The value of immune factors in monitoring the risk of patients with interstitial lung disease developing into lung cancer

2018 ◽  
Author(s):  
Ge  Wu
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Immune Factors

scholarly journals Value of immune factors for monitoring risk of lung cancer in patients with interstitial lung disease

2019 ◽  
Vol 47 (7) ◽  
pp. 3344-3353
Author(s):  
Ning Li ◽  
Haisheng Hu ◽  
Ge Wu ◽  
Baoqing Sun
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Serum Levels ◽  
Scaling Analysis ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Reactive Protein ◽  
Increased Risk ◽  
Immune Factors

Objective Patients with interstitial lung disease (ILD) are at increased risk of developing lung cancer. We aimed to investigate the clinical significance of serum immune factors in this progression. Methods We retrospectively screened a hospital database from January 2012 to December 2016 for patients with lung cancer and ILD. We measured serum levels of C3, C4, IgA, IgG, IgM, C-reactive protein (CRP), ceruloplasmin (CER), and rheumatoid factor in these patients and in healthy controls. Results We analyzed data for 262 patients with lung cancer, 220 with ILD, and 57 healthy controls. CER levels were significantly higher in patients with lung cancer (0.35 ± 0.10 g/L) compared with both ILD patients (0.31 ± 0.25 g/L) and healthy individuals (0.25 ± 0.04 g/L). C3 and C4 levels were both significantly higher in healthy individuals compared with patients with lung cancer (C3: 1.70 ± 0.29 vs 1.04 ± 0.26 g/L, C4: 0.27 ± 0.24 vs 0.24 ± 0.09 g/L) and ILD (C3: 1.70 ± 0.29 vs 0.97 ± 0.25 g/L, C4: 0.27 ± 0.24 vs 0.21 ± 0.09 g/L). Optimal scaling analysis demonstrated that lung cancer was closely associated with CRP, CER, C3, and C4. Conclusions Increased levels of CRP and CER and decreased levels of C3 and C4 may identify patients with ILD at high risk of developing lung cancer.

scholarly journals Risk factors for acute exacerbation in lung cancer complicated by interstitial lung disease with slight reticular shadows

2021 ◽  
Author(s):  
Yutaka Takahara ◽  
Takuya Tanaka ◽  
Yoko Ishige ◽  
Ikuyo Shionoya ◽  
Kouichi Yamamura ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Acute Exacerbation

scholarly journals Interstitial lung disease associated with amrubicin chemotherapy in patients with lung cancer: a single institutional study

2016 ◽  
Vol 46 (7) ◽  
pp. 674-680 ◽  
Author(s):  
Yukiko Miura ◽  
Yoshinobu Saito ◽  
Kenichiro Atsumi ◽  
Susumu Takeuchi ◽  
Akihiko Miyanaga ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease

scholarly journals Lung cancer development in patients with connective tissue disease–related interstitial lung disease

Medicine ◽  
2016 ◽  
Vol 95 (50) ◽  
pp. e5716 ◽  
Author(s):  
Yasunori Enomoto ◽  
Naoki Inui ◽  
Katsuhiro Yoshimura ◽  
Koji Nishimoto ◽  
Kazutaka Mori ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Connective Tissue ◽  
Lung Disease ◽  
Connective Tissue Disease ◽  
Cancer Development

scholarly journals Safety and efficacy of carboplatin plus nab-paclitaxel for treating advanced non-small-cell lung cancer with interstitial lung disease

2017 ◽  
Vol 7 (4) ◽  
pp. 604-608 ◽  
Author(s):  
Hideyuki Niwa ◽  
Yoshiro Nakahara ◽  
Masanori Yokoba ◽  
Hisashi Mitsufuji ◽  
Jiichiro Sasaki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Small Cell Lung Cancer ◽  
Lung Disease ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Safety And Efficacy

scholarly journals P2.17-29 Is Collagen Vascular Disease-Associated Interstitial Lung Disease a High Risk for Lung Cancer Surgery?

2018 ◽  
Vol 13 (10) ◽  
pp. S864
Author(s):  
Y. Watanabe ◽  
M. Fukui ◽  
T. Matsunaga ◽  
K. Takamochi ◽  
S. Oh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
High Risk ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Vascular Disease ◽  
Lung Cancer Surgery ◽  
Cancer Surgery ◽  
Collagen Vascular Disease
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