Preparation of Liposome Particle of Atractylone by Supercritical Carbon Dioxide Process

2010 ◽  
Vol 92 ◽  
pp. 177-182 ◽  
Author(s):  
Zhen Wen ◽  
Bo Liu ◽  
Zong Kun Zheng ◽  
Xin Kui You ◽  
Yi Tao Pu ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Physicochemical Properties ◽  
Drug Loading ◽  
Entrapment Efficiency ◽  
Liposome Suspension ◽  
Liposomal Suspension ◽  
Atractylodes Macrocephala ◽  
Average Size ◽  
Supercritical Carbon

The liposome particle entrapping atractylone extracted from Atractylodes macrocephala Koidz.was prepared and characterized. The liposome suspension of atractylone was formed by supercritical carbon dioxide (SC-CO2) expansion process and was dried by vacuum freezing. The physicochemical properties of the liposome particle including microstructure, size, entrapment efficiency and drug loading content were measured. The liposome formation could be controlled by adjusting the processing conditions such as pressure, temperature of SC-CO2 and mole fraction of ethanol in SC-CO2 [ x (CH3CH2OH)]. The entrapment efficiency, loading content, and average size of liposome particle were 83.1％, 5.1％ and 506.5nm respectively under the optimum conditions of 30MPa，338K and x (CH3CH2OH) = 15％.The liposome particle presented good performance of redispersion to liposomal suspension. The physicochemical properties of liposome particle including entrapment efficiency, dissolution rate and stability complied with the provisions of Chinese pharmacopoeia. The results show the liposome particle can be used as an solid immediate for hepatic target of drugs.

scholarly journals Effects of processing parameters on the properties of amphiphilic block copolymer micelles prepared by supercritical carbon dioxide evaporation method

2018 ◽  
Vol 20 (1) ◽  
pp. 81-86
Author(s):  
Zhen Jiao ◽  
Ziyi Wang ◽  
Xiudong Wang ◽  
Wenjing Fan
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Drug Loading ◽  
Volume Ratio ◽  
Spherical Shape ◽  
Entrapment Efficiency ◽  
Processing Parameters ◽  
Evaporation Method ◽  
Drug Entrapment Efficiency ◽  
Supercritical Carbon

Abstract The operation parameters for the supercritical carbon dioxide (ScCO2) evaporation method greatly affect the properties of the prepared drug-loaded micelles. In this study, the effects of those key parameters on the drug-loading content (LC) and drug entrapment efficiency (EE) are discussed. It is observed that EE and LC of the micelles are slightly increased with the enhancing temperature and the copolymer molecular ratio of hydrophilic/hydrophobic segment, while decreased with the enhancing ScCO2 evaporation rate. The pressure and volume ratio of ScCO2 to H2O are observed the optimum condition. In addition, the verification experiment is carried out under the obtained optimizing parameters. The prepared micelles exhibit relatively regular spherical shape and narrow size distribution with the EE and LC value of 70.7% and 14.1%, respectively.

Effect of Supercritical Carbon Dioxide on Physicochemical Properties of Freeze-Dried Bovine Liver

2015 ◽  
Vol 49 (4) ◽  
pp. 245-254
Author(s):  
Hye-Min Kim ◽  
◽  
Sung-Woon Woo ◽  
Sung-Won Kang ◽  
Ho-Jin Heo ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Physicochemical Properties ◽  
Bovine Liver ◽  
Freeze Dried ◽  
Supercritical Carbon

scholarly journals Physicochemical Properties of Gac (Momordica cochinchinensis (Lour.) Spreng) Seeds and Their Oil Extracted by Supercritical Carbon Dioxide and Soxhlet Methods

Technologies ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 94 ◽  
Author(s):  
Anh V. Le ◽  
Sophie E. Parks ◽  
Minh H. Nguyen ◽  
Paul D. Roach
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Physicochemical Properties ◽  
Unsaponifiable Matter ◽  
Seed Oil ◽  
Seed Kernel ◽  
Light Yellow ◽  
Momordica Cochinchinensis ◽  
Trolox Equivalent ◽  
Supercritical Carbon

Gac seeds are high in oil, but there are few studies on its extraction and characteristics. This study aimed to characterise Gac seeds and investigate the physicochemical properties of Gac seed oil extracted with supercritical carbon dioxide (SC-CO2) and hexane (Soxhlet). The Gac seed kernel accounted for 66.4 ± 2.7% of the seed weight, and 53.02 ± 1.27% of it was oil. The SC-CO2 oil had a higher quality than the Soxhlet oil for important criteria, such as peroxide (0.12 ± 0.02 vs. 1.80 ± 0.01 meq O2/kg oil), free fatty acid (1.74 ± 0.12 vs. 2.47 ± 0.09 mg KOH/g oil) and unsaponifiable matter (33.2 ± 1.5 vs. 52.6 ± 2.4 g/kg) values, respectively. It also had a better colour (light yellow vs. dark greenish brown) and a higher antioxidant capacity measured with the DPPH (52.69 ± 0.06 vs. 42.98 ± 0.02 µmol Trolox equivalent/g oil) and ABTS (2.10 ± 0.12 vs. 1.52 ± 0.06 µmol Trolox equivalent/g oil) assays. However, a higher yield (53.02 ± 1.27 vs. 34.1 ± 0.8%) was obtained for the Soxhlet oil. Unless refined, the oils would not be edible due to their high unsaponifiable matter, but the SC-CO2 oil would need less refining. Alternatively, the high unsaponifiable matter in the oil, especially in the Soxhlet oil, may make it useful for medicinal purposes.

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