scholarly journals Dynamics of Holter electrocardiogram monitoring in patients with chronic heart failure and atrial fibrillation on the background of cardiac contractility modulation

2021 ◽  
Vol 93 (9) ◽  
pp. 1044-1051
Author(s):  
Alfiya A. Safiullina ◽  
Tatiana M. Uskach ◽  
Yulduz S. Sharapova ◽  
Anatolii G. Kochetov ◽  
Oleg V. Sapelnikov ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Chronic Heart Failure ◽  
Cardiac Arrhythmias ◽  
Cardiac Contractility ◽  
Reverse Remodeling ◽  
Ecg Monitoring ◽  
Cardiac Contractility Modulation ◽  
Optimal Drug

Aim. To evaluate the dynamics of cardiac arrhythmias on the background of cardiac contractility modulation (MCC) in patients with chronic heart failure (CHF) and various forms of atrial fibrillation (AF) on the basis of daily electrocardiogram (ECG) monitoring. Materials and methods. In 100 patients with CHF and AF, the following studies were performed before implantation of the MCC device and after 12 months of follow-up: 12-channel ECG with an estimate of the width of the QRS complex, transthoracic echocardiography (EchoCG), and Holter ECG monitoring. All patients received long-term optimal drug therapy for CHF before surgery. Results. The results obtained indicate that there is no effect of MCC on the development and progression of ventricular arrhythmias in patients with CHF and AF during the year of follow-up, both extrasystole and tachyarrhythmias, regardless of the etiology and LVEF (less than 35% or more than 35%), and a decrease in the frequency of AF paroxysms in patients with CHF during treatment. These results are due to the reverse remodeling of the LV myocardium under the influence of the MCC device. Conclusion. The use of MСС in patients with CHF and AF is a safe method of therapy that does not induce cardiac arrhythmias, including ventricular extrasystole. Large-scale comparative studies are required to evaluate these results.

scholarly journals Implantation of a cardiac contractility modulator in chronic heart failure and atrial fibrillation: results of a 6-month follow-up of one hundred patients

2021 ◽  
Vol 23 (1) ◽  
pp. 30-37
Author(s):  
T. M. Uskach ◽  
O. V. Sapelnikov ◽  
A. A. Safiullina ◽  
I. R. Grishin ◽  
V. A. Amanatova ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Chronic Heart Failure ◽  
Cardiac Contractility ◽  
Treatment Method ◽  
Functional Class ◽  
Life Questionnaire ◽  
Medication Therapy ◽  
6 Minute Walk Test

Aim: to study the effect of cardiac contractility modulation (CCM) in patients with chronic heart failure (CHF) and atrial fibrillation (AF). Materials and methods. In a group of 100 patients with CHF and AF, the following studies were performed before implantation of the CCM and after 6 months of follow-up: 12-channel ECG, transthoracic Echocardiography, 6-minute walk test, determination of the level of pro-natriuretic N-terminal peptide (NT-proBNP), and a questionnaire based on the Minnesota quality of life questionnaire for patients with CHF (MHFLQ). All patients received long-term optimal medication therapy for CHF before surgery. Results. The results show a positive effect of the use of MCC in patients with CHF and AF on reverse LV remodeling, functional class of CHF, and levels of NT-pro-BNP regardless of the form of AF. Conclusion. The use of MCC may be a promising treatment method in addition to optimal medication therapy in patients with CHF and AF.

scholarly journals New approaches to assessing the contractile function of the left ventricular in patients with heart failure on the background of modulation of cardiac contractility.

2020 ◽  
pp. 4-13
Author(s):  
А.А. Сафиуллина ◽  
Т.М. Ускач ◽  
М.А. Саидова ◽  
С.В. Добровольская ◽  
С.Н. Терещенко
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Chronic Heart Failure ◽  
Left Ventricle ◽  
Left Atrium ◽  
Contractile Function ◽  
Cardiac Contractility ◽  
Left Ventricular ◽  
Reverse Remodeling ◽  
Heart Contractility

Обзор посвящен роли современной трансторакальной эхокардиографии и новому способу неинвазивной оценки сократительной функции левого желудочка – исследованию эффективности миокардиальной работы у пациентов хронической сердечной недостаточностью. Освещаются актуальные аспекты ремоделирования левого желудочка и левого предсердия у данной категории пациентов. Обсуждается роль и важность метода спекл-трекинг эхокардиографии в оценке механической функции левого предсердия. Представлены сведения об относительно новом электрофизиологическом методе лечения - модуляции сердечной сократимости у пациентов с хронической сердечной недостаточностью, как с фибрилляцией предсердий, так и без нее. Анализируются результаты обратного ремоделирования левого желудочка по данным эхокардиографических параметров основных исследований, посвященных модуляции сердечной сократимости. В статье оцениваются перспективы применения метода оценки эффективности миокардиальной работы левого желудочка как инструмента возможного обратного ремоделирования у пациентов с хронической сердечной недостаточностью и фибрилляцией предсердий на фоне модуляции сердечной сократимости The review is devoted to the role of modern transthoracic echocardiography and a new method of non-invasive assessment of left ventricular contractile function-the study of the effectiveness of myocardial work in patients with chronic heart failure. The current aspects of left ventricle and left atrium remodeling in this category of patients are highlighted. The role and importance of speckle-tracking echocardiography in evaluating the mechanical function of the left atrium is discussed. Information is provided about a relatively new electrophysiological method of treatment-modulation of heart contractility in patients with chronic heart failure, both with and without atrial fibrillation. The results of reverse remodeling of the left ventricle are analyzed according to the echocardiographic parameters of the main studies devoted to the modulation of heart contractility. The article assesses the prospects for using the method of evaluating the effectiveness of left ventricular myocardial function as a tool for possible reverse remodeling in patients with chronic heart failure and atrial fibrillation against the background of heart contractility modulation

scholarly journals Modulation of cardiac contractility in patients with chronic heart failure and atrial fibrillation

2020 ◽  
Vol 92 (9) ◽  
pp. 8-14
Author(s):  
T. M. Uskach ◽  
A. A. Safiullina ◽  
O. V. Sapel’nikov ◽  
V. A. Amanatova ◽  
O. A. Nikolaeva ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Chronic Heart Failure ◽  
Cardiac Contractility ◽  
Functional Class ◽  
Life Questionnaire ◽  
Optimal Drug ◽  
6 Minute Walk Test

Aim.to evaluate the effectiveness of cardiac contractility modulation (MSS) in patients with chronic heart failure (CHF) and atrial fibrillation (AF). Materials and methods.The following studies were performed in 40 patients with CHF and AF before implantation of the MSS device and after 2 and 6 months of follow-up: 12-channel ECG, transthoracic EchoCG, 6-minute walk test, determination of the level of Pro-natriuretic N-terminal peptide (NT-proBNP), daily ECG monitoring, and a questionnaire based on the Minnesota quality of life questionnaire for patients with CHF (MHFLQ). All patients received long-term optimal drug therapy for CHF before surgery. Results.The results obtained indicate a statistically significant positive effect of the use of MSS in patients with CHF and AF on LV FV, the functional class of CHF, and levels of NT-proBNP regardless of the etiology of CHF. Conclusion.The use of MSS may be promising for the treatment of heart failure in patients with CHF and AF.

scholarly journals Two-year follow-up of patients with heart failure with reduced ejection fraction receiving cardiac contractility modulation

2020 ◽  
Vol 25 (7) ◽  
pp. 3853
Author(s):  
M. A. Vander ◽  
E. A. Lyasnikova ◽  
L. A. Belyakova ◽  
M. A. Trukshina ◽  
V. L. Galenco ◽  
...  
Keyword(s):  
Heart Failure ◽  
Independent Predictor ◽  
Nyha Class ◽  
Cardiac Contractility ◽  
Composite Endpoint ◽  
Class Ii ◽  
Cardiac Contractility Modulation ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure

Aim. To assess the 2-year prognosis of patients with heart failure with reduced ejection fraction (HFrEF) receiving cardiac contractility modulation (CCM).Material and methods. This single-center observational study included 55 patients (46 men, mean age 53±11 years) with NYHA class II-III HFrEF receiving optimal medical therapy, with sinus rhythm, QRS <130 ms or QRS<150 ms with nonspecific intraventricular conduction delay. NYHA class II and III were established in 76% and 24% of patients, respectively. All patients were implanted with CCM devices between October 2016 and September 2017. Follow-up visits were carried out every 3 months during the 1st year and every 6 months during the 2nd year of observation. The primary composite endpoint was mortality and heart transplantation. Secondary composite endpoints included death, heart transplantation, paroxysmal ventricular tachycardia/ ventricular fibrillation, hospitalizations due decompensated HFResults. The one-year and two-year survival rate was 95% and 80%, respectively. Primary endpoint was observed in 20% of patients. NYHA class III and higher levels of N-terminal pro-brain natriuretic peptide (NTproBNP) were associated with unfavorable prognosis (p=0,014 and p=0,026, respectively). NTproBNP was an independent predictor of survival (p=0,018). CCM contributed to a significant decrease in hospitalizations due to decompensated HF (p<0,0001). The secondary endpoint was observed in 18 (33%) of patients during the 1st year. The predictor for the secondary composite endpoint was NTproBNP (p=0,047).Conclusion. CCM is associated with a significant decrease in hospitalization rate due to decompensated HF. The 2-year survival rate of patients with NYHA class II-III HF receiving CCM was 80%. The NTproBNP level was an independent predictor of survival in patients receiving CMM for 2 years. Further longer-term studies of the CCM efficacy are required.

Sign in / Sign up

Export Citation Format

Share Document