Malignant transformation of endometriosis on vaginal cuff after hysterectomy: a case report

2021 ◽  
Vol 6 (2) ◽  
pp. 161-165
Author(s):  
Orkun Ilgen ◽  
◽  
Sefa Kurt ◽  
Deniz Gokcay ◽  
Emine Cagnur Ulukus
Keyword(s):  
Case Report ◽  
Malignant Transformation ◽  
Hormone Replacement ◽  
Endometrioid Adenocarcinoma ◽  
Malignant Tissue ◽  
Previous Surgery ◽  
Vaginal Cuff ◽  
Examination Result ◽  
History Of ◽  
Abnormal Vaginal Bleeding

Objective. Endometriotic tissue implants rarely transform to malignant tissue, especially in a patient with a hysterectomy and bilaterally salpingo-oophorectomy. However, several cases with cancer arising from endometriosis after hysterectomy were reported in the literature. Hormone replacement therapy only with estrogen is a crucial risk factor for malignant transformation of persistent endometriotic tissue. Case Report. The present case demonstrates an endometrioid adenocarcinoma arising from persistent endometriosis tissue in a patient who was performed hysterectomy with bilateral salpingectomy 3 years ago. The histopathologic specimens of the previous surgery did not include any malignant tissue. After 3 years, she applied to the hospital with abnormal vaginal bleeding, and her histopathologic examination result found an ulcerated mass at the upper one-third of the vagina that is compatible with endometrioid adenocarcinoma. Conclusion. It is crucial to keep in mind the endometriosis history of the patient, to be able to diagnose cancer arising from endometriosis while evaluating the patient with a hysterectomy.

scholarly journals Condylomata Acuminata in Adolescent Girl 19th Years Old Successful with Multimodality Therapy and Combination with HPV Vaccination: A Case Report

2021 ◽  
Vol 5 (4) ◽  
pp. 1180-1187
Author(s):  
Dwi Sabtika Julia ◽  
Qaira Anum ◽  
Rina Gustia
Keyword(s):  
Cervical Cancer ◽  
Case Report ◽  
Anal Cancer ◽  
Adolescent Girl ◽  
Hpv Vaccination ◽  
Condylomata Acuminata ◽  
Papilloma Virus ◽  
Examination Result ◽  
Anogenital Region ◽  
History Of

Background: Condylomata acuminata (KA) or better known as genital warts disease is a genital area infectious disease caused by Human papilloma virus (HPV). The highest prevalence infection of the condylomata acuminata occurs during active sexual periods, namely age 17-33 years, with the peak occurring at the age of 20-24 years. Currently HPV 16 and 18 are known to cause malignancy in the genital and anogenital region including cervical cancer and anal cancer, while HPV 6 and 11 are the cause of 90% of condylomata acuminata. HPV is linked to the findings of 500,000 new cases of cervical cancer and 250,000 deaths from cervical cancer each year worldwide.1 Case report: One case of condylomata acuminata in a 19-year-old adolescent girl with a major complaint of warts around her genitals that felt itchy and gradually getting bigger since 2 weeks ago. Patient was a student and unmarried. History of sexual contact with men with genito-genital without using condoms since 5 months ago. Venereological state : on the vulva and perineal there were multiple vegetations with verucose surfaces with the largest size 0.8 cm x 0.5 cm x 0.1 cm and the smallest size 0.2 cm x 0.2 cm x 0.1 cm. Acetowhite examination result was positive and PCR examination results found positive HPV types 6,11,16 and 18. Discussion: Patients are diagnosed to condylomata acuminata with a history of free sex at an early age. The condylomata acuminata experienced by patients was type 6,11,16 and 18. These types of 16 and 18 HPV are know to cause malignancy in the genital and anogenital region including cervical cancer and anal cancer.

scholarly journals An Alternative Treatment for Vaginal Cuff Wart: a Case Report

2020 ◽  
Vol 63 (1) ◽  
pp. 49-51
Author(s):  
Victoria Psomiadou ◽  
Christos Iavazzo ◽  
Athanasios Douligeris ◽  
Alexandros Fotiou ◽  
Anastasia Prodromidou ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Case Report ◽  
Aloe Vera ◽  
Immunological Response ◽  
Hpv Infection ◽  
Vaginal Cuff ◽  
Significant Treatment ◽  
Postmenopausal Patient ◽  
History Of ◽  
Methods Of Treatment

Human papillomavirus (HPV) has been directly related to acuminate warts and cervical cancer, the second most common neoplasia among women. Given the lack of treatment against the virus itself, many medications have been utilised, mainly aiming in modifying the host’s immunological response. We present the case of a 54 years old postmenopausal patient with a history of vaginal cuff wart and HPV persistence that we managed in our clinic for 6 months with a mix of curcumin, aloe vera, amla and other natural ingredients. As the patient was found to be intolerant to imiquimod (one of the most common conservative methods of treatment) we attempted the use of curcumin, which was applied to the area of the wart three times per week for 6 months. Both clinical and colposcopical improvement was noted in regular clinic visits with regression of the lesion. The outcome of this case encourages our view that curcumin should be considered as a significant treatment modality against HPV infection and acuminate warts.

scholarly journals Malignant Transformation of Postmenopausal Endometriosis: A Systematic Review of the Literature

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4026
Author(s):  
Luca Giannella ◽  
Chiara Marconi ◽  
Jacopo Di Giuseppe ◽  
Giovanni Delli Carpini ◽  
Mariasole Fichera ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Previous History ◽  
Inverse Correlation ◽  
Major Surgery ◽  
Endometrioid Adenocarcinoma ◽  
History Of ◽  
Definitive Surgery ◽  
Clinical Conditions ◽  
Postmenopausal Endometriosis

Objective: This study aimed to systematically review the existing literature on malignant transformation of postmenopausal endometriosis to provide information about patient characteristics, hormonal replacement therapy (HRT) use, and outcomes over a period of 52 years (1969–2021). Methods: According to PRISMA guidelines, we searched for (endometriosis OR endometriotic) AND (cancer OR malignancy OR malignant transformation) AND (menopause OR menopausal OR postmenopause OR postmenopausal) in Pubmed (all fields) (accessed on 12 February 2021) and Scopus (Title/Abstract/Keywords) (accessed on 12 February 2021) databases. The only filter used was the English language. Relevant articles were obtained in full-text format and screened for additional references. Eligibility/inclusion criteria: studies including full case description of malignant transformation of endometriosis-related lesions in postmenopause. Results: 75 studies, including 90 cases, were retrieved. The mean age was 55.8 ± 8.5 years. Overall, about 65% of women had a positive personal history of endometriosis/adenomyosis, and 64% of women underwent previous hysterectomy ± bilateral salpingo-oophorectomy. Forty-nine of 74 women used HRT (66.2%). Among the women who used HRT, estrogen-only treatment was taken by approximately 75%. Duration of HRT was longer than five years in 63.3% of cases. About 70% of subjects had histology of endometrioid adenocarcinoma or clear cell carcinoma. Follow-up outcome, available for 61 women, showed a survival rate of 78.7%, recurrence of 9.8%, death of 11.5%. The duration of follow-up had a median of 12 months (interquartile range, 6.75–25 months). Interestingly, over the years of case publication there was a significant inverse correlation with previous history of endometriosis (r = −0.28, p = 0.007), HRT use (r = −0.31, p = 0.006), and previous definitive surgery (r = −0.42, p < 0.001). Conclusions: In the malignant transformation of postmenopausal endometriosis, there are some recurrent clinical conditions: previous endometriosis, major definitive surgery before menopause, and estrogen-only HRT for a relatively long time. However, these clinical conditions have shown a drastic decrease over time. This could likely be the consequence of different attitudes and management of gynecologists linked to up-to-date scientific evidence about the use of major surgery in gynecological pathologies. Malignant transformation of postmenopausal endometriosis is a clinical challenge to be explored further.

scholarly journals A case report of exophytic nasal papilloma with acute dacryocystitis as the first symptom

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ya Mo ◽  
Danning Long ◽  
Luoxiang Li ◽  
Yanlin Zheng
Keyword(s):  
Case Report ◽  
General Anesthesia ◽  
Malignant Transformation ◽  
Benign Tumor ◽  
Clinical Observation ◽  
Purulent Discharge ◽  
Lacrimal Sac ◽  
Case Presentation ◽  
History Of ◽  
The Right

Abstract Background This study aims to explore a case of exophytic nasal papilloma with acute dacryocystitis as the first symptom. Case presentation A 72-year-old male patient complaining of “a 10-year history of tearing and purulent discharge from the right eye, with subsequent redness and pain in the inner canthus for three days” was initially diagnosed with acute dacryocystitis of the right eye. The patient was treated with anti-inflammatory therapy. However, the redness and swelling of the inner canthus continued to increase. An endoscopic dacryocystorhinostomy of the right eye was performed under general anesthesia. A large amount of purulent secretion was drained during the operation. As a result, the swelling of the inner canthus was significantly reduced. A routine intra-operative biopsy of the wall of the lacrimal sac revealed an exophytic nasal papilloma. A second biopsy, 1 week after the surgery, revealed the same result. The patient was advised to undergo a dacryocystectomy once the swelling had subsided. However, the patient was reluctant to undergo this surgery and remains under clinical observation. Conclusion It is rare for an exophytic nasal papilloma, which is a benign tumor in the lacrimal sac, which has the potential for recurrence and malignant transformation, to manifest with acute dacryocystitis as the first symptom. Therefore, this case report could provide a reference for the future clinical diagnosis of this disease.

scholarly journals Penatalaksanaan Hemangioma Kavernosa Laring

2019 ◽  
Vol 48 (2) ◽  
pp. 189
Author(s):  
Vicky Eko ◽  
Rokhaeni Rokhaeni
Keyword(s):  
Case Report ◽  
Ct Scan ◽  
Cavernous Hemangioma ◽  
Evidence Based ◽  
Literature Study ◽  
Exclusion Criteria ◽  
Rigid Endoscopy ◽  
Report Result ◽  
Examination Result ◽  
History Of

Latar belakang: Hemangioma merupakan proliferasi dari pembuluh darah yang tidak normal dan dapat terjadi pada setiap jaringan pembuluh darah. Adanya massa di laring harus dibedakan sebagai suatu proses inflamasi, atau massa tumor seperti polip laring, karsinoma laring, atau hemangioma. Tujuan: Untuk mengetahui hemangioma kavernosa laring dan penatalaksanaannya. Laporan kasus: Pasien laki-laki, 45 tahun dengan keluhan suara serak yang terus-menerus sejak 1 tahun sebelum masuk rumah sakit. Keluhan serak makin lama makin berat dan dirasakan sangat parah dalam 1 bulan terakhir. Keluhan sesak dan batuk tidak ada, riwayat merokok ada, pekerjaan petani, dan sering terpapar obat hama. Pada pemeriksaan endoskopi kaku 700 didapatkan massa menutup laring, batas tidak tegas, dan pada pemeriksaan CT Scan laring didapatkan massa pada laring bilateral. Dari pemeriksaan Patologi Anatomi didapatkan kesimpulan hemangioma kavernosa. Penatalaksanaan pasien ini berupa trakeostomi dengan anestesi lokal, dan bedah laring mikroskopi dengan anestesi umum. Metode: Telaah literatur berbasis bukti mengenai hemangioma kavernosa laring melalui database Cochrane dan Pubmed Medline. Berdasarkan kriteria inklusi dan ekslusi didapatkan 3 jurnal yang relevan dengan kasus yang dilaporkan. Hasil: Berdasarkan literatur bahwa hemangioma kavernosa laring merupakan kasus jarang, dan lokasi yang sering terjadi di regio supraglotis dan glotis. Gejala tersering yaitu suara serak. Faktor yang mempengaruhi pilihan terapi adalah usia pasien, tipe, ukuran dan lokalisasi tumor. Kesimpulan: Penatalaksanaan hemangioma kavernosa laring berupa trakeostomi dan bedah laring mikroskopik dengan hasil yang baik. Background: Hemangioma is an abnormal proliferation of blood vessels and it can occur in any blood vessel tissue. The presence of laryngeal masses has to be differentiated as an inflammation process or tumor mass such as polyps of the larynx, laryngeal carcinoma, or hemangioma. Purpose: To gain knowledge of laryngeal cavernous hemangioma and its management. Case Report:  Male, 45 years old, complained of persistent hoarseness for about 1 year, and getting much worse since the last month. No complaint of breathing difficulty nor coughing. Had a positive history of smoking, worked as a farmer, often exposed to insecticides. A seventy degree rigid endoscopy examination showed an irregular shaped mass occluding the larynx, indistinct borders, and the CT scan confirmed an isodense mass in larynx bilaterally. The  Pathology Anatomy examination result concluded as cavernous hemangioma. The patient underwent tracheostomy with local anesthesia and microlaryngoscopic surgery under general anesthesia. Method:  An evidence based literature study on laryngeal cavernous hemangioma was performed through Cochrane and Pubmed Medline. Based on inclusion and exclusion criteria, there were 3 journals which were relevant with the case report. Result: Literature study revealed that laryngeal cavernous hemangioma is a rare case. The frequent  location was  in supraglotis and glotis regions. Conclusion: The management of laryngeal cavernous hemangioma consisted of tracheostomy and microlaryngoscopic surgery with good result.

scholarly journals Condylomata Acuminata in Adolescent Girl 19th Years Old Successful with Multimodality Therapy and Combination with HPV Vaccination: A Case Report

2021 ◽  
Vol 5 (10) ◽  
pp. 961-967
Author(s):  
Dwi Sabtika Julia ◽  
Qaira Anum ◽  
Rina Gustia
Keyword(s):  
Cervical Cancer ◽  
Case Report ◽  
Anal Cancer ◽  
Adolescent Girl ◽  
Hpv Vaccination ◽  
Condylomata Acuminata ◽  
Papilloma Virus ◽  
Examination Result ◽  
Anogenital Region ◽  
History Of

Background: Condylomata acuminata (KA) or better known as genital warts disease is a genital area infectious disease caused by Human papilloma virus (HPV). The highest prevalence infection of the condylomata acuminata occurs during active sexual periods, namely age 17-33 years, with the peak occurring at the age of 20-24 years. Currently HPV 16 and 18 are known to cause malignancy in the genital and anogenital region including cervical cancer and anal cancer, while HPV 6 and 11 are the cause of 90% of condylomata acuminata. HPV is linked to the findings of 500,000 new cases of cervical cancer and 250,000 deaths from cervical cancer each year worldwide.1 Case report: One case of condylomata acuminata in a 19-year-old adolescent girl with a major complaint of warts around her genitals that felt itchy and gradually getting bigger since 2 weeks ago. Patient was a student and unmarried. History of sexual contact with men with genito-genital without using condoms since 5 months ago. Venereological state : on the vulva and perineal there were multiple vegetations with verucose surfaces with the largest size 0.8 cm x 0.5 cm x 0.1 cm and the smallest size 0.2 cm x 0.2 cm x 0.1 cm. Acetowhite examination result was positive and PCR examination results found positive HPV types 6,11,16 and 18. Discussion: Patients are diagnosed to condylomata acuminata with a history of free sex at an early age. The condylomata acuminata experienced by patients was type 6,11,16 and 18. These types of 16 and 18 HPV are know to cause malignancy in the genital and anogenital region including cervical cancer and anal cancer.

A case report of recurrent maxillary ameloblastoma

2020 ◽  
Author(s):  
Mahdi Azadi ◽  
Farnoosh Mohammadi ◽  
Narges Hajiani
Keyword(s):  
Case Report ◽  
Aggressive Behavior ◽  
Excisional Biopsy ◽  
Alveolar Ridge ◽  
Previous Surgery ◽  
Anatomical Features ◽  
Unicystic Ameloblastoma ◽  
Second Surgery ◽  
History Of ◽  
The Right

Ameloblastoma is one of the most common types of oral odontogenic tumors. As per literature, ameloblastoma mostly occurs in the mandible butthe maxillary ameloblastoma has a more aggressive behavior due to anatomical features. Also,unicystic ameloblastoma may have lower recurrent rate. In this case report, we present a 60-year-old male patient with a history of unicystic ameloblastoma, whichtheintraluminaladenomatoid odontogenic tumor excisional biopsy surgery was performed but the patient didn’t follow the treatment completely, and after two years he came back with swellingof the right upper alveolar ridge. After the second surgery, the histopathologic report revealed a mixed plexiform-follicular ameloblastoma recurrence and it seemedthat previous surgery was not sufficient and more radical treatment is needed for the lesion

scholarly journals Chronic uterine inversion associated with uterine leiomyoma misdiagnosed as cervical fibroid: a case report

2019 ◽  
Vol 8 (11) ◽  
pp. 4593
Author(s):  
Swati Kochar ◽  
Ankur Nama ◽  
Santosh Khajotia ◽  
Neha Suthar
Keyword(s):  
Case Report ◽  
Endometrial Carcinoma ◽  
Vaginal Bleeding ◽  
Uterine Leiomyoma ◽  
Near Miss ◽  
Rare Clinical Entity ◽  
Uterine Inversion ◽  
History Of ◽  
Abnormal Vaginal Bleeding ◽  
High Index Of Suspicion

Chronic inversion of uterus is a rare clinical entity which is usually associated with obstetrics complication and rarely with gynaecological disorder like fibroid present at fundus of uterus. We here present a case of 40-year-old female P3L3 with chronic inversion of uterus with fundal fibroid which present with 3year history of abnormal vaginal bleeding. Ultrasonography and MRI revealed cervical fibroid. Due to AUB secondary to cervical fibroid decision of hysterectomy was taken. On laparotomy chronic uterine inversion was present which was corrected by haultain’s procedure. Then hysterectomy was done. Histopathology report suggestive of uterine leiomyoma at fundus of uterus. Chronic uterine inversion associated most commonly with fundal submucous leiomyoma. Other causes are leiomyosarcoma, endometrial carcinoma, cervical carcinoma, rhabdomyosarcoma, mixed mullerian sarcoma. It is an extremely rare gynaecological condition and can be misdiagnosed as cervical fibroid, advanced cervical malignancy or other causes of AUB in females. It could be labelled as gynaecological near miss so a high index of suspicion is necessary for it’s diagnosis.

scholarly journals Multiple familial trichoepitheliomas: a case report

2021 ◽  
Vol 7 (3) ◽  
pp. 487
Author(s):  
Priyadharshini N. ◽  
Harini Irri ◽  
Sathyanarayanan R.
Keyword(s):  
Case Report ◽  
Family History ◽  
Malignant Transformation ◽  
Autosomal Dominant ◽  
Positive Family History ◽  
Family Members ◽  
Histopathological Findings ◽  
Multiple Lesions ◽  
Adnexal Tumor ◽  
History Of

<p class="abstract">Trichoepithelioma is a rare benign adnexal tumor that differentiates towards the folliculo-sebaceous-apocrine unit (trichoblast). It may present as solitary non-familial lesion or multiple lesions as a part of autosomal dominant inherited syndrome known as multiple familial Trichoepithelioma. Multiple familial trichoepithelioma is a relatively rare, disfiguring, benign adnexal neoplasm diagnosed by centrofacial distribution of papules and nodules, positive family history, related histopathological findings and can rarely undergo malignant transformation. Treatment is mainly for cosmetic concern. Here we report a case who presented with multiple skin coloured facial papules and nodules, with a history of similar lesions in other family members. Dermoscopy and histopathology confirmed the diagnosis of trichoepitheliomas.</p>

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