target of drugs.


2015 ◽  
Vol 49 (4) ◽  
pp. 245-254
Author(s):  
Hye-Min Kim ◽  
◽  
Sung-Woon Woo ◽  
Sung-Won Kang ◽  
Ho-Jin Heo ◽  
...  

Technologies ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 94 ◽  
Author(s):  
Anh V. Le ◽  
Sophie E. Parks ◽  
Minh H. Nguyen ◽  
Paul D. Roach

Gac seeds are high in oil, but there are few studies on its extraction and characteristics. This study aimed to characterise Gac seeds and investigate the physicochemical properties of Gac seed oil extracted with supercritical carbon dioxide (SC-CO2) and hexane (Soxhlet). The Gac seed kernel accounted for 66.4 ± 2.7% of the seed weight, and 53.02 ± 1.27% of it was oil. The SC-CO2 oil had a higher quality than the Soxhlet oil for important criteria, such as peroxide (0.12 ± 0.02 vs. 1.80 ± 0.01 meq O2/kg oil), free fatty acid (1.74 ± 0.12 vs. 2.47 ± 0.09 mg KOH/g oil) and unsaponifiable matter (33.2 ± 1.5 vs. 52.6 ± 2.4 g/kg) values, respectively. It also had a better colour (light yellow vs. dark greenish brown) and a higher antioxidant capacity measured with the DPPH (52.69 ± 0.06 vs. 42.98 ± 0.02 µmol Trolox equivalent/g oil) and ABTS (2.10 ± 0.12 vs. 1.52 ± 0.06 µmol Trolox equivalent/g oil) assays. However, a higher yield (53.02 ± 1.27 vs. 34.1 ± 0.8%) was obtained for the Soxhlet oil. Unless refined, the oils would not be edible due to their high unsaponifiable matter, but the SC-CO2 oil would need less refining. Alternatively, the high unsaponifiable matter in the oil, especially in the Soxhlet oil, may make it useful for medicinal purposes.


e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Zhen Xiu Zhang ◽  
Shu Ling Zhang ◽  
Zhen Xiang Xin ◽  
Jin Kuk Kim

AbstractIn this study, processing-structure relationships in polypropylene (PP)/waste ground rubber tire powder (WGRT) foams made using supercritical carbon dioxide as a physical blowing agent were investigated. In order to investigate the relationship between structure and properties of PP/WGRT foams, it was necessary to make samples with a wide range of controlled structures. For this reason, a systematic investigation of the relationship between processing conditions and structure was performed based on a statistical experimental design. Regression analysis was conducted on the data and expressions were developed to quantify the relationships between structural parameters and processing conditions. The samples were saturated with carbon dioxide at high temperature and high pressure and the saturated specimens were expanded during the pressure-quench process. The importance of the individual processing parameters was determined. Statistical analysis of data showed that saturation temperature was the most important factor determining cell size, cell density and relative density. By controlling the foaming conditions, PP/WGRT samples having the same foam density and different cell size or having the same cell size and different foam density were produced.


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