Chitosan based in situ forming polyelectrolyte complexes: A potential sustained drug delivery polymeric carrier for high dose drugs

2017 ◽  
Vol 79 ◽  
pp. 491-498 ◽  
Author(s):  
Niharika Lal ◽  
Juhi Dubey ◽  
Praveen Gaur ◽  
Navneet Verma ◽  
Anurag Verma
Keyword(s):  
Drug Delivery ◽  
High Dose ◽  
Polymeric Carrier ◽  
Polyelectrolyte Complexes ◽  
Sustained Drug Delivery ◽  
In Situ Forming

scholarly journals Preparation and Investigation of Sustained Drug Delivery Systems Using an Injectable, Thermosensitive, In Situ Forming Hydrogel Composed of PLGA–PEG–PLGA

2012 ◽  
Vol 13 (2) ◽  
pp. 590-600 ◽  
Author(s):  
Elham Khodaverdi ◽  
Farnaz Sadat Mirzazadeh Tekie ◽  
Seyed Ahmad Mohajeri ◽  
Fariba Ganji ◽  
Gholamhossein Zohuri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Sustained Drug Delivery ◽  
In Situ Forming

Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy

2015 ◽  
Vol 49 ◽  
pp. 262-268 ◽  
Author(s):  
Yanbo Zhang ◽  
Jianxun Ding ◽  
Diankui Sun ◽  
Hai Sun ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Drug Delivery

In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

2007 ◽  
Vol 25 (6) ◽  
pp. 1347-1354 ◽  
Author(s):  
Heiko Kranz ◽  
Erol Yilmaz ◽  
Gayle A. Brazeau ◽  
Roland Bodmeier
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Forming

scholarly journals Dual Drug Delivery of Sorafenib and Doxorubicin from PLGA and PEG-PLGA Polymeric Nanoparticles

Polymers ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 895 ◽  
Author(s):  
György Babos ◽  
Emese Biró ◽  
Mónika Meiczinger ◽  
Tivadar Feczkó
Keyword(s):  
Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Single Agent ◽  
Double Emulsion ◽  
Controlled Drug Release ◽  
Chemical Characteristics ◽  
Solvent Evaporation Method ◽  
Polymeric Carrier ◽  
Sustained Drug Delivery ◽  
Dual Drug

Combinatorial drug delivery is a way of advanced cancer treatment that at present represents a challenge for researchers. Here, we report the efficient entrapment of two clinically used single-agent drugs, doxorubicin and sorafenib, against hepatocellular carcinoma. Biocompatible and biodegradable polymeric nanoparticles provide a promising approach for controlled drug release. In this study, doxorubicin and sorafenib with completely different chemical characteristics were simultaneously entrapped by the same polymeric carrier, namely poly(d,l-lactide-co-glycolide) (PLGA) and polyethylene glycol-poly(d,l-lactide-co-glycolide) (PEG-PLGA), respectively, using the double emulsion solvent evaporation method. The typical mean diameters of the nanopharmaceuticals were 142 and 177 nm, respectively. The PLGA and PEG-PLGA polymers encapsulated doxorubicin with efficiencies of 52% and 69%, respectively, while these values for sorafenib were 55% and 88%, respectively. Sustained drug delivery under biorelevant conditions was found for doxorubicin, while sorafenib was released quickly from the PLGA-doxorubicin-sorafenib and PEG-PLGA-doxorubicin-sorafenib nanotherapeutics.

Sign in / Sign up

Export Citation Format

Share Document