Basal Cell Carcinoma with Adnexal Differentiation, a Rare Entity and Challenging Histopathology Presentation. Case Report

2017 ◽  
Vol 1 (3) ◽  
pp. 177-181
Author(s):  
Lizy M Paniagua Gonzalez ◽  
Ikue Shimizu
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Frozen Section ◽  
Giant Cells ◽  
Skin Cancers ◽  
History Of ◽  
The Right ◽  
Stage 1 ◽  
Melanoma Skin

We report an 88 year-old male with a history of multiple non-melanoma skin cancers who presented for Mohs micrographic surgery with a biopsy proven infiltrative and nodular basal cell carcinoma located on the right posterior ear. During Mohs surgery, frozen sections revealed a typical nodular BCC on stage 1.   However, on stage 2, frozen section showed nodular aggregates of regular cuboidal cells with pale cytoplasm with areas mimicking multi-nucleated giant cells. Deeper permanent sections were consistent with BCC with adnexal differentiation. This histopathological presentation of basal cell carcinoma is uncommon and we sought to report the clinical and pathological features of this case. 

scholarly journals Climate change and its relationship with non-melanoma skin cancers

2018 ◽  
Vol 17 (12) ◽  
pp. 1913-1917 ◽  
Author(s):  
Rubén D. Piacentini ◽  
Lara Sofía Della Ceca ◽  
Adriana Ipiña
Keyword(s):  
Climate Change ◽  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Ambient Temperature ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Cancers ◽  
Melanoma Skin

The increase in ambient temperature due to climate change is expected to affect the carcinogenicity of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).

scholarly journals Analysis of the Histopathological Profile and Surgical Margins Resulting from Resection of Nonmelanoma Skin Cancers

2021 ◽  
Vol 5 (1) ◽  
pp. 22-26
Author(s):  
Marcus Vinícius Jardini Barbosa ◽  
◽  
Anna Rita de Cascia Carvalho Barbosa ◽  
Frederico Alonso Sabino de Freitas
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Risk Group ◽  
Surgical Margins ◽  
Cervical Region ◽  
Skin Cancers ◽  
Melanoma Skin

: Introduction: Non-melanoma skin cancer is a group of malignant neoplasms composed basically by sarcomas, basal cell carcinoma and squamous cell carcinoma. Its etiology is multifactorial with specificity for each of the two types, except for exposure to ultraviolet radiation, which is a common factor between both. When detected early, it has a high cure rate, and surgical excision with safety margins being the treatment of choice in most cases. Thus, it is important to recognize the profile of the patients, as well as the histopathological characteristics of the lesions and the medical approach used to avoid recurrences. Purpose: This study aimed to analyze the histopathological profile and surgical margins resulting from the resection of non-melanoma skin cancers in patients treated at a plastic surgery facility in Brazil. Methods: The cases of squamous cell carcinoma and the histopathological types of the basal cell carcinoma were individually analyzed for compromised margins, and later divided into a low-risk group and a high-risk group. Results: 228 lesions were resected from 141 patients. Gender distribution was 55.3% female and 44.6% male. The most affected age group was over 70 years old. The predominant histological type was basal cell carcinoma (74.6%) followed by squamous cell carcinoma (25.4%); the most affected site was the cephalic-cervical segment (71.92%). Surgical margins were compromised in 12.3% with no significant difference between the two types of carcinoma. Conclusion: There was a predominance of basal cell carcinoma (nodular type) in women over 40 years old, predominantly in the cephalic-cervical region. The number of recurrences was proportionally higher in the BCC, unrelated to the presence of positive margins. Keywords: Skin Neoplasms, Basal Cell Carcinoma, Squamous Cell Carcinoma, Recurrence, Margins of Excision.

Metachronous Eyelid Basal Cell Carcinoma on Opposite Eye and Lid: A Case Report

2020 ◽  
pp. 44-49
Author(s):  
Danielle C. Kalberer ◽  
Mattew A. DelMauro
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Lower Eyelid ◽  
Small Lesion ◽  
Upper Eyelid ◽  
History Of ◽  
The Right ◽  
Eyelid Lesions

Background: Basal cell carcinoma (BCC) is the most common eyelid malignancy, accounting for approximately 90% of malignant eyelid lesions.1 Despite its high occurrence rates, it is frequently misdiagnosed as one of the benign “lumps and bumps” that can be present on the eyelid. In the present case, a patient with a past BCC on the right upper eyelid presented with a left lower eyelid lesion which persisted for months before the patient sought evaluation by an eyecare provider. This benign-looking lash-line lesion was the only external sign of the malignancy found on the deep surface of the eyelid and later diagnosed as BCC. Case Report: A 74-year-old patient presented with a persistent eyelid lesion that was resistant to treatment for greater than 6 months. The small lesion was slightly suspicious in appearance. Further evaluation revealed a larger, more irregular lesion on the conjunctival surface of the eyelid. The patient was referred to an oculoplastic specialist for biopsy. Pathology confirmed the diagnosis of basal cell carcinoma. Conclusion: Once the lesion was properly diagnosed, the patient underwent Mohs micrographic surgery and eyelid reconstruction. This case will highlight the importance of prompt and thorough evaluation of suspicious eyelid lesions which are persistent and resistant to treatment in patients with a history of eyelid malignancy.

scholarly journals Locally advanced squamous cell carcinoma with extensive destruction of face

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Venumadhavi Gogineni ◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Locally Advanced ◽  
Medical Attention ◽  
Patient Centered ◽  
History Of ◽  
The Right

A 58-year-old male with a past medical history of squamous cell carcinoma and basal cell carcinoma presented to the emergency department with complaints of right facial mass, loss of vision, and frequent falls due to visual disturbances. The mass was also associated with pain and purulent drainage. On examination, the patient had a large necrotizing and ulcerative mass occupying the entire right hemiface with complete destruction of facial anatomy including the right eye and nose as shown (Figure 1). On further inquiry, the patient stated that he noticed a “Little Bubble” on his face 3 years ago, which has been progressively worsening since then. He was estranged from his family and had been living alone. The patient did not seek medical care earlier for reasons he did not want to share with the medical team despite our multiple attempts at patient-centered interviewing. He recently established contact with his daughter who ultimately convinced him to seek medical attention. The patient was diagnosed with squamous cell carcinoma and basal cell carcinoma over his face and scalp several years ago, which was successfully treated with surgery at that time. However, he did not follow up and had not seen a physician in several years.

scholarly journals Split Lateral Forehead Flap for Reconstruction of Upper and Lower Eyelids

2021 ◽  
Vol 4 (2) ◽  
pp. 48
Author(s):  
I G. A. N. Widya Pramana ◽  
Sitti Rizaliyana
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Tumor Resection ◽  
Forehead Flap ◽  
Donor Region ◽  
Operation Techniques ◽  
History Of ◽  
The Right ◽  
Reconstructive Plastic Surgery

Background: Eyelids reconstruction after tumor resection has be one of the most challenging procedures in reconstructive plastic surgery. Small defects may be closed by primary suture or covered by small local flaps or skin graft. But in large eyelids defects, we need to find a bigger source of color and texture matching tissue that will ensure functional and aesthetical outcomes. Many techniques have been described, but in this case, the author suggest a split lateral forehead flap designed to cover upper and lower eyelids. Patient and Operation Techniques: A Male 51 years-old-patient, presented himself in our clinic with a basal cell carcinoma involving the right upper and lower eyelids. The tumor had a history of 7 years, without any pain or vision disorders involved. Tumor was widely excised, leaving a full thickness on upper and lower eyelids. The inner lining palpebral was replaced by composite auricular graft following by lateral cantophexy. A lateral forehead flap raised with a right temporal pedicle, and the distal part of flap was split in half, and inset into the upper and lower eyelids defect. The donor region was closed with an STSG from Femur Dextra. After 14 days the flap was divided, the functional result was excellent. Discussion: At first, surgeons were worried of raising forehead flaps beyond the midline, fearing that by splitting the distal flap would cause its compropmise. However, rich anastomostic plexus exists between the major forehead angiosomes lined by the smaller calibre “choke” vessels. Conclusions: Periorbital Basal cell carcinoma resection may leave great defect to the underlying tissue. The need to provide adequate support to this structure requires complex techniques with minimum two flaps. In our case, we performed a split lateral forehead flap with a good functional and cosmetic outcome.

scholarly journals Colonisation of basal cell carcinoma and actinic keratosis by malignant melanoma in situ in a patient with xeroderma pigmentosum variant

2012 ◽  
Vol 2 (2) ◽  
pp. 47 ◽  
Author(s):  
Louise J. Smith ◽  
Ehab A. Husain
Keyword(s):  
Malignant Melanoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Actinic Keratosis ◽  
Xeroderma Pigmentosum ◽  
Clinical Impression ◽  
Anatomical Site ◽  
History Of

Although malignant melanoma (MM) and both basal cell carcinoma (BCC) and actinic keratosis (AK) are sun-induced lesions, the coexistence of these entities at the same anatomical site (collision tumour) is exceedingly rare. We report the case of a 54-year-old woman with a known history of xeroderma pigmentosum variant (XPV) who presented with 2 separate skin lesions over the middle and upper right forearm, respectively. The clinical impression was that of BCCs or squamous cell lesions. On histological examination, both specimens showed features of melanoma <em>in situ </em>(MIS). In the first lesion, MIS merged with and colonised a superficial and focally invasive BCC. In the second lesion, MIS merged with an AK. No separate invasive nests of malignant melanoma were seen in either specimen. The atypical melanocytes were highlighted by Melan-A and HMB-45 immunostaining, whereas the epithelial cells in both the BCC and AK stained with the pancytokeratin MNF-116. The patient had a previous history of multiple MMs and non-melanomatous skin cancers and finally developed widespread metastatic malignant melanoma, which proved fatal. The rare and interesting phenomenon of collision tumours may pose diagnostic difficulties. To our knowledge, this is the first reported simultaneous presentation of cytologically malignant collision tumours in a patient with XPV.

scholarly journals Late malignancy after 26 years of evolution on an untreated perianal fistula

2021 ◽  
Vol 28 (1) ◽  
pp. 99-101
Author(s):  
Lucian Sorin ANDREI ◽  
◽  
Adriana Corina ANDREI ◽  
Alexandru MICU ◽  
Radu Sorin POPISTEANU ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Squamous Cell ◽  
Basal Cell ◽  
Perianal Fistula ◽  
Transsphincteric Fistula ◽  
History Of ◽  
Histopathological Result

Squamous cell carcinoma and basal cell carcinoma are two types of neoplasms that rarely affect the perianal region, and their etiology is still a matter for debate. We present the case of a 75 year old patient with a 26 year history of perianal fistula, who presents with purulent and fecal perianal discharge and swelling at this level. Physical examination and anoscopy detected low transsphincteric fistula. The biopsy revealed the diagnosis of squamous cell carcinoma, for which a local excision was performed followed by adjuvant radiotherapy. Two years after this event, the patient presented with another perianal lession, which according to the histopathological result was a basal cell carcinoma; local excision was the only treatment performed for this malignancy.

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