Predictive value of electroencephalography for developmental outcome at 6 month of age in full term neonates with seizures

Neonatal pneumonia is a serious respiratory infectious disease with a high rate of case fatality in developing countries. Salivary cytokines could serve as interesting noninvasive markers in the diagnosis of neonatal pneumonia. The aim was to assess the diagnostic role of salivary and serum interleukin-6 (IL-6), C-reactive protein/mean platelet volume (CRP/MPV) ratio, and the combination of these markers in the diagnosis of late-onset neonatal pneumonia in full-term neonates. Seventy full-term neonates, 35 with late-onset neonatal pneumonia and 35 controls, were enrolled in this prospective case-control study. Complete blood count (CBC), salivary and serum IL-6, and CRP concentrations were measured for all the study subjects. The sensitivity, specificity, positive predictive value, and negative predictive value of salivary IL-6, serum IL-6, and CRP/MPV ratio for the diagnosis of late-onset neonatal pneumonia were determined. At the cutoff point of >34 pg/ml, salivary IL-6 showed 82.86% sensitivity and 91.43% specificity. CRP/MPV ratio showed a sensitivity of 97.14% and specificity of 85.71% at a cutoff value > 0.88 . The combination of salivary IL-6 and CRP/MPV ratio improved the sensitivity and specificity to 100%. The current study shows for the first time that both salivary IL-6 and CRP/MPV ratio are suitable markers for the diagnosis of late-onset neonatal pneumonia in full-term neonates.

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Urinary N-terminal Pro-Brain Natriuretic Peptide in Newborn Infants with Cardiac and Pulmonary Diseases

American Journal of Perinatology ◽

10.1055/s-0041-1740213 ◽

2021 ◽

Author(s):

Marwa M. Elgendy ◽

Rania Salah Elzayat ◽

Mostafa Abdo ◽

Hamed M. Elsharkawy ◽

Maha Allam ◽

...

Keyword(s):

Predictive Value ◽

Congenital Heart ◽

Screening Tool ◽

Heart Diseases ◽

Full Term ◽

Congenital Heart Diseases ◽

Control Groups ◽

Term Neonates ◽

And Control ◽

Cardiac Group

Abstract Objectives The aim of this study was to assess the feasibility of urinary N-terminal pro-brain natriuretic peptide (NT-proBNP) as noninvasive screening tool for congenital heart diseases in full-term neonates with respiratory distress. Study Design A prospective cohort study was conducted on 90 full-term infants. Newborn were assigned into three groups: pulmonary, cardiac, and control groups. Urinary NT-proBNP were measured in all studied groups at day 1 (NT-proBNP1) and day 5 (NT-proBNP5). Results Urinary NT-proBNP1 was higher in cardiac group compared with pulmonary and control groups (488 ± 91, 321 ± 80, and 218 ± 41 ng/L, respectively; p ≤ 0.001). NT-proBNP5 was lower in pulmonary and control group than cardiac group (245 ± 84, 137 ± 39, and 546 ± 284 ng/L, respectively, with p ≤ 0.001). Receiver operating characteristic (ROC) analysis was performed to assess predictive value of NT-proBNP1 in cardiac and pulmonary populations. ROC showed area under curve of 0.97 and cutoff point of ≥386.5 ng/L referring to a cardiac etiology with sensitivity of 93.3%, specificity of 86.7%, negative predictive value of 93%, and positive predictive value of 88%. Conclusion Urinary NT-proBNP is feasible to be a noninvasive screening tool to predict congenital heart diseases in full-term neonates. Further studies are needed to assess the correlation between plasma and urinary levels of NT-proBNP in congenital heart diseases in full-term and preterm infants.

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DEVELOPMENTAL OUTCOME OF TERM AND LATE PRE-TERM NEONATES REQUIRING THERAPEUTIC HYPOTHERMIA FOLLOWING PERINATAL HYPOXIC ISCHAEMIC ENCEPHALOPATHY.

10.26226/morressier.57d034d3d462b80292383c95 ◽

2016 ◽

Author(s):

Mansoor Ahmed

Keyword(s):

Therapeutic Hypothermia ◽

Developmental Outcome ◽

Term Neonates

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Assessment of serum levels of vitamin B12 in full term neonates with indirect hyperbilirubinemia

Annals of Neonatology Journal ◽

10.21608/anj.2019.45667 ◽

2019 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Gamal Mohamed ◽

Reem Abdel-Salam ◽

Rabie Mortada

Keyword(s):

Vitamin B12 ◽

Serum Levels ◽

Full Term ◽

Term Neonates

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Cord Blood Alkaline Phosphatase as a predictor of Neonatal Jaundice in full term neonates

Zagazig University Medical Journal ◽

10.21608/zumj.2020.43247.1948 ◽

2020 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Samah Esmail ◽

Ali Abdo ◽

Sherief Elgebaly ◽

Marwa Mostafa

Keyword(s):

Alkaline Phosphatase ◽

Cord Blood ◽

Neonatal Jaundice ◽

Full Term ◽

Term Neonates

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Midwifery/Nursing management of hypoglycaemia in healthy full term neonates

JBI Library of Systematic Reviews ◽

10.11124/jbisrir-2003-651 ◽

2003 ◽

Vol 1 (Supplement) ◽

pp. 1-8

Keyword(s):

Full Term ◽

Nursing Management ◽

Term Neonates

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Sufentanil Disposition and Pharmacokinetic Model-Based Dosage Regimen for Sufentanil in Ventilated Full-Term Neonates

Pharmacology ◽

10.1159/000515787 ◽

2021 ◽

pp. 1-6

Author(s):

Pavla Pokorná ◽

Martin Šíma ◽

Birgit Koch ◽

Dick Tibboel ◽

Ondřej Slanař

Keyword(s):

Linear Regression ◽

Dosage Regimen ◽

Regression Models ◽

Drug Disposition ◽

Prospective Trial ◽

Full Term ◽

Pharmacokinetic Parameters ◽

Therapeutic Drug ◽

Linear Regression Models ◽

Term Neonates

Introduction: Sufentanil is a potent synthetic opioid used for analgesia in neonates; however, data concerning drug disposition of sufentanil and dosage regimen are sparse in this population. Therefore, the aim of the study was to explore sufentanil disposition and to propose optimal loading and maintenance doses of sufentanil in ventilated full-term neonates. Methods: Individual sufentanil pharmacokinetic parameters were calculated based on therapeutic drug monitoring data using a 2-compartmental model. Linear regression models were used to explore the covariates. Results: The median (IQR) central volume of distribution (Vdc) and clearance (CL) for sufentanil were 4.7 (4.1–5.4) L/kg and 0.651 (0.433–0.751) L/h/kg, respectively. Linear regression models showed relationship between Vdc (L) and GA (r2 = 0.3436; p = 0.0452) as well as BW (r2 = 0.4019; p = 0.0268). Median optimal sufentanil LD and MD were 2.13 (95% CI: 1.78–2.48) μg/kg and 0.29 (95% CI: 0.22–0.37) μg/kg/h, respectively. Median daily COMFORT-B (IQR) scores ranged from 6 to 23 while no significant relationship between pharmacokinetic parameters and COMFORT-B scores was found. Discussion/Conclusion: Body weight and gestational age were found as weak covariates for sufentanil distribution, and the dosage regimen was developed for a prospective trial.

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