scholarly journals Cardiovascular risk factors in people with high normal blood pressure in Russian population (based on data obtained in ESSE-RF epidemiological study)

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Yu.E. Efremova ◽  
E.V. Oshchepkova ◽  
Yu.V. Zhernakova
2017 ◽  
Vol 14 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Yu E Efremova ◽  
E V Oshchepkova ◽  
Yu V Zhernakova ◽  
I E Chazova ◽  
E B Iarovaia ◽  
...  

Introduction. High normal blood pressure (HNBP) is reported to result in arterial hypertension (AH), especially when associated with various risk factors. Still only few studies on HNBP prevalence in Russian population have been carried out. Objective. To study the prevalence of HNBP and its association with age, gender, and traditional cardiovascular risk factors (CVRFs) in adult population of 12 regions of Russia. The study is based on data obtained in ESSE-RF (Epidemiology of Cardiovascular Diseases in Different Regions of Russian Federation) study. Materials and methods. The analysis of data obtained in ESSE-RF study, which included 21 887 patients aged 25-64 years, was performed. The group of patients not taking antihypertensive and/or statin therapy (n=12 897, 41 % male, 59% female) was selected for the analysis. The patients were divided into 3 groups according to blood pressure (BP) levels. The first group included 7095 patients with normal BP, the second group included 2415 patients with HNBP (130-139/85-89 mmHg), the third - 3387 patients with AH. A detailed analysis of CVRFs was performed, including family history, obesity, diabetes mellitus (DM), ischemic heart disease (IHD), low density lipoprotein (LDL) and cholesterol levels, and glucose level. Results. The prevalence of HNBP was 19% (22% in male population, 16% in female). The prevalence rates were higher in younger age male groups (< 45 years); in female groups the prevalence rates correlated with age. The patients with HNBP had more CVRFs than ones with normal BP. According to multivariant analysis, HNBP was associated with obesity with odds ratio (OR) from 1.32, (95% confidence interval [CI]), to 1.7 (95% CI); gender with OR from 1.54 (95% CI) to 3.89 (95% CI); high LDL and cholesterol levels, and high glucose levels. No direct relation between HNBP and positive family history, DM or IHD was found. Conclusion: The study demonstrates that HNBP is a relevant issue in Russia that requires further research. It also illustrates the necessity of targeting the individuals with HNBP in order to control CVRFs.


2020 ◽  
Vol 34 (4) ◽  
pp. 101-111
Author(s):  
O. N. Antropova ◽  
S. B. Silkina ◽  
I. V. Osipova ◽  
T. L. Smyshlyaeva ◽  
I. V. Batanina

2009 ◽  
Vol 27 (1) ◽  
pp. 102-108 ◽  
Author(s):  
Simona Bo ◽  
Roberto Gambino ◽  
Luigi Gentile ◽  
Gianfranco Pagano ◽  
Rosalba Rosato ◽  
...  

Author(s):  
Pēteris Apinis ◽  
Vilnis Dzērve ◽  
Anda Čakša ◽  
Iveta Bajāre ◽  
Andrejs Ērglis

Abstract The present review is designed to provide insight into population-based investigations of cardiovascular risk factors in Latvia. Most of them represent urban, rural and mixed populations. The results are age-standardised using the European Standard Population. All of the studies confirm a high prevalence of cardiovascular risk factors with wide differences across the studies. The differences are not consistent or regular and some of the underlying reasons are discussed. Analysis of the previous studies justifies the need for a nationwide cross-sectional epidemiological study, which in a small country can be carried out in compliance with all the requirements for a population-based epidemiological study.


1995 ◽  
Vol 48 (1) ◽  
pp. 75-88 ◽  
Author(s):  
Chen-Huan Chen ◽  
Jen-Hsiang Chuang ◽  
Hsu-Sung Kuo ◽  
Mau-Song Chang ◽  
Shih-Pu Wang ◽  
...  

Biomolecules ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 192 ◽  
Author(s):  
Moritz Koriath ◽  
Christian Müller ◽  
Norbert Pfeiffer ◽  
Stefan Nickels ◽  
Manfred Beutel ◽  
...  

(1) Background: Telomeres are repetitive DNA sequences located at the extremities of chromosomes that maintain genetic stability. Telomere biology is relevant to several human disorders and diseases, specifically cardiovascular disease. To better understand the link between cardiovascular disease and telomere length, we studied the effect of relative telomere length (RTL) on cardiovascular risk factors in a large population-based sample. (2) Methods: RTL was measured by a real-time quantitative polymerase chain reaction in subjects of the population-based Gutenberg Health Study (n = 4944). We then performed an association study of RTL with known cardiovascular risk factors of smoking status as well as systolic and diastolic blood pressure, body mass index (BMI), LDL cholesterol, HDL cholesterol, and triglycerides. (3) Results: A significant correlation was shown for RTL, with age as a quality control in our study (effect = −0.004, p = 3.2 × 10−47). Analysis of the relation between RTL and cardiovascular risk factors showed a significant association of RTL in patients who were current smokers (effect = −0.016, p = 0.048). No significant associations with RTL were seen for cardiovascular risk factors of LDL cholesterol (p = 0.127), HDL cholesterol (p = 0.713), triglycerides (p = 0.359), smoking (p = 0.328), diastolic blood pressure (p = 0.615), systolic blood pressure (p = 0.949), or BMI (p = 0.903). In a subsequent analysis, we calculated the tertiles of RTL. No significant difference across RTL tertiles was detectable for BMI, blood pressure, lipid levels, or smoking status. Finally, we studied the association of RTL and cardiovascular risk factors stratified by tertiles of age. We found a significant association of RTL and LDL cholesterol in the oldest tertile of age (effect = 0.0004, p = 0.006). (4) Conclusions: We determined the association of relative telomere length and cardiovascular risk factors in a population setting. An association of telomere length with age, current smoking status, as well as with LDL cholesterol in the oldest tertile of age was found, whereas no associations were observed between telomere length and triglycerides, HDL cholesterol, blood pressure, or BMI.


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