scholarly journals Extramedullary plasmacytoma with intranasal localization

2020 ◽  
Vol 10 (38) ◽  
pp. 45-50
Author(s):  
Alexandru Pirvu ◽  
Codrut Sarafoleanu ◽  
Gabriela Musat
Keyword(s):  
Multiple Myeloma ◽  
Nasal Septum ◽  
The Elderly ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Tissue Necrosis ◽  
Soft Or ◽  
Facial Swelling ◽  
Nasal Pyramid ◽  
Cardinal Symptoms

AbstractPlasmacytoma is a rare, non-epithelial, malignant tumor, affecting soft or bony tissues, which can have a unique location (solitary or extramedullary solitary plasmacytoma), or multiple (multiple myeloma). In the ENT sphere, it is most commonly encountered in its extramedullary form, which develops in the region of the head and neck, at the level of the submucosa. Most commonly, it affects the elderly, who have cardinal symptoms such as unilateral nasal obstruction, nasal or facial swelling, tissue necrosis or mucosal ulcerations, perforation of the nasal septum with dysmorphia of the nasal pyramid, recurrent unilateral epistaxis. Radiotherapy is the treatment of choice for extramedullary plasmacytoma. The prognosis is a reserved one, the risk of recurrence or conversion to multiple myeloma also existing 15 years after treatment.

scholarly journals Pulsatile Midline Solitary Plasmacytoma in the Frontal Head Region-A Case Report”

2016 ◽  
Vol 32 (1) ◽  
pp. 39-42
Author(s):  
Md Atikur Rahman ◽  
Aklaque Hossain Khan ◽  
Kanak Kanti Barua
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Case Report ◽  
Histological Examination ◽  
Plasma Cells ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Rare Entity ◽  
Head Region ◽  
Malignant Plasma Cell

Primary craniocerebral plasmacytomas are uncommon and represent only 0.7 % of all plasmacytomas. In this case solitary plasmacytoma in the midline frontal head region of the skull and discuss the clinical features and prognosis of this tumor. Plasmacytoma can present as multiple myeloma, solitary plasmacytoma of the bone or extramedullary plasmacytoma. Solitary plasmacytoma is a rare entity that composes of malignant plasma cells and involves the bone to form only one or two lesions without evidence of disease dissemination. It accounts for only 4% of malignant plasma cell tumors. 50 years old male was suffering from plasmacytoma in the frontal head region in our case which is pulsatile. On images showed multiple differential diagnosis but after operation histological examination revealed plasmacytoma. Bangladesh Journal of Neuroscience 2016; Vol. 32 (1): 39-42

scholarly journals Rare Presentation of Primary Extramedullary Plasmacytoma as Lip Lesion

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Mali Him ◽  
Maggie Meier ◽  
Vikas Mehta
Keyword(s):  
Multiple Myeloma ◽  
Cell Proliferation ◽  
Plasma Cell ◽  
Light Chain ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Rare Presentation ◽  
Lower Lip ◽  
Light Chain Disease ◽  
Extramedullary Plasmacytomas

Malignant plasma cell proliferation can be presented as part of disseminated disease of multiple myeloma, as solitary plasmacytoma of bone, or in soft tissue as extramedullary plasmacytoma. Extramedullary plasmacytomas represented approximately 3% of all plasma cell proliferation. Approximately 80% of extramedullary plasmacytomas occur in the head and neck region while the other 4% occur in the skin and to a lesser extent in the lip. In this paper, we report a rare case of primary cutaneous plasmacytoma involving the lip in a 65-year-old male. The patient presented with a nonhealing lower lip sore for the past 3 years. Upon further workup, there was no evidence of multiple myeloma or light chain disease. The patient was treated with radiation therapy and his last follow-up revealed no evidence of multiple myeloma or light chain disease.

scholarly journals Duodenal Ulcer with Massive Gastrointestinal Hemorrhage as an Initial Manifestation in Multiple Myeloma with Extramedullary Disease: A Case Report

Medicina ◽  
2022 ◽  
Vol 58 (1) ◽  
pp. 134
Author(s):  
Hao-Tse Chiu ◽  
Po-Huang Chen ◽  
Hao Yen ◽  
Chao-Yang Chen ◽  
Chih-Wei Yang ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Small Bowel ◽  
Small Bowel Obstruction ◽  
Bowel Obstruction ◽  
Bone Marrow Aspiration ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Initial Manifestation ◽  
Upper Gi ◽  
Plasma Cell Neoplasms

Plasma cell neoplasms are characterized by dysregulated proliferation of mature B cells, which can present with either single (solitary plasmacytoma) or systemic (multiple myeloma (MM)) involvement. MM with extramedullary plasmacytoma (EMP) is a rare disease that accounts for approximately 3–5% of all plasmacytomas. EMP with gastrointestinal (GI) system involvement is an even rarer entity, accounting for <1% of MM cases. We present a case of aggressive MM with EMP invading the duodenum, initially presented with massive upper GI hemorrhage and small bowel obstruction. A 67-year-old woman was admitted to our hospital owing to a lack of either gas or feces passage for 3 days. Abdominal distention and vomit with a high coffee ground content were observed for 24 h. The patient’s condition was initially diagnosed as small bowel obstruction, upper gastrointestinal bleeding, severe anemia, acute renal failure, and hypercalcemia. Furthermore, an analysis of immunoelectrophoresis in the blood, bone marrow aspiration, and tissue biopsy supported the diagnosis of MM and EMP invading the duodenum, upper GI hemorrhage, and small bowel obstruction. Our study provided the possible involvement of MM and EMP in the differential diagnosis of patients with unexplained GI hemorrhage and small bowel obstruction. A thorough review of the literature regarding the association between MM, GI hemorrhage, and small bowel obstruction is presented in this study.

scholarly journals SOLITARY PLASMACYTOMA

2017 ◽  
Vol 9 (1) ◽  
pp. e2017052 ◽  
Author(s):  
Sara Grammatico ◽  
Emilia Scalzulli ◽  
Maria Teresa Petrucci
Keyword(s):  
Multiple Myeloma ◽  
Plasma Cells ◽  
Systemic Disease ◽  
Extramedullary Plasmacytoma ◽  
Bone Lesions ◽  
Solitary Plasmacytoma ◽  
Systemic Involvement ◽  
Number Of Patients ◽  
Solitary Bone Plasmacytoma ◽  
Solitary Extramedullary Plasmacytoma

Solitary plasmacytoma is a rare disease characterized by a localized proliferation of neoplastic monoclonal plasma cells, without evidence of systemic disease. It can be subdivided into solitary bone plasmacytoma, if the lesion originates in bone, or solitary extramedullary plasmacytoma, if the lesion involves a soft tissue. Incidence of solitary bone plasmacytoma is higher than solitary extramedullary plasmacytoma. Also prognosis is different: even if both forms respond well to treatment, overall survival and progression free survival of solitary bone plasmacytoma is poorer than solitary extramedullary plasmacytoma due to its higher rate of evolution in multiple myeloma. However, the recent advances in the diagnosis of multiple myeloma can better refine also the diagnosis of plasmacytoma. Flow cytometry studies and molecular analysis may reveal clonal plasma cells in the bone marrow; magnetic resonance imaging or 18 Fluorodeoxyglucose positron emission tomography could better define osteolytic bone lesions. A more precise exclusion of eventual occult systemic involvement can avoid cases of misdiagnosed multiple myeloma patients, that were previously considered solitary plasmacytoma and less treated, with an unavoidable poor prognosis.Due to the rarity of the disease, there is no uniform consensus about prognostic factors and treatment. Radiotherapy is the treatment of choice; however, some authors debates about the radiotherapy dose and the relationship with the response rate. Moreover, the role of surgery and chemotherapy is still under debate. Nevertheless, we must consider that the majority of studies include a small number of patients and analyze the efficacy of conventional chemotherapy; few cases are reported concerning the efficacy of novel agents.Keywords: solitary plasmacytoma; myeloma; radiotherapy; osteolytic lesions  

Solitary Plasmacytoma of Bone and Extramedullary Plasmacytoma: Two Different Nosological Entities?

1994 ◽  
Vol 80 (5) ◽  
pp. 370-377 ◽  
Author(s):  
Michele Guida ◽  
Addolorata Casamassima ◽  
Ines Abbate ◽  
Angelo Paradiso ◽  
Alfredo Zito ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Disease Activity ◽  
Extramedullary Plasmacytoma ◽  
S Phase ◽  
Nuclear Antigen ◽  
Phase Cell ◽  
Solitary Plasmacytoma ◽  
Adequate Treatment ◽  
Serum Factors ◽  
Serum Parameters

Background The relationship between solitary plasmacytoma and multiple myeloma is still unclear, but they can be distinguished by their different clinical course. Indicators of disease activity and extension, and of a possible evolution to multiple myeloma, have not been identified as yet. Methods Two cases of solitary plasmacytoma are described: one of the mandible and one extramedullary plasmacytoma (EMP) of the rhinopharynx. Pathologic data included immunohistochemical staining for heavy and light Ig chains, and for the proliferating cell nuclear antigen (PCNA). Analysis of the peripheral immunological status and serum parameters ( β2 microglobulin, thymidine kinase, IL-2, IL-6 and soluble IL-2 receptor) was performed and correlation was made with the clinical status. Flow cytometry analysis of nuclear DNA content and S-phase cell fraction were also studied in both neoplasms. Results Solitary plasmacytoma of bone (SPB) showed important basal immunologic alterations and a marked increase in all serum parameters considered with respect to EMP. Ploidy analysis demonstrated an almost complete aneuploidy cell population for the SPB patient (80%), whereas in the EMP patient only 2% of the cells were aneuploid. The S-phase ceils were 16% and 4%, respectively. PCNA index was 60% in SPB and 10% in EMP. Conclusions Solitary plasmacytoma of the bone appeared to be a more aggressive form of plasmacellular neoplasia, distinct from EMP and similar to multiple myeloma. The study of serum parameters, together with analysis of PCNA, ploidy and S-phase fraction, can aid in better understanding disease activity, and in the choice of more adequate treatment. Moreover, serial analysis of some serum factors might be useful markers for monitoring the disease.

Solitary plasmacytoma and extramedullary plasmacytoma of the paranasal sinuses and soft palate

2002 ◽  
Vol 116 (11) ◽  
pp. 962-965 ◽  
Author(s):  
S. Majumdar ◽  
U. Raghavan ◽  
N. S. Jones
Keyword(s):  
Multiple Myeloma ◽  
Soft Palate ◽  
Paranasal Sinuses ◽  
B Lymphocyte ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Upper Respiratory Tract ◽  
Local Manifestation ◽  
The Common ◽  
Upper Respiratory

Solitary plasmacytoma of the paranasal sinuses are uncommon neoplasms of B lymphocyte origin. They comprise one per cent of all head and neck tumours of the upper respiratory tract. They can be solitary plasmacytomas of the bone (SPB), an extramedullary plasmacytoma or a local manifestation of multiple myeloma. Conversion to multiple myeloma happens more frequently in SPB. Radiotherapy is the common modality of treatment with, or without, adjuvant chemotherapy. Extramedullary plasmacytoma carries a better prognosis than a solitary plasmacytoma of the bone. We report four cases of solitary plasmacytoma of the bone and an extramedullary plasmacytoma of the paranasal sinuses and soft palate.

scholarly journals Pancreatic Extramedullary Plasmacytoma Presenting as a Pancreatic Mass

2018 ◽  
Vol 11 ◽  
pp. 117955221880160 ◽  
Author(s):  
Michelle Le ◽  
Balarama Krishna Surapaneni ◽  
Vardhmaan Jain ◽  
Rakesh Vinayek ◽  
Sudhir K Dutta
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow Involvement ◽  
Needle Aspiration ◽  
Celiac Artery ◽  
Interesting Case ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Reliable Technique ◽  
Plasma Cell Neoplasm ◽  
Radiologic Findings

Extramedullary plasmacytomas (EMP) are a subcategory of plasma cell neoplasm that involves organs outside the bone marrow. Involvement of the pancreas is relatively rare, reported in only 2.3% of autopsies. Radiologic findings in plasmacytoma are nonspecific, but endoscopic ultrasound fine-needle aspiration is a fast and reliable technique to acquire a histologic sample for initial diagnosis. Recently, the use of fluorine-18 fluorodeoxyglucose PET/CT has been recommended in patients with active multiple myeloma and solitary plasmacytoma. We present an interesting case of primary EMP in the pancreatic body encasing the portal vein as well as the celiac artery, which was detected before the patient was diagnosed of multiple myeloma.

Sign in / Sign up

Export Citation Format

Share Document