scholarly journals CLINICAL PROBLEMS OF DIRECT DOSIMETRY (IN VIVO) IN CONTACT RADIATION THERAPY

2018 ◽  
Vol 7 (2) ◽  
pp. 19-24
Author(s):  
V. A. Titova ◽  
D. A. Kokontsev ◽  
T. S. Belle
Keyword(s):  
Radiation Therapy ◽  
Photodynamic Therapy ◽  
Fiber Optic ◽  
Absorbed Dose ◽  
Special Treatment ◽  
Effective Use ◽  
Contact Radiation ◽  
Clinical Problems ◽  
Treatment Surgery

The use of multicomponent methods of special treatment (surgery, polychemotherapy, radiation therapy, laser photodynamic therapy) in oncology requires the control of doses in the tumor and healthy organs with high accuracy. A method of direct dosimetry using fiber-optic scintillation dosimeter MCD-4 is proposed. The dosimeter is fixed on endostats and is visualized on CT/MRI. The coordinates are entered into the anatomical units and dosimetry calculations, the data are mapped, the doses are adjusted on medical grounds. The developed technique of direct dosimetry allows monitoring of the contact radiation therapy (CRT) procedure in real time and making the necessary changes and corrections during the treatment. The refinement of the absorbed dose values using calculations and direct dosimetry minimizes the risk of complications and ensures the possibility of effective use of other treatment methods, including photodynamic therapy, after CRT.

Beyond radiation therapy: photodynamic therapy maintains structural integrity of irradiated healthy and metastatically involved vertebrae in a pre-clinical in vivo model

2012 ◽  
Vol 135 (2) ◽  
pp. 391-401 ◽  
Author(s):  
Victor C. K. Lo ◽  
Margarete K. Akens ◽  
Sara Moore ◽  
Albert J. M. Yee ◽  
Brian C. Wilson ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Photodynamic Therapy ◽  
Structural Integrity ◽  
In Vivo Model

scholarly journals CONTACT RADIATION THERAPY (BRACHYTHERAPY): CLINICAL CONCEPT OF DIRECT DOSIMETRY [IN VIVO] AND QUALITY ASSURANCE OF RADIATION THERAPY

2020 ◽  
Vol 66 (4) ◽  
pp. 398-403
Author(s):  
Vladimir Solodkiy ◽  
Andrey Pavlov ◽  
V. Titova ◽  
A. Tsybulsky
Keyword(s):  
Quality Assurance ◽  
Radiation Therapy ◽  
Improve Quality ◽  
Planning Systems ◽  
Calculation Data ◽  
Measurement Results ◽  
Clinical Concept ◽  
Contact Radiation

Contact radiation therapy (brachytherapy): the clinical concept of direct dosimetry [in vivo] and quality assurance of radiation therapy the issues of organizing the brachytherapy process with the possibility of confirming the calculated doses obtained on planning systems by direct dosimetry with scintillation small-size dosimeters with the technology of their placement, fixation and visualization are Considered. The coincidence of the calculation data with the measurement results helps to improve quality assurance, especially when using the fractionation mode of a single focal dose of more than 5-6 Gr.

Dual-selective photodynamic therapy with a mitochondria-targeted photosensitizer and fiber optic cannula for malignant brain tumors

2019 ◽  
Vol 7 (7) ◽  
pp. 2812-2825 ◽  
Author(s):  
Ji Hee Kang ◽  
Young Tag Ko
Keyword(s):  
Photodynamic Therapy ◽  
Brain Tumors ◽  
Fiber Optic ◽  
Malignant Brain Tumors

In vivo application of dual-selective photodynamic therapy with a mitochondria-targeted photosensitizer and fiber optic cannula to orthotopic GBM-xenografted mice.

Radio-opaque isotropic fiber optic probes for in vivo photodynamic therapy dosimetry

1994 ◽  
Author(s):  
Emma J. Hudson ◽  
Mark R. Stringer ◽  
Hugo J. van Staveren ◽  
Michael A. Smith
Keyword(s):  
Photodynamic Therapy ◽  
Fiber Optic ◽  
Fiber Optic Probes

Ruthenium Complexes for 1- and 2-Photon Photodynamic Therapy: From In Silico Prediction to In Vivo Applications

2020 ◽  
Author(s):  
Johannes Karges ◽  
Shi Kuang ◽  
Federica Maschietto ◽  
Olivier Blacque ◽  
Ilaria Ciofini ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Silico ◽  
Aqueous Solubility ◽  
The Body ◽  
Photon Absorption ◽  
Multicellular Tumor Spheroids ◽  
Spectral Window ◽  
Photon Excitation ◽  
Polypyridine Complexes

<div>The use of photodynamic therapy (PDT) against cancer has received increasing attention overthe recent years. However, the application of the currently approved photosensitizers (PSs) is somehow limited by their poor aqueous solubility, aggregation, photobleaching and slow clearance from the body. To overcome these limitations, there is a need for the development of new classes of PSs with ruthenium(II) polypyridine complexes currently gaining momentum. However, these compounds generally lack significant absorption in the biological spectral window, limiting their application to treat deep-seated or large tumors. To overcome this drawback, ruthenium(II) polypyridine complexes designed in silico with (E,E’)-4,4´-bisstyryl 2,2´-bipyridine ligands showed impressive 1- and 2-Photon absorption up to a magnitude higher than the ones published so far. While non-toxic in the dark, these compounds were found phototoxic in various 2D monolayer cells, 3D multicellular tumor spheroids and be able to eradicate a multiresistant tumor inside a mouse model upon clinically relevant 1-Photon and 2 Photon excitation.</div>

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