Correlation of the M235T polymorphism of the AGT gene with arterial hypertension and its risk factors in the indigenous people of the arctic territory of Yakutia

2019 ◽  
pp. 16-19
Author(s):  
S.I. Sofronova ◽  
A.N. Romanova ◽  
M.P. Kirillina
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Indigenous People ◽  
The Arctic ◽  
Agt Gene ◽  
M235t Polymorphism

scholarly journals Association of the AGT Gene M235T (rs699) Polymorphism with Arterial Hypertension and Metabolic Risk Factors in the Indigenous People of Yakutia

2019 ◽  
Vol 9 (4) ◽  
pp. 287-291
Author(s):  
Sargylana Sofronova ◽  
Maria Kirillina ◽  
Irina Kononova ◽  
Anna Romanova ◽  
Vyacheslav Nikolaev ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Indigenous People ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Agt Gene

scholarly journals High blood pressure levels and cardiovascular risk among Munduruku indigenous people

2021 ◽  
Vol 29 ◽  
Author(s):  
Neuliane Melo Sombra ◽  
Hanna Lorena Moraes Gomes ◽  
António Manuel Sousa ◽  
Gilsirene Scantelbury de Almeida ◽  
Zilmar Augusto de Souza Filho ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Waist Circumference ◽  
Arterial Hypertension ◽  
Indigenous People ◽  
P Value ◽  
Continuous Variables ◽  
Cross Sectional ◽  
Significance Level

Objective: to identify the risk factors associated with prehypertension and arterial hypertension among Munduruku indigenous people in the Brazilian Amazon. Method: a cross-sectional study carried out with 459 Munduruku indigenous people selected by means of stratified random sampling. Sociodemographic variables, habits and lifestyles, anthropometric data, fasting glucose and lipid profiles were evaluated. An automatic device calibrated and validated to measure blood pressure was used. The analyses of the data collected were carried out in the R software, version 3.5.1. For continuous variables, the Kruskall-Wallis test was used; for the categorical ones, Fischer’s Exact. The significance level was set at 5% and p-value≤0.05. Results: the prevalence of altered blood pressure levels was 10.2% for values suggestive of hypertension and 4.1% for pre-hypertension. The risk of prehypertension among indigenous people was associated with being male (OR=1.65; 95% CI=0.65-4.21) and having a substantially increased waist circumference (OR=7.82; 95% CI=1.80-34.04). Regarding the risk for arterial hypertension, it was associated with age (OR=1.09; 95% CI=1.06-1.12), with increased waist circumference (OR=3.89; 95% CI=1.43-10, 54) and with substantially increased waist circumference (OR=5.46; 95% CI=1.78-16.75). Conclusion: among Munduruku indigenous people, men were more vulnerable to developing hypertension; age and increased waist circumference proved to be strong cardiovascular risk factors.

scholarly journals Ethnicity as a model for the development of cardiovascular diseases and their risk factors in epidemiological studies

2021 ◽  
Vol 102 (5) ◽  
pp. 736-746
Author(s):  
T A Mulerova ◽  
M Yu Ogarkov ◽  
D P Tsygankova ◽  
Yu V Kazachek ◽  
O M Polikutina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Indigenous People ◽  
Organ Damage ◽  
Epidemiological Studies ◽  
Left Ventricular ◽  
Lipid Metabolism Disorders ◽  
Second Period

Aim. To assess the indigenous small population of the Shor people in terms of the ethnic-specific development of cardiovascular diseases and their risk factors during the epidemiological studies in the Mountain Shoria. Methods. The study was carried included the indigenous and non-indigenous population of the Mountain Shoria during two different time periods: the first period (19982002) 1215 people (550 indigenous Shors and 665 non-indigenous people) and the second period (20132017) 1409 people (901 and 508, respectively). The prevalence of cardiovascular risk factors, arterial hypertension (AH) and ischemic heart disease (CHD) was studied. In the second period of the study, the genotype frequencies of the genes ACE (I/D, r 4340), AGT (c.803TC, rs699), AGTR1 (A1166C, rs5186), ADRB1 (c.145AG, Ser49Gly, rs1801252), ADRA2B (I/D, rs28365031), MTHFR (c.677CT, Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a) and their associations with arterial hypertension were identified. There was data on organ damage obtained among patients with high blood pressure (left ventricular myocardial hypertrophia, carotid arteries intima-media complex thickening, albumin level). Results. The first period of the studies showed that the Shors differed from the incoming population in an extremely low prevalence of lipid metabolism disorders, obesity, and an almost complete absence of diabetes mellitus. At the same time, there was a high prevalence of tobacco smoking and alcohol consumption. The second period of the studies demonstrated significant differences between different ethnic cohorts according to the genetic passport towards a more favorable profile among the indigenous people. However, the Shor people with arterial hypertension had a more severe course of hypertensive disease, defined as frequent organ damage. In addition, the profile of a patient with coronary heart disease differed depending on the place of residence, in urban or rural. Epidemiological studies contribute to the acquisition of new knowledge about different ethnic groups, their lifestyles and agricultural practices, regions of residence, and the features of candidate gene polymorphism. This provides valuable material for individualizing the prevention and treatment of diseases. Conclusion. Ethnicity makes adjustments to the patient's profile; understanding the ethnic specificity allows developing targeted preventive measures, thereby preserving the peoples health.

Risk factors and subclinical carotid atherosclerosis in rotating scheme conditions in the Arctic

2019 ◽  
Vol 18 (4) ◽  
pp. 86-91
Author(s):  
N. P. Shurkevich ◽  
A. S. Vetoshkin ◽  
L. I. Gapon ◽  
A. A. Simonyan
Keyword(s):  
Risk Factors ◽  
Carotid Atherosclerosis ◽  
The Arctic

Assessment of risk factors for multifocal atherosclerosis in the workers of the main professions of coal enterprises in the South of Kuzbass

2020 ◽  
pp. 157-161
Author(s):  
E. S. Filimonov ◽  
O. Yu. Korotenko ◽  
O. A. Rumpel ◽  
O. N. Blazhina
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Glycated Hemoglobin ◽  
Significant Risk ◽  
Coal Industry ◽  
Atherosclerotic Plaques ◽  
The South ◽  
Coal Miners ◽  
Coal Enterprises

Introduction. The problem of high mortality from cardiovascular diseases is caused, among other things, by asymptomatic atherosclerosis, which proceeds latently for a long time and manifests itself as a serious vascular catastrophe, which is of particular importance for people working at production facilities with difficult and dangerous working conditions.The aim of the study was to assess the risk factors for atherosclerosis and the state of the vascular wall in the workers of the main professions of coal enterprises in the South of Kuzbass.Material and methods. In total, the study included 384 people (men), of whom 266 were the workers in coal mines in the South of Kuzbass and 118 people who were not employed in the coal industry, aged 40 to 55 years. The diagnosis of atherosclerosis was carried out on the ultrasound system “Vivid E9” of the manufacturing company GE using a linear sensor for measuring the thickness of the intima-media complex and visualization of atherosclerotic plaques. To identify significant risk factors, anthropometric, anamnestic data, indices of lipid and carbohydrate metabolism, and the presence of arterial hypertension were studied.Results. Significant differences in the frequency of asymptomatic atherosclerosis in the form of an increase in intima-media thickness by more than 1 mm and / or the presence of atherosclerotic plaques in both groups were not found: 60.2% among the miners and 62.3% among non-coal mining workers (p=0.703); at the same time, the percentage of detection of atherosclerotic plaques in arteries was significantly lower among coal workers — 46.9% versus 60.5% among people in the comparison group (p=0.016). The common risk factors for all examined subjects were arterial hypertension and increased level of glycated hemoglobin; in turn, in coal miners additional risk factors were increased values of low density lipoproteins and waist-hip index, as well as burdened heredity for cardiovascular diseases, and among the individuals not employed in the coal industry it was smoking.Conclusions. The most significant risk factors for atherosclerosis in coal industry workers were arterial hypertension, raised values of glycated hemoglobin, low density lipoproteins and waist-hip index, as well as burdened heredity for cardiovascular diseases. Significant differences in the frequency of asymptomatic atherosclerosis in the form of an increase in the thickness of the intima-media complex of the main arteries and the presence of atherosclerotic plaques in both groups were not established, but the percentage of the detection of atherosclerotic plaques was lower among coal miners.The authors declare no conflict of interests.

Clinical case of a comorbid patient with arterial hypertension

2020 ◽  
pp. 31-39
Author(s):  
Ella Polozova ◽  
Vsevolod Skvortsov ◽  
Olga Radaykina ◽  
Mariya Narvatkina ◽  
Anastasiya Seskina ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Arterial Hypertension ◽  
Clinical Picture ◽  
Clinical Case ◽  
Diagnosis And Treatment ◽  
The Moment

The widespread prevalence of comorbid pathology determines the relevance of this problem. Comorbid pathology due to the interaction of diseases, drug pathomorphism, age characteristics of the patient, significantly changes clinical picture and course of the main nosology, affects severity of complications and their nature, significantly affects quality of life and prognosis of patients. Diagnosis and treatment of many diseases is complicated in the conditions of comorbidity. The article presents a clinical case of a comorbid patient with arterial hypertension from the moment of exposure to risk factors and ending with the formation of many concomitant diseases, as an example of trans-nosological comorbidity.

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