Human papillomavirus 16 is an independent predictor of better survival among patients with early cervical cancer

2016 ◽  
Author(s):  
Maria Luiza Genta
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Independent Predictor ◽  
Human Papillomavirus 16 ◽  
Early Cervical Cancer

scholarly journals Prognostic significance of serum antibodies to human papillomavirus-16 E4 and E7 peptides in cervical cancer

Cancer ◽  
1994 ◽  
Vol 74 (8) ◽  
pp. 2307-2313 ◽  
Author(s):  
Katja N. Gaarenstroom ◽  
Gemma G. Kenter ◽  
J. Baptist Trimbos ◽  
Johannes M. G. Bonfrer ◽  
Catharina M. Korse ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Prognostic Significance ◽  
Serum Antibodies ◽  
Human Papillomavirus 16

Cervical cancer: monitoring of the main indicators characterizing this pathology in Khabarovsk Krai (2009–2019)

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (2) ◽  
pp. 155-160
Author(s):  
Tatyana Yu. Pestrikova ◽  
Ainur F. Ismaylova ◽  
Sergey N. Kiselev
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Graphical Analysis ◽  
Reproductive Age ◽  
Annual Growth Rate ◽  
Khabarovsk Krai ◽  
Female Population ◽  
Human Papillomavirus 16 ◽  
Cervical Cancer Mortality ◽  
Advanced Stages

Aim. Conduct a comparative assessment of the main indicators of the incidence of cervical cancer in Khabarovsk Krai (20092019) аnd the prevalence of types of human papillomavirus among the female population. Materials and methods. A comparative analysis of the data of the official statistics of the Ministry of Health of Khabarovsk Krai, using the Rosstat database for the period 20092019, taking into account the incidence, mortality, prevalence of types of human papillomavirus, was carried out. The dynamics trend was determined in the process of graphical analysis of the diagram and by modeling trends. The results of the studies were subjected to the methods of statistical information processing. Results. The results revealed in our study indicate that the increase in the incidence of cervical cancer in Khabarovsk Krai from 2009 to 2019 was 44.4% (with an average annual growth rate of 4.5%). Most often, cervical cancer in Khabarovsk Krai is detected in urban residents. The share of urban women with this pathology in 2019 reached 77.2%. The proportion of stage III cancer detected exceeds the proportion of stage IIIIV cancer by 2.5 times. Mortality in patients with cervical cancer in Khabarovsk Krai exceeds that in the Russian Federation. Of the 1617 residents of the city of Khabarovsk of reproductive age, 883 (54%) women had the presence of human papillomavirus. For our region, most often, women had highly oncogenic types of human papillomavirus 16, 56, 51. Conclusion. Statistical analysis based on the results of diagnosing early and advanced stages of cervical cancer, mortality from this nosological form, and the spread of the human papillomavirus remain among the most important criteria. The data obtained make it possible to assess the effectiveness of the chosen tactics in the regions and take timely corrective measures aimed at both early detection of cervical cancer and a decrease in the persistence of the human papillomavirus in women with background cervical pathology.

Long noncoding RNA SNHG12 modulated by human papillomavirus 16 E6/E7 promotes cervical cancer progression via ERK/Slug pathway

2020 ◽  
Vol 235 (11) ◽  
pp. 7911-7922 ◽  
Author(s):  
Shu‐Yu Lai ◽  
Hong‐Mei Guan ◽  
Jie Liu ◽  
Li‐Jun Huang ◽  
Xiao‐Lin Hu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Human Papillomavirus 16

Pre-immature dendritic cells pulsed with human papillomavirus 16 E7 peptide vaccine in advanced cervical cancer

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 2522-2522 ◽  
Author(s):  
M. S. Achtar ◽  
R. Ibrahim ◽  
V. E. Herrin ◽  
B. Gause ◽  
S. Steinberg ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dendritic Cells ◽  
Human Papillomavirus ◽  
Peptide Vaccine ◽  
Advanced Cervical Cancer ◽  
Human Papillomavirus 16 ◽  
Immature Dendritic Cells

scholarly journals Analysis of mutations in the E6/E7 oncogenes and L1 gene of human papillomavirus 16 cervical cancer isolates from China

2006 ◽  
Vol 87 (5) ◽  
pp. 1181-1188 ◽  
Author(s):  
Yuping Wu ◽  
Yulong Chen ◽  
Longyu Li ◽  
Guifang Yu ◽  
Ying He ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Patients ◽  
Hpv Infection ◽  
Typing Method ◽  
Hpv16 E6 ◽  
Human Papillomavirus 16 ◽  
Human Papillomavirus Type 16 ◽  
New Variant

Human papillomavirus type 16 (HPV16) has a number of intratypic variants; each has a different geographical distribution and some are associated with enhanced oncogenic potential. Cervical samples were collected from 223 cervical cancer patients and from 196 age-matched control subjects in China. DNA samples were amplified by using primers specific for the E6, E7 and partial L1 regions. Products were sequenced and analysed. It was found by using a PCR–sequence-based typing method that HPV infection rates in China were 92·8 % in cervical cancer patients and 15·8 % in healthy controls. HPV16 was detected in 70·4 % of cervical cancer patients and in 6·1 % of controls. In HPV16-positive cervical cancers, 23·6 % belonged to the prototype, 65·5 % were of the Asian variant, 5·5 % were of African type 1 and 3·6 % were European variants, whilst only one was a new variant that differed from any variant published so far. Prevalences of HPV16 E6 D25E and E113D variants were 67·3 and 9 %, respectively. In addition to D25E and E113D, the following E6 variations were found in this study: R129K, E89Q, S138C, H78Y, L83V and F69L. The results also showed that the prevalences of three hot spots of E7 nucleotide variation, N29S, S63F and a silent variation, nt T846C, were 70·2 % (33/47), 51·1 % (24/47) and 61·7 % (29/47), respectively. The following L1 variations were found in this study: S377A, K387E, E378D, K382E and T379P. It was also found that the average age of Asian variant-positive cervical cancer patients (42·98±10·43 years) was 7·56 years lower than that of prototype-positive patients (50·54±10·91). It is suggested that the high frequency of HPV16 Asian variants might contribute to the high incidence of cervical cancer in China.

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