scholarly journals Clinical features and endoscopic findings of granular cell tumor of the sellar region: A case report and review of the literature

2020 ◽  
Vol 11 ◽  
pp. 101
Author(s):  
Akari Kusakawa ◽  
Akihiro Inoue ◽  
Yawara Nakamura ◽  
Naoya Nishida ◽  
Mana Fukushima ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Anterior Pituitary ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Accurate Diagnosis ◽  
Sellar Region ◽  
Posterior Pituitary ◽  
Resonance Imaging

Background: Granular cell tumor (GCT) of the sellar region is a rare tumor of the sellar and suprasellar regions that originate from the neurohypophysis. This tumor is very difficult to differentiate from other pituitary neoplasms, such as pituitary adenoma, pituicytoma, and spindle cell oncocytoma. We report a rare case of GCT arising from the posterior pituitary of the sellar region and suggest a useful indicator for accurate diagnosis and pitfalls for surgical procedures. Case Description: A 42-year-old woman was admitted to our hospital with bitemporal hemianopsia. Neuroimaging showed a large pituitary tumor in the sellar and suprasellar regions with a hypointense part on T2-weighted magnetic resonance imaging, and the enhanced anterior pituitary gland was displaced anteriorly. Laboratory findings showed mild hyperprolactinemia. Subtotal resection of the tumor was achieved using an endoscopic endonasal transsphenoidal approach. Histological findings showed round or polygonal cells with abundant granular eosinophilic cytoplasm staining strongly for thyroid transcription factor 1. The tumor was, therefore, diagnosed as a GCT of the sellar region, belonging to tumors of the posterior pituitary. After surgery, visual impairment and anterior pituitary function were improved. Follow-up neuroimaging after 1 year showed no signs of recurrence. Conclusion: GCT of the sellar region is difficult to diagnose on routine neuroimaging. Therefore, accurate diagnosis requires careful identification of clinical signs, magnetic resonance imaging including hypointensity on T2-weighted imaging, and analysis of combined morphological and immunohistochemical studies.

Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation

2005 ◽  
Vol 34 (10) ◽  
pp. 625-631 ◽  
Author(s):  
Marcia F. Blacksin ◽  
Lawrence M. White ◽  
Meera Hameed ◽  
Rita Kandel ◽  
Francis R. Patterson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Resonance Imaging ◽  
Pathologic Correlation ◽  
Imaging Characteristics

scholarly journals Granular cell tumor of the breast: correlations between imaging and pathology findings

2020 ◽  
Vol 53 (2) ◽  
pp. 105-111
Author(s):  
Natacha Abreu ◽  
Juliana Filipe ◽  
Saudade André ◽  
José Carlos Marques
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Granular Cell Tumor ◽  
Kinetic Curve ◽  
Granular Cell ◽  
Cell Tumor ◽  
Imaging Features ◽  
Resonance Imaging ◽  
Diagnostic Challenge ◽  
Picture Archiving And Communication

Abstract Objective: To review the imaging features of granular cell tumors of the breast (on mammography, ultrasound, and magnetic resonance imaging), establishing a pathological correlation, in order to familiarize radiologists with this entity and make them aware of the differential diagnoses, other than malignancy, of lesions with spiculated margins. Materials and Methods: We reviewed the medical records (from a clinical-pathology database and picture archiving and communication system) of five patients with a pathologically confirmed diagnosis of granular cell tumor of the breast, treated at the Portuguese Oncology Institute of Lisbon, in the city of Lisbon, Portugal, between January 2012 and December 2018. Results: All five tumors exhibited imaging features highly suggestive of malignancy (BI-RADS 5 lesions), namely spiculated margins, significant depth, and posterior acoustic shadowing (on ultrasound). One tumor showed a kinetic curve indicative of washout on magnetic resonance imaging, two were adherent to the pectoralis muscle, and one was accompanied by skin retraction. Pathology provided the definitive diagnosis in all cases. Conclusion: Granular cell tumors of the breast pose a diagnostic challenge because they can present with clinical and imaging features mimicking malignancy, and the diagnosis is therefore provided by pathology. Radiologists should be familiarized with this entity, so they can be aware of the fact that breast lesions with spiculated margins can be indicative of diagnoses other than malignancy.

Granular cell tumor of the breast: Tip and tricks on conventional and magnetic resonance imaging

2020 ◽  
Author(s):  
Giuliana Moffa ◽  
Francesca Galati ◽  
Giovanna Panzironi ◽  
Veronica Rizzo ◽  
Endi Kripa ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Resonance Imaging

Granular Cell Tumor of the Posterior Tibial Nerve as a Rare Cause of Heel Pain

2009 ◽  
Vol 99 (3) ◽  
pp. 254-257
Author(s):  
Yunus Dogramaci ◽  
Aydiner Kalaci ◽  
Teoman Toni Sevinc ◽  
Sibel Hakverdi ◽  
Serefettin Canda ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Peripheral Nerves ◽  
Granular Cell Tumor ◽  
Tibial Nerve ◽  
Granular Cell ◽  
Heel Pain ◽  
Cell Tumor ◽  
Posterior Tibial Nerve ◽  
Resonance Imaging ◽  
Posterior Tibial

Granular cell tumor of peripheral nerves is extremely rare. We present the case of a patient with a well-capsulated intraneural granular cell tumor involving the posterior tibial nerve, who presented with chronic heel pain mimicking plantar fasciitis. Magnetic resonance imaging revealed a well-defined intraneural soft-tissue mass within the substance of the posterior tibial nerve. Histopathologic examination showed a granular cell tumor, which is extremley rare in the peripheral nerves. Heel pain is one of the common conditions handled by physicians, podiatrists, and orthopedic surgeons. Posterior tibial nerve lesions at the leg should be kept in mind in the differential diagnosis of patients with persistent heel and foot pain. Magnetic resonance imaging is a useful method in the anatomical evaluation of focal intraneural lesions. (J Am Podiatr Med Assoc 99(3): 254–257, 2009)

scholarly journals Novel HESX1 Mutations Associated with a Life-Threatening Neonatal Phenotype, Pituitary Aplasia, but Normally Located Posterior Pituitary and No Optic Nerve Abnormalities

2006 ◽  
Vol 91 (11) ◽  
pp. 4528-4536 ◽  
Author(s):  
Marie-Laure Sobrier ◽  
Mohamad Maghnie ◽  
Marie-Pierre Vié-Luton ◽  
Andrea Secco ◽  
Natascia di Iorgi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Anterior Pituitary ◽  
Magnetic Resonance Imaging Examination ◽  
Posterior Pituitary ◽  
Disease Phenotype ◽  
Resonance Imaging ◽  
Life Threatening ◽  
Ectopic Posterior Pituitary

Abstract Context: Hesx1 is one of the earliest homeodomain transcription factors expressed during pituitary development. Very few HESX1 mutations have been identified in humans; although in those cases the disease phenotype shows considerable variability, all but one of the patients display an ectopic posterior pituitary and/or optic nerve abnormalities. Objective: The objectives of the study were to describe the complex phenotype associated with the panhypopituitarism of two unrelated Italian patients who, at birth, presented with hypoglycemic seizures and respiratory distress complicated by shock, in a familial context of neonatal death in one family and spontaneous miscarriage in both families and to identify the molecular basis of this unusual syndrome. Main Outcome Measures: Magnetic resonance imaging of the pituitary region, study of HESX1 gene and transcripts, and assessment of the ability of mutated HESX1 proteins to repress transcription were measured. Results: Magnetic resonance imaging examination showed an anterior pituitary aplasia in a flat sella turcica and a normally located posterior pituitary in both patients. A constellation of extrapituitary developmental defects were found in the two patients, but without any optic nerve abnormalities. Sequencing of HESX1 exons and their flanking intronic regions revealed two different homozygous mutations. A frameshift (c.449_450delAC) was identified in one case, whereas the other patient carried a splice defect (c.357 + 2T>C) confirmed by the study of HESX1 transcripts. If translated, these mutations would lead to the synthesis of truncated proteins partly or entirely lacking the homeodomain, with no transcriptional repression, as shown by their inability to inhibit PROP1 activity. Conclusions: These observations reveal two novel HESX1 mutations in a so-far-undescribed disease phenotype characterized by a life-threatening neonatal condition associated with anterior pituitary aplasia, in the absence of ectopic posterior pituitary and optic nerve abnormalities, two features classically associated with HESX1 defects.

scholarly journals Intraparenchymal extravasation of gadolinium mimicking an enhancing brain tumor

2019 ◽  
Vol 32 (4) ◽  
pp. 273-276 ◽  
Author(s):  
David J Ritchie ◽  
Charles Q Li ◽  
Reid Hoshide ◽  
Daniel Vinocur
Keyword(s):  
Magnetic Resonance Imaging ◽  
Brain Tumor ◽  
Magnetic Resonance ◽  
Pediatric Patient ◽  
Essential Role ◽  
Accurate Diagnosis ◽  
Resonance Imaging ◽  
Intracranial Neoplasms ◽  
Vascular Abnormalities ◽  
First Case

Gadolinium (Gd)-enhanced magnetic resonance imaging plays an essential role in the detection, characterization, and staging of intracranial neoplasms and vascular abnormalities. Although Gd is helpful in a majority of situations, it can lead to diagnostic misinterpretation in the setting of active vascular extravasation. Scarce reports of intracranial extravasation of Gd are present in the literature. Here, we report the first case of surgically proven spontaneous intraparenchymal extravasation of Gd mimicking an enhancing intra-axial neoplasm in a pediatric patient. Early and accurate recognition of Gd extravasation is critical in obtaining the accurate diagnosis and triaging patients expeditiously into proper avenues of care.

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