The issue of enhancing regional innovation and investment development is one of the important elements of the development of the Russian economy in the realities of the modern economy. Like any economic process, investment and innovation regional development depends on many factors with varying degrees of influence. Existing domestic studies provide a different range of influencing factors and do not determine the degree of this impact on the innovative and investment development of regions. In the works, where economic calculations are presented, there is also a question of choice as a resultant and explanatory indicators. The purpose of this article is to identify the factors influencing the investment and innovative development of the constituent entities of the Russian Federation. In the course of the study, an econometric model of innovative and investment development of the constituent entities of the Russian Federation was built. Modeling was carried out using the Gretl 1.9.11 software product using the least squares method. The model includes factors that, for the most part, were not used in the study of innovation and investment development using mathematical modeling. A number of factors have been replaced with more appropriate ones or taking into account more activities. As a result of the tests carried out, the model can be recognized as correct and is a theoretical proof of the existence of a relationship between the volume of produced innovative goods, works and services in the country and specific economic indicators.