scholarly journals A comparison of virtual touch tissue quantification and digital rectal examination for discrimination between prostate cancer and benign prostatic hyperplasia

2012 ◽  
Vol 46 (1) ◽  
Author(s):  
Xiaozhi Zheng ◽  
Ping Ji ◽  
Hongwei Mao ◽  
Jianqun Hu
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Digital Rectal Examination ◽  
Prostatic Hyperplasia ◽  
Rectal Examination ◽  
Virtual Touch Tissue Quantification ◽  
Tissue Quantification

scholarly journals Effect of different manipulations on serum PSA in patients with benign prostatic hyperplasia.

2021 ◽  
Vol 28 (06) ◽  
pp. 866-871
Author(s):  
Muhammad Iqbal ◽  
M. Adil Khurshid ◽  
Sohail Hassan ◽  
Manzoor Ahmad Naeem ◽  
Shahid Niaz ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Digital Rectal Examination ◽  
Management Plan ◽  
Significant Rise ◽  
Prostatic Hyperplasia ◽  
Transurethral Resection Of Prostate ◽  
Ultrasound Guided ◽  
Prostatic Biopsy ◽  
Rectal Examination ◽  
Rectal Ultrasound

Objectives: To evaluate the effect of different urological manipulations on the serum PSA level in patients with benign prostatic hyperplasia. Study Design: Quasi-experimental study. Setting: Department of Urology, Nawaz Sharif Social Security Hospital, Lahore. Period: January 2018 to December 2018. Material & Methods: A series of 60 patients were included in the study who fulfill the inclusion criteria. All the patients were above 50 years of age and presented with symptoms of benign prostatic hyperplasia. These patients were divided into four groups equally. In group A digital rectal examination, in group B transurethral resection of prostate, in group C Foley’s catheterization and in group D Trans rectal ultrasound guided prostatic biopsy was done. Pre-manipulation and post-manipulation blood samples for serum PSA were taken after 30 minutes, 72 hours and one week. Results: Trans urethral resection of prostate, Foley's catheterization and trans rectal ultrasound guided prostatic biopsy caused a statistically significant rise in serum PSA level (p < 0.05) while digital rectal examination did not raise serum PSA level significantly. Conclusion: Different manipulations do cause alteration in the serum PSA level which may change the management plan.

scholarly journals Is there a PSA cut-off value indicating incidental prostate cancer in patients undergoing surgery for benign prostatic hyperplasia?

2021 ◽  
Vol 93 (1) ◽  
pp. 31-34
Author(s):  
Senol Tonyali ◽  
Cavit Ceylan ◽  
Erdogan Aglamis ◽  
Serkan Dogan ◽  
Sedat Tastemur ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Prostate Biopsy ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Clinical Problem ◽  
Prostatic Hyperplasia ◽  
Open Prostatectomy ◽  
Incidental Prostate Cancer ◽  
Preoperative Serum

Aim: To investigate incidental prostate cancer (IPCa) rate and to determine prostate specific antigen (PSA) cut-off value indicating PCa in patients who underwent surgery by being diagnosed with benign prostatic hyperplasia (BPH) clinically or by standard prostate biopsy. Methods: Data of 317 patients, who underwent transurethral resection of the prostate (TURP) or open prostatectomy (OP) with pre-diagnosis of BPH, were evaluated retrospectively. The examined parameters included patients’ demographics, preoperative serum PSA values, digital rectal examination (DRE) findings, surgical method, histopathological findings and Gleason Scores.Results: A total of 317 patients were included the study. The median age of patients was 69 years (min: 51-max: 79) and the median PSA value was 3.24 ng/dl (min: 0.17-max: 34.9). In 21 patients (6.6%); DRE findings were in favor of malignancy, but prostate biopsy resulted as BPH. While 281 (88.6%) of the patients underwent TURP, 36 (11.4%) underwent open prostatectomy. PCa was detected in 21 (6.6%) patients. PSA was statistically higher in patients who underwent OP compared to patient who underwent TUR-P, 5.9 (min: 1.2 - max: 27.6, IR: 8.7) vs. 2.8 (min: 0.1-max: 34.9, IR: 4.2) ng/dl, p < .001. The rate of IPCa among four PSA group was similar (p = 0.46). There was no difference between the rate of IPCa in patients younger and older than 70 years, (p = 0.11). Please change whole sentence as 'The median PSA level was slightly higher in patients diagnosed with BPH compared to patients diagnosed with IPCa, 3.2 (min: 0.1-max: 34.9) vs. 2.7 (min: 0.3-max: 26.5) ng/dL, p = 0.9. Conclusions: IPCa still remains an important clinical problem. We were not able to find any correlation of PSA and age with incidental PCa.

Frequency of Carcinoma Prostate in Patients with Clinically Diagnosed Benign Prostatic Hyperplasia (BPH) and Prostate Specific Antigen d" 4ng/ml

2020 ◽  
Vol 15 (2) ◽  
pp. 44-47
Author(s):  
Md Shafiqur Rahman ◽  
Sudip Das Gupta ◽  
Sajid Hasan ◽  
Prodyut Kumar Saha ◽  
Amanur Rasul ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Flow Rate ◽  
Histopathological Examination ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Prostatic Hyperplasia ◽  
Urinary Flow Rate ◽  
Transurethral Resection Of Prostate ◽  
Urinary Flow

Objectives: The present study was carried out in the Department of Urology, Sir Salimullah Medical College Mitford Hospital Dhaka between July 2009 to May 2010. To determine the frequency of prostate cancer in patients with BPH & PSA level d” 4 ngm/ml. Methods: A total of 198 subjects aged above 50 years with serum PSA level of not more than 4.0 ng per milliliter , no suspicious nodule on digital rectal examination , homogenous echogenicity of prostate on ultrasonographic findings, peak urinary flow rate (Qmax) < 10ml/sec in uroflowmetry and no clinically significant coexisting conditions were included in the study. All the patients presented with obstructive urinary symptoms attended at four tertiary hospitals in Dhaka city during the study period were evaluated with clinical history, physical examination and some investigations. All the patients were treated with transurethral resection of prostate (TURP). Chips were collected carefully and sent for histopathology. Results: The mean age was 65.1 ± 7.3 years. About 32% of patients had serum PSA level 2 ng/ml or less and 68.2% more than 2 ng/ml. The peak urinary flow rate was 7.2 ± 2.7 ml/sec. One hundred and ninety three (98%) patients were diagnosed as having benign prostatic hyperplasia (BPH) on histopathological examination and 5(2.5%) as having prostate carcinoma. Conclusion: Prostate cancer is not rare among men with PSA levels of 4.0 ng per milliliter or less Bangladesh Journal of Urology, Vol. 15, No. 2, July 2012 p.44-47

scholarly journals Ratio of Free or Complexed Prostate-specific Antigen (PSA) to Total PSA: Which Ratio Improves Differentiation between Benign Prostatic Hyperplasia and Prostate Cancer?

2000 ◽  
Vol 46 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Klaus Jung ◽  
Ulrike Elgeti ◽  
Michael Lein ◽  
Brigitte Brux ◽  
Pranav Sinha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Prostate Specific Antigen ◽  
Serum Proteins ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Tumor Stage ◽  
Prostatic Hyperplasia ◽  
Serum Samples ◽  
Total Psa

Abstract Background: The aim of this study was to compare the diagnostic utility of a new assay that measures all forms of prostate-specific antigen complexed (cPSA) to serum proteins except α2-macroglobulin with the assay of free PSA (fPSA) and the corresponding ratios to total PSA (tPSA) to improve the differentiation between benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Methods: Serum samples were collected from 91 men without prostate disease and with normal digital rectal examination (controls), 144 untreated patients with PCa, and 89 patients with BPH. tPSA and cPSA were measured using the Bayer Immuno 1 system; fPSA and the additional tPSA were measured with the Roche Elecsys system. Results: The median cPSA/tPSA, fPSA/tPSA, and fPSA/cPSA ratios were significantly different between patients with BPH and PCa (78.7% vs 90.7%, 25.5% vs 12.1%, and 36.8% vs 14.3%, respectively; P &lt;0.001). No correlations of cPSA and its ratios to tumor stage and grade were found. ROC analysis showed that cPSA was not different from tPSA (areas under the curve, 0.632 vs 0.568), whereas the cPSA/tPSA ratio was similar to the fPSA/tPSA ratio in increasing discrimination between BPH and PCa patients with tPSA concentrations in the tPSA gray zone between 2 and 10 μg/L (areas under the curve, 0.851 vs 0.838). Conclusions: Compared with tPSA, the fPSA/tPSA and cPSA/tPSA ratios both improve the differentiation between BPH and PCa comparably and are similarly effective in reducing the rate of unnecessary biopsies, whereas cPSA alone does not have any effect.

468: Polymorphic CA Repeats in IGF-I Gene is a Common Genetic Modifier in the Etiology of Prostate Cancer and Benign Prostatic Hyperplasia

2004 ◽  
Vol 171 (4S) ◽  
pp. 125-125
Author(s):  
Lizhong Wang ◽  
Kazunari Sato ◽  
Norihiko Tsuchiya ◽  
Chikara Ohyama ◽  
Shigeru Satoh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Genetic Modifier ◽  
Prostatic Hyperplasia ◽  
Igf I ◽  
I Gene

scholarly journals Light-controlled calcium signalling in prostate cancer and benign prostatic hyperplasia

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Vipin Sharma ◽  
Rita Rana ◽  
Ruma Baksi ◽  
Swapnil P. Borse ◽  
Manish Nivsarkar
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Calcium Signalling ◽  
Prostatic Hyperplasia

scholarly journals Clinical diagnosis of prostate cancer using digital rectal examination and prostate-specific antigen tests: a systematic review and meta-analysis of sensitivity and specificity

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Nelson C. Okpua ◽  
Simon I. Okekpa ◽  
Stanley Njaka ◽  
Augusta N. Emeh
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Sensitivity And Specificity ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Antigen Test ◽  
Rectal Examination ◽  
Prostate Specific Antigen Test ◽  
Prostate Cancers ◽  
Antigen Tests

Abstract Background Being diagnosed with cancer, irrespective of type initiates a serious psychological concern. The increasing rate of detection of indolent prostate cancers is a source of worry to public health. Digital rectal examination and prostate-specific antigen tests are the commonly used prostate cancer screening tests. Understanding the diagnostic accuracies of these tests may provide clearer pictures of their characteristics and values in prostate cancer diagnosis. This review compared the sensitivities and specificities of digital rectal examination and prostate-specific antigen test in detection of clinically important prostate cancers using studies from wider population. Main body We conducted literature search in PubMed, Medline, Science Direct, Wiley Online, CINAHL, Scopus, AJOL and Google Scholar, using key words and Boolean operators. Studies comparing the sensitivity and specificity of digital rectal examination and prostate-specific antigen tests in men 40 years and above, using biopsy as reference standard were retrieved. Data were extracted and analysed using Review manager (RevMan 5.3) statistical software. The overall quality of the studies was good, and heterogeneity was observed across the studies. The result comparatively shows that prostate-specific antigen test has higher sensitivity (P < 0.00001, RR 0.74, CI 0.67–0.83) and specificity (P < 0.00001, RR 1.81, CI 1.54–2.12) in the detection of prostate cancers than digital rectal examination. Conclusion Prostate-specific antigen test has higher sensitivity and specificity in detecting prostate cancers from men of multiple ethnic origins. However, combination of prostate-specific antigen test and standardized digital rectal examination procedure, along with patients history, may improve the accuracy and minimize over-diagnoses of indolent prostate cancers.

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