scholarly journals The Quercetine Containing Drugs in Pharmacological Correction of Experimental Diabetes with Myocardial Injury

2019 ◽  
Vol 26 (4) ◽  
pp. 393-399 ◽  
Author(s):  
Iryna Stechyshyn ◽  
Bohdana Pavliuk
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Age Groups ◽  
Diene Conjugates ◽  
National Medical ◽  
Experimental Type

Abstract Background and aims: The prevalence of diabetes mellitus is becoming an epidemic. The diversity of etiological factors contributes to the fact that both types of diabetes mellitus occur among different age groups and among different segments of the population. Activation of various types of processes that lead to oxidative stress, endothelial dysfunction, the development of atherosclerotic changes, increases the risk of macro- and microvascular complications in diabetes mellitus. Material and methods: The experiments were performed on 172 white Wistar rats weighing 120–150 g. All animals were kept on a standard I. Horbachevsky Ternopil National Medical University (TNMU), vivarium diet. In our studies, for the first time was established a distinct cardioprotective effect of quercetin-containing drugs, Corvitin and Lipoflavon, for the purpose of normalizing disorders in type 1 and type 2 diabetes mellitus coupled with obesity, which opens wide opportunities for the introduction of these drugs into diabetic cardiomyopathy. Results: The results obtained are an experimental rationale for extending the indications of clinical use of Corvitin and Lipoflavon. Conclusion: Lipoflavon in the experimental type 1 and type 2 diabetes mellitus coupled with obesity significantly outperforms Corvitin in terms of TBA-active products and diene conjugates.

scholarly journals THE PATHOGENETIC RATIONALE THE WAYS OF EXPERIMENTAL TYPE 2 DIABETES MELLITUS MODELING

2019 ◽  
Vol 15 (3-4) ◽  
pp. 10-18
Author(s):  
L.V. Natrus ◽  
Yu.S. Osadchuk ◽  
D.O. Labudzinskyi ◽  
Yu.B. Chaykovskii ◽  
A.S. Smirnov
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Microvascular Complications ◽  
The Body ◽  
Metabolic Disturbances ◽  
Experimental Type ◽  
Homeostasis Regulation ◽  
Pharmacological Correction

Relevance. When modeling experimental type 2 diabetes mellitus (T2DM), various schools and research groups receive significant variability in tissue changes, which is difficult to compare and extrapolate as a specific pathogenic or pharmacological effect. The lack of standard operating procedures agreed upon in the scientific community greatly complicates the interpretation of the result. Therefore, the creation of a uniquely pathogenetic animal model of CD2 in animals is an urgent task. Objective. Determination of the complex of exogenous effects for the most efficient reproduction of the experimental model of T2DM in rats and the pathogenetic justification of the changes in the body to study the central mechanisms of homeostasis regulation and their pharmacological correction. Materials and methods. T2DM was model in rats by feeding a high-fat diet (HFD) with additional streptozotocin induction. The model was evaluated by anthropometric measurements, studies of biochemical parameters, an insulin tolerance test, analysis of the spectrum of fatty acids in the composition of tissues. Statistical data processing was performed with using the IBM SPSS Statistics 23. Results. The obtained data were compared with our studies of the lipid metabolism of patients with varying degrees of diabetic retinopathy on the background of T2DM and analysis of the information content of biochemical markers to assess lipid metabolic disturbances on the background of hyperglycemia in patients. It was found that the simulation in rats of experimental T2DM by a food load of HFD (45%) + fructose 20% for 3 months followed by a single induction of streptozotocin (25 mg/kg) causes changes in lipid and carbohydrate metabolism in animals similar changes which are in the human with a diagnosed long-term diabetes and the development of microvascular complications. Conclusion. We determined the optimal combination of effects and developed a consistent experimental load scheme that allows us to obtain a symptom model of type 2 diabetes in an animal experiment. Using the diagnostic algorithm, which includes physiological and laboratory methods, the degree of damage to organs and systems was determined, a comparison was made with the level of metabolic disorders in patients with T2DM and people without diabetes. The given model is a pathogenetically grounded approach for further study of the central mechanisms of homeostasis regulation and their pharmacological correction

scholarly journals Significance of HbA1c targets based on an individual approach to the treatment of patients with type 2 diabetes mellitus

2014 ◽  
Vol 17 (2) ◽  
pp. 4-9 ◽  
Author(s):  
Inna Vladimirovna Misnikova ◽  
Alexander Vasil'evich Dreval ◽  
Yulia Alexandrovna Kovaleva ◽  
Valeria Alekseevna Gubkina ◽  
Aleksey Leonidovich Odnosum
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Age Groups ◽  
Individual Approach ◽  
The Past ◽  
Hba1c Target ◽  
Hba1c Levels

Background. Over the past few years, special attention has been paid to achieving glycaemic control for type 2 diabetes mellitus (T2DM) patients, since it is a factor for determining the risk of developing macro- and microvascular complications of diabetes. Certain modern guidelines suggest an individual approach to the choice of HbA1c target. Objective. Objective.  . of this study was to estimate the percentage of T2DM patients who have reached the HbA1c levels. This was determined based on their age and the presence of severe complications. Materials and Methods. A total of 2195 patients with T2DM were studied. The patients were divided into the following age groups:

Lack of Evidence Linking Infant Feeding Regimen and Type 1 or Type 2 Diabetes Mellitus

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 237A-237A
Author(s):  
Robin S. Feldman ◽  
Michael Falk ◽  
Kathy A. Grako ◽  
Dawn A. Groenke ◽  
Allison Cooke ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Infant Feeding ◽  
Feeding Regimen

scholarly journals 958: Congenital malformation rates in a contemporary cohort with type 1 and type 2 diabetes mellitus

2020 ◽  
Vol 222 (1) ◽  
pp. S595
Author(s):  
Robert Martin ◽  
Elaine Duryea ◽  
Anne Ambia ◽  
Angela R. Seasely ◽  
Donald D. McIntire ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Congenital Malformation

Hunger sensation in patients with compensated and uncompensated type 1 and type 2 Diabetes Mellitus

1996 ◽  
Vol 20 (1) ◽  
pp. 85-98 ◽  
Author(s):  
Pietro Cugini ◽  
Giuseppe Fatati ◽  
Anna Paggi ◽  
Stefano Coaccioli ◽  
Francesca Paci ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hunger Sensation

Insulin Dose Adjustment Following Bariatric Surgery, a Review of Available Literature

2021 ◽  
pp. 193229682110288
Author(s):  
Lynn E. Kassel ◽  
Jessica J. Berei ◽  
Jamie M. Pitlick ◽  
Joel E. Rand
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Type 2 Diabetes Mellitus ◽  
Dose Adjustment ◽  
Insulin Dose ◽  
Appraisal Tool

Bariatric surgery is a known and effective treatment for type 2 diabetes mellitus. Patients with type 1 diabetes mellitus and exogenous insulin-requiring type 2 diabetes mellitus require adjusted insulin dosing after surgery to avoid hypoglycemia. This review describes insulin dose adjustments following a variety of bariatric procedures. After searching the available literature and assessing for eligibility, 8 articles were included. The Johns Hopkins Research Evidence Appraisal Tool for literature appraisal was used. The results of this review reveal insulin dose adjustment varies based upon surgical procedure type and time of follow-up from the procedure.

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