Evaluation of the impacts of some antihypertensive drugs on hydrodynamics in patients with primary open-angle glaucoma

2020 ◽  
pp. 49-50
Author(s):  
K.K. Abulkasimova ◽  
◽  
M.K. Karimova ◽  
M.A. Zakirhodjayeva ◽  
◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Antihypertensive Drugs ◽  
Open Angle Glaucoma ◽  
Open Angle

Актуальность. Одним из главных патогенетических звеньев, определяющих характер течения глаукомы, является нарушение гидродинамики глаза. Цель. Сравнительная оценка влияния гипотензивных препаратов на гидродинамику глаза у больных с первичной открытоугольной глаукомой с нестабилизированным уровнем внутриглазного давления (ВГД). Материал и методы. На базе РСНПМЦМГ нами обследованы 60 больных (106 глаз) с ПОУГ I, II и III стадии с нестабилизированным уровнем ВГД и были разделены на 2 группы: 1-группа – 30 больных (52 глаза), которым в качестве гипотензивного средства применялся препарат Офтан-Тимолол 0,5% («Santen») 2 раза в сутки, 30 больным (54 глаза) 2-группы был назначен новый гипотензивный препарат Прессимол («Aseptica») 0,5% 2 раза в день. Динамическое и контрольное исследование гидродинамики глаза проводили до лечения, через 10 дней и через 1 месяц в процессе лечения по методу упрощенной тонографии по А.П. Нестерову. Результаты. В обеих группах отмечалось достоверное снижение коэффициента Беккера (КБ) в среднем в 1,9 раза по сравнению с исходным (р<0,05), а P0 снизилось в среднем на 1,4–1,7 мм.рт. ст. Среднее значение коэффициента легкости оттока достигло 0,49 мм3/мин. Однако, продукция водянистой влаги менялась в значительной степени, на 16-19% от исходного уровня. Выводы. Указанные препараты в обеих исследуемых группах достоверно нормализовали показатели гидродинамики глаз больных глаукомой за счет снижения выработки водянистой влаги.

Problems of treatment of primary openangle glaucoma in combination with thrombosis of the central retinal vein

GlaucomaNews ◽  
2020 ◽  
pp. 65-69
Author(s):  
T.E. Lipatkina ◽  
◽  
Е.V. Karlova ◽  
A.V. Zolotarev ◽  
◽  
...  
Keyword(s):  
Macular Edema ◽  
Primary Open Angle Glaucoma ◽  
Antihypertensive Drugs ◽  
Open Angle Glaucoma ◽  
Vascular Wall ◽  
Open Angle ◽  
Retinal Edema ◽  
Long Term Preservation ◽  
Central Retinal Vein

Patients with primary open-angle glaucoma (POAG) and ophthalmic hypertension have an increased likelihood of developing occlusions (thrombosis) of the central retinal vein. Different groups of antihypertensive drugs differ in their mechanism of action and may affect concomitant ocular pathology, in particular, retinal edema, which occurs, for example, in occlusion of the central retinal vein. Used in most patients with glaucoma, prostaglandin analogs can contribute to the long-term preservation of macular edema due to the effect on the permeability of the vascular wall. Preparations of other pharmacological groups, reducing the production of aqueous humor, on the contrary, may contribute to its regression. Therefore, the question of choosing a drug for antihypertensive therapy in patients with primary open-angle glaucoma and concomitant macular edema is relevant and is for further study.

Effects of the time of antihypertensive drugs administration on the stage of primary open-angle glaucoma in patients with arterial hypertension

2012 ◽  
Vol 21 (4) ◽  
pp. 240-248 ◽  
Author(s):  
Beata Krasińska ◽  
Małgorzata Karolczak-Kulesza ◽  
Zbigniew Krasiński ◽  
Katarzyna Pawlaczyk-Gabriel ◽  
Paweł łopatka ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Antihypertensive Drugs ◽  
Open Angle Glaucoma ◽  
Open Angle

The incidence of dry eye syndrome depending on the duration of antihypertensive drops use in patients with primary open-angle glaucoma

Reflection ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 56-61
Author(s):  
A.D. Pilipenko ◽  
◽  
R.A. Burya ◽  
A.V. Romanova ◽  
◽  
...  
Keyword(s):  
Antihypertensive Therapy ◽  
Dry Eye ◽  
Ocular Surface ◽  
Primary Open Angle Glaucoma ◽  
Antihypertensive Drugs ◽  
Open Angle Glaucoma ◽  
Dry Eye Syndrome ◽  
Open Angle ◽  
Inclusion Criteria ◽  
Systemic Pathology

Aim. To conduct a clinical assessment of the incidence of dry eye syndrome (DES) in patients with primary open-angle glaucoma (POAG), depending on the timing of the use of local antihypertensive therapy. Methods. The main group included 45 patients (45 eyes) with POAG. Inclusion criteria - use of local antihypertensive therapy for at least one month; absence of previous laser and microsurgery operations, systemic pathology that can cause DES (thyroid lesions, diabetes mellitus, autoimmune and rheumatoid diseases). The patients’ age averaged 61.2±8.7 years (from 47 to 82 years). There were 29 men and 16 women. The design of the work consisted of a comparative assessment of the frequency of DES formation in the studied groups and subgroups, as well as the degree of its severity. Results. The results of the study showed that with an increase in the duration of the use of local antihypertensive drugs by patients with POAG the incidence of DES development increases. Moderate changes in the studied functional parameters of the ocular surface were recorded as early as 1-3 years from the start of antihypertensive therapy. Especially often DES was formed in the 3rd subgroup and proceeded in more severe clinical forms. Conclusion. The initial statistically insignificant changes in the indicators of the state of the ocular surface in patients with POAG using local antihypertensive therapy took place at the time of their instillation from 1 to 3 years. Most often, according to our data, DES developed in patients with POAG after three years of using antihypertensive drugs (9 out of 15 patients). Key words: dry eye syndrome; glaucoma; antihypertensive therapy.

Effectiveness of combined glaucoma and cataract surgery with the use of a modified anti-glaucoma surgery

2021 ◽  
pp. 41-44
Author(s):  
O.I. Orenburkina ◽  
◽  
A.E. Babushkin ◽  
G.Z. Israfilova ◽  
◽  
...  
Keyword(s):  
Visual Acuity ◽  
Primary Open Angle Glaucoma ◽  
Antihypertensive Drugs ◽  
Open Angle Glaucoma ◽  
Glaucoma Surgery ◽  
Functional Results ◽  
Open Angle ◽  
Combined Operation ◽  
Combined Intervention

Purpose. To evaluate the clinical and functional results of a combined intervention – simultaneous cataract phacoemulsification (femtolaser assisted in some cases) and a developed partially fistulizing anti-glaucoma surgery in patients with primary open-angle glaucoma (POAG). Material and methods. 15 patients (45 eyes) aged 65-73 years with stage I-III POAG. The frequency of complications, dynamics of visual acuity's visual functions, and ophthalmotonus were analyzed before, during, and 6 months after surgery. Results. By the end of observation, the level of normalized IOP was defined in all patients, while in 78.6% of cases without drug correction and in 21.4% with the help of antihypertensive drugs (on average, 1.1±0.5). At the day of discharge from the hospital visual acuity after a simultaneous combined operation averaged 0.53±0.05, in the long term-0.77±0.06, while stabilization of glaucoma optical neuropathy after surgery occurred in 92.9%. Conclusion. A simultaneous combined intervention, including cataract phacoemulsification with a developed partially fistulizing anti-glaucoma operation, is an effective way to increase visual acuity, normalize ophthalmotonus and stabilize glaucoma optical neuropathy as well as reduce the drug load. Key words: cataract, glaucoma, surgical treatment, phacoemulsification, anti-glaucoma surgeries.

scholarly journals To the question of the advantages of using a preservative-free form of F2 alpha prostaglandins in patients with primary open-angle glaucoma

2021 ◽  
Vol 8 (3) ◽  
pp. 13-18
Author(s):  
P.A. Bezdetko ◽  
N.V. Bezdetko ◽  
E.P. Muzhichuk
Keyword(s):  
Ocular Surface ◽  
Primary Open Angle Glaucoma ◽  
Antihypertensive Drugs ◽  
Open Angle Glaucoma ◽  
Pressure Control ◽  
Free Form ◽  
Open Angle ◽  
Ocular Surface Disease Index ◽  
Drug Free ◽  
Preservative Free

There are at least 4 reasons for choosing synthetic prostaglandins as the first-line drugs in glaucoma patients: efficacy, stable 24-hour intraocular pressure control, safety and compliance. Such qualities of these antihypertensive drugs are attracting the attention of ophthalmologists around the world. The use of synthetic prostaglandins is also associated with side effects such as eye irritation. One of the ways to solve this problem is to create a preservative-free form of the drug, free of benzalkonium chloride, including latanoprost. Our 10-week studies have convincingly shown that the use of a preservative-free form of latanoprost (monoprost) allows you to be gentle to the ocular surface, to improve the tolerance of the drug by almost 26.7–37.0 % on the Ocular Surface Disease Index. The use of a preservative-free form of latanoprost (monoprost) in patients with primary open-angle glaucoma increases the hypotensive efficacy of the drug by 9.4–15.4 % in comparison with classical latanoprost.

scholarly journals Eye Hydrodynamics after Combined Treatment of Primary Open-Angle Glaucoma and Complicated Cataract

2019 ◽  
Vol 4 (4) ◽  
pp. 129-133
Author(s):  
T. V. Sokolovskaya ◽  
P. L. Volodin ◽  
V. N. Yashina ◽  
V. V. Teplovodskaya
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Antihypertensive Drugs ◽  
Open Angle Glaucoma ◽  
Combined Treatment ◽  
Control Group ◽  
Study Group ◽  
Minimal Risk ◽  
Open Angle ◽  
Complicated Cataract

Aim: To study hydrodynamics of the eye after combined treatment – a combination of laser activation of trabecula and cataract phacoemulsification – in a comparative aspect.Material and methods. The study included 65 patients (65 eyes) with initial and advanced stages (I–II stages) of primary open-angle glaucoma (POAG) and complicated cataract. Among the patients there were 38 women (58.5 %) and 27 men (41.5 %), the average age was 68.8 ± 8.2 years. The follow-up period is 12 months after the treatment. The patients were divided into two groups: the main one – 33 patients (33 eyes) who underwent combined treatment – YAG-laser activation of trabecula (YAG-LAT) and phacoemulsification of cataract with intraocular lens (IOL) implantation, the control group – 32 patients (32 eyes) who underwent only phacoemulsification.Initially, the average intraocular pressure (IOP) (P0) in the main and control groups was 20.72 ± 3.39 mm Hg and 21.02 ± 3.55 mm Hg respectively. The average number of antihypertensive drugs used in the study group was 1.53 ± 0.64, in the control group – 1.34 ± 0.55.Results. There were no intraand postoperative complications. By the end of the follow-up period, a significant decrease in the average IOP level compared to its preoperative value by 29.2 % was determined in the main group, and 9.8 % in the control. The average number of antihypertensive drugs used in the study group decreased from 1.53 ± 0.64 to 0.67 ± 0.59 (p < 0.05), in the control group of patients, on the contrary, the average number of antihypertensive agents increased from 1.34 ± 0.55 to 1.91 ± 0.70 (p < 0.05).Conclusion. In the long-term postoperative period after combined treatment (YAG-LAT + phaco), IOP normalization was achieved in 96.9 % of cases, as well as a significant increase in visual acuity of patients. The developed method of treatment is safe, has a minimal risk of complications and can be used for the treatment of patients with initial stages of POAG in combination with complicated cataracts with increased IOP level, inefficiency of antihypertensive therapy.

Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

2020 ◽  
pp. 97-105
Author(s):  
E. N. Simakova ◽  
O. V. Stenkova
Keyword(s):  
Intraocular Pressure ◽  
Drug Therapy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Open Angle ◽  
Complex Treatment ◽  
Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

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