216 Genomic regions and pathways associated with resistance to gastrointestinal parasites in tropical sheep breed

Abstract Helminth and protozoan infections are responsible for important diseases in grazing sheep, which can be especially threatening in an autochthonous breed at risk of extinction like the Churra Galega Mirandesa Portuguese sheep breed. The aim of the present study was to determine the diversity, prevalence and burden of gastrointestinal parasites in these sheep and to assess the effects of deworming practices, cohabiting animals on the farm and feed management. Coprological qualitative and quantitative analysis (flotation, natural sedimentation and McMaster method) were used to identify and quantify gastrointestinal parasites and a questionnaire was designed and applied. A total of 512 faecal samples were collected from 49 flocks, and 49 replies to the questionnaire were received. Parasites were identified in 100% of the flocks, and in 97% of the samples. The genera or species that have been morphologically identified were: strongyle-type, Nematodirus spp., Skrjabinema spp., Moniezia expansa, Moniezia benedeni, Trichuris spp., Capillaria spp., Eimeria spp., Dicrocoelium spp. and Fasciola hepatica. This is the first report in Portugal of Skrjabinema spp. The burden of parasites’ oocysts and eggs per gram in faecal samples ranged, respectively, from 50 to 17,550 for Eimeria spp., and from 50 to 6250 for strongyle-type eggs. Factors affecting parasitic infections were evaluated using a multivariate logistic regression. Grazing time and a lack of anthelmintic treatment were positively associated with Nematodirus spp. infection. This study showed that there is a high prevalence and diversity of gastrointestinal parasites in the Churra Galega Mirandesa sheep breed.

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Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate

Journal of Animal Science and Biotechnology ◽

10.1186/s40104-017-0190-4 ◽

2017 ◽

Vol 8 (1) ◽

Cited By ~ 12

Author(s):

Mariana Piatto Berton ◽

Rafael Medeiros de Oliveira Silva ◽

Elisa Peripolli ◽

Nedenia Bonvino Stafuzza ◽

Jesús Fernández Martin ◽

...

Keyword(s):

Tropical Climate ◽

Gastrointestinal Parasites ◽

Santa Inês ◽

Genomic Regions

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Relative expression analysis ofIL-5andIL-6genes in tropical sheep breed Pelibuey infected withHaemonchus contortus

Parasite Immunology ◽

10.1111/pim.12211 ◽

2015 ◽

Vol 37 (9) ◽

pp. 446-452 ◽

Cited By ~ 3

Author(s):

Z. M. Estrada-Reyes ◽

A. G. López-Reyes ◽

A. Lagunas-Martínez ◽

G. Ramírez- Vargas ◽

S. Olazarán-Jenkins ◽

...

Keyword(s):

Expression Analysis ◽

Sheep Breed ◽

Relative Expression ◽

Tropical Sheep

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Analysis of selection signatures reveals important insights into the adaptability of high-altitude Indian sheep breed Changthangi

10.1101/2020.12.05.412916 ◽

2020 ◽

Author(s):

Sheikh Firdous Ahmad ◽

Arnav Mehrotra ◽

Sona Charles ◽

Nazir Ahmad Ganai

Keyword(s):

High Altitude ◽

Sheep Breed ◽

Selection Signatures ◽

Sheep Breeds ◽

Functional Regions ◽

Population Comparisons ◽

Genetic Mechanisms ◽

Altitude Adaptation ◽

Genomic Regions ◽

Indian Sheep

AbstractChangthangi is a high-altitude sheep breed of India that is adapted to cold and hypoxic climate of Himalayas. In the present study, we analysed population structure of Changthangi and contrasted it with selected Indian and European commercial sheep breeds to detect genomic regions under positive selection. The studied domesticated sheep breeds included Changthangi, Indian Garole, Deccani, Tibetan, Rambouillet and Australian Merino. While the PCA results revealed Changthangi clustered with Tibetan sheep; TREEMIX and ADMIXTURE results also detected the introgression of lowland Indian sheep inheritance in Changthangi. Cross-population comparisons of Changthangi using XP-EHH showed multiple functional regions present on OAR 7, 15 and 16, to be under selection in Changthangi sheep. These regions are related to adaptation to climatic and hypoxic stressors, nervous system and mitochondrial functioning. The genes present in these regions are suitable candidates for future studies on the genetic mechanisms underlying high-altitude adaptation.

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Genome-Wide SNP Analysis for Milk Performance Traits in Indigenous Sheep: A Case Study in the Egyptian Barki Sheep

Animals ◽

10.3390/ani11061671 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1671

Author(s):

Ibrahim Abousoliman ◽

Henry Reyer ◽

Michael Oster ◽

Eduard Murani ◽

Ismail Mohamed ◽

...

Keyword(s):

Candidate Genes ◽

Milk Yield ◽

Milk Composition ◽

Sheep Breed ◽

Snp Analysis ◽

Quality Traits ◽

Genome Wide ◽

Performance Traits ◽

Milk Performance ◽

Genomic Regions

Sheep milk yield and milk composition traits play an important role in supplying newborn lambs with essential components such as amino acids, energy, vitamins and immune antibodies and are also of interest in terms of the nutritional value of the milk for human consumption. The aim of this study was to identify genomic regions and candidate genes for milk yield and milk composition traits through genome-wide SNP analyses between high and low performing ewes of the Egyptian Barki sheep breed, which is well adapted to the harsh conditions of North-East Africa. Therefore, out of a herd of 111 ewes of the Egyptian Barki sheep breed (IBD = 0.08), ewes representing extremes in milk yield and milk quality traits (n = 25 for each group of animals) were genotyped using the Illumina OvineSNP50 V2 BeadChip. The fixation index (FST) for each SNP was calculated between the diversified groups. FST values were Z-transformed and used to identify putative SNPs for further analysis (Z(FST) > 10). Genome-wide SNP analysis revealed genomic regions covering promising candidate genes related to milk performance traits such as SLC5A8, NUB1, TBC1D1, KLF3 and ABHD5 for milk yield and PPARA and FBLN1 genes for milk quality trait. The results of this study may contribute to the genetic improvement of milk performance traits in Barki sheep breed and to the general understanding of the genetic contribution to variability in milk yield and quality traits.

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CHARACTERISTICS OF ALLELE POOL OF THE ROMANOV SHEEP BREED FOR THE PRION PROTEIN GENE ASSOCIATED WITH GENETIC SUSTAINABILITY TO SCRAPIE

Sel skokhozyaistvennaya Biologiya ◽

10.15389/agrobiology.2017.6.1157eng ◽

2017 ◽

Vol 52 (6) ◽

pp. 1157-1165

Author(s):

E.A. Gladyr ◽

◽

T.E. Deniskova ◽

V.A. Bagirov ◽

O.V. Kostyunina ◽

...

Keyword(s):

Prion Protein ◽

Protein Gene ◽

Sheep Breed ◽

Prion Protein Gene ◽

Allele Pool

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Faculty Opinions recommendation of Classification of human genomic regions based on experimentally determined binding sites of more than 100 transcription-related factors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718061745.793481765 ◽

2013 ◽

Author(s):

Hans Lehrach

Keyword(s):

Binding Sites ◽

Related Factors ◽

Human Genomic ◽

Genomic Regions

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Genetic Effects of Key Genomic Regions Controlling Yield-Related Traits in Wheat Founder Parent Fan 6

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1006.2018.00706 ◽

2018 ◽

Vol 44 (5) ◽

pp. 706

Author(s):

Mei DENG ◽

Yuan-Jiang HE ◽

Lu-Lu GOU ◽

Fang-Jie YAO ◽

Jian LI ◽

...

Keyword(s):

Genetic Effects ◽

Genomic Regions ◽

Founder Parent

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Identification of genomic islands in Synechococcus sp. WH8102 using genomic barcode and whole-genome microarray analyses

Current Bioinformatics ◽

10.2174/1574893615666200121160615 ◽

2020 ◽

Vol 15 ◽

Author(s):

Jiahui Pan ◽

Xizi Luo ◽

Tong Shao ◽

Chaoying Li ◽

Tingting Zhao ◽

...

Keyword(s):

Genomic Islands ◽

Whole Genome ◽

Photosynthetic Organisms ◽

Depth Study ◽

Whole Genome Microarray ◽

Integrated Methods ◽

Synechococcus Sp ◽

Intuitive View ◽

Genomic Regions ◽

Different Origins

Background: Synechococcus sp. WH8102 is one of the most abundant photosynthetic organisms in many ocean regions. Objective: The aim of this study is to identify genomic islands (GIs) in Synechococcus sp. WH8102 with integrated methods. Methods: We have applied genomic barcode to identify the GIs in Synechococcus sp. WH8102, which could make genomic regions of different origins visually apparent. The gene expression data of the predicted GIs was analyzed through microarray data which was collected for functional analysis of the relevant genes. Results: Seven GIs were identified in Synechococcus sp. WH8102. Most of them are involved in cell surface modification, photosynthesis and drug resistance. In addition, our analysis also revealed the functions of these GIs, which could be used for in-depth study on the evolution of this strain. Conclusion: Genomic barcodes provide us with a comprehensive and intuitive view of the target genome. We can use it to understand the intrinsic characteristics of the whole genome and identify GIs or other similar elements.

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