DEVELOPMENTAL OUTCOME OF TERM AND LATE PRE-TERM NEONATES REQUIRING THERAPEUTIC HYPOTHERMIA FOLLOWING PERINATAL HYPOXIC ISCHAEMIC ENCEPHALOPATHY.

2016 ◽  
Author(s):  
Mansoor Ahmed
Keyword(s):  
Therapeutic Hypothermia ◽  
Developmental Outcome ◽  
Term Neonates

scholarly journals Dexmedetomidine for Sedation of Neonates with HIE Undergoing Therapeutic Hypothermia: A Single-Center Experience

2018 ◽  
Vol 08 (03) ◽  
pp. e168-e173 ◽  
Author(s):  
Keliana O'Mara ◽  
Michael Weiss
Keyword(s):  
Therapeutic Hypothermia ◽  
Hypoxic Ischemic Encephalopathy ◽  
Limited Data ◽  
Single Center ◽  
Short Term ◽  
Term Neonates ◽  
Risk Of Death ◽  
Single Center Experience ◽  
Dexmedetomidine Infusion ◽  
Ischemic Encephalopathy

AbstractHypoxic-ischemic encephalopathy (HIE) is a significant cause of morbidity and mortality in neonates. Therapeutic hypothermia reduces the risk of death or disability. Providing optimal sedation while neonates are undergoing therapeutic hypothermia is likely beneficial but may present therapeutic challenges. There are limited data describing the use of dexmedetomidine for sedation in patients undergoing therapeutic hypothermia. The objective of this study is to evaluate the efficacy and short-term safety of dexmedetomidine infusion for sedation in term neonates undergoing therapeutic hypothermia for HIE.

Topical Review: Long-Term Developmental Outcome of Asphyxiated Term Neonates

2001 ◽  
Vol 16 (11) ◽  
pp. 781-792 ◽  
Author(s):  
Marie-Emmanuelle Dilenge ◽  
Annette Majnemer ◽  
Michael I. Shevell
Keyword(s):  
Developmental Outcome ◽  
Term Neonates ◽  
Topical Review

scholarly journals P.096 Optimizing the Use of Continuous EEG Monitoring in Neonatal Encephalopathy

2021 ◽  
Vol 48 (s3) ◽  
pp. S46-S47
Author(s):  
F Din ◽  
S MacFarland ◽  
D Wilson ◽  
CD Hahn
Keyword(s):  
Risk Factors ◽  
Therapeutic Hypothermia ◽  
Potential Risk ◽  
Clinical Signs ◽  
Term Neonates ◽  
Continuous Eeg ◽  
Continuous Eeg Monitoring ◽  
Potential Risk Factors ◽  
Ischemic Encephalopathy

Background: Newborns with hypoxic-ischemic encephalopathy (HIE) are at high risk for seizures, the majority of which have no clinical signs and therefore require continuous electroencephalographic (cEEG) monitoring for their detection. We sought to determine which neonates are at highest risk for seizures in order to optimize allocation of scarce cEEG resources. Methods: We identified term neonates diagnosed with HIE who underwent at least 24 hours of protocol-based cEEG monitoring between 2016 and 2019. We quantified seizure incidence, timing and burden, and correlated these with potential risk factors such as HIE severity, use of therapeutic hypothermia, preceding suspected clinical seizures, amplitude-integrated EEG (aEEG) background and patterns suspicious for seizures, and use of anti-seizure drugs. Results: cEEG monitoring was completed in 218 neonates with HIE, of whom 164 (75%) underwent therapeutic hypothermia. Preceding clinical/aEEG seizures occurred in 147 (67%), 99 (67%) of whom had been cooled but only 22 (10%) had cEEG-confirmed seizures. Characterization of seizure burden and correlation with potential risk factors is ongoing. Conclusions: Although seizures are commonly suspected in neonates with HIE, they are infrequently confirmed during cEEG monitoring, creating opportunities for more efficient risk-based allocation of cEEG resources.

scholarly journals QTc Intervals Are Prolonged in Late Preterm and Term Neonates During Therapeutic Hypothermia but Normalize Afterwards

2021 ◽  
Author(s):  
Karel Allegaert ◽  
Thomas Salaets ◽  
Robert M. Ward ◽  
Pieter Annaert ◽  
Anne Smits
Keyword(s):  
Body Temperature ◽  
Therapeutic Hypothermia ◽  
Newborn Infant ◽  
Reference Values ◽  
Qtc Interval ◽  
Neonatal Encephalopathy ◽  
Qtc Prolongation ◽  
Specific Population ◽  
Individual Values ◽  
Term Neonates

Background: There are anecdotal reports on reversible QTc prolongation during therapeutic hypothermia (TH) for moderate to severe neonatal encephalopathy after asphyxia. As the QTc interval is a relevant biomarker to assess safety during medication development, a structured search and review on published neonatal QTc values to generate reference values is warranted to facilate medication development in this specific population. Methods: A structured search and literature assessment (PubMed, Embase, Google Scholar) with ‘Newborn/Infant, QT and hypothermia’ was conducted (October 2021). Retrieved individual values were converted to QTc (Bazett) over postnatal age (day 1-7). Results: We retrieved 94 QTc intervals [during TH (n=50, until day 3) or subsequent normothermia (n=44, day 4-7)] in 33 neonates from 6 publications. The median (range) of QTc intervals during TH was 508 (430-678), and 410 (317-540) ms afterwards (difference 98 ms, or +28 ms/°C decrease). Four additional cohorts (without individual QTc intervals) confirmed the pattern and magnitude of the effect of body temperature on the QTc interval. Conclusions: We added a relevant non-maturational covariate (TH, °C dependent) and generated reference values for the QTc interval in this specific neonatal subpopulation. This knowledge on QTc during TH should be considered and integrated in neonatal medication development.

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