PROTON PUMP INHIBITORS AS RISK FACTOR FOR METABOLIC SYNDROME AND HEPATIC STEATOSIS IN PATIENTS WITH CELIAC DISEASE ON GLUTEN FREE-DIET

2017 ◽  
Author(s):  
Nicola Imperatore
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Celiac Disease ◽  
Hepatic Steatosis ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals Erratum to: Proton pump inhibitors as risk factor for metabolic syndrome and hepatic steatosis in coeliac disease patients on gluten-free diet

2017 ◽  
Vol 53 (4) ◽  
pp. 578-578 ◽  
Author(s):  
Nicola Imperatore ◽  
Raffaella Tortora ◽  
Anna Testa ◽  
Nicolò Gerbino ◽  
Nicola Caporaso ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Coeliac Disease ◽  
Hepatic Steatosis ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Gluten Free Diet ◽  
Gluten Free

Proton pump inhibitors as risk factor for metabolic syndrome and hepatic steatosis in coeliac disease patients on gluten-free diet

2017 ◽  
Vol 53 (4) ◽  
pp. 507-516 ◽  
Author(s):  
Nicola Imperatore ◽  
Raffaella Tortora ◽  
Anna Testa ◽  
Nicolò Gerbino ◽  
Nicola Caporaso ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Coeliac Disease ◽  
Hepatic Steatosis ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Gluten Free Diet ◽  
Gluten Free

The Gluten-Free Diet: A Nutritional Risk Factor for Adolescents with Celiac Disease?

1998 ◽  
Vol 27 (5) ◽  
pp. 519-523 ◽  
Author(s):  
Paolo Mariani ◽  
Maria Grazia Viti ◽  
Monica Montouri ◽  
Alessandra La Vecchia ◽  
Elsa Cipolletta ◽  
...  
Keyword(s):  
Risk Factor ◽  
Celiac Disease ◽  
Gluten Free Diet ◽  
Nutritional Risk ◽  
Gluten Free

scholarly journals PNPLA3 rs738409 Polymorphism Predicts Development and Severity of Hepatic Steatosis but Not Metabolic Syndrome in Celiac Disease

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1239 ◽  
Author(s):  
Raffaella Tortora ◽  
Antonio Rispo ◽  
Anna Alisi ◽  
Nicola Imperatore ◽  
Annalisa Crudele ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Celiac Disease ◽  
Hepatic Steatosis ◽  
Odds Ratio ◽  
Binary Logistic Regression ◽  
Control Group ◽  
Gluten Free ◽  
Key Factor ◽  
Severe Grade

Metabolic syndrome (MS) and hepatic steatosis (HS) have been described in patients with celiac disease (CD) after starting a gluten-free diet (GFD), but data on predictive factors for these conditions are scarce. Recently, the patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 has been identified as a key factor for HS development in the general population. The aim of the study was to evaluate the role of PNPLA3 rs738409 in the development of MS and HS in CD patients after starting GFD. Between June 2014 and September 2016, we consecutively enrolled CD patients with HS, while those without steatosis served as a control group. All patients underwent anthropometric and serologic investigations, ultrasonography (US) to assess the degree and severity of HS, and genotyping of the PNPLA3 rs738409 polymorphism. Finally, 370 subjects were enrolled (136 with and 234 without HS). At genotyping assays, the CC genotype was found in 194 subjects (52.4%), the CG genotype in 138 subjects (37.3%), and the GG genotype in 38 subjects (10.2%). At binary logistic regression, only CG and GG alleles were predictive for the development of HS (odds ratio (OR) 1.97; p < 0.01 for CG and OR 6.9; p < 0.001 for GG). Body mass index (BMI) (OR 3.8; p < 0.001) and waist circumference (OR 2.8; p = 0.03) at CD diagnosis were the only independent factors for the development of MS. Intergroup comparisons showed that the severe grade of HS was more frequently observed in GG than in CC carriers (74% vs. 11.3%, p < 0.001, OR 21.8). PNPLA3 CG and GG carriers with CD have a higher susceptibility to hepatic steatosis, but not to metabolic syndrome. Moreover, patients with GG alleles display more severe forms of HS based on ultrasound.

scholarly journals Multidimensional Disadvantages of a Gluten-Free Diet in Celiac Disease: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 643
Author(s):  
Martyna Marciniak ◽  
Aleksandra Szymczak-Tomczak ◽  
Dagmara Mahadea ◽  
Piotr Eder ◽  
Agnieszka Dobrowolska ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Celiac Disease ◽  
Lipid Metabolism ◽  
Narrative Review ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Nutritional Counselling ◽  
Glucose And Lipid Metabolism ◽  
The Metabolic Syndrome

A gluten-free diet is the mainstay method of treatment and the prevention of celiac disease complications. However, an inadequately balanced gluten-free diet can increase the risk of obesity, negatively affect glucose and lipid metabolism, and increase the risk of the metabolic syndrome. Therefore, an adequate nutritional counselling is necessary for patients diagnosed with celiac disease in order to prevent and treat the components of the metabolic syndrome.

scholarly journals Bone Mineral Density at Diagnosis of Celiac Disease and after 1 Year of Gluten-Free Diet

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Stefano Pantaleoni ◽  
Massimo Luchino ◽  
Alessandro Adriani ◽  
Rinaldo Pellicano ◽  
Davide Stradella ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Risk Factor ◽  
Celiac Disease ◽  
Bone Mineral ◽  
Dual Energy ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Mineral Density ◽  
X Ray ◽  
New Diagnosis

Atypical or silent celiac disease may go undiagnosed for many years and can frequently lead to loss of bone mineral density, with evolution to osteopenia or osteoporosis. The prevalence of the latter conditions, in case of new diagnosis of celiac disease, has been evaluated in many studies but, due to the variability of epidemiologic data and patient features, the results are contradictory. The aim of this study was to evaluate bone mineral density by dual-energy X-ray absorptiometry in 175 consecutive celiac patients at time of diagnosis (169 per-protocol, 23 males, 146 females; average age 38.9 years). Dual-energy X-ray absorptiometry was repeated after 1 year of gluten-free diet in those withT-score value <−1 at diagnosis. Stratification of patients according to sex and age showed a higher prevalence of low bone mineral density in men older than 30 years and in women of all ages. A 1-year gluten-free diet led to a significant improvement in lumbar spine and femoral neck meanT-score value. We propose that dual-energy X-ray absorptiometry should be performed at diagnosis of celiac disease in all women and in male aged >30 years, taking into account each risk factor in single patients.

A Clinical and Histochemical Study of Celiac Disease Before and During a Gluten-Free Diet

1965 ◽  
Vol 48 (2) ◽  
pp. 155-172 ◽  
Author(s):  
I. Michael Samloff ◽  
John S. Davis ◽  
Eric A. Schenk
Keyword(s):  
Celiac Disease ◽  
Histochemical Study ◽  
Gluten Free Diet ◽  
Gluten Free

Severe Alveolar Hemorrhage – What’s in it for the Gastroenterologist?

2016 ◽  
Vol 25 (4) ◽  
pp. 555-558
Author(s):  
Alina Popp
Keyword(s):  
Celiac Disease ◽  
International Normalized Ratio ◽  
Gluten Free Diet ◽  
Alveolar Hemorrhage ◽  
Severe Anemia ◽  
Gluten Free ◽  
Pulmonary Infiltrates ◽  
Pulmonary Hemosiderosis ◽  
Threatening Condition ◽  
Life Threatening

Background: Alveolar hemorrhage is a potentially life-threatening condition which is usually managed by the pulmonologist. When considering its etiology, there is a rare association that sets the disease into the hands of the gastroenterologist. Case presentation: We report the case of a 48 year-old female who was admitted to the intensive care unit for severe anemia and hemoptysis. On imaging, diffuse pulmonary infiltrates suggestive of alveolar hemorrhage were detected and a diagnosis of pulmonary hemosiderosis was made. She received cortisone therapy and hematologic correction of anemia, with slow recovery. In search of an etiology for the pulmonary hemosiderosis, an extensive workup was done, and celiac disease specific serology was found positive. After confirmation of celiac disease by biopsy, a diagnosis of Lane-Hamilton syndrome was established. The patient was recommended a gluten-free diet and at 6 months follow-up, resolution of anemia and pulmonary infiltrates were observed. Conclusion: Although the association is rare, celiac disease should be considered in a patient with idiopathic pulmonary hemosiderosis. In our case, severe anemia and alveolar infiltrates markedly improved with glucocorticoids and gluten-free diet. Abbreviations: APTT: activated partial thromboplastin time; BAL: bronchoalveolar lavage; CD: celiac disease; Cd: crypt depth; GFD: gluten-free diet; GI: gastrointestinal; IEL: intraepithelial lymphocyte; INR: international normalized ratio; IPH: idiopathic pu

Sign in / Sign up

Export Citation Format

Share Document