scholarly journals A study of the microcirculation of the skin and eyelids in patients with rosacea by laser doppler flowmetry

2016 ◽  
Vol 15 (2) ◽  
pp. 40-44
Author(s):  
V. A. Shrubey ◽  
S. B. Tkachenko ◽  
N. P. Tepluk
Keyword(s):  
Laser Doppler Flowmetry ◽  
Azelaic Acid ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Tacrolimus Ointment ◽  
Eyelid Skin ◽  
Before And After ◽  
Background Therapy ◽  
The Face ◽  
Acid Gel

Introduction and aim. Currently, the study of the pathogenesis of rosacea is very important on disorders of microcirculation. Due to the feature of the structure of the eyelid skin microcirculation disorders learning in this area seems an urgent task. The aim of the study was to study the microcirculation of the face skin and eyelid skin in patients with rosacea by laser Doppler flowmetry (LDF) before and after treatment with tacrolimus ointment 0.1 % and 15 % azelaic acid gel, Blefarogel 2 and Blefaroloson. Mathereals and methods. The study involved 70 patients with different clinical forms of rosacea. Patients surveyed microcirculation in the skin of the face and eyelid skin by laser Doppler flowmetry. Patients were divided into 2 groups: who applied 0.1 % tacrolimus ointment on the skin of the face and eyelids and who applied 15 % azelaic acid gel on the face skin, Blefarogel 2 and Blefaroloson on the eyelid skin. A month study was conducted again to measure the effectiveness of the therapy. Results and discussion. Patients with rosacea marked increase in IM (index of microcirculation) in the face skin and the affected eyelid skin. The study of amplitude-frequency spectrum of LDF-grams of the face skin revealed stagnation in the arterial and in the affected eyelids skin - in the venous link microvasculature. In both groups of patients background therapy showed a significant improvement of microcirculation parameters. Conclusions. Laser Doppler flowmetry is an effective method for the investigation of violations of the microcirculation in the skin and the affected eyelid skin in rosacea, as well as to evaluate the effectiveness of therapy in these patients.

scholarly journals The Effect of Aqua-trainings are in Fresh Water in Patients with Hypertension on the Microcirculation

2020 ◽  
Vol 100 (6) ◽  
pp. 25-32
Keyword(s):  
Fresh Water ◽  
Laser Doppler Flowmetry ◽  
Warm Pool ◽  
T Test ◽  
Laser Doppler ◽  
Venous Stasis ◽  
Doppler Flowmetry ◽  
Before And After ◽  
Aquatic Training ◽  
Positive Effect

Walking in water (Aquatic Physiotherapy) is a simple, reproducible and affordable method. Warm pool water reduces peripheral vascular resistance. Purpose of the study was to assess the effect of dosed physical activity in a fresh water on the microcirculation of patients with arterial hypertension (AH) when applied externally. Materials and methods. The study included 14 subjects (7 men, 7 women) aged 18 to 70, with AH stage I. The patients were administered aqua training course in the form of walking in a fresh water for the 30 minutes duration, the course of treatment included 10 procedures, the water temperature in the pool was 30–32C. Before and after the end of the intervention, several parameters were monitored, including the assessment of microcirculation using laser Doppler flowmetry. Results: In patients receiving aqua training in a fresh water, there was a significant decrease of arterio-venular bypass grafting by 25.0%from the initial (Wilcoxon T-test = 310.0; p = 0.004) and an increase in the muscle component of microcirculation regulation (Wilcoxon T-test = 399.0; p <0.05), which indicates an improvement in microcirculation under the influence of aqua training. The optimal duration of training in fresh water was found to be equal to five days, after which the indicators characterizing microcirculation remain at the plateau level, without significantly changing. Significantly more often, the positive effect of aqua training was achieved in the group of patients with microcirculation disorders of the type of venous stasis (χ2 = 10.6; p <0.001). Conclusion. Laser Doppler flowmetry screening may be useful method to select patients with AH in a greatest need of aquatic training.

NON-INVASIVE METHODS FOR STUDYING AGE-RELATED SKIN CHANGES IN VARIOUS MORPHOTYPES OF AGING

2021 ◽  
pp. 558-565
Author(s):  
Н.П. Теплюк ◽  
С.В. Лебедева
Keyword(s):  
Laser Doppler Flowmetry ◽  
Ultrasound Examination ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Skin Changes ◽  
Non Invasive ◽  
Age Related ◽  
The Face ◽  
Type 3

Цель работы - оценка изменений функционального состояния микроциркуляторного русла, изучение особенностей морфологических параметров кожи неинвазивными методами исследования при различных морфотипах старения. В исследовании приняли участие 55 человек 35-65 лет с инволюционными изменениями нижней трети лица. Выделены четыре морфотипа старения, в зависимости от которых пациенты были разделены на группы: 1-я - 19 пациенток с деформационным типом; 2-я - 17 пациенток с усталым; 3-я - 8 пациенток с мелкоморщинистым; 4-я - 11 пациенток со смешанным морфотипом. Для изучения состояния кожи использовали лазерную допплеровскую флоуметрию и УЗИ кожи (22 Mhz). Методом лазерной допплеровской флоуметрии выявлены достоверные изменения при сравнении показателей микроциркуляции и ультразвуковым методом исследования кожи - деформационного и мелкоморщинистого типов (p<0,05). У деформационного и смешанного типов наблюдали преимущественно атонический тип микроциркуляции (9,42±3,71 и 9,56±2,31 перф. ед. соответственно), а при мелкоморщинистом - спастический тип (7,86±1,6 перф. ед.), при усталом морфотипе показатель микроциркуляции был в пределах нормы (7,86±1,6 перф. ед.). Данные УЗИ кожи позволили выявить у пациенток с деформационным морфотипом старения наиболее высокие значения толщины эпидермиса (125,94±27,84 мкм), дермы (1 439±118,11 мкм), плотности дермы (12±2,59 у. е.) по сравнению с толщиной эпидермиса (85±22,01 мкм), толщиной дермы (1 130±68,55 мкм) и плотностью дермы (7,87±2,1 у. е.) при мелкоморщинистом морфотипе старения. The purpose of the work is to assess changes in the functional state of the microvasculature, study of the features of the morphological parameters of the skin by non-invasive research methods for various morphotypes of aging. The study involved 55 patients with involutional changes in the lower third of the face aged 35 to 65 years, included according with the inclusion and exclusion criteria. 4 morphotypes of aging were identified, depending on which patients were divided into corresponding groups: 1 - 19 patients with deformational type, 2 - 17 with tired type, 3 - 8 with fine wrinkled type, 4 - 11 with mixed morphotype of aging. To study the condition of the patients’ skin, laser Doppler flowmetry and ultrasound examination of the skin (22 Mhz) were used. The method of laser Doppler flowmetry revealed significant changes when comparing microcirculation indices and the ultrasound method for examining deformational and fine wrinkled type (p<0,05). In the deformational type and mixed type, a predominantly atonic type of microcirculation was observed (9,42±3,71 and 9,56±2,31 perf. u., respectively), and in fine wrinkled spastic type of microcirculation (7,86±1,6 perf. u.), in the oral morphotype the microcirculation index was within the normal range of 7,86±1,6 perf. u. The data of ultrasound examination of the skin made it possible to reveal in the deformational morphotype of aging high values of the thickness of the epidermis (125,94±27,84 μm), the dermis (1 439±118,11 μm) and the density of the dermis (12±2,59 a. u.) compared with the thickness of the epidermis 85±22,01 μm, the thickness of the dermis (1 130±68,55 μm) and the density of the dermis (7,87±2,1 c. u.) in the fine wrinkled morphotype of aging.

scholarly journals Combined assessment of intestinal viability using laser doppler flowmetry and laser fluorescence spectroscopy

2021 ◽  
Vol 20 (2) ◽  
pp. 70-76
Author(s):  
A. A. Zacharenko ◽  
M. A. Belyaev ◽  
A. A. Trushin ◽  
D. A. Zaytcev ◽  
R. V. Kursenko ◽  
...  
Keyword(s):  
Fluorescence Spectroscopy ◽  
Laser Doppler Flowmetry ◽  
Ischemia Reperfusion ◽  
Diagnostic Value ◽  
Laser Doppler ◽  
Laser Fluorescence ◽  
Doppler Flowmetry ◽  
Intraoperative Assessment ◽  
Before And After ◽  
Laser Fluorescence Spectroscopy

Introduction. The development of an objective non-invasive method for intraoperative assessment of intestinal viability remains urgent for modern surgery. In this context, the method of laser fluorescence spectroscopy (LFS) of coenzymes of oxidative metabolism, as well as a combination of this technique with the simultaneous use of laser Doppler flowmetry (LDF) seems promising. Materials and methods. The model of ischemia-reperfusion of the small intestine of 4 Californian Rabbits was used to study the relationship of the parameters of LFS and LDF with the histological picture. A model of intraoperative ischemia was used by temporarily clamping the trunk of the cranial mesenteric vascular bundle for 90 min, followed by intraoperative and postoperative reperfusion for 60 minutes and 24 hours, respectively. LDF and LFS data were recorded from intestine at the end of the intraoperative reperfusion period. 24 hours after the surgery, the animals were subjected to histologic evaluation of intestine ischemic changes, which were compared with the LDF and LFS data. Diagnostic value of LDF and LFS, and their combination for intraoperative assessment of intestinal viability were analyzed. Results. A significant correlation was found between the parameters of LDF, LFS and the degree of ischemic changes according to the histological data. The method of isolated assessment of the difference in the fluorescence of reduced nicotin adenine dinucleotide (NADH) before and after ischemia-reperfusion (77.3 %) has the greatest diagnostic value. The method has the highest sensitivity with a combination of differences in LDF and LFS values before and after ischemia-reperfusion (85.7 %) (P<0.05). Conclusions. LFS, as well as its combination with LDF, is a useful method for objective assessment of intestinal viability, which requires further research and has potential for clinical use.

Microcirculatory blood and lymph flow examination in eyelid skin by laser Doppler flowmetry

2017 ◽  
Vol 133 (3) ◽  
pp. 16 ◽  
Author(s):  
T. N. Safonova ◽  
N. P. Kintyukhina ◽  
V. V. Sidorov ◽  
O. V. Gladkova ◽  
E. S. Reyn
Keyword(s):  
Laser Doppler Flowmetry ◽  
Lymph Flow ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Eyelid Skin

The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

Sign in / Sign up

Export Citation Format

Share Document