scholarly journals Vitamin D and multiple sclerosis

2021 ◽  
Vol 23 (2) ◽  
pp. 165-169
Author(s):  
Viktoriia R. Cheredanova ◽  
◽  
Ivan A. Chabin ◽  
Raisa Ts. Bembeeva ◽  
◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Vitamin D ◽  
Nervous System ◽  
Autoimmune Disease ◽  
Young People ◽  
Clinical Course ◽  
Current Data ◽  
Vitamin D Levels ◽  
The Central Nervous System

Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system and is a major cause of disability in able-bodied young people. Recently, the question of the effect of vitamin D on the risk of occurrence and clinical course of MS has been widely discussed. The review presents pathogenesis of this disease and estimated mechanisms of the effect of cholecalciferol on it, current data on the effect of vitamin D levels on the risk of MS, the course and outcome of this disease.

Immune and Infectious Diseases

2018 ◽  
pp. 430-470
Author(s):  
Andrea C. Adams
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Young People ◽  
Connective Tissue ◽  
Infectious Diseases ◽  
Temporal Profile ◽  
Immune Mediated ◽  
The Central Nervous System ◽  
The Common

Many immune-mediated diseases and infections affect the central and peripheral nervous systems. The common feature that characterizes both immune-mediated diseases and infections is a subacute temporal profile. Immune-mediated disease can affect only the nervous system or involve the nervous system as part of a systemic illness, as in vasculitis and connective tissue disease. Multiple sclerosis (MS), the most common disabling neurologic illness of young people, is the prototypical immune-mediated disease of the central nervous system (CNS).

The Immunobiology of Multiple Sclerosis: An Autoimmune Disease of the Central Nervous System

1999 ◽  
Vol 6 (3) ◽  
pp. 149-166 ◽  
Author(s):  
Paul Conlon ◽  
Jorge R. Oksenberg ◽  
Jingwu Zhang ◽  
Lawrence Steinman
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Autoimmune Disease ◽  
The Central Nervous System

scholarly journals Multiple Sclerosis

2020 ◽  
Author(s):  
Amirhossein Azari Jafari ◽  
Seyyedmohammadsadeq Mirmoeeni
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Optic Nerve ◽  
Autoimmune Disease ◽  
The Central Nervous System ◽  
Genetic And Environmental Factors ◽  
Chronic Autoimmune Disease ◽  
The Brain

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), caused by genetic and environmental factors. It is characterized by intermittent and recurrent episodes of inflammation that result in the demyelination and subsequent damage of the underlying axons present in the brain, optic nerve and spinal cord [1][2][3].

scholarly journals Erythrocytes in multiple sclerosis – forgotten contributors to the pathophysiology?

2016 ◽  
Vol 2 ◽  
pp. 205521731664998
Author(s):  
Kira Groen ◽  
Vicki E Maltby ◽  
Katherine A Sanders ◽  
Rodney J Scott ◽  
Lotti Tajouri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Autoimmune Disease ◽  
Genetic Predisposition ◽  
Immune Cells ◽  
Lymphocytic Infiltration ◽  
Disease Modifying Therapies ◽  
The Central Nervous System ◽  
Disease Modifying

Multiple sclerosis (MS) is an autoimmune disease characterised by lymphocytic infiltration of the central nervous system and subsequent destruction of myelin and axons. On the background of a genetic predisposition to autoimmunity, environmental triggers are assumed to initiate the disease. The majority of MS research has focused on the pathological involvement of lymphocytes and other immune cells, yet a paucity of attention has been given to erythrocytes, which may play an important role in MS pathology. The following review briefly summarises how erythrocytes may contribute to MS pathology through impaired antioxidant capacity and altered haemorheological features. The effect of disease-modifying therapies on erythrocytes is also reviewed. It may be important to further investigate erythrocytes in MS, as this could broaden the understanding of the pathological mechanisms of the disease, as well as potentially lead to the discovery of novel and innovative targets for future therapies.

scholarly journals Vitamin D and neurospecific proteins in children with inflammatory demyelinating diseases of central nervous system

2019 ◽  
Vol 10 (3) ◽  
pp. 17-24
Author(s):  
Marina A. Bukhalko ◽  
Elena Yu. Skripchenko ◽  
Lidiya A. Alekseeva ◽  
Nataliya V. Skripchenko ◽  
Nina E. Monakhova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Vitamin D ◽  
Nervous System ◽  
Blood Serum ◽  
Inflammatory Diseases ◽  
Disease Course ◽  
Neurospecific Proteins ◽  
Autoimmune Pathology ◽  
Vitamin D Levels ◽  
The Central Nervous System

The relevance of studying the provision of vitamin D in children with inflammatory diseases of the central nervous system (CNS) is due to a high prevalence of vitamin D deficiency conditions in children population, which, according to current literature data, leads to the imbalance of the immune system and a predisposition to a severe disease course, chronization of the process, development of autoimmune pathology. The study of the concentration of neurospecific proteins (NSP) in blood serum and cerebrospinal fluid (CSF) has been recently used to analyze the degree and nature of nervous tissue damage in case of various CNS diseases. The study included investigation of blood serum and CSF samples obtained from 107 children (34 – with encephalitis, 28 – with disseminated encephalomyelitis (DEM), 20 – with multiple sclerosis (MS), 25 – control group). Determination of vitamin D levels (25(OH)D) was performed by the method of electrochemiluminescence immunoassay, concentrations of myelin basic protein, neuron-specific enolase, S100 protein and glial fibrillary acidic protein – by ELISA method. A decrease in the concentration of vitamin D under 30 ng/ml was found in 95% of children with inflammatory diseases of the central nervous system, while the severity of the deficiency of 25(OH)D was associated with the severity of the disease course. In the early stages of the disease in all groups, a significant increase in the level of the main myelin protein was found, while an increase in the concentration of other NSP was observed less frequently and was associated with a severe and complicated course of the disease. Correlations of different intensity and direction between NSP and 25(OH)D were found, which indicates their importance in the pathogenesis of inflammatory diseases of CNS.

scholarly journals Vitamin D and Multiple Sclerosis-Is there a Link?

2019 ◽  
Vol 25 (2) ◽  
pp. 61-63
Author(s):  
Cioabla Anabella-Cristiana ◽  
Adumitresi Cecilia ◽  
Radulescu Ninela ◽  
Ion Ileana
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Vitamin D ◽  
Vitamin D Intake ◽  
Vitamin D Levels ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
Genetic And Environmental Factors ◽  
25 Oh Vitamin D ◽  
Relapsing Remitting Multiple Sclerosis

Abstract Multiple sclerosis is a chronic demyelinating and inflammatory disease affecting the central nervous system. The etiology is unknown. The risk of MS is influenced by genetic and environmental factors. One environmental factor for MS is vitamin D deficiency. (1) The connection between multiple sclerosis, and vitamin D levels is not completely known. According to many studies, subjects with insufficient vitamin D intake or low 25- OH vitamin D concentration are at higher risk for MS. The fact that vitamin D is implicated in the course of MS is indicated by the indirect correlation between vitamin D concentration and the activity of the disease, revealed by many studies. (3) In this study we intend to determin how the concentration of 25-OH vitamin D is correlated with relapsing remitting multiple sclerosis.

scholarly journals Some modern methods of diagnosis and pathogenetic therapy of multiple sclerosis

2002 ◽  
Vol XXXIV (1-2) ◽  
pp. 65-72
Author(s):  
I. D. Stolyarov ◽  
G. N. Bisaga ◽  
M. V. Votintseva ◽  
A. G. Ilves ◽  
I. G. Nikiforova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Chronic Disease ◽  
Young People ◽  
Neurological Disease ◽  
Genetically Engineered ◽  
Modern Methods ◽  
Pathogenetic Therapy ◽  
The Central Nervous System

Multiple sclerosis (MS) is a severe chronic disease of the central nervous system (CNS) that affects young people and quickly leads to disability. Until now, the pathogenesis of this neurological disease, which is the most expensive for society, has not been fully elucidated, and the drugs used to treat MS patients can only slightly suspend but not interrupt the development of the disease. At the same time, the possibilities of diagnosing and treating MS have expanded due to the active study and implementation of neuroimaging, neuroimmunological and neurophysiological methods, and the use of new immunocorrecting genetically engineered drugs.

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