scholarly journals The relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction

2011 ◽  
Vol 34 (1) ◽  
pp. 14 ◽  
Author(s):  
Ender Ornek ◽  
Sani Murat ◽  
Mustafa Duran ◽  
Murat Turfan ◽  
Alparslan Kurtul ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Control Group ◽  
Clinical Form ◽  
Variable Nature ◽  
Acute Mi ◽  
Artery Disease ◽  
The Relationship

Purpose: The present study aimed to investigate the relationship between the severity of coronary artery disease (CAD) and level of Lipoprotein (LP)(a). Methods: The study included 52 CAD patients and a control group consisting of 38 individuals. The patients were classified into three groups based on the clinical form of CAD (stable angina pectoris, SAP, unstable angina pectoris,UAP, and myocardial infarction,MI), and were further divided into three groups based on CAD severity (1-, 2- and 3-vessel). Serum Lp(a) levels were monitored 4, 8, and 24 h, 10 and 30 days following acute MI in 18 patients. Results: Based on regression analysis, Lp(a) was not correlated with other lipoproteins or with risk factors of CAD, such as body mass index, smoking, family history, diabetes, age, gender, and hypertension (r = 0.08-0.22). 72% of the patients in the CAD group and 24% of the control group had an Lp(a) level > 30 mg dL–1 (P = 0.004), and Lp(a) levels were higher in 3-vessel patients than in 2-vessel and 1-vessel CAD patients (86% vs. 68%, P = 0.02 and 86% vs. 62%, P=0.01, respectively). Serum Lp(a) levels were higher in the UAP and MI groups than in the SAP group (48 ± 44.7 mg dL–1, 49 ± 36.1 mg dL–1 and 31.2 ± 22.3 mg dL–1 , respectively,P=0.02). Lp(a) levels increased after acute MI, and reached peak levels 10 days post-MI (41% increase, P=0.001) and remained considerably elevated (18%) 30 days post-MI (P=0.01). Conclusion: Serum Lp(a) was higher in the UAP and MI patients in comparison with the SAP patients, and was higher in 3-vessel CAD in comparison with 1- and 2-vessel CAD patients.

Relationship between mild renal dysfunction and coronary artery disease in young patients with stable angina pectoris

2020 ◽  
Author(s):  
Mustafa Duran ◽  
Deniz Elcik ◽  
Mehmet T Inanc ◽  
Mikail Yarlıoglues ◽  
Ibrahim E Celik ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Renal Dysfunction ◽  
Stable Angina ◽  
Control Group ◽  
Stable Angina Pectoris ◽  
Number Of Patients ◽  
Study Results ◽  
Artery Disease

Aim: We investigated the relationship between mild renal dysfunction (MRD) and the presence of coronary artery disease (CAD) in people under 60. Materials & methods: A total of 634 (317 patients with vessel stenosis ≥50% and 317 with normal angiography) individuals diagnosed with stable angina pectoris and estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 were included in the present study. Results: The mean eGFR was lower (95.3 ± 23.7 vs 109.7 ± 22.3, respectively, p = 0.002) and the number of patients with MRD was higher in patients with CAD (137, 43.2%) than in the control group (52, 16.4%, p < 0.001). The multivariate analysis showed that lower eGFR is an independent risk factor for presence of CAD in people under 60 with stable angina pectoris. Conclusion: According to our retrospective study, the risk of developing CAD appears to be slightly increased in individuals under 60 with MRD.

scholarly journals The Association between theLPAGene Polymorphism and Coronary Artery Disease in Chinese Han Population

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Zi-Kai Song ◽  
Hai-Di Wu ◽  
Hong-Yan Cao ◽  
Ling Qin
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chinese Han Population ◽  
Control Group ◽  
Case Group ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Artery Disease ◽  
The Relationship

Lp(a) has been well known as an independent risk factor for coronary artery disease (CAD). TheLPAgene, as it encodes apo(a) of the Lp(a) lipoprotein particle, was associated with increased risk of CAD. The purpose of this study was to analyze the relationship between the polymorphisms ofLPAgene and CAD in Chinese Han population. Five SNPs (rs1367211, rs3127596, rs6415085, rs9347438, and rs9364559) in theLPAgene were genotyped using Sequenom MassARRAY time-of-flight mass spectrometer (TOF) in 560 CAD patients as case group and 531 non-CAD subjects as control group. The numbers of these two groups were from Chinese Han ancestry. The results showed that allele (P=0.046) and genotype (P=0.026) of rs9364559 in theLPAgene was associated with CAD. The frequency of rs9364559 minor allele (G) in case group was obviously higher than that in control group. Results of haplotype analysis showed that 4 haplotypes which contained rs9364559-G were associated with increased risk of CAD in this population. This study explored rs9364559 in theLPAgene may be associated with the pathogenesis of CAD; and the risk of CAD might be higher in the population carrying 4 haplotypes of different blocks in theLPAgene.

Serum Selenium and Glutathione Peroxidase Concentrations in Iranian Patients with Angiography-Defined Coronary Artery Disease

Angiology ◽  
2008 ◽  
Vol 60 (2) ◽  
pp. 186-191 ◽  
Author(s):  
Parizadeh Seyyed Mohammad Reza ◽  
Mohsen Moohebati ◽  
Fahimeh Ghafoori ◽  
Majid Ghayour-Mobarhan ◽  
Seyyed Mohammad Reza Kazemi-Bajestani ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Glutathione Peroxidase ◽  
Fasting Blood Glucose ◽  
Mean Value ◽  
Control Group ◽  
Serum Selenium ◽  
Artery Disease ◽  
The Relationship ◽  
Iranian Patients

This study investigated the relationship between serum selenium (Se) and glutathione peroxidase (GPx) levels and the presence of coronary artery disease (CAD) among Iranian patients. Three groups were compared: patients undergoing angiography with angiographically defined CAD, individuals with a normal angiogram, and apparently healthy controls with no evidence of overt CAD. Anthropometric measurements, blood pressure, fasting blood glucose and lipid profiles, serum Se and GPx measurements, and angiographic assessment were carried out using standard protocols. Mean serum Se concentrations were not significantly different between patients with and without CAD and the control group. The mean value of serum GPx in the control group was significantly higher than in patients with or without CAD. Selenium status did not differentiate between patients with and without CAD, which may be related to the fact that angiography is not a very sensitive index of global atherosclerosis, and it is possible that patients who were CAD negative by angiogram still have significant disease. It may also be that Se is not a good marker of CAD.

ID: 35: ASSOCIATION BETWEEN HELICOBACTER PYLORI INFECTION WITH CORONARY ARTERY DISEASE AND ACUTE MYOCARDIAL INFARCTION: A RETROSPECTIVE CHART ANALYSIS

2016 ◽  
Vol 64 (4) ◽  
pp. 940-941
Author(s):  
N Vyas ◽  
H Alkhawam ◽  
E Saker ◽  
R Sogomonian ◽  
RA Ching Companioni ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Myocardial Infarction ◽  
Helicobacter Pylori ◽  
Risk Factor ◽  
Coronary Artery ◽  
Medical Center ◽  
Control Group ◽  
Igg Antibody ◽  
Artery Disease

IntroductionHelicobacter pylori (HP) infection is known to target the gastrointestinal system and is associated with extra gastrointestinal manifestations, but there is limited literature on cardiac associations. The most supported pathogenesis uses chronic inflammation as a risk factor causing atherosclerosis resulting in cardiovascular disease. Our aim is to evaluate whether there is an association between HP infection and acute myocardial infarction (AMI) and coronary artery disease (CAD).MethodWe performed a retrospective single center study at our medical center from 2005 to 2014 consisting of 1,671 patients who underwent Coronary Angiography (CA). We divided these patients into two groups based on CA reports. Patients with CAD defined as left main stenosis of ≥50% or any stenosis of ≥70% versus normal coronaries. We reviewed each patient chart to determine the prevalence of positive serum HP IgG antibody. Smoking, hypertension, dyslipidemia and obesity were also considered in each group.ResultsOf 1,671 patients, 1,237 had evidence of CAD vs 434 with normal coronary arteries. Twelve percent of CAD patients were found to have seropositive HP (SPHP) versus 1% in the control group (OR: 7.3, 95% CI: 3.5–15, p<0.0001) as depicted in figure 1. When we looked at the CAD group and compared SPHP patients to seronegative HP (SNHP) patients we found a greater amount of multiple coronary vessels disease in the SPHP group (OR: 1.4, 95% CI: 1.1–2, P=0.04). With regards to AMI, 30% of the SPHP group presented with AMI versus 10% seen in the SNHP group (OR: 4.3, 95% CI: 3–6.5, p<0.0001). In the CAD group with SPHP there was more hyperlipidemia and a higher BMI than in the CAD SNHP group (p<0.0001 and <0.0001, respectively), but there was no statistical difference between the two groups for the risk factors of smoking, hypertension and diabetes.ConclusionAccording to this study, the results showed a correlation with SPHP patients and CAD. Patients with HP seropositivity also tend to have multiple coronary artery vessel disease. In addition, our results also confirmed that there is an association between with HP infection and AMI. We hypothesize that the associated maybe secondary to inflammatory reaction associated with HP. Additional studies with larger sample groups are needed to investigate the possible role of this pathogen as a risk factor for heart disease.Abstract ID: 35 Figure 1Twelve percent of CAD patients were found to have seropositive HP (SPHP) versus 1% in the control group (OR: 7.3, 95% CI: 3.5–15, p<0.0001).

scholarly journals Serum resistin: A possible link between inflammation, hypertension and coronary artery disease

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Sobia Niaz ◽  
Javaria Latif ◽  
Shaista Hussain
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Leukocyte Count ◽  
Total Leukocyte Count ◽  
C Reactive Protein ◽  
Hypertensive Patients ◽  
Reactive Protein ◽  
Artery Disease

Background & Objectives: Inflammation is considered as the main triggering factor in evolution of atherosclerotic pathology of heart and blood vessels. Resistin, an inflammatory cytokine is proved to be a main mediator of initiation and progression of mechanisms leading to atherosclerosis, hypertension and ultimately to coronary artery disease. Our objective was to compare the levels of serum resistin, C-reactive protein and total leucocyte count in subjects of hypertension and coronary artery disease; and to observe the correlation of serum resistin with CRP and TLC in the study participants. Methods: Eighty selected participants were divided into four equal groups including normal healthy participants, newly diagnosed cases of hypertension, stable angina pectoris and myocardial infarction, both with hypertension. The study was conducted in the physiology department of Post Graduate Medical Institute Lahore, during 2013. After consent, history and examination, fasting blood samples of the participants were collected. Serum resistin and C-reactive protein were determined by using standard techniques of enzyme linked immunosorbent assay, while total leukocyte count by automated hematology analyzer. Results: The values of serum resistin, C- reactive protein and total leukocyte count were found significantly raised in patients of hypertension, angina pectoris and myocardial infarction with hypertension as compared to normal participants (p<0.001 for all). Significantly positive correlation of resistin was observed with TLC only in hypertensive patients of myocardial infarction (r = 0.459, n = 20, p = 0.042) while in other study groups correlation between resistin and TLC as well as CRP was non-significant. Conclusion: Serum resistin levels along with CRP and TLC are significantly raised in patients of hypertension and coronary artery disease while resistin levels revealed significantly positive correlation with TLC in hypertensive patients of myocardial infarction. doi: https://doi.org/10.12669/pjms.35.3.274 How to cite this:Niaz S, Latif J, Hussain S. Serum resistin: A possible link between inflammation, hypertension and coronary artery disease. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.274 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Gambaran aritmia pada pasien penyakit jantung koroner di RSUP Prof. Dr. R. D. Kandou Manado periode 1 Januari 2015 – 31 Desember 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Cathleen S. Kalangi ◽  
Edmond L. Jim ◽  
Victor F.F. Joseph
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Premature Ventricular Contraction ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Old Myocardial Infarction ◽  
Artery Disease

Abstract: Arrhythmia is an abnormal heart rhythm which refer to every disturbance in frequency, regularity, original location or electrical impulses conduction of the heart. Ischemic myocardium characterized by ionic and biochemical alterations creates an unstable electrical substrate capable of initiating and sustaining arrhythmias, meanwhile infarction creates areas of electrical inactivity and blocks conduction, which also promotes arrhythmogenesis. This study was aimed to obtain the description of arrhythmias in coronary artery disease patients at Prof. Dr. R. D. Kandou Hospital Manado from 1 January 2015 to 31 December 2015. This was a descriptive retrospective study. There were 101 data of patients with Coronary Artery Disease (CAD) associated with arrhythmia, as follows: 57 cases (56%) of Stable Angina Pectoris (SAP), 6 cases (6%) of Old Myocardial Infarction (OMI), 16 cases (16%) of Unstable Angina Pectoris (UAP), 20 cases (20%) of Non ST Segment Elevation Myocardial Infarction (NSTEMI), and 2 cases (2%) of ST Segment Elevation Myocardial Infarction (STEMI). The majority of cases were males (66%) and aged 51-60 years old (35%). There were 62 cases (41%) of CAD patients associated with arrhythmia that had hypertension as the highest risk factor and 19 cases (12%) for smoker as the lowest risk factor. The highest number of patients was Angina Pectoris Stabil (APS), and the dominant arrhythmia was Premature Ventricular Contraction (PVC).Keywords: description, arrhythmia, coronary artery disease Abstrak: Aritmia merupakan gangguan irama jantung yang merujuk kepada setiap gangguan frekuensi, regularitas, lokasi asal atau konduksi impuls listrik jantung. Iskemik miokardium ditandai dengan perubahan ion dan biokimiawi, mengakibatkan aktivitas listrik yang tidak stabil yang memicu dan mempertahankan aritmia, dan infark menciptakan daerah aktif dan blok konduksi listrik, yang juga memromosikan aritmogenesis. Penelitian ini bertujuan untuk mengetahui gambaran aritmia pada pasien penyakit jantung koroner (PJK) di RSUP Prof. Dr. R. D. Kandou Manado periode 1 Januari 2015-31 Desember 2015. Jenis penelitian ialah deskriptif retrospektif. Hasil penelitian mendapatkan 101 data pasien PJK yang mengalami aritmia, diantaranya Angina Pektoris Stabil (APS) 57 kasus (56%), Old Myocardial Infarction (OMI) 6 kasus (6%), Unstable Angina Pectoris (UAP) 16 kasus (16%), Non ST Segment Elevation Myocardial Infarction (NSTEMI) 20 kasus (20%), dan ST Segment Elevation Myocardial Infarction (STEMI) 2 kasus (2%). Mayoritas kasus ialah jenis kelamin laki-laki (66%), usia 51-60 tahun (35%). Faktor risiko tertinggi pada pasien PJK dengan aritmia ialah hipertensi (41%) dan terendah ialah merokok (12%). Kasus tertinggi ialah APS, dengan aritmia terbanyak ialah Premature Ventricular Contraction (PVC), Kata kunci: gambaran, aritmia, penyakit jantung koroner

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