Synthesis of 3-Unsubstituted 4-Aryl-4,7-Dihydrothieno[2,3-b]Pyridine-2,5-Dicarboxylates / 3-Neaizvietotu 4-Aril-4,7-Dihidrotiēno[2,3-B]Piridīn-2,5-Dikarbonskābes Esteru Sintēze

2012 ◽  
Vol 51 (3) ◽  
pp. 257-263
Author(s):  
I. Adlere ◽  
A. Krauze ◽  
G. Duburs
Keyword(s):  
Acetic Acid ◽  
Aromatic Aldehyde ◽  
Glacial Acetic Acid ◽  
Ammonium Acetate ◽  
Sodium Ethoxide ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Methyl Acetoacetate

Novel 3-unsubstituted 4,7-dihydrothieno[2,3-b]pyridines were prepared by heterocyclization of methyl acetoacetate, an aromatic aldehyde and Meldrum’s acid in the presence of ammonium acetate in glacial acetic acid, followed by treatment of formed intermediates - pyridones with Wilsmeier-Haack reagent and with ethyl mercaptoacetate in the presence of sodium ethoxide in dry ethanol.

scholarly journals Mechanisms of the Electrohydrodimerization of Activated Olefins. V. Substituted Benzylidene Meldrum's Acid Anion Radical Reactions in the Presence of Acetic Acid.

1982 ◽  
Vol 36b ◽  
pp. 260-262 ◽  
Author(s):  
Paul Margaretha ◽  
Vernon D. Parker ◽  
S.-O. Lawesson ◽  
Toshiaki Nishida ◽  
Curt R. Enzell ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Anion Radical ◽  
Radical Reactions ◽  
Meldrum's Acid ◽  
Acid Anion ◽  
Meldrum’S Acid ◽  
Activated Olefins

Enaminones as Building Blocks In Heterocyclic Synthesis: A New One Pot Synthesis of Polyfunctional Substituted Pyridines

2001 ◽  
Vol 56 (10) ◽  
pp. 1074-1078 ◽  
Author(s):  
Samia Michel Agamy ◽  
Mervat Mohammed Abdel-Khalik ◽  
Mona Hassan Mohamed ◽  
Mohammed Hilmy Elnagdi
Keyword(s):  
Acetic Acid ◽  
Double Bond ◽  
Aromatic Aldehyde ◽  
Michael Addition ◽  
Ammonium Acetate ◽  
Building Blocks ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
Active Methyl ◽  
Substituted Pyridines

Enaminones react with a variety of active methyl and methylene reagents in presence of ammonium acetate to yield functionally substituted pyridines in good yields. The reaction proceeded via initial Michael addition across the double bond followed by cyclization. The reaction of enaminone with aromatic aldehyde in acetic acid/ammonium acetate afforded the dihydropyridine that was oxidized to the corresponding pyridine.

Reaction of Meldrum's Acid with an Aminomethylating Agent and Nitroalkanes

2017 ◽  
Vol 41 (2) ◽  
pp. 72-74 ◽  
Author(s):  
Jun-Wei Zhang ◽  
Jin-Hui Xue ◽  
Hua-He Zhang ◽  
Fan Xu ◽  
Qing-Guang Chen ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Weak Acid ◽  
Tandem Reaction ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
Isopropylidene Malonate ◽  
Meldrum's Acids ◽  
Prime 2

5-(2-Nitroalkyl)isopropylidene malonate and 5,5′-(2-nitro-1,3-propylidene)bis(isopropylidene malonate) were easily synthesised by one-pot tandem reaction of substituted Meldrum's acids with the aminomethylating agent (Me2NCH2OAc) and nitroalkanes in the presence of a weak acid, such as acetic acid.

scholarly journals New Oligothienyl-Imidazo-Phenanthroline Chromophores for NLO Applications

2008 ◽  
Vol 587-588 ◽  
pp. 263-267 ◽  
Author(s):  
Rosa M.F. Batista ◽  
Susana P.G. Costa ◽  
Carlos Lodeiro ◽  
Michael Belsley ◽  
E. de Matos Gomes ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Optical Materials ◽  
Nonlinear Optical ◽  
Glacial Acetic Acid ◽  
Ammonium Acetate ◽  
Solvent Polarity ◽  
Nonlinear Optical Materials ◽  
Optical Nonlinearities ◽  
Thiophene Derivatives

A new series of oligothienyl-imidazo-phenanthrolines 3 were synthesised in good to excellent yields by condensation of 5,6-phenantroline-dione 2 with formyl-thiophene derivatives 1 in the presence of ammonium acetate in glacial acetic acid. Furthermore, their solvatochromism and molecular optical nonlinearities were determined and comparatively studied. The experimental results indicate that phenanthrolines 3, due to their moderate solvatochromic properties and good optical nonlinearities, could be used as suitable probes for the determination of solvent polarity and as nonlinear optical materials.

A Facile Procedure for Synthesis of Several 1, 4, 5-Trisubstituted-1Himidazole- 2(3H)-ones and -thiones via a One-pot Three-portion Reaction in Solvent and Microwave Irradiation

2019 ◽  
Vol 16 (2) ◽  
pp. 104-109
Author(s):  
Mohammad Shaker
Keyword(s):  
Acetic Acid ◽  
Microwave Irradiation ◽  
Glacial Acetic Acid ◽  
Ammonium Acetate ◽  
Fluorescence Properties ◽  
Irradiation Condition ◽  
One Pot ◽  
Three Component Reaction

An ordinary procedure for the synthesis of several 1, 4, 5-trisubstituted-1H-imidazole- 2(3H)-ones and -thiones by a one-pot three-component reaction of glacial acetic acid under solvent, microwave irradiation condition is proposed. The products were formed through cyclization of benzoin with isothiocyanates or isocyanates and ammonium acetate. All incorporated combinations were determined for their spectral and microanalytical information. These compounds were subsequently studied for their fluorescence properties.

scholarly journals Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles

2010 ◽  
Vol 60 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Satyajit Dutta
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Ammonium Acetate ◽  
Anthelmintic Activity ◽  
Test Results ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Death Time ◽  
Activity Test

Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazolesA series of 2-substituted-4,5-diphenyl imidazoles1a-jwere synthesized by refluxing benzil with different substituted aldehydes in the presence of ammonium acetate and glacial acetic acid. Structures of the synthesized compounds were confirmed on the basis of IR,1H NMR and mass spectral data. Compounds1a-jwere screened for anthelmintic activity. Test results revealed that compounds showed paralysis time of 0.24 to 1.54 min and death time of 0.39 to 4.40 min while the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 min and death time of 2.16 and 2.47 min, respectively, at the same concentration of 1% (m/V). Five compounds, 2-[2-hydroxyphenyl]-4,5-diphenyl imidazole (1b), 2-[3-methoxyphenyl]-4,5-diphenyl imidazole (1c), 2-[2-phenylethenyl]-4,5-diphenyl imidazole (1e), 2-[4-fluorophenyl]-4,5-diphenyl imidazole (1g) and 2-[3-nitrophenyl]-4,5-diphenyl imidazole (1h) showed significant anthelmintic activity compared to the standard drugs.

A Short and Productive Synthesis of (R)-α-Lipoic Acid

1999 ◽  
Vol 54 (5) ◽  
pp. 655-661 ◽  
Author(s):  
Gerhard Bringmann ◽  
Daniela Herzberg ◽  
Geo Adam ◽  
Friedhelm Balkenhohl ◽  
Joachim Paust
Keyword(s):  
Lipoic Acid ◽  
Acid Ester ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Methyl Acetoacetate ◽  
Key Steps ◽  
Stereogenic Center

(R )-α-Lipoic acid is synthesized in seven steps from the base chemicals methyl acetoacetate or Meldrum’s acid and monomethyl adipate. The key steps are the introduction of the stereogenic center by fermentative or homogeneously catalyzed hydrogenation of 3-oxooctanedioic acid diester to (3S)-3-hydroxyoctanedioic acid diester and its regioselective reduction to (6S)-6 ,8-dihydroxyoctanoic acid ester. The overall yield of (R )-α-lipoic acid, starting from 3-oxooctanedioic acid diester, is 40%.

A Convenient Method of Synthesis of 3-(4, 5-diphenyl-1H imidazole2-yl) From Benzil in Absence of Catalyst

10.26524/sa3 ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 20-27
Author(s):  
L Ilavarasan ◽  
A Ravi ◽  
M Ganapathi ◽  
R Sapthagiri ◽  
K Mohanraj ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Melting Point ◽  
Glacial Acetic Acid ◽  
Ammonium Acetate ◽  
Simple Procedure ◽  
Low Cost ◽  
Sodium Cyanide ◽  
Component System ◽  
Second Stage ◽  
Work Up

In this study new imidazoles derivatives were synthesized.The first stage involved preparation of 3-(4,5-diphenyl-1Himidazole-2-yl)phenol(AA1)by reacting Benzil with Substituted benzaldehyde in presence of sodium cyanide catalyst .The second stage involved the synthesis of Synthesis of 3-(4, 5 - diphenyl-1H imidazole-2-yl) sulfonamide(AA2) using TEA in glacial acetic acid. Finally the compound were synthesized using the three component system (Compound AA2), Substituted benzaldehyde and ammonium acetate. The structure of all compounds were confirmed by elemental analysis ,NMR and IR data and by melting point. In conclusion this method give some advantages such as good yield, simple procedure , low cost of chemicals and easy work up.

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