EMERGING SEROTYPE 10A (S-10A) STREPTOCOCCUS PNEUMONIAE (SPN) INVASIVE INFECTIONS IN COSTA RICA (CR) CHILDREN

2016 ◽  
Author(s):  
Gloriana Malavassi-Viales
Keyword(s):  
Streptococcus Pneumoniae ◽  
Costa Rica ◽  
Invasive Infections

scholarly journals Serotype Distribution of Streptococcus pneumoniae Carriage ‎in Six-Month-Old Infants: A Cross-sectional Study During 2017-18, Tehran, ‎Iran

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Shirin Sayyahfar ◽  
Abdoulreza Esteghamati ◽  
Seyed Alireza Fahimzad ◽  
Safura Hajisadeghi Isfahani ◽  
Ali Nazari Alam ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Multiplex Pcr ◽  
Positive Culture ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Serotype Distribution ◽  
Cross Sectional ◽  
Non Invasive ◽  
Healthy Infants ◽  
Invasive Infections

Background: Streptococcus pneumoniae is recognized as one of the main pathogens inducing several invasive and non-invasive infections in children. Objective: The present study aimed to evaluate the serotype distribution of S. pneumoniae in six–month–old carriers. Methods: This study encompassed 600 six-month-old healthy infants whose pharyngeal swap samples were collected and then cultured to isolate S. pneumoniae. Twenty- five different serotypes were defined on positive culture samples by multiplex PCR. Results: In this study, 13 cases (2.2%) were positive S. pneumonia. The most common isolated serotypes of S. pneumoniae were serotypes 23F (n = 6, 1%) and 3 (n = 3, 0.5%), respectively. Notably, the most frequent serotype in formula-fed infants (n = 300) was Serotype 23F (n = 5, 1.7%); however, Serotype 3 (n = 3, 1%) was the most frequent one in breastfed participants (n = 300). According to the findings, the overall coverage of PCV10, PCV13, and PPSV23 on the S. pneumoniae serotypes at the age of six months was 50%, 73%, and 85%, respectively. Conclusions: At this age, the type of feeding could not significantly affect the frequency rate of S. pneumoniae colonization, while the serotype distributions in the two breastfed and formula-fed groups were different.

Inflamación en el oído medio

2009 ◽  
Vol 46 (3) ◽  
Author(s):  
Oscar Porras Madrigal
Keyword(s):  
Streptococcus Pneumoniae ◽  
Costa Rica ◽  
Otitis Media

Como muchos otros niños y niñas de Costa Rica, a los 7 meses de edad presentó una otitis media aguda no supurada, con una timpanocentesis se obtuvo material que cultivo un Streptococcus pneumoniae sensible a la mayoría de las alternativas de antibióticos disponibles y recibió tratamiento por el tiempo adecuado de manos de una madre cuidadosa. Sin embargo, su oído continuo dándole problemas hasta llevarlo al Hospital Nacional de Niños con una otitis media supurada bilateral.........

scholarly journals A New Phage Lysin Isolated from the Oral Microbiome Targeting Streptococcus pneumoniae

2020 ◽  
Vol 13 (12) ◽  
pp. 478
Author(s):  
Imme van der Kamp ◽  
Lorraine A. Draper ◽  
Muireann K. Smith ◽  
Colin Buttimer ◽  
R. Paul Ross ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Multidrug Resistant ◽  
Oral Microbiome ◽  
Lytic Activity ◽  
Host Strain ◽  
Pneumococcal Infections ◽  
Highly Pathogenic ◽  
Cell Counts ◽  
Colony Forming Units ◽  
Invasive Infections

Streptococcus pneumoniae is highly pathogenic and causes several mucosal and invasive infections. Due to the rising number of multidrug-resistant (MDR) strains of S. pneumoniae, new antimicrobials with alternative mechanisms of action are urgently needed. In this study, we identified two new Streptococcal phages from the oral microbiome, 23TH and SA01. Their lysins, 23TH_48 and SA01_53, were recombinantly expressed, characterized and tested for their lethality. SA01_53 was found to only lyse its host strain of S. anginosus, while 23TH_48 was found to possess a broader lytic activity beyond its host strain of S. infantis, with several S. pneumoniae isolates sensitive to its lytic activity. 23TH_48 at a concentration of five activity units per mL (U/mL) was found to reduce cell counts of S. pneumoniae DSM 24048 by 4 log10 colony forming units per mL (CFU/mL) within 1 h and effectively prevented and destroyed biofilms of S. pneumoniae R6 at concentrations of 228.8 ng/µL and 14.3 ng/µL, respectively. Given its high lytic activity, 23TH_48 could prove to be a promising candidate to help combat pneumococcal infections.

Clinical Outcome of Invasive Infections in Children Caused by Highly Penicillin-Resistant Streptococcus pneumoniae Compared with Infections Caused by Penicillin-Susceptible Strains

2000 ◽  
Vol 31 (6) ◽  
pp. 592-598 ◽  
Author(s):  
Demóstenes Gómez-Barreto ◽  
Ernesto Calderón-Jaimes ◽  
Romeo S Rodrı́guez ◽  
Luz Elena Espinosa de los Monteros
Keyword(s):  
Streptococcus Pneumoniae ◽  
Clinical Outcome ◽  
Invasive Infections

TLR2–TLR4/CD14 polymorphisms and predisposition to severe invasive infections by Neisseria meningitidis and Streptococcus pneumoniae

2014 ◽  
Vol 38 (6) ◽  
pp. 356-362
Author(s):  
J.J. Tellería-Orriols ◽  
A. García-Salido ◽  
D. Varillas ◽  
A. Serrano-González ◽  
J. Casado-Flores
Keyword(s):  
Streptococcus Pneumoniae ◽  
Neisseria Meningitidis ◽  
Invasive Infections

Streptococcus pneumoniae Penicillin-Nonsusceptible Strains in Invasive Infections in Sao Paulo, Brazil

1996 ◽  
Vol 15 (11) ◽  
pp. 1051-1053 ◽  
Author(s):  
Eitan N. Berezin ◽  
Eduardo S. Carvalho ◽  
Silvana Casagrande ◽  
Maria Cristina Brandileone ◽  
Igor M. Mimica ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Sao Paulo ◽  
São Paulo ◽  
Invasive Infections

Invasive Streptococcus Pneumoniae Infections in Pediatric Cancer Patients: High Morbidity and Mortality with Several Vaccine Failures.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3321-3321
Author(s):  
Lynn Weber ◽  
Charlet A. Allen ◽  
Patricia Ackerman ◽  
Yoav Messinger
Keyword(s):  
Streptococcus Pneumoniae ◽  
Pediatric Oncology ◽  
Pneumococcal Infection ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Invasive Infection ◽  
Pneumococcal Infections ◽  
Oncology Patients ◽  
Invasive Infections ◽  
Invasive Pneumococcal Infection

Abstract Invasive pneumococcal infections can be devastating in the setting of immune deficiency. These infections have been seen in pediatric oncology practices, but the outcome has not been reported. With the introduction of routine 7- valent pneumococcal conjugate vaccine (PCV7) the rate of pneumococcal infections dramatically decreased in the general pediatric population. It is unclear if a similar reduction in rate would be seen in pediatric oncology patients. A total of 44 pneumococcal infections occurred in 34 oncology patients at Childrens Hospital and Clinics of Minnesota over a 5-year period (5/1/2001 – 4/30/2006). Twenty-five episodes of invasive infection were identified in 24 patients, of which 4 (16.7%) required intensive care admissions and 2 of them died (8.3%). During this period 863 new malignancies were diagnosed, therefore our rate of invasive infection is estimated to be 28 per 1000 oncology patients. This is higher than the reported rate of 3.8 8.1 infections per 1000 stem cell transplantation patients. Fifteen patients (62%) with invasive infections were diagnosed with leukemia, of which 12 had acute lymphoblastic leukemia. The invasive infections occurred a median of 15.2 months (range 0–36) after diagnosis and the median patient age at time of infection was 5.6 years (range 1.5 - 14). The average length of hospitalization for patients was 8.3 days (range 0–38), with six patients receiving outpatient therapy alone. Pneumococcal serotypes were known in 21 of the 25 episodes of invasive pneumococcal infection and in 1 non-invasive infection. Of the 22 serotypes identified, 19 were covered by either PCV7 or the 23-valent pneumococcal polysaccharide vaccine (PS23). Eleven patients who were immunized with either PCV7 or PS23 later developed a pneumococcal strain that should have been covered by the immunization. Three patients who received immunization acquired a strain of streptococcus pneumoniae not included in either vaccine. Invasive pneumococcal infection is a potentially preventable complication with a high morbidity and mortality. Use of PCV7 or PS23 may not prevent the development of pneumococcal infection in pediatric oncology patients with vaccine-susceptible strains. It is unclear whether immunization before and during the immunocompromised period results in protective immunity against streptococcus pneumoniae.

scholarly journals Molecular characterization of predominant Streptococcus pneumoniae serotypes causing invasive infections in Canada: the SAVE study, 2011–15

2018 ◽  
Vol 73 (suppl_7) ◽  
pp. vii20-vii31 ◽  
Author(s):  
Alyssa R Golden ◽  
Heather J Adam ◽  
James A Karlowsky ◽  
Melanie Baxter ◽  
Kimberly A Nichol ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Molecular Characterization ◽  
Invasive Infections
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