Ruthenium(II)-Catalyzed Intermolecular Cyclo(co)trimerization of 3-Halopropiolamides with Internal Alkynes
<div>A highly chemo- and regioselective cyclo(co)trimerization between 3-halopropiolamides and symmetrical internal alkynes is reported. The reaction is catalyzed by Ru(II)-complexes and proceeds at ambient temperature in ethanol to deliver fully substituted dihalogenated isophthalamides. 1,4-Butynediol was found to undergo spontaneous lactonization with halopropiolamides after trimerization to provide 5,7-dihalo-phthalide products.</div>
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1972 ◽
Vol 30
◽
pp. 672-673
1968 ◽
Vol 26
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pp. 290-291
1968 ◽
Vol 26
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pp. 266-267
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1993 ◽
Vol 140
(4)
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pp. 305
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