scholarly journals Blood pressure and lipid profiles improvement in patients with obesity after lifestyle intervention-induced weight loss

2021 ◽  
pp. 0
Author(s):  
Inês Barros ◽  
Mariana Barbosa ◽  
Sara Lopes ◽  
Cláudia Matta-Coelho ◽  
Ana Monteiro ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Lifestyle Intervention ◽  
Lipid Profiles

scholarly journals Lifestyle Intervention Enabled by Mobile Technology on Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: Randomized Controlled Trial (Preprint)

2019 ◽  
Author(s):  
Su Lin Lim ◽  
Jolyn Johal ◽  
Kai Wen Ong ◽  
Chad Yixian Han ◽  
Yiong Huak Chan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Fatty Liver ◽  
Lifestyle Intervention ◽  
Controlled Trial ◽  
Intervention Group ◽  
Mobile App ◽  
Control Group ◽  
Nonalcoholic Fatty Liver ◽  
Randomized Controlled

BACKGROUND The prevalence of nonalcoholic fatty liver disease (NAFLD) reaches up to 30% in the Asian adult population, with a higher prevalence in obese patients. Weight reduction is typically recommended for patients at high risk or diagnosed with NAFLD, but is a challenge to achieve. OBJECTIVE We aimed to evaluate the effect of a lifestyle intervention with a mobile app on weight loss in NAFLD patients. METHODS This prospective randomized controlled trial included 108 adults with NAFLD confirmed by steatosis on ultrasound and a body mass index ≥23 kg/m<sup>2</sup> who were recruited from a fatty liver outpatient clinic. The patients were randomly allocated to either a control group (n=53) receiving standard care, consisting of dietary and lifestyle advice by a trained nurse, or an intervention group (n=55) utilizing the Nutritionist Buddy (nBuddy) mobile app in addition to receiving dietary and lifestyle advice by a dietitian. Body weight, alanine aminotransferase (ALT), aspartate aminotransferase (AST), waist circumference, and blood pressure were measured at baseline, and then at 3 and 6 months. Intention-to-treat and per-protocol analyses were used for statistical comparisons. RESULTS The intervention group had a 5-fold higher likelihood (relative risk 5.2, <i>P</i>=.003, 95% CI 1.8-15.4) of achieving ≥5% weight loss compared to the control group at 6 months. The intervention group also showed greater reductions in weight (mean 3.2, SD 4.1 kg vs mean 0.5, SD 2.9 kg; <i>P</i>&lt;.001), waist circumference (mean 2.9, SD 5.0 cm vs mean –0.7, SD 4.4 cm; <i>P</i>&lt;.001), systolic blood pressure (mean 12.4, SD 14.8 mmHg vs mean 2.4, SD 12.4 mmHg; <i>P</i>=.003), diastolic blood pressure (mean 6.8, SD 8.9 mmHg vs mean –0.9, SD 10.0 mmHg; <i>P</i>=.001), ALT (mean 33.5, SD 40.4 IU/L vs mean 11.5, SD 35.2 IU/L; <i>P</i>=.004), and AST (mean 17.4, SD 27.5 U/L vs mean 7.4, SD 17.6 IU/L, <i>P</i>=.03) at 6 months. CONCLUSIONS Lifestyle intervention enabled by a mobile app can be effective in improving anthropometric indices and liver enzymes in patients with NAFLD. This treatment modality has the potential to be extended to a larger population scale. CLINICALTRIAL Australian New Zealand Clinical Trials Registry ACTRN12617001001381; https://tinyurl.com/w9xnfmp

scholarly journals Lifestyle Intervention Enabled by Mobile Technology on Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: Randomized Controlled Trial

10.2196/14802 ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. e14802
Author(s):  
Su Lin Lim ◽  
Jolyn Johal ◽  
Kai Wen Ong ◽  
Chad Yixian Han ◽  
Yiong Huak Chan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Fatty Liver ◽  
Lifestyle Intervention ◽  
Controlled Trial ◽  
Intervention Group ◽  
Mobile App ◽  
Control Group ◽  
Nonalcoholic Fatty Liver ◽  
Randomized Controlled

Background The prevalence of nonalcoholic fatty liver disease (NAFLD) reaches up to 30% in the Asian adult population, with a higher prevalence in obese patients. Weight reduction is typically recommended for patients at high risk or diagnosed with NAFLD, but is a challenge to achieve. Objective We aimed to evaluate the effect of a lifestyle intervention with a mobile app on weight loss in NAFLD patients. Methods This prospective randomized controlled trial included 108 adults with NAFLD confirmed by steatosis on ultrasound and a body mass index ≥23 kg/m2 who were recruited from a fatty liver outpatient clinic. The patients were randomly allocated to either a control group (n=53) receiving standard care, consisting of dietary and lifestyle advice by a trained nurse, or an intervention group (n=55) utilizing the Nutritionist Buddy (nBuddy) mobile app in addition to receiving dietary and lifestyle advice by a dietitian. Body weight, alanine aminotransferase (ALT), aspartate aminotransferase (AST), waist circumference, and blood pressure were measured at baseline, and then at 3 and 6 months. Intention-to-treat and per-protocol analyses were used for statistical comparisons. Results The intervention group had a 5-fold higher likelihood (relative risk 5.2, P=.003, 95% CI 1.8-15.4) of achieving ≥5% weight loss compared to the control group at 6 months. The intervention group also showed greater reductions in weight (mean 3.2, SD 4.1 kg vs mean 0.5, SD 2.9 kg; P<.001), waist circumference (mean 2.9, SD 5.0 cm vs mean –0.7, SD 4.4 cm; P<.001), systolic blood pressure (mean 12.4, SD 14.8 mmHg vs mean 2.4, SD 12.4 mmHg; P=.003), diastolic blood pressure (mean 6.8, SD 8.9 mmHg vs mean –0.9, SD 10.0 mmHg; P=.001), ALT (mean 33.5, SD 40.4 IU/L vs mean 11.5, SD 35.2 IU/L; P=.004), and AST (mean 17.4, SD 27.5 U/L vs mean 7.4, SD 17.6 IU/L, P=.03) at 6 months. Conclusions Lifestyle intervention enabled by a mobile app can be effective in improving anthropometric indices and liver enzymes in patients with NAFLD. This treatment modality has the potential to be extended to a larger population scale. Trial Registration Australian New Zealand Clinical Trials Registry ACTRN12617001001381; https://tinyurl.com/w9xnfmp

scholarly journals Effect of Lifestyle Intervention on Features of Polycystic Ovarian Syndrome, Metabolic Syndrome, and Intima-Media Thickness in Obese Adolescent Girls

2011 ◽  
Vol 96 (11) ◽  
pp. 3533-3540 ◽  
Author(s):  
Nina Lass ◽  
Michaela Kleber ◽  
Katrin Winkel ◽  
Rainer Wunsch ◽  
Thomas Reinehr
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Lifestyle Intervention ◽  
Adolescent Girls ◽  
Polycystic Ovarian Syndrome ◽  
Intima Media Thickness ◽  
Obese Adolescent ◽  
Media Thickness ◽  
The Impact ◽  
Ovarian Syndrome

Abstract Context: Polycystic ovarian syndrome (PCOS) is associated with cardiovascular risk factors (CRF). Lifestyle intervention is regarded as therapy of choice even if studies in adolescent girls with PCOS are scarce. Objective: Our objective was to analyze the impact of lifestyle intervention on menses irregularities, hyperandrogenemia, CRF, and intima-media thickness (IMT) in adolescent girls with PCOS. Patients: Patients included 59 obese girls with PCOS aged 12–18 yr. Intervention: Intervention was a 1-yr lifestyle intervention based on nutrition education, exercise training, and behavior therapy. Main Outcome Measures: Menses cycles, IMT, waist circumference, blood pressure, fasting lipids, insulin, glucose, testosterone, dehydroepiandrosterone sulfate, androstenedione, and SHBG were evaluated. Results: In contrast to the 33 girls without weight loss, the 26 girls reducing their body mass index during the lifestyle intervention (by a mean of −3.9 kg/m2) improved most CRF and decreased their IMT (by a mean of −0.01 cm). Testosterone concentrations decreased (by a mean of −0.3 nmol/liter) and SHBG concentrations increased (by a mean of +8 ng/ml) significantly in girls with weight loss in contrast to girls with increasing weight. The prevalence of amenorrhea (−42%) and oligoamenorrhea (−19%) decreased in the girls with weight loss. The changes in insulin in the 1-yr follow-up were significantly correlated to changes in testosterone (r = 0.38; P = 0.002) and SHBG (r = −0.35; P = 0.048). A linear regression model with changes in IMT as dependent variable demonstrated a significant association with changes in blood pressure and weight status but not with changes in testosterone. Conclusions: Weight loss due to lifestyle intervention is effective to treat menses irregularities, normalize androgens, and improve CRF and IMT in obese adolescent girls with PCOS.

Abstract P235: Employing the DASH Diet to Treat Non-dippers: A Two-month Intervention Study

Hypertension ◽  
2015 ◽  
Vol 66 (suppl_1) ◽  
Author(s):  
Arjun K Pandey
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Lifestyle Intervention ◽  
Pressure Pattern ◽  
Dash Diet ◽  
Circadian Blood Pressure ◽  
Nocturnal Blood Pressure ◽  
Blood Pressure Patterns ◽  
The Impact ◽  
Diet And Lifestyle

Introduction: Hypertensive patients with abnormal circadian blood pressure patterns, including a lack of nocturnal blood pressure dipping or rises in blood pressure from daytime to night-time, are at an increased risk for numerous cardiovascular events including strokes, heart failure and renal failure. Currently, limited therapeutic strategies exist to treat non-dippers. In this study, we examine the role of obesity on circadian blood pressure patterns and the impact of lifestyle intervention on nocturnal dip. Methodology: 24-hour ambulatory blood pressure monitoring was performed before and after a 2-month intervention employing the DASH diet and lifestyle program with a targeted 5% weight loss in 80 volunteers. 20 control patients had a healthy nocturnal dip, 30 patients had a non-dipping blood pressure pattern, and 30 patients had a rise in blood pressure nocturnally from daytime. Results: At baseline, there was a linear correlation between individuals' BMI and nocturnal blood pressure aberrancies (r= 0.60, p<0.0001). The control group had the lowest average BMI of 28.1 kg/m2. Non-dippers had a slightly higher average BMI of 30.3 kg/m2, and those with a rise in blood pressure nocturnally had the greatest average BMI of 35.3 kg/m2. After the two-month lifestyle intervention, individuals who achieved weight loss had significantly greater average reductions in nocturnal blood pressure (24.3 mm Hg), compared to daytime (12.1 mm Hg), resulting in the restoration of a more normal nocturnal dip and circadian blood pressure pattern. Non-dippers who achieved a 5% reduction in weight during the intervention had an average 8.31% nocturnal dip by the end of the study. Individuals who lost less than 5% of their weight or who gained weight continued to have a non-dipping blood pressure pattern by the end of the study. Conclusions: The results of this study would suggest that perhaps reducing weight by adhering to the DASH diet and lifestyle intervention could be examined as therapeutic avenues for non-dippers in the future. The long-term effects of a restoration of normal circadian blood pressure pattern warrants further investigation.

scholarly journals Long-Term Weight Loss From Lifestyle Intervention Benefits Blood Pressure?

Hypertension ◽  
2009 ◽  
Vol 54 (4) ◽  
pp. 756-762 ◽  
Author(s):  
Lorna Aucott ◽  
Helen Rothnie ◽  
Linda McIntyre ◽  
Mohan Thapa ◽  
Charles Waweru ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Lifestyle Intervention

742-P: Magnitude of A1C Improvement in Relation to Weight Loss after Intensive Lifestyle Intervention in Real-World Diabetes Practice: Thirteen Years of Observation

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 742-P
Author(s):  
AHMED H. ELDIB ◽  
SHAHEEN TOMAH ◽  
ADHAM MOTTALIB ◽  
SAHAR ASHRAFZADEH ◽  
OSAMA HAMDY
Keyword(s):  
Weight Loss ◽  
Lifestyle Intervention ◽  
Real World ◽  
Intensive Lifestyle Intervention

Improvement of Insulin Sensitivity Contributes to Blood Pressure Reduction After Weight Loss in Hypertensive Subjects With Obesity

Hypertension ◽  
1996 ◽  
Vol 27 (5) ◽  
pp. 1180-1186 ◽  
Author(s):  
Toshio Ikeda ◽  
Tomoko Gomi ◽  
Nobuhito Hirawa ◽  
Jun Sakurai ◽  
Nori Yoshikawa
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Insulin Sensitivity ◽  
Blood Pressure Reduction ◽  
Pressure Reduction

scholarly journals Bariatric Surgery vs Lifestyle Intervention for Diabetes Treatment: 5-Year Outcomes From a Randomized Trial

2020 ◽  
Vol 105 (3) ◽  
pp. 866-876 ◽  
Author(s):  
Anita P Courcoulas ◽  
James W Gallagher ◽  
Rebecca H Neiberg ◽  
Emily B Eagleton ◽  
James P DeLany ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Lifestyle Intervention ◽  
Controlled Trial ◽  
The United States ◽  
Diabetes Remission ◽  
University Of Pittsburgh ◽  
Lifestyle Treatment ◽  
Surgical Treatments ◽  
The University

Abstract Context Questions remain about bariatric surgery for type 2 diabetes mellitus (T2DM) treatment. Objective Compare the remission of T2DM following surgical or nonsurgical treatments. Design, setting, and participants Randomized controlled trial at the University of Pittsburgh, in the United States. Five-year follow-up from February 2015 until June 2016. Interventions 61 participants with obesity and T2DM who were initially randomized to either bariatric surgical treatments (Roux-en-Y gastric bypass [RYGB] or laparoscopic adjustable gastric banding [LAGB]) or an intensive lifestyle weight loss intervention (LWLI) program for 1 year. Lower level lifestyle weight loss interventions (LLLIs) were then delivered for 4 years. Main Outcomes and Measures Diabetes remission assessed at 5 years. Results The mean age of the patients was 47 ± 6.6 years, 82% were women, and 21% African American. Mean hemoglobin A1c level 7.8% ± 1.9%, body mass index (BMI) 35.7 ± 3.1 kg/m2, and 26 participants (43%) had BMI &lt; 35 kg/m2. Partial or complete T2DM remission was achieved by 30% (n = 6) of RYGB, 19% (n = 4) of LAGB, and no LWLI participants (P = .0208). At 5 years those in the RYGB group had the largest percentage of individuals (56%) not requiring any medications for T2DM compared with those in the LAGB (45%) and LWLI (0%) groups (P = .0065). Mean reductions in percent body weight at 5 years was the greatest after RYGB 25.2% ± 2.1%, followed by LAGB 12.7% ± 2.0% and lifestyle treatment 5.1% ± 2.5% (all pairwise P &lt; .01). Conclusions Surgical treatments are more effective than lifestyle intervention alone for T2DM treatment.

Long-term effects (>24 months) of multiple lifestyle intervention on major cardiovascular risk factors among high risk subjects: a meta-analysis

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
H Bergum ◽  
I Sandven ◽  
TO Klemsdal
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Systolic Blood Pressure ◽  
Total Cholesterol ◽  
Cardiovascular Risk Factors ◽  
Lifestyle Intervention ◽  
Small Study ◽  
Long Term Effects

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Norwegian health department Background The evidence of the long-term effects of multiple lifestyle intervention on cardiovascular risk is uncertain. We aimed to summarize the evidence from randomized clinical trials examining the efficacy of lifestyle intervention on major cardiovascular risk factors in subjects at high cardiovascular risk. Methods  Eligible trials investigated the impact of lifestyle intervention versus usual care with minimum 24 months follow-up, reporting more than one major cardiovascular risk factor. A literature search updated April 15, 2020 identified 12 eligible studies. The results from individual trials were combined using fixed and random effect models, using the standardized mean difference (SMD) to estimate effect sizes. Small-study effect was evaluated, and heterogeneity between studies examined by subgroup and meta-regression analyses considering patient- and study-level variables. Results  Small-study effect was not identified. Lifestyle intervention reduced systolic blood pressure modestly with an estimated SMD of -0.13, 95% confidence interval (CI): -0.21 to -0.04, with moderate heterogeneity (I² = 59%), corresponding to a mean difference of approximately 2 mmHg (MD = -1.86, 95% CI: -3.14 to -0.57, p = 0.0046). This effect disappeared in the subgroup of trials judged at low risk of bias (SMD = 0.02, 95% CI: -0.08 to 0.11). For the outcome total cholesterol SMD was -0.06, 95% CI: -0.13 to 0.00, with no heterogeneity (I² = 0%), indicating no effect of the intervention. Conclusion  Lifestyle intervention resulted in only a modest effect on systolic blood pressure and no effect on total cholesterol after 24 months. Further lifestyle trials should consider the challenge of maintaining larger long-term benefits to ensure impact on cardiovascular outcomes.

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