scholarly journals The role of systemic inflammation in the pathogenesis of insulin resistance and metabolic syndrome in patients with chronic hepatitis C

2018 ◽  
Vol 90 (11) ◽  
pp. 24-31
Author(s):  
L.I. TKACHENKO ◽  
◽  
V.V. MALEEV ◽  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Systemic Inflammation

scholarly journals The role of systemic inflammation in the pathogenesis of insulin resistance and metabolic syndrome in patients with chronic hepatitis C

2018 ◽  
Vol 90 (11) ◽  
pp. 24-31
Author(s):  
L I Tkachenko ◽  
V V Maleev
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Iron ◽  
Homa Index ◽  
Nonspecific Inflammation

The systemic inflammatory response plays a key role in the development of atherosclerosis, insulin resistance (IR) and diabetes mellitus 2-type (diabetes mellitus). IR in patients with chronic hepatitis C (CHC) is considered as a possible factor in the progression of fibrosis, a predictor of the development of DM T2 and a component of the metabolic syndrome. The use of biomarkers of non-specific inflammation can be a valuable tool for assessing the risks of IR and cardiovascular diseases in patients with chronic hepatitis C. Aim of the study. To determine the role of nonspecific inflammation in the formation of IR and metabolic syndrome in patients with chronic hepatitis C. Materials and methods. The study included 205 patients with CHC aged 18 to 69 years. Patients with CHC are randomized into two groups depending on the presence of IR: group 1 - patients with a HOMA index ≥2.77, which corresponded to IR (n=110); group 2 (n=95). The levels of serum iron, C-reactive protein (CRP), serum ferritin and adipose tissue hormones [leptin, resistin, adiponectin and tumor necrosis factor-α (TNF-α)] were additionally investigated. Results. At all stages of development of IR, nonspecific inflammation was detected (according to ferritin, CRP and serum iron), increasing with increasing HOMA index [Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR)] (Matthews D., 1985), metabolic syndrome and its components. In the analysis of indicators in patients with chronic hepatitis C with a body mass index

scholarly journals Chronic hepatitis c genotype-4 infection: role of insulin resistance in hepatocellular carcinoma

2011 ◽  
Vol 8 (1) ◽  
Author(s):  
Amal A Mohamed ◽  
Samah A Loutfy ◽  
James D Craik ◽  
Abdel Gawad M Hashem ◽  
Ibrahem Siam
Keyword(s):  
Hepatocellular Carcinoma ◽  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Genotype 4

495 Steatosis and fibrosis in chronic hepatitis C: Relative role of lipid peroxidation, leptinemia and insulin resistance

2004 ◽  
Vol 40 ◽  
pp. 146
Author(s):  
A. Muzzi ◽  
G. Leandro ◽  
L. Rubbia-Brandt ◽  
R. James ◽  
O. Keiser ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Peroxidation ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Relative Role

scholarly journals Insulin resistance and chronic hepatitis C

2016 ◽  
Vol 88 (11) ◽  
pp. 29-36
Author(s):  
L I Tkachenko ◽  
V V Maleev
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Comparison Group ◽  
The Impact

Aim. To estimate the spread of insulin resistance (IR) in patients with chronic hepatitis C (CHC) and to define the role of IR in the development of hepatic steatosis (HS) and in the progression of liver fibrosis (LF), as well as the impact of IR on the results of antiviral therapy (AVT). Subjects and methods. A total of 211 patients with CHC were examined. A comparison group consisted of 75 patients with chronic hepatitis B (CHB). The patients were divided according to the presence and absence of IR and type 2 diabetes mellitus (DM). IR was analyzed in patients with CHC with a body mass index (BMI) of

scholarly journals Hepatitis C Virus-Infected Patients Are ‘Spared’ from the Metabolic Syndrome but Not from Insulin Resistance. A Comparative Study of Nonalcoholic Fatty Liver Disease and Hepatitis C Virus-Related Steatosis

2009 ◽  
Vol 23 (4) ◽  
pp. 273-278 ◽  
Author(s):  
Amedeo Lonardo ◽  
Stefano Ballestri ◽  
Luigi E Adinolfi ◽  
Enrico Violi ◽  
Lucia Carulli ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
The Metabolic Syndrome

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C feature steatosis and insulin resistance (IR), conditions associated with the metabolic syndrome (MS).OBJECTIVES: To assess the prevalence of MS and determinants of IR in patients with NAFLD and chronic hepatitis C.METHODS: Ninety-three consecutive patients with NAFLD, 97 with chronic hepatitis C virus (HCV) genotypes 1 and 2, and 182 ‘healthy’ controls without steatosis were enrolled in the present study. The prevalence of MS was assessed by modified Adult Treatment Panel III criteria and IR by the homeostasis model assessment of insulin resistance (HOMA-IR). IR was defined as the 75th percentile of the HOMA-IR of control subjects.RESULTS: While the prevalence of IR was similar in NAFLD and HCV-infected subjects (70.0% and 78.7%, respectively), the prevalence of MS was significantly higher in NAFLD patients than in HCV-infected patients (27.9% versus 4.1%) and in controls (5.6%). With multivariate analysis, IR was predicted by body mass index (OR 1.263; 95% CI 1.078 to 1.480) and triglyceridemia (OR 1.011; 95% CI 1.002 to 1.020) in NAFLD and by sex (OR for female sex 0.297; 95% CI 0.094 to 0.940) and fibrosis stage (OR 2.751; 95% CI 1.417 to 5.340) in chronic hepatitis C.CONCLUSIONS: IR is independently associated with body mass index and triglyceridemia in NAFLD, sex and fibrosis in chronic HCV infection, and has a higher prevalence in NAFLD and chronic hepatitis C than in controls. However, the frequency of MS in HCV-infected patients, similar to that of controls, is significantly lower than that seen in NAFLD patients. The current diagnostic criteria of MS are more likely to ‘capture’ patients with NAFLD than with chronic hepatitis C, although both groups are insulin resistant.

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