scholarly journals Therapy of bronchial asthma in children: age-related aspects

2021 ◽  
pp. 113-122
Author(s):  
Natalia A. Geppe ◽  
Elena G. Kondiurina ◽  
Vera A. Reviakina ◽  
Aleksandr B. Malakhov ◽  
Natalia G. Kolosova
Keyword(s):  
Bronchial Asthma ◽  
Low Dose ◽  
Clinical Symptoms ◽  
Bronchial Obstruction ◽  
Shortness Of Breath ◽  
Treatment And Prevention ◽  
Age Related ◽  
Asthma In Children ◽  
Global Initiative ◽  
Effective Drugs

Bronchial asthma (BA) is a disease that is one of the most frequent chronic diseases of childhood. Characteristic clinical symptoms of BA are wheezing, cough, difficulty in breathing, shortness of breath and, of course, recurrent episodes of bronchial obstruction. They require mandatory clarification of family and individual allergoanamnesis, assessment of symptoms, differential diagnosis with other diseases that may occur with BA. The Global Initiative for the Treatment and Prevention of Bronchial Asthma (GINA 20202021) preserves and develops the ageappropriate approach to verification of diagnosis and therapy selection, which is supported in the Russian National Program "Bronchial Asthma in Children" and in the Russian clinical guidelines "Bronchial Asthma 2021 When the diagnosis of BA is made, therapy should be started as early as possible. Administration of low-dose inhaled glucocorticosteroids (IGCS) immediately after the diagnosis allows not only to control the inflammatory process, which is the basis of BA, but also to reduce the severity of exacerbations. IGCS are the most effective drugs for children of any age, they ensure control of the disease and reduce the risk of AD exacerbations.

scholarly journals FEATURES OF CLINICAL SYMPTOMS AND THE INFLUENCE OF RISK FACTORS ON THE OCCURRENCE OF BRONCHIAL ASTHMA IN CHILDREN OF LVIV REGION OF DIFFERENT AGES

2021 ◽  
pp. 96-101
Author(s):  
O. R. Trutiak ◽  
O. L. Lychkovska ◽  
R. R. Holovyn ◽  
M. I. Dats-Opoka
Keyword(s):  
Risk Factors ◽  
Preschool Children ◽  
Bronchial Asthma ◽  
Clinical Symptoms ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Physical Development ◽  
Shortness Of Breath ◽  
Different Ages ◽  
Asthma In Children

Bronchial asthma (BA) is a common chronic pathology of the lower respiratory tract in children. The first manifestations of the disease can begin at any age, but the clinical features, of the course, are different in different periods of childhood. Manifestations and course of asthma may disappear or progress with age. Therefore, it is likely that there are differences in the pathophysiology, inflammatory response of the body and the features of the clinic of asthma in children of different ages, which affects the diagnosis and treatment. The aim of the study was to determine the features of clinical symptoms and the influence of risk factors for asthma on its occurrence in children of different ages. Materials and methods. We analyzed the anamnesis and clinical symptoms of 57 children aged 3 to 18 years, who were treated from September 2020 to June 2021 in the Lviv Regional Children's Clinical Hospital “OHMATDYT” and in the Lviv Municipal City Children's Clinical Hospital. The age groups did not differ statistically in the severity of asthma (P> 0.05). Thus, in group 1 was 1 patient (9.09%) with mild form, 1 patient (9.09%) - moderate persistent form, 8 patients (72.73%) - with severe persistent form. Among patients of age group 2 was 1 patient (3.85%) with mild persistent form, 3 children (11.54%) - moderate and 21 children (80.77%) - with severe persistent form. In group 3 was 1 patient (5%) with a mild persistent form, 6 patients (30%) - moderate and 12 children (80%) - with a severe persistent form. The vast majority of patients were boys (84.21 ± 4.83%). All patients underwent general clinical examinations, spirometry, and allergy tests. We used the clinical-anamnestic method to perform the tasks of the work, which consisted in collecting a detailed somatic and genealogical anamnesis during the parents` questionnaire. Physical development of children was assessed using centile tables. Statistics were evaluated by calculating Student's t-test and Pearson's consistency test. Preschool children with asthma were more likely to experience shortness of breath during exercise and a wet low-yielding cough, and children of primary and secondary school age were more characterized by concomitant allergic rhinitis. Autumn was more unfavorable period for the exacerbation of clinical manifestations of asthma in children of Lviv region was period. We did not find correlation of birth weight on the timing of asthma. However, a burdensome obstetric history contributed to the early development of clinical manifestations of asthma. Preschool children were more likely to be exposed to nicotine during the antenatal period and had a shorter duration of breastfeeding, which may be a probable risk factor for asthma in preschool children. In 77% of children from different age groups were burdened with a history of allergies, with 66% of cases more pronounced in the maternal line. An analysis of physical development revealed that most preschool children were overweight. Conclusions. Asthma has features of clinical symptoms in children of different ages - shortness of breath during exercise and whooping cough are characteristic of preschool children, and concomitant chronic persistent rhinitis - for older age groups. Seasonal exacerbations are characteristic of asthma in children; in particular, the autumn period is more unfavorable, common for asthmatics in children of all ages among patients in Lviv region. Maternal smoking during pregnancy has a significant effect on the risk of developing asthma in children. Also, a burdened maternal allergy history and overweight child contributes to the development of asthma in children.

scholarly journals Childhood asthma – how to recognize and treat?

Alergoprofil ◽  
2021 ◽  
Vol 17 (2) ◽  
pp. 10-17
Author(s):  
Zbigniew Doniec ◽  
Mariusz Woźniak ◽  
Kamila Woźniak ◽  
Adam J. Sybilski ◽  
Agnieszka Mastalerz-Migas
Keyword(s):  
Clinical Improvement ◽  
Childhood Asthma ◽  
Clinical Symptoms ◽  
Inhalation Therapy ◽  
Bronchial Obstruction ◽  
Shortness Of Breath ◽  
Asthma Treatment ◽  
Variable Intensity ◽  
Asthma In Children ◽  
Chronic Use

Asthma in children up to 5 years of age is a disease that is diagnosed on the basis of the clinical symptoms of bronchial obstruction, such as: wheezing, cough and shortness of breath of variable intensity and duration, clinically proven reversibility of obstruction and clinical improvement after chronic use of inhaled glucocorticosteroids and lack of grounds for suspecting causes of obstruction other than asthma. Treatment of childhood asthma is a graded therapy with a range of intensity to control the course of the disease and the main form of treatment is inhalation therapy. During the COVID-19 pandemic, it is necessary to continue treatment in accordance with the previously adopted principles, including the use of inhaled glucocorticosteroids.

scholarly journals CHARACTERIZATION OF VEGETATIVE CHANGES IN BRONCHIAL ASTHMA OF VARIOUS SEVERITIES IN CHILDREN

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Hurmatoy Khankeldieva ◽  
Ibrohim Alimjanov ◽  
Habiba Negmatshaeva ◽  
Mavjuda Abdullaeva ◽  
Temur Tojiboev ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bronchial Asthma ◽  
Clinical Course ◽  
Allergic Inflammation ◽  
Treatment And Prevention ◽  
Lowered Sensitivity ◽  
Asthma In Children ◽  
Barrier Tissues ◽  
Significant Factors

This article presents a study of the state of vegetative balance and prognostic possibilities of quantitative parameters of functional activity of VNS to estimate a state of bodily adaptive reserves in children with severe BA. Bronchial asthma, being one of the most common chronic diseases in childhood, requires further research into predisposing and causally-significant factors, mechanisms of pathogenesis and peculiarities of a clinical course, improvement of methods of diagnostics, treatment, and prevention. Great importance in the development of bronchial asthma in children is given to genetically-fixed functional insufficiency of barrier tissues of the respiratory system, increased ability to synthesize allergic antibodies and produce certain cytokines, high bronchopulmonary sensitivity to mediators of allergic inflammation, lowered sensitivity of 3g-adrenoreceptors to endogenous catecholamins, changes in immunologic responsiveness, and disorder of neuroendocrinal regulation of immune responses. Implementation of genetic predisposition to bronchial asthma development is promoted by influence of adverse environmental factors.

scholarly journals ON THE OPTIMIZATION OF VERIFICATION OF BRONCHIAL ASTHMA IN CHILDREN WITH MANIFESTATIONS OF BRONCHOOBSTRUCTIVE SYNDROME

2018 ◽  
pp. 55-60
Author(s):  
O. K. Koloskova ◽  
L. A. Ivanova ◽  
T. M. Bilous ◽  
L. V. Mykaliuk
Keyword(s):  
Family History ◽  
Bronchial Asthma ◽  
Immunoglobulin E ◽  
Nitrogen Monoxide ◽  
Allergic Diseases ◽  
First Episode ◽  
Bronchial Obstruction ◽  
Neutrophil Granulocytes ◽  
History Of ◽  
Asthma In Children

Bronchial asthma in children has different causes of development, and examination of markers to verify the disease in case of the first signs of bronchial obstruction is an important issue to find transitory or persisting asthma phenotypes. There were examined 156 children with signs of bronchial obstruction syndrome.They were divided into three clinical groups: the first (І) group included 36 children with acute obstructive bronchitis (average age 6,1 ± 0,6 years, 36 % of girls), the second (ІІ) group – 74 children with relapsing obstructive bronchitis (average age 5,60 ± 0,34 years, 38 % of girls), the third (ІІІ) group included 46 children suffering from bronchial asthma for two years (average age 11,6 ± 0,5 years, 33 % of girls).The family history of one of the parents and of both parents, aggravated by allergic diseases, was most often found in patients with bronchial asthma: in 34,8 % of children on maternal side (Р ˂ 0,05 with І, ІІ : ІІІ), in 17,4 % of cases on paternal side (Р ˃ 0,05) and in 4,3 % – on both sides (Р ˃ 0,05). Patients suffering from bronchial asthma in 78,3 % of cases demonstrated domestic, food or medical allergy, that was reliably higher than that of an appropriate number of children in І (33,3 %) and ІІ groups (37,2 %), Р ˂ 0,05. In case of complicated family anamnesis with allergic diseases and the level of nitrogen monoxide metabolites more than 40 µmol/l the diagnostic value of this test in detection of bronchial asthma is the following: sensitivity 87,5 %, specificity 89,5 %, predicted value of a negative result 97,1 % with realization odds ratio 59,5, relative risk 22,3. Relative blood eosinophilia (Р ˂ 0,05 with ІІІ : І, ІІ) and sputum eosinophilia (Р ˂ 0,05 with ІІІ : І, ІІ) in children suffering from bronchial asthma as compared to the patients with obstructive bronchitis were found. In patients with verified asthma compared with children with acute and recurrent obstructive bronchitis, a significantly higher number of eosinophils, alveolar macrophages and epithelial cells in sputum is observed, which is accompanied by a lower content of neutrophil granulocytes and lymphocytes.Thus, in children with bronchial obstruction, even at its first episode, to identify the risk of bronchial asthma, a family history should be carefully collected on the burden of allergic diseases, the history of the child on allergic manifestations, in the dynamics to determine the number of eosinophils in the peripheral blood and induced sputum, the level serum immunoglobulin E and the content of metabolites of nitric oxide in the condensate of exhaled air.

scholarly journals Rational therapy of asthma in children with inhaled corticosteroids

2016 ◽  
Vol 1 (1) ◽  
pp. 63-67
Author(s):  
N. A. Geppe ◽  
N. G. Kolosova ◽  
S. I. Shatalina
Keyword(s):  
Bronchial Asthma ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
Initial Therapy ◽  
Rational Therapy ◽  
Asthma In Children ◽  
Effective Drugs

Currently, the most effective drugs for the treatment and management of bronchial asthma (BA) are inhaled corticosteroids (ICS) which, according to global guidelines, are indicated as initial therapy for persistent asthma of any severity.

scholarly journals ON THE OPTIMIZATION OF VERIFICATION OF BRONCHIAL ASTHMA IN CHILDREN WITH MANIFESTATIONS OF BRONCHOOBSTRUCTIVE SYNDROME

2018 ◽  
pp. 55-60
Author(s):  
O. K. Koloskova ◽  
L. A. Ivanova ◽  
T. M. Bilous ◽  
L. V. Mykaliuk
Keyword(s):  
Family History ◽  
Bronchial Asthma ◽  
Immunoglobulin E ◽  
Nitrogen Monoxide ◽  
Allergic Diseases ◽  
First Episode ◽  
Bronchial Obstruction ◽  
Neutrophil Granulocytes ◽  
History Of ◽  
Asthma In Children

Bronchial asthma in children has different causes of development, and examination of markers to verify the disease in case of the first signs of bronchial obstruction is an important issue to find transitory or persisting asthma phenotypes. There were examined 156 children with signs of bronchial obstruction syndrome.They were divided into three clinical groups: the first (І) group included 36 children with acute obstructive bronchitis (average age 6,1 ± 0,6 years, 36 % of girls), the second (ІІ) group – 74 children with relapsing obstructive bronchitis (average age 5,60 ± 0,34 years, 38 % of girls), the third (ІІІ) group included 46 children suffering from bronchial asthma for two years (average age 11,6 ± 0,5 years, 33 % of girls).The family history of one of the parents and of both parents, aggravated by allergic diseases, was most often found in patients with bronchial asthma: in 34,8 % of children on maternal side (Р ˂ 0,05 with І, ІІ : ІІІ), in 17,4 % of cases on paternal side (Р ˃ 0,05) and in 4,3 % – on both sides (Р ˃ 0,05). Patients suffering from bronchial asthma in 78,3 % of cases demonstrated domestic, food or medical allergy, that was reliably higher than that of an appropriate number of children in І (33,3 %) and ІІ groups (37,2 %), Р ˂ 0,05. In case of complicated family anamnesis with allergic diseases and the level of nitrogen monoxide metabolites more than 40 µmol/l the diagnostic value of this test in detection of bronchial asthma is the following: sensitivity 87,5 %, specificity 89,5 %, predicted value of a negative result 97,1 % with realization odds ratio 59,5, relative risk 22,3. Relative blood eosinophilia (Р ˂ 0,05 with ІІІ : І, ІІ) and sputum eosinophilia (Р ˂ 0,05 with ІІІ : І, ІІ) in children suffering from bronchial asthma as compared to the patients with obstructive bronchitis were found. In patients with verified asthma compared with children with acute and recurrent obstructive bronchitis, a significantly higher number of eosinophils, alveolar macrophages and epithelial cells in sputum is observed, which is accompanied by a lower content of neutrophil granulocytes and lymphocytes.Thus, in children with bronchial obstruction, even at its first episode, to identify the risk of bronchial asthma, a family history should be carefully collected on the burden of allergic diseases, the history of the child on allergic manifestations, in the dynamics to determine the number of eosinophils in the peripheral blood and induced sputum, the level serum immunoglobulin E and the content of metabolites of nitric oxide in the condensate of exhaled air.

The Use of Dry Carbon Dioxide Baths in the Medical Rehabilitation of Children with Various Diseases

2020 ◽  
Vol 98 (4) ◽  
pp. 62-70
Author(s):  
Y.V. Nikityuk ◽  
M.A. Khan ◽  
N.A. Mikitchenko ◽  
I.I. Ivanova ◽  
A.V. Dedurina
Keyword(s):  
Carbon Dioxide ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Clinical Symptoms ◽  
Respiratory Infections ◽  
Allergic Inflammation ◽  
Medical Rehabilitation ◽  
Health Improvement ◽  
Bronchial Obstruction ◽  
Acute Respiratory Diseases

The purpose of this article is systematization and analysis of the results of studies on the effectiveness of using dry carbon dioxide baths in the medical rehabilitation of children with various diseases. Dry carbon dioxide baths allow to dose carbon dioxide during the procedure. The method eliminates the hydrostatic component and excludes the penetration of carbon dioxide into the respiratory tract during the procedure. The article presents the main aspects of the formation of the mechanism of the therapeutic action of dry carbon dioxide baths in bronchial asthma, atopic dermatitis, vegetative dystonia syndrome, health improvement of children who often suffer from acute respiratory diseases. The use of dry carbon dioxide bath in medical rehabilitation of children with bronchial asthma helps to reduce the intensity of allergic inflammation, bronchial obstruction, the frequency of exacerbations of the disease. The use of SUV in atopic dermatitis in children allows you to stop or reduce the manifestations of the main clinical symptoms of the disease, improves the psycho-emotional state of the child. The effectiveness of dry carbonic bath in the vegetative dystonia is shown (mainly in the sympathicotonic type). The improvement of autonomic regulation and the reduction of tension in the work of the sympathetic department of the autonomic nervous system have been established. The application of dry carbon dioxide bath in sickly children helps to reduce clinical symptoms of acute respiratory infections, improves mucosal immunity, and reduces the frequency of recurrent infections throughout the year.

scholarly journals The Role Of The Nurse In The Prevention Of Bronchial Asthma In Children

2021 ◽  
Vol 03 (05) ◽  
pp. 34-40
Author(s):  
Jamilakhon Erkinovna Kamilova ◽  
Keyword(s):  
Bronchial Asthma ◽  
Childhood Diseases ◽  
Child Population ◽  
Asthma In Children ◽  
Effective Drugs ◽  
Timely Treatment

The relevance of the topic is determined by the increase in morbidity among the child population. Bronchial asthma is one of the most common childhood diseases, a formidable complication of which is asthmatic status, as well as the fact that the timely treatment of the disease, taking into account its severity and characteristics, the use of modern effective drugs are the key to the success of therapy, allow you to quickly stabilize the child's condition and further control bronchial asthma.

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