scholarly journals Anti-Inflammatory Drugs in the Treatment of Meconium Aspiration Syndrome

2011 ◽  
Vol 11 (Supplement-1) ◽  
pp. 15-23
Author(s):  
D. Mokra ◽  
J. Mokry ◽  
A. Calkovska
Keyword(s):  
Lung Parenchyma ◽  
Meconium Aspiration Syndrome ◽  
Experimental Models ◽  
Lung Edema ◽  
Meconium Aspiration ◽  
Pulmonary Vasoconstriction ◽  
Severe Impairment ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Changes

Anti-Inflammatory Drugs in the Treatment of Meconium Aspiration SyndromeMeconium aspiration syndrome (MAS) is a major cause of respiratory distress in both the term and post-term neonates. Obstruction of the airways, dysfunction of pulmonary surfactant, inflammation, lung edema, pulmonary vasoconstriction and bronchoconstriction participate in the pathogenesis of this disorder. Since the inflammatory changes associated with meconium aspiration cause a severe impairment of the lung parenchyma including surfactant and influence the reactivity of both vascular and airway smooth muscle, administration of anti-inflammatory drugs may be of benefit also in the management of MAS. This article reviews effects of various anti-inflammatory drugs used in experimental models of MAS as well as in the treatment of newborns with meconium aspiration.

scholarly journals A REVIEW ON IN VIVO AND IN VITRO EXPERIMENTAL MODELS TO INVESTIGATE THE ANTI-INFLAMMATORY ACTIVITY OF HERBAL EXTRACTS

2018 ◽  
Vol 11 (11) ◽  
pp. 29
Author(s):  
Inayat Kabir ◽  
Imtiyaz Ansari
Keyword(s):  
Reference Model ◽  
Experimental Models ◽  
Inflammatory Activity ◽  
Herbal Extracts ◽  
Double Positive ◽  
Arthritis Models ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The article emphasizes the anti-inflammatory effects of herbal extracts on different experimental models that are repeatedly used to test the in vivo anti-inflammatory activity of herbal components. Edema, granuloma and arthritis models are used to test the anti-inflammatory activity of plant extracts whereas formalin or acetic acid-induced writhing test and hot plate methods are the most repeatedly used to evaluate anti-nociceptive potentials of the herbal extracts. Although adjuvant-induced and collagen-induced arthritis models are also quite efficient, they have been used seldom to evaluate anti-inflammatory tendencies of the herbs. Here, we suggest a double positive reference model using both steroid and nonsteroidal anti-inflammatory drugs at the same time, instead of using only one of them either.

scholarly journals SAPHO Syndrome: An Unusual Cause of Dysphagia

2021 ◽  
Vol 5 (4) ◽  
pp. 476-478
Author(s):  
Megan Hoffer ◽  
Michaela Salvo ◽  
Sonal Batra
Keyword(s):  
Sapho Syndrome ◽  
Rheumatic Disorder ◽  
Case Presentation ◽  
Infectious Process ◽  
Bony Destruction ◽  
Life Threatening ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Fluid Collections ◽  
Inflammatory Changes

Case Presentation: This case describes a 51-year-old male who presented to the emergency department with a complaint of two weeks of progressively worsening dysphagia as well as the emergence of superficial fluid collections on the anterior chest and leg during the same period. Computed tomography showed retropharyngeal and paratracheal fluid collections with adjacent vertebral osteitis; however, biopsies were negative for any infectious or mycobacterial source, and instead showed chronic inflammatory changes. Discussion: Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare rheumatic disorder that presents with multifocal osteitis and sterile neutrophilia. SAPHO syndrome may be easily mistaken for a diffuse infectious process on initial evaluation and imaging; however, it is treated with anti-inflammatory medications, including non-steroidal anti-inflammatory drugs and corticosteroids. Although most patients achieve remission of symptoms with treatment, the location of the fluid collections and resultant bony destruction may be life-threatening if undiagnosed.

scholarly journals Lung Inflammatory and Oxidative Alterations After Exogenous Surfactant Therapy Fortified With Budesonide in Rabbit Model of Meconium Aspiration Syndrome

2016 ◽  
pp. S653-S662 ◽  
Author(s):  
P. MIKOLKA ◽  
J. KOPINCOVÁ ◽  
P. KOŠÚTOVÁ ◽  
D. ČIERNY ◽  
A. ČALKOVSKÁ ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Expression Profiles ◽  
Rabbit Model ◽  
Weight Ratio ◽  
Meconium Aspiration Syndrome ◽  
Exogenous Surfactant ◽  
Lung Edema ◽  
Edema Formation ◽  
Meconium Aspiration ◽  
Cell Counts

Meconium aspiration syndrome (MAS) triggers inflammatory and oxidative pathways which can inactivate both pulmonary surfactant and therapeutically given exogenous surfactant. Glucocorticoid budesonide added to exogenous surfactant can inhibit inflammation and thereby enhance treatment efficacy. Neonatal meconium (25 mg/ml, 4 ml/kg) was administered intratracheally (i.t.) to rabbits. When the MAS model was prepared, animals were treated with budesonide i.t. (Pulmicort, 0.25 mg/kg, M+B); with surfactant lung lavage (Curosurf®, 10 ml/kg, 5 mg phospholipids/ml, M+S) followed by undiluted Curosurf® i.t. (100 mg phospholipids/kg); with combination of budesonide and surfactant (M+S+B); or were untreated (M); or served as controls with saline i.t. instead of meconium (C). Animals were oxygen-ventilated for additional 5 h. Cell counts in the blood and bronchoalveolar lavage fluid (BAL), lung edema formation (wet/dry weight ratio), oxidative damage of lipids/ proteins and inflammatory expression profiles (IL-2, IL-6, IL-13, TNF-α) in the lung homogenate and plasma were determined. Combined surfactant+budesonide therapy was the most effective in reduction of neutrophil counts in BAL, oxidative damage, levels and mRNA expression of cytokines in the lung, and lung edema formation compared to untreated animals. Curosurf fortified with budesonide mitigated lung inflammation and oxidative modifications what indicate the perspectives of this treatment combination for MAS therapy.

Analysis of the results of endoscopic examination of the upper git in decompensated OA

2020 ◽  
pp. 26-34
Author(s):  
Timur Bulatovich Minasov ◽  
Anzhela Yurievna Vershinina ◽  
Radmir Amirovich Saubanov ◽  
Aigul Abuzarovna Akhmeldinova ◽  
Yekaterina Rishatovna Yakupova ◽  
...  
Keyword(s):  
High Risk ◽  
Endoscopic Examination ◽  
History Of ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Changes

Results of fibrogastroduodenoscopy examination of 69 patients with OA of the knee are presented. A long history of non-steroidal anti-inflammatory drugs administration, a high risk of NSAID-associated gastropathy development. The fibrogastroduodenoscopy results of patients with OA showed that 97.1 % of the examined had changes in the upper GIT. The predominance of superficial inflammatory changes was detected but erosive changes in the oesophagus (10.9 %), stomach (29.6 %) and duodenum (14%) were also present.

Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models

2013 ◽  
Vol 12 (1) ◽  
pp. 24-35 ◽  
Author(s):  
Nolwenn Merlet ◽  
David Busseuil ◽  
Eric Rheaume ◽  
Jean-Claude Tardif
Keyword(s):  
Experimental Models ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Sesquiterpenes from Essential Oils and Anti-Inflammatory Activity

2015 ◽  
Vol 10 (10) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Rita de Cássia Da Silveira e Sá ◽  
Luciana Nalone Andrade ◽  
Damião Pergentino De Sousa
Keyword(s):  
Side Effects ◽  
Essential Oil ◽  
Therapeutic Potential ◽  
Relevant Information ◽  
Mechanisms Of Action ◽  
Experimental Models ◽  
Inflammatory Activity ◽  
Chemical Structures ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

This review is aimed at presenting relevant information on the therapeutic potential of essential oil sesquiterpenes with anti-inflammatory activity. The data reviewed provide a basis for seeking new anti-inflammatory drugs from natural products that do not exhibit the undesirable side effects often displayed by anti-inflammatory drugs. In this review the experimental models, possible mechanisms of action, and chemical structures of 12 sesquiterpenes are presented.

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