ROLE OF HUMAN LEUKOCYTE ANTIGEN (HLA) ON IMMUNOGLOBULIN A DEFICIENCY (IGAD) PATHOGENESIS: MULTICASE FAMILIES STUDY AND HIGH RESOLUTION SNP INVESTIGATION IN IGAD PATIENTS

2016 ◽  
Author(s):  
Che Kang Lim
Keyword(s):  
High Resolution ◽  
Human Leukocyte Antigen ◽  
Immunoglobulin A ◽  
Human Leukocyte ◽  
Leukocyte Antigen

Low-Risk Human Leukocyte Antigen Genes and Mild Villous Atrophy Typify Celiac Disease with Immunoglobulin A Deficiency

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Enrico Schirru ◽  
Rita Désirée Jores ◽  
Rossano Rossino ◽  
Mara Corpino ◽  
Francesco Cucca ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Human Leukocyte Antigen ◽  
Villous Atrophy ◽  
Immunoglobulin A ◽  
Human Leukocyte ◽  
Low Risk ◽  
Leukocyte Antigen

scholarly journals Multiple sclerosis and human leukocyte antigen genotypes: Focus on the Middle East and North Africa region

2020 ◽  
Vol 6 (1) ◽  
pp. 205521731988177
Author(s):  
Zhila Maghbooli ◽  
Mohammad Ali Sahraian ◽  
Abdorreza Naser Moghadasi
Keyword(s):  
Multiple Sclerosis ◽  
Middle East ◽  
Human Leukocyte Antigen ◽  
North Africa ◽  
Human Leukocyte ◽  
Genetic Studies ◽  
Leukocyte Antigen ◽  
Genetic Components ◽  
Control Designs

Recent reports have demonstrated that the prevalence of multiple sclerosis (MS) is increasing in the Middle East and North Africa region. There is also emerging evidence regarding the genetic components of MS risk. This review provides an overview of the role of genetic factors in MS susceptibility by examining human leukocyte antigen loci in patients within the Middle East and North Africa region. Most of the genetic studies conducted in the Middle East and North Africa region have been based on case–control designs, which cannot confirm direct causality of genetic variants on MS susceptibility. Moreover, there are very limited and inconsistent studies on human leukocyte antigen class I and II (DQA and DQB) in MS patients of the Middle East and North Africa region. To identify common risk haplotypes in the Middle East and North Africa region or its sub-populations, further longitudinal studies will be required.

scholarly journals Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of “Humanized” Multiple Sclerosis-like Disease

2015 ◽  
Vol 290 (24) ◽  
pp. 15260-15278 ◽  
Author(s):  
Nathali Kaushansky ◽  
Miriam Eisenstein ◽  
Sigalit Boura-Halfon ◽  
Bjarke Endel Hansen ◽  
Claus Henrik Nielsen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen

scholarly journals The Many Faces of Human Leukocyte Antigen-G: Relevance to the Fate of Pregnancy

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Mette Dahl ◽  
Snezana Djurisic ◽  
Thomas Vauvert F. Hviid
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Future Research ◽  
Placental Development ◽  
Leukocyte Antigen ◽  
Polymorphic Genes ◽  
Membrane Bound ◽  
The Many ◽  
Human Leukocyte Antigen G

Pregnancy is an immunological paradox, where fetal antigens encoded by polymorphic genes inherited from the father do not provoke a maternal immune response. The fetus is not rejected as it would be theorized according to principles of tissue transplantation. A major contribution to fetal tolerance is the human leukocyte antigen (HLA)-G, a nonclassical HLA protein displaying limited polymorphism, restricted tissue distribution, and a unique alternative splice pattern. HLA-G is primarily expressed in placenta and plays multifaceted roles during pregnancy, both as a soluble and a membrane-bound molecule. Its immunomodulatory functions involve interactions with different immune cells and possibly regulation of cell migration during placental development. Recent findings include HLA-G contributions from the father and the fetus itself. Much effort has been put into clarifying the role of HLA-G during pregnancy and pregnancy complications, such as preeclampsia, recurrent spontaneous abortions, and subfertility or infertility. This review aims to clarify the multifunctional role of HLA-G in pregnancy-related disorders by focusing on genetic variation, differences in mRNA stability betweenHLA-Galleles, differences in HLA-G isoform expression, and possible differences in functional activity. Furthermore, we highlight important observations regardingHLA-Ggenetics and expression in preeclampsia that future research should address.

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