MRI prognostic factors of tongue cancer: potential predictors of cervical lymph nodes metastases

Abstract Background This study aimed to evaluate the efficacy of three MR imaging parameters, which are tumour thickness, para-lingual distance and apparent diffusion coefficient (ADC) value for prediction of cervical lymph nodes metastasis in cancer tongue patients. Patients and methods Fifty patients with proved cancer tongue by histopathological examination underwent MRI examination. T1 and T2- weighted MRI, diffusion-weighted images and post-contrast T1 fat suppression sequences were used. Results The patients were classified according to lymph nodes involvement as seen by MRI into two groups. Significant differences between positive and negative nodes groups were observed regarding tumour thickness and para-lingual distance (p-values = 0.008 and 0.003 respectively). ROC curve analyses revealed cut-off values >13.8 mm and ≤ 3.3 mm for tumour thickness and para-lingual distance respectively for prediction of nodes involvement. No significant differences between patients with and without cervical lymph nodes metastasis were found regarding corresponding ADC value of the tumour (p-value = 0.518). Conclusions Para-lingual distance and tumour thickness are factors that could influence pre-operative judgment and prognosis of tongue cancer patients. ADC value of the tumour itself seem not to be a reliable index of cancer progression to regional lymph nodes.

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The association between tumor’s location and cervical lymph nodes metastasis in papillary thyroid cancer

Gland Surgery ◽

10.21037/gs.2019.10.02 ◽

2019 ◽

Vol 8 (5) ◽

pp. 557-568 ◽

Cited By ~ 1

Author(s):

Ting-Ting Zhang ◽

Xiu-Zhu Qi ◽

Jian-Ping Chen ◽

Rong-Liang Shi ◽

Shi-Shuai Wen ◽

...

Keyword(s):

Thyroid Cancer ◽

Lymph Nodes ◽

Papillary Thyroid Cancer ◽

Papillary Thyroid ◽

Cervical Lymph Nodes ◽

Lymph Nodes Metastasis

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Ocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes

European Journal of Ophthalmology ◽

10.1177/1120672119870079 ◽

2019 ◽

pp. 112067211987007

Author(s):

Jayati Sarangi ◽

Aanchal Kakkar ◽

Diya Roy ◽

Rishikesh Thakur ◽

Chirom Amit Singh ◽

...

Keyword(s):

Lymph Nodes ◽

Histopathological Examination ◽

Previous History ◽

Rare Presentation ◽

Cervical Lymph Nodes ◽

Extranodal Extension ◽

Positron Emission ◽

Parotid Neoplasm ◽

History Of ◽

The Right

Purpose: To describe a rare presentation of a case of intraocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes. Case description: A 9-year-old male child with previous history of ciliary body non-teratoid medulloepithelioma presented with a swelling in the right pre-auricular region for 1 month. Magnetic resonance imaging and positron emission tomography–computed tomography showed a right intraparotid mass with enlarged ipsilateral cervical lymph nodes. A core biopsy was taken from the lesion, which on microscopy showed a tumor composed of small round cells arranged in cords, tubules lined by multilayered cells, and in cribriform pattern. These cells were embedded in a hypocellular, loose myxoid matrix. Based on the histopathological characteristics and previous history, a diagnosis of medulloepithelioma metastastic to ipsilateral parotid gland was made. The patient underwent right total conservative parotidectomy and bilateral neck dissection. Histopathological examination revealed metastatic medulloepithelioma in five out of eight intraparotid lymph nodes, with extranodal extension into the adjacent parotid parenchyma. Foci of hyaline cartilage were identified within the tumor, leading to a diagnosis of metastatic teratoid medulloepithelioma. Conclusion: Intraparotid lymph node metastases from intraocular medulloepithelioma is a rare possibility and we recommend that the parotid should be evaluated in cases of intraocular medulloepithelioma at initial presentation as well as during the follow-up period. Also, metastasis should be considered in all pediatric patients with solitary mass lesions showing unconventional histology for a primary parotid neoplasm.

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Development of follicular lymphoma of the cervical lymph nodes in a postoperative patient with tongue cancer

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.tripleo.2011.08.026 ◽

2012 ◽

Vol 113 (6) ◽

pp. e35-e39 ◽

Cited By ~ 1

Author(s):

Hiroshi Yamazaki ◽

Noriko Nakatogawa ◽

Yoshihide Ota ◽

Kazunari Karakida ◽

Mitsunobu Otsuru ◽

...

Keyword(s):

Lymph Nodes ◽

Follicular Lymphoma ◽

Tongue Cancer ◽

Postoperative Patient ◽

Cervical Lymph Nodes

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Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study

Journal of Enam Medical College ◽

10.3329/jemc.v2i1.11915 ◽

2012 ◽

Vol 2 (1) ◽

pp. 8-14

Author(s):

Md Atiqur Rahman ◽

Md Mamun Ali Biswas ◽

Syeda Tasfia Siddika ◽

Abdul Mannan Sikder

Keyword(s):

Lymph Node ◽

Lymph Nodes ◽

Hodgkin Lymphoma ◽

Histopathological Examination ◽

Age Groups ◽

The Body ◽

Cross Sectional ◽

Cervical Lymph Nodes ◽

Female Ratio ◽

Histopathological Evaluation

Background: Lymphadenopathy is a common manifestation of a large variety of disorders,both benign and malignant. It is essential to define the pattern of disorders presenting primarily as lymph node enlargement in a particular environment. Histopathological examination of the lymph node biopsies is a gold standard test in the distinction between reactive and malignant lymphoid proliferations as well as for detailed subtyping oflymphomas. We designed this study in our population for histopathological evaluation of lymph nodes that might be helpful for clinical management of these lesions. Objective: Histopathological evaluation of lymphadenopathy from excised specimen, in relation to ageand sex of the patients, and distribution of the lymph nodes. Materials and Methods: It was a retrospective cross sectional study conducted in the department of Pathology, Enam MedicalCollege & Hospital, Savar, Dhaka during the period from January 2006 to December 2010. Lymph node biopsies of all patients of both sexes and all age groups were included.Metastatic lymph nodes associated with evidence of primaries elsewhere in the body were excluded from the study. Total 191 lymph node biopsies were selected for histopathological evaluation. Among these 90 (47.12%) were from males and 101 (52.88%) were from females with male to female ratio being 1:2.1. The age of the patients ranged from 2 to 85 years with a mean age of 35.73 ± 18 years. Results: Cervical lymph nodes were the most common (56%) biopsied group. Of the 191 cases 59 cases (30.89%) were reactive lymphadenitis, 64 cases (33.5%) were tuberculosis, 2 cases (1.05%) were non-caseous granuloma, 11 cases (5.76%) were Hodgkin lymphoma, 22 cases (11.52%) were non-Hodgkin lymphoma, 24 cases (12.57%) were metastatic neoplasm and 9 cases (4.7%) were other lesions.Conclusion: Tuberculosis was the most common cause of lymphadenopathy, followed by reactive lymphadenitis and the cervical group of lymph nodes was most frequently affected. DOI: http://dx.doi.org/10.3329/jemc.v2i1.11915 J Enam Med Col 2012; 2(1):8 -14

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Thyroglobulin measurement in fine-needle aspirates of lymph nodes in patients with differentiated thyroid cancer

Endocrine Surgery ◽

10.14341/serg9824 ◽

2019 ◽

Vol 13 (1) ◽

pp. 17-25

Author(s):

Zamira T. Zuraeva ◽

Larisa V. Nikankina ◽

Galina S. Kolesnikova ◽

Fatima M. Abdulhabirova ◽

Pavel O. Rumiantsev ◽

...

Keyword(s):

Lymph Nodes ◽

Prognostic Significance ◽

Diagnostic Methods ◽

Automated System ◽

Youden Index ◽

Serum Thyroglobulin ◽

Cervical Lymph Nodes ◽

Fine Needle ◽

Lymph Nodes Metastasis ◽

Diagnostic Threshold

Background: The high incidence of cervical lymph nodes metastasis in highly differentiated thyroid carcinoma (DTC) and insufficient of existing diagnostic methods determines the urgency of finding reliable and more effective tests. Aims: The aim of our study is to determine the prognostic significance of the thyroglobulin measurement in washout fluid from fine-needle aspiration biopsy (FNA-Tg) and the cut-off value in the diagnosis of DTC lymph nodes metastasis. Materials and methods: 245 patients evaluated for suspicious cervical lymph nodes were retrospectively reviewed. All patients underwent FNA-Tg, serum thyroglobulin (sTg) levels, thyroglobulin antibodies (Tg-Ab), thyroid-stimulating hormone (TSH) were measured. 125 patients with malignant changes according to FNA and/or high FNA-Tgvalues underwent surgical treatment. Patients were divided into 2 groups with reactive (n = 23) and metastatic (n = 102) changes. FNA-TG was assayed on automated system Cobas 601 (Roche, France). Results: All patients were comparable by sex, age and levels of TSH, sTG, Tg-Ab. The FNA-Tg median in metastatic group was 537.0 [0.1; 1000], and in benign group – 17.9 [0.5; 158.0], p = 0.003. The sensitivity of isolated FNA was 85%, specificity 57%, AUC = 0.618, 95% CI 0.516–0.713. The sensitivity and specificity of FNA-Tg was 73% and 100%, respectively, AUC = 0.865, 95% CI 0.78–0.92. The optimal cut-off point for malignancy was >9.2 ng/ml (sensitivity 75%, specificity 100%), Youden Index 0.73. Conclusions: Additional FNA-Tg may increase the sensitivity of isolated FNA in evaluation of DTC lymph node metastasis. The optimized cut-off value >9.2 ng/ml can be proposed as a diagnostic threshold for the definition of malignancy.

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Intraparotid and cervical lymph nodes metastasis in primary parotid gland carcinoma—impact on clinical outcome

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2020.01.010 ◽

2020 ◽

Vol 129 (6) ◽

pp. 570-574

Author(s):

Sven Schneider ◽

Ulana Kotowski ◽

Lorenz Kadletz ◽

Markus Brunner ◽

Isabella Stanisz ◽

...

Keyword(s):

Clinical Outcome ◽

Parotid Gland ◽

Lymph Nodes ◽

Cervical Lymph Nodes ◽

Lymph Nodes Metastasis ◽

Gland Carcinoma ◽

Parotid Gland Carcinoma

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Determination of Cervical Lymph Nodes Metastasis and Extra Nodal Extension Status by Quantitative Assessment of Border Irregularity and Apparent Diffusion Coefficient in Patients With Tongue Squamous Cell Carcinoma

Journal of Computer Assisted Tomography ◽

10.1097/rct.0000000000001170 ◽

2021 ◽

Vol 45 (3) ◽

pp. 477-484

Author(s):

Gongxin Yang ◽

Min Rao ◽

Jiliang Ren ◽

Xing Yang ◽

Jingbo Wang ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Diffusion Coefficient ◽

Apparent Diffusion Coefficient ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Quantitative Assessment ◽

Cervical Lymph Nodes ◽

Lymph Nodes Metastasis ◽

Apparent Diffusion

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An analysis of cervical lymph nodes metastasis in oral squamous cell carcinoma

International Journal of Oral and Maxillofacial Surgery ◽

10.1054/ijom.2002.0303 ◽

2003 ◽

Vol 32 (3) ◽

pp. 284-288 ◽

Cited By ~ 32

Author(s):

Y. Okada ◽

I. Mataga ◽

M. Katagiri ◽

K. Ishii

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Lymph Nodes ◽

Lymph Nodes Metastasis

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INTRAOCULAR TRANSMISSIBLE VENEREAL TUMOR IN A DOG

Ciência Rural ◽

10.1590/s0103-84782001000100023 ◽

2001 ◽

Vol 31 (1) ◽

pp. 141-143 ◽

Cited By ~ 2

Author(s):

Geórgia Nadalini Rodrigues ◽

Antonio Carlos Alessi ◽

José Luiz Laus

Keyword(s):

Lymph Nodes ◽

Histopathological Examination ◽

Intact Male ◽

Susceptible Host ◽

Cytologic Examination ◽

Lymph Nodes Metastasis ◽

Subcutaneous Nodules ◽

Inguinal Area ◽

History Of ◽

The Right

Canine transmissible venereal tumor (TVT) is a round cell neoplasm occurring on the external genital mucosa of male and female dogs. Transmission is by cell implantation during coitus, licking, or other interaction between an affected dog and a susceptible host. Metastasis of the tumor rarely occurs. This report describes an unusual presentation of TVT with intraocular involvement and inguinal lymph nodes metastasis. The subject was a six-year-old, intact, male, Brazilian Terrier dog with a history of abnormal masses in the right eye, penis and several subcutaneous nodules in the inguinal area. Histopathological examination of the eye specimens as well as cytologic examination of penile mass and subcutaneous nodules revealed similar findings. The examination revealed round cells containing a large nuclei with prominent, central located nucleoli and a pale cytoplasm containing few small, clear round vacuoles. Histologically, the subcutaneous nodules in the inguinal area were lymph nodes. The diagnosis of TVT with intraocular involvement and lymph nodes metastasis was based on clinical, cytologic and histopathologic findings.

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